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2020 28
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257 results

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High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy.
Guan H, Chen J, Kaur K, Amreen B, Lesseur C, Dolios G, Andra SS, Narasimhan S, Pulivarthi D, Midya V, De Witte LD, Bergink V, Rommel AS, Petrick LM. Guan H, et al. bioRxiv [Preprint]. 2024 Dec 17:2024.12.16.628663. doi: 10.1101/2024.12.16.628663. bioRxiv. 2024. PMID: 39763891 Free PMC article. Preprint.
OBJECTIVE: We previously found that per- and polyfluoroalkyl substances (PFAS) mixture exposure is inversely associated with SARS-CoV-2 IgG (IgG) antibody levels in pregnant individuals. Here, we aim to identify metabolites mediating this relationship to eluc …
OBJECTIVE: We previously found that per- and polyfluoroalkyl substances (PFAS) mixture exposure is inversely associated with SARS- …
Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis.
Lee S, Lee J, Lyoo KS, Shin Y, Shin DM, Kim JW, Yang JS, Kim KC, Lee JY, Hwang GS. Lee S, et al. Front Immunol. 2024 Dec 11;15:1473895. doi: 10.3389/fimmu.2024.1473895. eCollection 2024. Front Immunol. 2024. PMID: 39759510 Free PMC article.
INTRODUCTION: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, notably delta and omicron, has significantly accelerated the global pandemic, worsening conditions worldwide. ...Additionally, metabolic pathways determined …
INTRODUCTION: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, notably delta and …
Microbiota-related metabolites correlated with the severity of COVID-19 patients.
Wang XS, Wang JY, Yu F, Shi D, Xie JJ, Li LJ, Wang BH. Wang XS, et al. Hepatobiliary Pancreat Dis Int. 2024 Dec 21:S1499-3872(24)00168-1. doi: 10.1016/j.hbpd.2024.12.006. Online ahead of print. Hepatobiliary Pancreat Dis Int. 2024. PMID: 39734160
Previous studies reported the altered gut microbiota in severe COVID-19. But there are no comprehensive data on the role of microbial metabolites in COVID-19 patients. ...These results indicated the important role of gut microbiota in the progression o …
Previous studies reported the altered gut microbiota in severe COVID-19. But there are no comprehensive data on the role of mi …
Longitudinal Metabolomics Reveals Metabolic Dysregulation Dynamics in Patients with Severe COVID-19.
Uchimido R, Kami K, Yamamoto H, Yokoe R, Tsuchiya I, Nukui Y, Goto Y, Hanafusa M, Fujiwara T, Wakabayashi K. Uchimido R, et al. Metabolites. 2024 Nov 25;14(12):656. doi: 10.3390/metabo14120656. Metabolites. 2024. PMID: 39728437 Free PMC article.
Background/Objective: A dysregulated metabolism has been studied as a key aspect of the COVID-19 pathophysiology, but its longitudinal progression in severe cases remains unclear. ...Conclusions: This study elucidated the temporal differences in metabolic dysregulat …
Background/Objective: A dysregulated metabolism has been studied as a key aspect of the COVID-19 pathophysiology, but its long …
Serotonin levels in children with cognitive impairment in delayed speech development in non-alcoholic fatty liver disease with obesity and Covid-19.
Oros MM, Soroka LV. Oros MM, et al. Wiad Lek. 2024;77(10):1956-1961. doi: 10.36740/WLek/195158. Wiad Lek. 2024. PMID: 39661888
OBJECTIVE: Aim: To identify features of changes in serum serotonin and tryptophan levels in children with cognitive impairment (CI) and delayed speech development (DSD) at non-alcoholic fatty liver disease (NAFLD) and COVID-19. ...Tryptophan levels wer …
OBJECTIVE: Aim: To identify features of changes in serum serotonin and tryptophan levels in children with cognitive impairment (CI) a …
Time-resolved fluorescence studies reveal differences in dynamic motion between main proteases of SARS-CoV-2 and SARS-CoV.
Li F, Zhang J. Li F, et al. Int J Biol Macromol. 2024 Dec 4;287:138313. doi: 10.1016/j.ijbiomac.2024.138313. Online ahead of print. Int J Biol Macromol. 2024. PMID: 39643167
In our research, we constructed three single-tryptophan mutants (W31IN, W207IN, and W218IN) of M(pro) from SARS-CoV-2 and SARS-CoV to monitor the motion of M(pro) at the nano-second timescale using the time-resolved fluorescence assay. We found that th …
In our research, we constructed three single-tryptophan mutants (W31IN, W207IN, and W218IN) of M(pro) from SARS-CoV- …
Regulation of protein thermal stability and its potential application in the development of thermo-attenuated vaccines.
Wang M, Wu C, Liu N, Jiang X, Dong H, Zhao S, Li C, Xu S, Gu L. Wang M, et al. Eng Microbiol. 2024 Jun 25;4(3):100162. doi: 10.1016/j.engmic.2024.100162. eCollection 2024 Sep. Eng Microbiol. 2024. PMID: 39629114 Free PMC article.
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the importance of developing novel vaccines. An ideal vaccine should trigger an intense immune reaction without causing significant side effects. In this study we found that substitution of tryptoph …
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the importance of developing novel vaccines. An ideal vaccine …
Central and peripheral kynurenine pathway metabolites in COVID-19: Implications for neurological and immunological responses.
Li X, Edén A, Malwade S, Cunningham JL, Bergquist J, Weidenfors JA, Sellgren CM, Engberg G, Piehl F, Gisslen M, Kumlien E, Virhammar J, Orhan F, Rostami E, Schwieler L, Erhardt S. Li X, et al. Brain Behav Immun. 2024 Nov 29;124:163-176. doi: 10.1016/j.bbi.2024.11.031. Online ahead of print. Brain Behav Immun. 2024. PMID: 39615604
Long-term symptoms such as pain, fatigue, and cognitive impairments are commonly observed in individuals affected by coronavirus disease 2019 (COVID-19). Metabolites of the kynurenine pathway have been proposed to account for cognitive impairment in COVID- …
Long-term symptoms such as pain, fatigue, and cognitive impairments are commonly observed in individuals affected by coronavirus disease 201 …
LED-emitted blue light improves quality of life and reduces fatigue after COVID-19 infection.
Nolberczak D, Lesiak A, Czajkowski R, Bednarski IA, Narbutt J. Nolberczak D, et al. Postepy Dermatol Alergol. 2024 Oct;41(5):515-520. doi: 10.5114/ada.2024.144522. Epub 2024 Oct 28. Postepy Dermatol Alergol. 2024. PMID: 39606594 Free PMC article.
AIM: To evaluate the effects of blue light therapy in treatment of fatigue among COVID-19 survivors. MATERIAL AND METHODS: The study comprised of 43 adults who underwent COVID-19 infection with a subjective feeling of fatigue 4 weeks after the infectio …
AIM: To evaluate the effects of blue light therapy in treatment of fatigue among COVID-19 survivors. MATERIAL AND METHODS: The …
Metabolomic Insights into COVID-19 Severity: A Scoping Review.
Pimentel E, Banoei MM, Kaur J, Lee CH, Winston BW. Pimentel E, et al. Metabolites. 2024 Nov 12;14(11):617. doi: 10.3390/metabo14110617. Metabolites. 2024. PMID: 39590853 Free PMC article. Review.
RESULTS: Metabolites were identified that were repeatedly noted to change with COVID-19 and its severity. Phenylalanine, glucose, and glutamic acid increased with severity, while tryptophan, proline, and glutamine decreased, highlighting their association wit …
RESULTS: Metabolites were identified that were repeatedly noted to change with COVID-19 and its severity. Phenylalanine, gluco …
257 results