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2020 15
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108 results

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Page 1
Nuclear Magnetic Resonance-Based Urinary Metabolic Profiling for Assessing Heat Stress-Related Incident Kidney Injury in Health-Care Workers.
Ting CY, Chen CT, Yen TH, Wei Lee JK, Lee SH, Chang SJ, Hung TH, Liang HJ, Yang HY, Lin CY. Ting CY, et al. Geohealth. 2026 Jun 2;10(6):e2025GH001583. doi: 10.1029/2025GH001583. eCollection 2026 Jun. Geohealth. 2026. PMID: 42255321 Free PMC article.
During the COVID-19 pandemic, heat stress (HS) was a serious occupational risk for health-care workers (HCWs) wearing personal protective equipment, which limits heat dissipation and increases the risk of kidney injury. In this exploratory study, we assessed HS-rela …
During the COVID-19 pandemic, heat stress (HS) was a serious occupational risk for health-care workers (HCWs) wearing personal …
SARS-CoV-2 3CLpro mutations T21I and E166A confer differential resistance to simnotrelvir, bofutrelvir, and ensitrelvir.
Chen L, Su H, Shang W, Nie T, Kuang W, Wang C, Shao Q, Zhang L, Liu W, Xu Y, Zhang Y. Chen L, et al. J Virol. 2026 May 19;100(5):e0222325. doi: 10.1128/jvi.02223-25. Epub 2026 Apr 27. J Virol. 2026. PMID: 42037412 Free PMC article.
In this work, we first investigated the resistance profile of simnotrelvir, an approved anti-SARS-CoV-2 drug that targets 3CLpro. We found that the T21I/E166A mutations in 3CLpro equally emerged when SARS-CoV-2 was passaged in the HEK293T …
In this work, we first investigated the resistance profile of simnotrelvir, an approved anti-SARS-CoV-2 drug that targe …
NMR-Based Metabolomics Profiling Reveals Dose-Dependent Cardiotoxic Effects of Favipiravir in Rats.
Erdoğan A, Mumcu A, Çevik ZR, Özkan ÖL, Doğan B. Erdoğan A, et al. Magn Reson Chem. 2026 Jul;64(7):629-640. doi: 10.1002/mrc.70104. Epub 2026 Apr 5. Magn Reson Chem. 2026. PMID: 41936427
Favipiravir, a drug widely used during the COVID-19 pandemic, has been associated with damage to various organs, including the heart. ...Bioinformatics analysis results showed significant dose-dependent changes in key metabolites in the favipiravir-treated groups. D …
Favipiravir, a drug widely used during the COVID-19 pandemic, has been associated with damage to various organs, including the …
Dimerization of SARS-CoV-2 3CLpro and the Role of the A7G/V125G Zipper Interface.
Razali R, Budiman C, Kumar V. Razali R, et al. Protein Pept Lett. 2026;33(1):379-393. doi: 10.2174/0109298665442327260216063524. Protein Pept Lett. 2026. PMID: 41928683
INTRODUCTION/OBJECTIVES: The 3-chymotrypsin-like protease (3CLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for viral replication and is catalytically active only in its dimeric form. ...This study aimed to character …
INTRODUCTION/OBJECTIVES: The 3-chymotrypsin-like protease (3CLpro) of severe acute respiratory syndrome coronavirus 2 (SARS- …
Characterizing Origin of Differences in Chemical Composition, Rumen Degradability, Intestinal Digestibility and Amino Acid Profile of Traditional Beer Brewing Byproducts.
Tadesse A, De Neve N, Tesfay Y, Vermeir P, De Meulenaer B, Fievez V. Tadesse A, et al. Food Sci Nutr. 2025 Dec 30;14(1):e71380. doi: 10.1002/fsn3.71380. eCollection 2026 Jan. Food Sci Nutr. 2025. PMID: 41476711 Free PMC article.
Heat treatment did not influence the ruminal degradation of DM, CP and AA, except for valine. Intestinal digestibility of bypass CP and all AA was affected (p < 0.05) by cereal type or heat treatment. ...
Heat treatment did not influence the ruminal degradation of DM, CP and AA, except for valine. Intestinal digestibility of bypass CP a …
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.
Massonnaud CR, Peiffer-Smadja N, Poignard P, Jamard S, Goehringer F, Danion F, Reignier J, de Castro N, Garot D, Lapique EL, Lacombe K, Tolsma V, Faure E, Malvy D, Staub T, Courjon J, Cazenave-Roblot F, Dyrhol Riise AM, Leturnier P, Martin-Blondel G, Roger C, Akinosoglou K, Le Moing V, Piroth L, Sellier P, Lescure X, Trøseid M, Clevenbergh P, Dalgard O, Gallien S, Gousseff M, Loubet P, Vardon-Bounes F, Visée C, Belkhir L, Botelho-Nevers É, Cabié A, Kotanidou A, Lanternier F, Rouveix-Nordon E, Silva S, Thiery G, Carcelain G, Diallo A, Mercier N, Terzić V, Bouscambert-Duchamp M, Gaymard A, Destras G, Josset L, Belhadi D, Billard N, Guedj J, Han TH, Couffin-Cadiergues S, Dechanet A, Delmas C, Esperou H, Fougerou-Leurent C, Le Mestre S, Métois A, Noret M, Bally I, Dergan-Dylon S, Tubiana S, Kalif O, Bergaud N, Leveau B, Eustace J, Greil R, Hajdu E, Halanova M, Paiva JA, Piekarska A, Baño JR, Tonby K, Trojánek M, Tsiodras S, Unal S, Burdet C, Costagliola D, Yazdanpanah Y, Mentré F, Ader F, Hites M; DisCoVeRy study group. Massonnaud CR, et al. Clin Microbiol Infect. 2026 Apr;32(4):618-628. doi: 10.1016/j.cmi.2025.12.014. Epub 2025 Dec 20. Clin Microbiol Infect. 2026. PMID: 41429349 Clinical Trial.
OBJECTIVES: To report long-term clinical efficacy, safety, pharmacokinetics, immunogenicity and seroneutralization results of AZD7442 (monoclonal antibodies tixagevimab-cilgavimab) in patients hospitalized with COVID-19. METHODS: In this phase 3, double-blind, rando …
OBJECTIVES: To report long-term clinical efficacy, safety, pharmacokinetics, immunogenicity and seroneutralization results of AZD7442 (monoc …
Innovative design and comprehensive characterization of a valine-enhanced lipid nanoparticle-coated mRNA vaccine targeting the SARS-CoV-2 S-RBD antigen.
Duran T, Cine N, Karaselek MA, Gul N, Kuccukturk S, Hatipoglu D, Ates MB, Calıskan U, Kocak N. Duran T, et al. Sci Rep. 2025 Sep 30;15(1):33898. doi: 10.1038/s41598-025-08142-8. Sci Rep. 2025. PMID: 41028822 Free PMC article.
The SARS-CoV-2 pandemic has led to major advances in mRNA vaccine development. This study aimed to develop a cationic lipid nanoparticle (LNP) coated mRNA vaccine targeting the receptor binding domain (RBD) against the SARS-CoV-2 virus an …
The SARS-CoV-2 pandemic has led to major advances in mRNA vaccine development. This study aimed to develop a cationic l …
Assessment of direct-acting antiviral treatment outcomes in patients with chronic hepatitis C infected with various HCV genotypes: Insights from a real-world cohort in West Bengal, India.
Dutta S, Nath S, Das R, Bakshi S, Majumdar M, Ghosh A, Baskey U, Chowdhury PK, Sadhukhan PC. Dutta S, et al. BMC Infect Dis. 2025 Sep 29;25(1):1180. doi: 10.1186/s12879-025-11565-3. BMC Infect Dis. 2025. PMID: 41023889 Free PMC article.
Additionally, real-world treatment challenges encountered during the COVID-19 pandemic and the transitional phase of implementing the National Viral Hepatitis Control Program (NVHCP) guidelines have also been addressed. ...
Additionally, real-world treatment challenges encountered during the COVID-19 pandemic and the transitional phase of implement …
Immunoglobulin GM (gamma marker) and FcgammaR genotypes interact to contribute to the magnitude of ADCC against SARS CoV-2 S-transfected cells.
Pandey JP, Namboodiri AM, Nietert PJ. Pandey JP, et al. Immunogenetics. 2025 Sep 1;77(1):27. doi: 10.1007/s00251-025-01385-9. Immunogenetics. 2025. PMID: 40888900 Free PMC article.
Immunoglobulin GM (gamma marker) and KM (kappa marker) allotypes have been shown to be associated with antibody responses to several viruses, but their role in immunity to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-the causative agent …
Immunoglobulin GM (gamma marker) and KM (kappa marker) allotypes have been shown to be associated with antibody responses to several viruses …
Causal Effects of Life-Course Adiposity and Metabolic Mediators on the Immune Response to COVID-19 Vaccination.
Liang P, Li C, Li Y, Xiong J, Mi J, Xiao P. Liang P, et al. J Med Virol. 2025 Aug;97(8):e70540. doi: 10.1002/jmv.70540. J Med Virol. 2025. PMID: 40751707
Despite adiposity's potential role in modulating immune responses, the causal effects of adiposity at different life stages on immune responses to COVID-19 vaccines remain poorly understood. Thus, we aimed to investigate the causal association between life-course ad …
Despite adiposity's potential role in modulating immune responses, the causal effects of adiposity at different life stages on immune respon …
108 results