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2020 24
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129 results

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Repurposing Drugs for Infectious Diseases by Graph Convolutional Network with Sensitivity-Based Graph Reduction.
Yue R, Dutta A. Yue R, et al. Interdiscip Sci. 2024 Dec 4. doi: 10.1007/s12539-024-00672-5. Online ahead of print. Interdiscip Sci. 2024. PMID: 39630350
This cost-effective pipeline focuses on computational methods for drug repurposing, targeting infectious diseases such as Zika virus and COVID-19 infection. Applied to these infections, our methodology integrates 659 proteins and 703 drugs for Zika virus, and 495 pr …
This cost-effective pipeline focuses on computational methods for drug repurposing, targeting infectious diseases such as Zika virus and …
Identifying Mechanism of RSV for the Treatment of COVID-19 and Idiopathic Pulmonary Fibrosis via Suppressing Inflammation Response Through IL-17 Signaling Pathway from the Perspectives of in silico Study.
Wang J, Shi J, Jia N, Sun Q. Wang J, et al. Curr Med Chem. 2024 Oct 11. doi: 10.2174/0109298673308841240930044555. Online ahead of print. Curr Med Chem. 2024. PMID: 39400013
BACKGROUND: Both coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis (IPF) could cause severe pulmonary injury and have extremely dismal prognoses with a high risk of mortality. ...OBJECTIVE: The purpose of this research was to investigate the uncl …
BACKGROUND: Both coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis (IPF) could cause severe pulmonary inju …
Exploration of the link between COVID-19 and gastric cancer from the perspective of bioinformatics and systems biology.
Ma X, Huang T, Li X, Zhou X, Pan H, Du A, Zeng Y, Yuan K, Wang Z. Ma X, et al. Front Med (Lausanne). 2024 Sep 20;11:1428973. doi: 10.3389/fmed.2024.1428973. eCollection 2024. Front Med (Lausanne). 2024. PMID: 39371335 Free PMC article.
BACKGROUND: Coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has caused a global pandemic. Gastric cancer (GC) poses a great threat to people's health, which is a …
BACKGROUND: Coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus …
Kaempferol as a novel inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase.
Medoro A, Benedetti F, Intrieri M, Jafar TH, Ali S, Trung TT, Passarella D, Ismail S, Zella D, Scapagnini G, Davinelli S. Medoro A, et al. J Biomol Struct Dyn. 2024 Sep 11:1-10. doi: 10.1080/07391102.2024.2402695. Online ahead of print. J Biomol Struct Dyn. 2024. PMID: 39258938
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly become a global health pandemic. Among the viral proteins, RNA-dependent RNA polymerase (RdRp) is responsible for viral genome replication and has emerged as a promising target against …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly become a global health pandemic. Among the vir …
COVID-19-Associated Sepsis: Potential Role of Phytochemicals as Functional Foods and Nutraceuticals.
de Souza Goncalves B, Sangani D, Nayyar A, Puri R, Irtiza M, Nayyar A, Khalyfa A, Sodhi K, Pillai SS. de Souza Goncalves B, et al. Int J Mol Sci. 2024 Aug 3;25(15):8481. doi: 10.3390/ijms25158481. Int J Mol Sci. 2024. PMID: 39126050 Free PMC article. Review.
The inflammatory cytokine storm accompanied by an imbalance in the pro-inflammatory and anti-inflammatory host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to severe and critical septic shock. The sepsis signature i …
The inflammatory cytokine storm accompanied by an imbalance in the pro-inflammatory and anti-inflammatory host response to severe acute resp …
Beneficial Effects on Exercise Capacity Associated with a Combination of Lactoferrin, Lysozyme, Lactobacillus, Resveratrol, Vitamins, and Oligoelements in Patients with Post-COVID-19 Syndrome: A Single-Center Retrospective Study.
Marra AM, Giardino F, Anniballo A, Ferazzoli S, Salzano A, Arcopinto M, D'Assante R, De Mare A, Esposito G, Saldamarco L, Rurgo S, Sarnelli G, Cittadini A. Marra AM, et al. J Clin Med. 2024 Jul 29;13(15):4444. doi: 10.3390/jcm13154444. J Clin Med. 2024. PMID: 39124710 Free PMC article.
Background/Objectives: Although long-term COVID-19 symptoms are common, little is known about the management of post-COVID-19 condition. The aim of the current report is to evaluate the effects of a combination of lactoferrin, lysozyme, lactobacillus, …
Background/Objectives: Although long-term COVID-19 symptoms are common, little is known about the management of post-COVID …
An integrated bioinformatics approach reveals the potential role of microRNA-30b-5p and let-7a-5p during SARS CoV-2 spike-1 mediated neuroinflammation.
Pawar P, Akolkar K, Saxena V. Pawar P, et al. Int J Biol Macromol. 2024 Oct;277(Pt 4):134329. doi: 10.1016/j.ijbiomac.2024.134329. Epub 2024 Aug 7. Int J Biol Macromol. 2024. PMID: 39098684 Free article.
SARS-CoV-2 induced neuroinflammation contributing to neurological sequelae is one of the critical outcomes of long-COVID, however underlying regulatory mechanisms involved therein are poorly understood. ...Thus, targeting of these microRNAs and/or thei …
SARS-CoV-2 induced neuroinflammation contributing to neurological sequelae is one of the critical outcomes of long-C …
Investigation of the relationship between COVID-19 and pancreatic cancer using bioinformatics and systems biology approaches.
Fang C, Sun H, Wen J, Wu X, Wu Q, Zhai D. Fang C, et al. Medicine (Baltimore). 2024 Aug 2;103(31):e39057. doi: 10.1097/MD.0000000000039057. Medicine (Baltimore). 2024. PMID: 39093763 Free PMC article.
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, poses a huge threat to human health. ...CONCLUSION: This study unveils potential shared pathogenic me …
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 ( …
Phytochemicals in antiviral drug development against human respiratory viruses.
Mehta SK, Pradhan RB. Mehta SK, et al. Drug Discov Today. 2024 Sep;29(9):104107. doi: 10.1016/j.drudis.2024.104107. Epub 2024 Jul 18. Drug Discov Today. 2024. PMID: 39032810 Review.
It emphasizes the diverse functionalities of compounds such as epigallocatechin-3-gallate (EGCG), quercetin, griffithsin (GRFT,) resveratrol, linalool, and carvacrol in the context of respiratory virus infections, including SARS-CoV-2. ...
It emphasizes the diverse functionalities of compounds such as epigallocatechin-3-gallate (EGCG), quercetin, griffithsin (GRFT,) resverat …
Biological potential, chemical profiling, and molecular docking study of Morus alba L. extracts.
Mahmutović-Dizdarević I, Mesic A, Jerković-Mujkić A, Žujo B, Avdić M, Hukić M, Omeragić E, Osmanović A, Špirtović-Halilović S, Ahmetovski S, Mujkanović S, Pramenković E, Salihović M. Mahmutović-Dizdarević I, et al. Fitoterapia. 2024 Sep;177:106114. doi: 10.1016/j.fitote.2024.106114. Epub 2024 Jul 5. Fitoterapia. 2024. PMID: 38971331
Our results showed that extracts were rich in vitamin C, phenols, and flavonoids, with quercetin and pterostilbene concentrated in the leaf, while fisetin, hesperidin, resveratrol, and luteolin were detected in fruit. Extracts exhibited antimicrobial activity against all t …
Our results showed that extracts were rich in vitamin C, phenols, and flavonoids, with quercetin and pterostilbene concentrated in the leaf, …
129 results