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SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signaling pathway to facilitate viral replication.
Zhou S, Hui X, Wang W, Zhao C, Jin M, Qin Y, Chen M. Zhou S, et al. Emerg Microbes Infect. 2025 Jan 2:2447620. doi: 10.1080/22221751.2024.2447620. Online ahead of print. Emerg Microbes Infect. 2025. PMID: 39745173 Free article.
Specifically, the viral non-structural protein nsp14 upregulates the expression of S-adenosylmethionine synthase MAT2A in an mTORC1-dependent manner. This mTORC1-MAT2A axis subsequently stimulates the synthesis of S-adenosylmethionine (SAM). ...Our fin …
Specifically, the viral non-structural protein nsp14 upregulates the expression of S-adenosylmethionine synthase MAT2A in an m …
Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Kalnins G, Rudusa L, Bula AL, Zelencova-Gopejenko D, Bobileva O, Sisovs M, Tars K, Jirgensons A, Jaudzems K, Bobrovs R. Kalnins G, et al. ChemMedChem. 2024 Dec 16;19(24):e202400618. doi: 10.1002/cmdc.202400618. Epub 2024 Nov 4. ChemMedChem. 2024. PMID: 39258386 Free PMC article.
Coronaviruses, including SARS-CoV-2, possess an mRNA 5' capping apparatus capable of mimicking the natural eukaryotic capping signature. ...
Coronaviruses, including SARS-CoV-2, possess an mRNA 5' capping apparatus capable of mimicking the natural eukaryotic c …
The Chameleon Strategy-A Recipe for Effective Ligand Screening for Viral Targets Based on Four Novel Structure-Binding Strength Indices.
Latosińska M, Latosińska JN. Latosińska M, et al. Viruses. 2024 Jul 3;16(7):1073. doi: 10.3390/v16071073. Viruses. 2024. PMID: 39066235 Free PMC article.
The RNA viruses SARS-CoV, SARS-CoV-2 and MERS-CoV encode the non-structural Nsp16 (2'-O-methyltransferase) that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the first ribonucleotide in mRNA. ...Subsequently the sel …
The RNA viruses SARS-CoV, SARS-CoV-2 and MERS-CoV encode the non-structural Nsp16 (2'-O-methyltransferase) that catalyz …
Structural and functional insights into the 2'-O-methyltransferase of SARS-CoV-2.
Deng J, Gong F, Li Y, Tan X, Liu X, Yang S, Chen X, Wang H, Liu Q, Shen C, Zhou L, Chen Y. Deng J, et al. Virol Sin. 2024 Aug;39(4):619-631. doi: 10.1016/j.virs.2024.07.001. Epub 2024 Jul 3. Virol Sin. 2024. PMID: 38969340 Free PMC article.
Despite considerable advances in the ultrastructure of SARS-CoV-2 nsp16/nsp10, insights into its molecular mechanism have so far been limited. ...However, a single residue substitution (K58T) in SARS-CoV-2 nsp10 restricted the functional …
Despite considerable advances in the ultrastructure of SARS-CoV-2 nsp16/nsp10, insights into its molecular mechanism ha …
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch.
Pham H, Kumar M, Martinez AR, Ali M, Lowery RG. Pham H, et al. SLAS Discov. 2024 Jun;29(4):100161. doi: 10.1016/j.slasd.2024.100161. Epub 2024 May 22. SLAS Discov. 2024. PMID: 38788976 Free PMC article.
Because of the diversity of MTs and their products, assay methods that detect S-adenosylhomocysteine (SAH) - the invariant product of S-adenosylmethionine (SAM)-dependent methylation reactions - offer some advantages over methods that detect specific methylation eve …
Because of the diversity of MTs and their products, assay methods that detect S-adenosylhomocysteine (SAH) - the invariant product of S …
SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-kappaB activation.
Tofaute MJ, Weller B, Graß C, Halder H, Dohai B, Falter-Braun P, Krappmann D. Tofaute MJ, et al. Biosci Rep. 2024 Jan 31;44(1):BSR20231418. doi: 10.1042/BSR20231418. Biosci Rep. 2024. PMID: 38131452 Free PMC article.
Upon SARS-CoV-2 infection, patients with severe forms of COVID-19 often suffer from a dysregulated immune response and hyperinflammation. ...NSP14 WT, but not an MTase-defective mutant, is poorly expressed and inherent post-translational instabi …
Upon SARS-CoV-2 infection, patients with severe forms of COVID-19 often suffer from a dysregulated immune …
Development of Pan-Anti-SARS-CoV-2 Agents through Allosteric Inhibition of nsp14/nsp10 Complex.
Chen J, Zhou Y, Wei X, Xu X, Qin Z, Ong CP, Ye ZW, Jin DY, Boitrel B, Yuan S, Chan JF, Li H, Sun H. Chen J, et al. ACS Infect Dis. 2024 Mar 8;10(3):858-869. doi: 10.1021/acsinfecdis.3c00356. Epub 2023 Oct 28. ACS Infect Dis. 2024. PMID: 37897418 Free article.
SARS-CoV-2 nsp14 functions both as an exoribonuclease (ExoN) together with its critical cofactor nsp10 and as an S-adenosyl methionine-dependent (guanine-N7) methyltransferase (MTase), which makes it an attractive target for the development of pan-anti-SAR …
SARS-CoV-2 nsp14 functions both as an exoribonuclease (ExoN) together with its critical cofactor nsp10 and as an S-aden …
Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors.
Inniss NL, Kozic J, Li F, Rosas-Lemus M, Minasov G, Rybáček J, Zhu Y, Pohl R, Shuvalova L, Rulíšek L, Brunzelle JS, Bednárová L, Štefek M, Kormaník JM, Andris E, Šebestík J, Li ASM, Brown PJ, Schmitz U, Saikatendu K, Chang E, Nencka R, Vedadi M, Satchell KJF. Inniss NL, et al. ACS Infect Dis. 2023 Oct 13;9(10):1918-1931. doi: 10.1021/acsinfecdis.3c00203. Epub 2023 Sep 20. ACS Infect Dis. 2023. PMID: 37728236 Free PMC article.
A collaborative, open-science team undertook discovery of novel small molecule inhibitors of the SARS-CoV-2 nsp16-nsp10 2'-O-methyltransferase using a high throughput screening approach with the potential to reveal new inhibition strategies. This screen yield …
A collaborative, open-science team undertook discovery of novel small molecule inhibitors of the SARS-CoV-2 nsp16-nsp10 …
Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
Kottur J, White KM, Rodriguez ML, Rechkoblit O, Quintana-Feliciano R, Nayar A, García-Sastre A, Aggarwal AK. Kottur J, et al. PLoS Pathog. 2023 Jul 31;19(7):e1011546. doi: 10.1371/journal.ppat.1011546. eCollection 2023 Jul. PLoS Pathog. 2023. PMID: 37523415 Free PMC article.
The RNA N7-methyltransferase (MTase) activity of SARS-CoV-2's nsp14 protein is essential for viral replication and is a target for the development of new antivirals. ...We have succeeded in identifying two such compounds (SGC0946 and SGC8158) that display sig …
The RNA N7-methyltransferase (MTase) activity of SARS-CoV-2's nsp14 protein is essential for viral replication and is a …
Treatment of Mood and Depressive Disorders With Complementary and Alternative Medicine: Efficacy Review.
Cutler JBR, Pane O, Panesar SK, Updike W, Moore TR. Cutler JBR, et al. J Midwifery Womens Health. 2023 Jul-Aug;68(4):421-429. doi: 10.1111/jmwh.13527. Epub 2023 Jun 24. J Midwifery Womens Health. 2023. PMID: 37354040 Review.
The further increase in stress and depression in the early part of the COVID-19 pandemic was accompanied by an increase in unmet mental health needs. Many have turned to complementary and alternative medicine (CAM) therapies such as bright-light therapy, yoga, medit …
The further increase in stress and depression in the early part of the COVID-19 pandemic was accompanied by an increase in unm …
56 results