In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys.
Aweda TA, Cheng SH, Lenhard SC, Sepp A, Skedzielewski T, Hsu CY, Marshall S, Haag H, Kehler J, Jagdale P, Peter A, Schmid MA, Gehman A, Doan M, Mayer AP, Gorycki P, Fanget M, Colas C, Smith B, Maier CC, Alsaid H.
Aweda TA, et al.
Eur J Nucl Med Mol Imaging. 2023 Feb;50(3):667-678. doi: 10.1007/s00259-022-06012-3. Epub 2022 Oct 28.
Eur J Nucl Med Mol Imaging. 2023.
PMID: 36305907
Free PMC article.
PURPOSE: Sotrovimab (VIR-7831), a human IgG1kappa monoclonal antibody (mAb), binds to a conserved epitope on the SARS-CoV-2 spike protein receptor binding domain (RBD). The Fc region of VIR-7831 contains an LS modification to promote neonatal Fc receptor (FcR …
PURPOSE: Sotrovimab (VIR-7831), a human IgG1kappa monoclonal antibody (mAb), binds to a conserved epitope on the SARS-CoV-2 …