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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2011 1
2020 46
2021 65
2022 52
2023 43
2024 40
2025 32
2026 8

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257 results

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Page 1
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses.
Mulloy RP, Evseev D, Sharlin N, Bui-Marinos MP, Lacasse É, Dubuc I, Flamand L, Corcoran JA. Mulloy RP, et al. PLoS Biol. 2026 Apr 1;24(4):e3003646. doi: 10.1371/journal.pbio.3003646. eCollection 2026 Apr. PLoS Biol. 2026. PMID: 41920932 Free PMC article.
However, due to their limited genome size, viruses must adopt unique strategies to confront cellular sensors. Since its emergence in humans, SARS-CoV-2 accrued many mutations; however, the functional consequence of many such genetic changes remains unexplored …
However, due to their limited genome size, viruses must adopt unique strategies to confront cellular sensors. Since its emergence in humans, …
The research progress on the role of glucose-6-phosphate dehydrogenase in immune regulation.
Zhang D, Wang Y. Zhang D, et al. PeerJ. 2026 Mar 19;14:e20971. doi: 10.7717/peerj.20971. eCollection 2026. PeerJ. 2026. PMID: 41873421 Free PMC article. Review.
It mediates the production of nicotinamide adenine dinucleotide phosphate (NADPH) and ribose-5-phosphate (R5P), which are essential for the activation, proliferation, and effector function of T lymphocytes, B lymphocytes, macrophages, and neutrophils-specifically promoting …
It mediates the production of nicotinamide adenine dinucleotide phosphate (NADPH) and ribose-5-phosphate (R5P), which are essential f …
Inflammaging-Induced Bioenergetic Gap Exhausts Pulmonary Nucleotide Pools to Exacerbate SARS-CoV-2 Outcomes in Early Stage Aging.
Li X, Wu ZE, Wang X, Luo F, Deng C, Chen Y, Wan H, Tang X, Zhang Y, Shi P, Wu Z, Ning C, Yang W, Yang H, Liu J, Li F. Li X, et al. J Proteome Res. 2026 Apr 3;25(4):2066-2083. doi: 10.1021/acs.jproteome.5c01034. Epub 2026 Mar 23. J Proteome Res. 2026. PMID: 41870358
Age is a key risk factor for morbidity in coronavirus disease 2019 (COVID-19). This study investigates how "inflammaging" predisposes older hosts to severe SARS-CoV-2 outcomes through systemic and localized metabolic shifts. SARS-CoV …
Age is a key risk factor for morbidity in coronavirus disease 2019 (COVID-19). This study investigates how "inflammaging" pred …
Preferential remdesivir triphosphate incorporation by SARS-CoV-2 polymerase is altered to ATP by the S759A mutation.
Gordon CJ, Oliva MF, Lee HW, Goovaerts Q, De Wijngaert B, Götte M, Das K. Gordon CJ, et al. Commun Biol. 2026 Mar 13. doi: 10.1038/s42003-026-09844-z. Online ahead of print. Commun Biol. 2026. PMID: 41826755 Free article.
Here, enzymatic assays, mass spectrometry, and cryo-EM structures demonstrate that SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) preferentially incorporates remdesivir triphosphate (RTP), outcompeting 10-fold excess ATP; however, successive RTP incorporation …
Here, enzymatic assays, mass spectrometry, and cryo-EM structures demonstrate that SARS-CoV-2 RNA-dependent RNA polymer …
Exploring the Natural Products Atlas (NPAtlas) Database for Hunting Prospective Irreversible Covalent DprE1 Inhibitors With Antitubercular Activity: An Integrated In-Silico Approach.
Ibrahim MAA, Mahmoud DGM, Ebada SS, Sidhom PA, Mekhemer GAH, Hegazy MF, Han Y, Abalkhail T. Ibrahim MAA, et al. J Trop Med. 2026 Feb 14;2026:8879019. doi: 10.1155/jotm/8879019. eCollection 2026. J Trop Med. 2026. PMID: 41695983 Free PMC article.
As the second most deadly infectious disease worldwide after COVID-19, tuberculosis (TB) remains a pressing global health issue, further aggravated by multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) strains. There is an urgent need to iden …
As the second most deadly infectious disease worldwide after COVID-19, tuberculosis (TB) remains a pressing global health issu …
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1.
Zhang Y, Liu Y, Yao Z, Lai H, Chen X, Wang Z, Bao Y, Li T, Zhou X, Chen X, Yang P. Zhang Y, et al. Adv Sci (Weinh). 2026 Apr;13(20):e17009. doi: 10.1002/advs.202517009. Epub 2026 Jan 27. Adv Sci (Weinh). 2026. PMID: 41591303 Free PMC article.
This mechanism is conserved across the alphavirus family but is not shared by the nucleocapsid of SARS-CoV-2 or other endemic viruses examined. Notably, expression of a peptide from SFV capsid is sufficient to inhibit SG formation induced by Amyotrophic Later …
This mechanism is conserved across the alphavirus family but is not shared by the nucleocapsid of SARS-CoV-2 or other e …
CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.
Herasymenko O, Silva M, Correy GJ, Abu-Saleh AAA, Ackloo S, Arrowsmith C, Ashworth A, Ban F, Beck H, Bishop KP, Bohórquez HJ, Bolotokova A, Breznik M, Chau I, Chen Y, Cherkasov A, Dehaen W, Della Corte D, Denzinger K, Doering NP, Edfeldt K, Edwards A, Fayne D, Gentile F, Gibson E, Gokdemir O, Gunnarsson A, Günther J, Irwin JJ, Jensen JH, Harding RJ, Hillisch A, Hoffer L, Hogner A, Hutchinson A, Kandwal S, Karlova A, Koirala K, Kotelnikov S, Kozakov D, Lee J, Lee S, Lessel U, Liu S, Liu X, Loppnau P, Meiler J, Moretti R, Moroz YS, Muvva C, Oprea TI, Paige B, Pandit A, Park K, Poda G, Protopopov MV, Pütter V, Ravichandran R, Rognan D, Rosta E, Sabnis Y, Scott T, Seitova A, Sharma P, Sindt F, Song M, Steinmann C, Stevens R, Talagayev V, Tararina VV, Tarkhanova O, Tingey D, Trant JF, Treleaven D, Tropsha A, Walters P, Wells J, Westermaier Y, Wolber G, Wortmann L, Zheng S, Fraser JS, Schapira M. Herasymenko O, et al. J Chem Inf Model. 2026 Feb 9;66(3):1566-1581. doi: 10.1021/acs.jcim.5c02441. Epub 2026 Jan 21. J Chem Inf Model. 2026. PMID: 41565251 Free PMC article.
The third Critical Assessment of Computational Hit-finding Experiments (CACHE) challenged computational teams to identify chemically novel ligands targeting the macrodomain 1 of SARS-CoV-2 Nsp3, a promising coronavirus drug target. Twenty-three groups deploye …
The third Critical Assessment of Computational Hit-finding Experiments (CACHE) challenged computational teams to identify chemically novel l …
Mechanism of SARS-CoV-2 resistance to nucleotide analog-based antivirals.
Liu C, Li Y, Cao X, Gleason RJ, Liu B, Yang Y. Liu C, et al. Nat Commun. 2026 Jan 13;17(1):1601. doi: 10.1038/s41467-026-68304-8. Nat Commun. 2026. PMID: 41530153 Free PMC article.
The remarkable ability of SARS-CoV-2 to resist many nucleotide analog (NA)-based antivirals represents a formidable challenge to therapeutic efforts. ...These discoveries provide a molecular framework for understanding SARS-CoV-2 resistan …
The remarkable ability of SARS-CoV-2 to resist many nucleotide analog (NA)-based antivirals represents a formidable cha …
A Phase II Pilot Study of Anti-PD-L1, Durvalumab, and a PARP Inhibitor, Olaparib in Patients With Metastatic Triple-Negative Breast Cancer With or Without Germline BRCA Mutation.
Fujii T, Cimino-Mathews A, Lipkowitz S, Lee MJ, Nair J, Solarz BB, Zimmer A, Redd B, Levy EB, Rastogi S, Sato N, McCoy A, Steinberg SM, Lee JM. Fujii T, et al. Cancer Med. 2025 Dec;14(23):e71220. doi: 10.1002/cam4.71220. Cancer Med. 2025. PMID: 41360639 Free PMC article. Clinical Trial.
RESULTS: Fifteen patients (12 gBRCAwt and 3 gBRCAm) were enrolled. gBRCAm and gBRCAwt cohorts are reported as a combined dataset because of small sample size due to COVID-19 and slow accrual. The median number of prior therapies was three (range 0-8). ...
RESULTS: Fifteen patients (12 gBRCAwt and 3 gBRCAm) were enrolled. gBRCAm and gBRCAwt cohorts are reported as a combined dataset because of …
Structural basis for selective remdesivir incorporation by SARS-CoV-2 polymerase, and S759A resistance.
Das K, Gordon C, Oliva M, Lee H, Goovaerts Q, De Wijngaert B, Gotte M. Das K, et al. Res Sq [Preprint]. 2025 Oct 30:rs.3.rs-7793649. doi: 10.21203/rs.3.rs-7793649/v1. Res Sq. 2025. Update in: Commun Biol. 2026 Mar 13. doi: 10.1038/s42003-026-09844-z. PMID: 41282143 Free PMC article. Updated. Preprint.
Here, enzymatic assays, mass spectrometry, and cryo-EM demonstrate that SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) preferentially incorporates remdesivir triphosphate (RTP), outcompeting 10-fold excess ATP; however, successive RTP incorporations are disfa …
Here, enzymatic assays, mass spectrometry, and cryo-EM demonstrate that SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) …
257 results