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Randomized open-label controlled study of cancer vaccine OSE2101 versus chemotherapy in HLA-A2-positive patients with advanced non-small-cell lung cancer with resistance to immunotherapy: ATALANTE-1.
Besse B, Felip E, Garcia Campelo R, Cobo M, Mascaux C, Madroszyk A, Cappuzzo F, Hilgers W, Romano G, Denis F, Viteri S, Debieuvre D, Galetta D, Baldini E, Razaq M, Robinet G, Maio M, Delmonte A, Roch B, Masson P, Schuette W, Zer A, Remon J, Costantini D, Vasseur B, Dziadziuszko R, Giaccone G; ATALANTE-1 study group. Besse B, et al. Ann Oncol. 2023 Oct;34(10):920-933. doi: 10.1016/j.annonc.2023.07.006. Epub 2023 Sep 11. Ann Oncol. 2023. PMID: 37704166 Free article. Clinical Trial.
In April 2020 at the time of interim analysis, a decision was taken to prematurely stop the accrual due to coronavirus disease 2019 (COVID-19). Final analysis was carried out in all patients and in the subgroup of patients with ICB secondary resistance defined as fa …
In April 2020 at the time of interim analysis, a decision was taken to prematurely stop the accrual due to coronavirus disease 2019 (COVI …
Smartphone-Based Photothermal Lateral Flow Immunoassay Using Rhenium Diselenide Nanosheet.
Hao W, Huang Y, Wang L, Liang J, Yang S, Su L, Zhang X. Hao W, et al. ACS Appl Mater Interfaces. 2023 Feb 13. doi: 10.1021/acsami.2c22616. Online ahead of print. ACS Appl Mater Interfaces. 2023. PMID: 36780303
The human anti-SARS-COV-2 S protein IgG antibodies in buffer solution can be detected in a portable box within 10 min, with a thermal signal detection limit of 0.86 ng mL(-1), which was 108-fold lower than that of the colorimetric signal. The integrated devic …
The human anti-SARS-COV-2 S protein IgG antibodies in buffer solution can be detected in a portable box within 10 min, …
Rhenium(V) Complexes as Cysteine-Targeting Coordinate Covalent Warheads.
Karges J, Cohen SM. Karges J, et al. J Med Chem. 2023 Feb 23;66(4):3088-3105. doi: 10.1021/acs.jmedchem.2c02074. Epub 2023 Feb 8. J Med Chem. 2023. PMID: 36752718 Free PMC article.
To demonstrate the utility of these Re(V) complexes, their reactivity with SARS-CoV-2-associated cysteine proteases is presented, including the SARS-CoV-2 main protease and papain-like protease and human enzymes cathepsin B and L. ...
To demonstrate the utility of these Re(V) complexes, their reactivity with SARS-CoV-2-associated cysteine proteases is …
Enantioselective inhibition of the SARS-CoV-2 main protease with rhenium(i) picolinic acid complexes.
Karges J, Giardini MA, Blacque O, Woodworth B, Siqueira-Neto JL, Cohen SM. Karges J, et al. Chem Sci. 2022 Dec 13;14(3):711-720. doi: 10.1039/d2sc05473f. eCollection 2023 Jan 18. Chem Sci. 2022. PMID: 36741526 Free PMC article.
Infections of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have triggered a global pandemic with millions of deaths worldwide. Herein, the synthesis of functionalized Re(i) tricarbonyl complexes as inhibitors of the SARS-CoV- …
Infections of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have triggered a global pandemic with mi …
Pre- and Post-publication Verification for Reproducible Data Mining in Macromolecular Crystallography.
Helliwell JR. Helliwell JR. Methods Mol Biol. 2022;2449:235-261. doi: 10.1007/978-1-0716-2095-3_10. Methods Mol Biol. 2022. PMID: 35507266
The work of a person as a referee or user with a narrative and its underpinning data may well be complemented in future by artificial intelligence with machine learning, the former for specific refereeing and the latter for the more general validation, both ideally before publica …
The work of a person as a referee or user with a narrative and its underpinning data may well be complemented in future by artificial intell …
Re(I) Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease.
Karges J, Kalaj M, Gembicky M, Cohen SM. Karges J, et al. Angew Chem Int Ed Engl. 2021 May 3;60(19):10716-10723. doi: 10.1002/anie.202016768. Epub 2021 Mar 26. Angew Chem Int Ed Engl. 2021. PMID: 33606889 Free PMC article.
Since its outbreak, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted the quality of life and cost hundreds-of-thousands of lives worldwide. ...
Since its outbreak, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted the quality of life a …