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Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5' untranslated region.
Tang Z, Hegde S, Hao S, Selvaraju M, Qiu J, Wang J. Tang Z, et al. Nat Commun. 2025 Jan 8;16(1):483. doi: 10.1038/s41467-024-55608-w. Nat Commun. 2025. PMID: 39779694 Free PMC article.
In this report, we discovered a series of coumarin derivatives that bind to a four-way RNA helix called SL5 in the 5' UTR of the SARS-CoV-2 RNA genome. To locate the binding site, we developed a sequencing-based method namely cgSHAPE-seq, in which an acylatin …
In this report, we discovered a series of coumarin derivatives that bind to a four-way RNA helix called SL5 in the 5' UTR of the SARS …
Structural Insights into the Assembly and Regulation of 2'- O RNA Methylation by SARS-CoV-2 nsp16/nsp10.
Misra A, Rahisuddin R, Parihar M, Arya S, Viswanathan T, Jackson N, Qi S, Chan SH, Harris RS, Martinez-Sobrido L, Gupta YK. Misra A, et al. bioRxiv [Preprint]. 2024 Dec 20:2024.12.19.628950. doi: 10.1101/2024.12.19.628950. bioRxiv. 2024. PMID: 39764039 Free PMC article. Preprint.
2'- O -ribose methylation of the first transcribed base (adenine or A (1) in SARS-CoV-2) of viral RNA mimics the host RNAs and subverts the innate immune response. How nsp16, with its obligate partner nsp10, assembles on the 5'-end of SARS-Co …
2'- O -ribose methylation of the first transcribed base (adenine or A (1) in SARS-CoV-2) of viral RNA mimics the …
An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.
Jia X, Jing X, Li M, Gao M, Zhong Y, Li E, Liu Y, Li R, Yao G, Liu Q, Zhou M, Hou Y, An L, Hong Y, Li S, Zhang J, Wang W, Zhang K, Gong P, Chiu S. Jia X, et al. Nat Commun. 2024 Dec 30;15(1):10750. doi: 10.1038/s41467-024-54918-3. Nat Commun. 2024. PMID: 39737930 Free PMC article.
Importantly, treatment with HNC-1664 demonstrate anti-SARS-CoV-2 efficacy in infected K18-human ACE2 mice, with reduced viral titer and mortality, as well as improved lung injury. ...The cryo-EM structures of HNC-1664-bound RdRP-RNA complexes from both SAR …
Importantly, treatment with HNC-1664 demonstrate anti-SARS-CoV-2 efficacy in infected K18-human ACE2 mice, with reduced …
SARS-CoV-2 N protein recruits G3BP to double membrane vesicles to promote translation of viral mRNAs.
Long S, Guzyk M, Perez Vidakovics L, Han X, Sun R, Wang M, Panas MD, Urgard E, Coquet JM, Merits A, Achour A, McInerney GM. Long S, et al. Nat Commun. 2024 Dec 5;15(1):10607. doi: 10.1038/s41467-024-54996-3. Nat Commun. 2024. PMID: 39638802 Free PMC article.
Ras-GTPase-activating protein SH3-domain-binding proteins (G3BP) are critical for the formation of stress granules (SGs) through their RNA- and ribosome-binding properties. SARS-CoV-2 nucleocapsid (N) protein exhibits strong binding affinity for G3BP and inhi …
Ras-GTPase-activating protein SH3-domain-binding proteins (G3BP) are critical for the formation of stress granules (SGs) through their RNA- …
Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication.
Pfannenstiel JJ, Duong MTH, Cluff D, Sherrill LM, Colquhoun I, Cadoux G, Thorne D, Pääkkönen J, Schemmel NF, O'Connor J, Saenjamsai P, Feng M, Hageman MJ, Johnson DK, Roy A, Lehtiö L, Ferraris DV, Fehr AR. Pfannenstiel JJ, et al. bioRxiv [Preprint]. 2024 Oct 29:2024.10.28.620664. doi: 10.1101/2024.10.28.620664. bioRxiv. 2024. PMID: 39554145 Free PMC article. Preprint.
All CoVs encode for a macrodomain (Mac1) that binds to and removes ADP-ribose from target proteins. SARS-CoV-2 Mac1 promotes virus replication in the presence of interferon (IFN) and blocks the production of IFN, though the mechanisms by which it media …
All CoVs encode for a macrodomain (Mac1) that binds to and removes ADP-ribose from target proteins. SARS-CoV-2 M …
The effects of Remdesivir's functional groups on its antiviral potency and resistance against the SARS-CoV-2 polymerase.
Sama B, Selisko B, Falcou C, Fattorini V, Piorkowski G, Touret F, Donckers K, Neyts J, Jochmans D, Shannon A, Coutard B, Canard B. Sama B, et al. Antiviral Res. 2024 Dec;232:106034. doi: 10.1016/j.antiviral.2024.106034. Epub 2024 Nov 5. Antiviral Res. 2024. PMID: 39510431 Free article.
Remdesivir (RDV, Veklury) is the first FDA-approved antiviral treatment for COVID-19. It is a nucleotide analogue (NA) carrying a 1'-cyano (1'-CN) group on the ribose and a pseudo-adenine nucleobase whose contributions to the mode of action (MoA) are not clea …
Remdesivir (RDV, Veklury) is the first FDA-approved antiviral treatment for COVID-19. It is a nucleotide analogue (NA) carryin …
SARS-CoV-2 Nucleocapsid Protein Antagonizes GADD34-Mediated Innate Immune Pathway through Atypical Foci.
Liu J, Guan G, Wu C, Wang B, Chu K, Zhang X, He S, Zhang N, Yang G, Jin Z, Zhao T. Liu J, et al. Molecules. 2024 Oct 10;29(20):4792. doi: 10.3390/molecules29204792. Molecules. 2024. PMID: 39459161 Free PMC article.
We have shown that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein induces atypical N(+)/G3BP1(+) foci (N(+)foci), leading to the inhibition of host immunity and facilitation of viral infection. However, the precise m …
We have shown that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein induces at …
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir.
Rahman MR, Kawasumi R, Hirota K. Rahman MR, et al. DNA Repair (Amst). 2024 Dec;144:103773. doi: 10.1016/j.dnarep.2024.103773. Epub 2024 Oct 9. DNA Repair (Amst). 2024. PMID: 39405747
Remdesivir is a 1'-cyano-modified adenine nucleotide analog used for the treatment of COVID-19. Recently, the anti-carcinogenic effect of remdesivir has been also identified in human cancers. ...
Remdesivir is a 1'-cyano-modified adenine nucleotide analog used for the treatment of COVID-19. Recently, the anti-carcinogeni …
Mutation of a highly conserved isoleucine residue in loop 2 of several beta-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24. Epub 2024 Oct 10. J Virol. 2024. PMID: 39387584 Free article.
To determine how the biochemical activities of these residues impact CoV replication, the isoleucine and the phenylalanine residues were mutated to alanine (I-A/F-A) in both recombinant Mac1 proteins and recombinant CoVs, including murine hepatitis virus, Middle East respiratory …
To determine how the biochemical activities of these residues impact CoV replication, the isoleucine and the phenylalanine residues were mut …
217 results