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Searching for New Gold(I)-Based Complexes as Anticancer and/or Antiviral Agents.
Checconi P, Mariconda A, Catalano A, Ceramella J, Pellegrino M, Aquaro S, Sinicropi MS, Longo P. Checconi P, et al. Molecules. 2025 Apr 11;30(8):1726. doi: 10.3390/molecules30081726. Molecules. 2025. PMID: 40333653 Free PMC article. Review.
Taking inspiration from the well-known anticancer platinum complexes, successive studies about the complexation of organic compounds with other late transition metals, such as silver, gold, palladium, rhodium, ruthenium, iridium, and osmium, have led to remarkable anticanc …
Taking inspiration from the well-known anticancer platinum complexes, successive studies about the complexation of organic compounds with ot …
Enantioselective Reductive Cyclization of Alkynyl-Tethered Cyclohexadienones Catalyzed by Rhodium Complexes.
Wang YF, Wang F, Yang DD, Kittakoop P, Tan YX, Tian P. Wang YF, et al. Org Lett. 2024 Jul 12;26(27):5614-5619. doi: 10.1021/acs.orglett.4c01276. Epub 2024 Jul 2. Org Lett. 2024. PMID: 38953701
In this study, the enantioselective reductive cyclization of alkynyl-tethered cyclohexadienones (1,6-enynes) has been developed via a chiral pincer rhodium catalyst, affording cis-hydrobenzofurans and cis-hydroindoles with high enantioselectivities (90-99% ee). Furthermore …
In this study, the enantioselective reductive cyclization of alkynyl-tethered cyclohexadienones (1,6-enynes) has been developed via a chiral …
Rh(I)-Catalyzed Allenic Pauson-Khand Reaction to Access the Thapsigargin Core: Influence of Furan and Allenyl Chloroacetate Groups on Enantioselectivity.
Deihl ED, Jesikiewicz LT, Newman LJ, Liu P, Brummond KM. Deihl ED, et al. Org Lett. 2022 Feb 4;24(4):995-999. doi: 10.1021/acs.orglett.1c03951. Epub 2022 Jan 26. Org Lett. 2022. PMID: 35081313
Thapsigargin (Tg) is a potent SERCA pump inhibitor with the potential to treat cancer and COVID-19. We have extended the scope of the asymmetric allenic Pauson-Khand reaction to furan-tethered allene-ynes, a stereoconvergent transformation affording the 5,7,5-ring s …
Thapsigargin (Tg) is a potent SERCA pump inhibitor with the potential to treat cancer and COVID-19. We have extended the scope …
Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2.
Chuong C, DuChane CM, Webb EM, Rai P, Marano JM, Bernier CM, Merola JS, Weger-Lucarelli J. Chuong C, et al. Viruses. 2021 May 25;13(6):980. doi: 10.3390/v13060980. Viruses. 2021. PMID: 34070524 Free PMC article.
SARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what led to the current global pandemic. ...Our findings demonstrate that two pentamethylcyclopentadienyl (Cp*) rhodium piano stool comple …
SARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what …
Pt-, Rh-, Ru-, and Cu-Single-Wall Carbon Nanotubes Are Exceptional Candidates for Design of Anti-Viral Surfaces: A Theoretical Study.
Aasi A, Aghaei SM, Moore MD, Panchapakesan B. Aasi A, et al. Int J Mol Sci. 2020 Jul 23;21(15):5211. doi: 10.3390/ijms21155211. Int J Mol Sci. 2020. PMID: 32717853 Free PMC article.
As SARS-CoV-2 is spreading rapidly around the globe, adopting proper actions for confronting and protecting against this virus is an essential and unmet task. ...
As SARS-CoV-2 is spreading rapidly around the globe, adopting proper actions for confronting and protecting against thi …