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SARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation.
Luo M, Mo J, Wang Z, Wei H, Chen K, Shen L, Wang Y, Li L, Chen Y, Chen W, Li X, Feng H, Wang X, Zhou H, Li B, Xu F, Zhao Q, Xu Y, Che J, Zou P, Zhang R, Dong X, Xie W. Luo M, et al. Nat Commun. 2025 Nov 3;16(1):9671. doi: 10.1038/s41467-025-64674-7. Nat Commun. 2025. PMID: 41184286 Free PMC article.
SARS-CoV-2 NSP14, an N7-guanosine methyltransferase, plays a critical role in viral RNA capping, enabling viral replication and immune evasion. ...The antiviral efficacy of C10 is further validated in a transgenic mouse model of SARS-CoV-2 …
SARS-CoV-2 NSP14, an N7-guanosine methyltransferase, plays a critical role in viral RNA capping, enabling viral replica …
SARS-CoV-2 N7-methyltransferase inhibitors: Towards selective and potent antivirals.
Sujova K, Frecer V. Sujova K, et al. Eur J Pharm Sci. 2025 Nov 1;214:107312. doi: 10.1016/j.ejps.2025.107312. Epub 2025 Oct 6. Eur J Pharm Sci. 2025. PMID: 41061826 Free article. Review.
Recent studies have identified nsp14 N7-methyltransferase (N7-MTase) as a promising therapeutic target for the development of new antiviral agents against SARS-CoV-2. Utilising S-adenosyl-L-methionine (SAM) as a methyl donor, N7-MT …
Recent studies have identified nsp14 N7-methyltransferase (N7-MTase) as a promising therapeutic target for the development of new antiviral …
An Allele of the MTHFR one-carbon metabolism gene predicts severity of COVID-19.
Petrova B, Syphurs C, Culhane AJ, Chen J, Chen E, Cotsapas C, Esserman D, Montgomery R, Kleinstein S, Smolen K, Mendez K; IMPACC Network; Lasky-Su J, Steen H, Levy O, Diray-Arce J, Kanarek N. Petrova B, et al. medRxiv [Preprint]. 2025 Mar 3:2025.02.28.25323089. doi: 10.1101/2025.02.28.25323089. medRxiv. 2025. PMID: 40093216 Free PMC article. Preprint.
While the public health burden of SARS-CoV-2 infection has lessened due to natural and vaccine-acquired immunity, the emergence of less virulent variants, and antiviral medications, COVID-19 continues to take a significant toll. There are > 1 …
While the public health burden of SARS-CoV-2 infection has lessened due to natural and vaccine-acquired immunity, the e …
SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication.
Zhou S, Hui X, Wang W, Zhao C, Jin M, Qin Y, Chen M. Zhou S, et al. Emerg Microbes Infect. 2025 Dec;14(1):2447620. doi: 10.1080/22221751.2024.2447620. Epub 2025 Feb 24. Emerg Microbes Infect. 2025. PMID: 39745173 Free PMC article.
Specifically, the viral non-structural protein nsp14 upregulates the expression of S-adenosylmethionine synthase MAT2A in an mTORC1-dependent manner. This mTORC1-MAT2A axis subsequently stimulates the synthesis of S-adenosylmethionine (SAM). ...Our fin …
Specifically, the viral non-structural protein nsp14 upregulates the expression of S-adenosylmethionine synthase MAT2A in an m …
Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Kalnins G, Rudusa L, Bula AL, Zelencova-Gopejenko D, Bobileva O, Sisovs M, Tars K, Jirgensons A, Jaudzems K, Bobrovs R. Kalnins G, et al. ChemMedChem. 2024 Dec 16;19(24):e202400618. doi: 10.1002/cmdc.202400618. Epub 2024 Nov 4. ChemMedChem. 2024. PMID: 39258386 Free PMC article.
Coronaviruses, including SARS-CoV-2, possess an mRNA 5' capping apparatus capable of mimicking the natural eukaryotic capping signature. ...
Coronaviruses, including SARS-CoV-2, possess an mRNA 5' capping apparatus capable of mimicking the natural eukaryotic c …
The Chameleon Strategy-A Recipe for Effective Ligand Screening for Viral Targets Based on Four Novel Structure-Binding Strength Indices.
Latosińska M, Latosińska JN. Latosińska M, et al. Viruses. 2024 Jul 3;16(7):1073. doi: 10.3390/v16071073. Viruses. 2024. PMID: 39066235 Free PMC article.
The RNA viruses SARS-CoV, SARS-CoV-2 and MERS-CoV encode the non-structural Nsp16 (2'-O-methyltransferase) that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the first ribonucleotide in mRNA. ...Subsequently the sel …
The RNA viruses SARS-CoV, SARS-CoV-2 and MERS-CoV encode the non-structural Nsp16 (2'-O-methyltransferase) that catalyz …
Structural and functional insights into the 2'-O-methyltransferase of SARS-CoV-2.
Deng J, Gong F, Li Y, Tan X, Liu X, Yang S, Chen X, Wang H, Liu Q, Shen C, Zhou L, Chen Y. Deng J, et al. Virol Sin. 2024 Aug;39(4):619-631. doi: 10.1016/j.virs.2024.07.001. Epub 2024 Jul 3. Virol Sin. 2024. PMID: 38969340 Free PMC article.
Despite considerable advances in the ultrastructure of SARS-CoV-2 nsp16/nsp10, insights into its molecular mechanism have so far been limited. ...However, a single residue substitution (K58T) in SARS-CoV-2 nsp10 restricted the functional …
Despite considerable advances in the ultrastructure of SARS-CoV-2 nsp16/nsp10, insights into its molecular mechanism ha …
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch.
Pham H, Kumar M, Martinez AR, Ali M, Lowery RG. Pham H, et al. SLAS Discov. 2024 Jun;29(4):100161. doi: 10.1016/j.slasd.2024.100161. Epub 2024 May 22. SLAS Discov. 2024. PMID: 38788976 Free PMC article.
Because of the diversity of MTs and their products, assay methods that detect S-adenosylhomocysteine (SAH) - the invariant product of S-adenosylmethionine (SAM)-dependent methylation reactions - offer some advantages over methods that detect specific methylation eve …
Because of the diversity of MTs and their products, assay methods that detect S-adenosylhomocysteine (SAH) - the invariant product of S …
SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-kappaB activation.
Tofaute MJ, Weller B, Graß C, Halder H, Dohai B, Falter-Braun P, Krappmann D. Tofaute MJ, et al. Biosci Rep. 2024 Jan 31;44(1):BSR20231418. doi: 10.1042/BSR20231418. Biosci Rep. 2024. PMID: 38131452 Free PMC article.
Upon SARS-CoV-2 infection, patients with severe forms of COVID-19 often suffer from a dysregulated immune response and hyperinflammation. ...NSP14 WT, but not an MTase-defective mutant, is poorly expressed and inherent post-translational instabi …
Upon SARS-CoV-2 infection, patients with severe forms of COVID-19 often suffer from a dysregulated immune …
Development of Pan-Anti-SARS-CoV-2 Agents through Allosteric Inhibition of nsp14/nsp10 Complex.
Chen J, Zhou Y, Wei X, Xu X, Qin Z, Ong CP, Ye ZW, Jin DY, Boitrel B, Yuan S, Chan JF, Li H, Sun H. Chen J, et al. ACS Infect Dis. 2024 Mar 8;10(3):858-869. doi: 10.1021/acsinfecdis.3c00356. Epub 2023 Oct 28. ACS Infect Dis. 2024. PMID: 37897418 Free article.
SARS-CoV-2 nsp14 functions both as an exoribonuclease (ExoN) together with its critical cofactor nsp10 and as an S-adenosyl methionine-dependent (guanine-N7) methyltransferase (MTase), which makes it an attractive target for the development of pan-anti-SAR …
SARS-CoV-2 nsp14 functions both as an exoribonuclease (ExoN) together with its critical cofactor nsp10 and as an S-aden …
59 results