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Benefits of melatonin on mortality in severe-to-critical COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials.
Qin J, Wang G, Han D. Qin J, et al. Clinics (Sao Paulo). 2025 Apr 4;80:100638. doi: 10.1016/j.clinsp.2025.100638. eCollection 2025. Clinics (Sao Paulo). 2025. PMID: 40187234 Free PMC article.
CONCLUSIONS: Melatonin significantly reduced in-hospital mortality in patients with severe-to-critical COVID-19. Melatonin should be considered for severe-to-critical COVID-19 patients....
CONCLUSIONS: Melatonin significantly reduced in-hospital mortality in patients with severe-to-critical COVID-19. Mel …
Pilot Trial: Impact of a Virtual Reality Stress Reduction Program on Healthcare and Information Technology Professionals During the COVID-19 Pandemic.
Kwon D, Im W, Kim Y, Yoo J, Jeon H, Choi H, Kim H. Kwon D, et al. Psychiatry Investig. 2025 Apr;22(4):451-461. doi: 10.30773/pi.2025.0059. Epub 2025 Mar 28. Psychiatry Investig. 2025. PMID: 40143703 Free PMC article.
OBJECTIVE: This study evaluated the effectiveness of a virtual reality (VR) based stress reduction program tailored for healthcare and information technology (IT) professionals during the coronavirus disease-2019 pandemic. METHODS: The 2-week program, based on forest heali …
OBJECTIVE: This study evaluated the effectiveness of a virtual reality (VR) based stress reduction program tailored for healthcare and infor …
[The use of melatonin continues to increase - rational prescribing and follow-up is important].
Dahlén E, Bergman Perland E, Maria Bergsten E, Arthurson V, Kimland E. Dahlén E, et al. Lakartidningen. 2025 Mar 21;122:24073. Lakartidningen. 2025. PMID: 40135269 Free article. Swedish.
During the COVID pandemic, the over-the-counter sales of melatonin increased despite jet lag in adults being the only approved indication. The Swedish Medical Products Agency notes an increased interest in melatonin and signals of unwarranted sale of melatonin …
During the COVID pandemic, the over-the-counter sales of melatonin increased despite jet lag in adults being the only approved indica …
Melatonin from Plants: Going Beyond Traditional Central Nervous System Targeting-A Comprehensive Review of Its Unusual Health Benefits.
Laurindo LF, Simili OAG, Araújo AC, Guiguer EL, Direito R, Valenti VE, de Oliveira V, de Oliveira JS, Yanaguizawa Junior JL, Dias JA, Maria DA, Rici REG, Bueno MDS, Sloan KP, Sloan LA, Barbalho SM. Laurindo LF, et al. Biology (Basel). 2025 Jan 30;14(2):143. doi: 10.3390/biology14020143. Biology (Basel). 2025. PMID: 40001911 Free PMC article. Review.
These effects result in neuro- and cardioprotection, improvement of liver diseases, rheumatoid arthritis, dermatitis, COVID-19, polycystic ovaries, and sepsis. We conclude that plant melatonin can benefit patients with many diseases besides sleep problems and …
These effects result in neuro- and cardioprotection, improvement of liver diseases, rheumatoid arthritis, dermatitis, COVID-19 …
Prescription Trends of Medications Used to Treat Sleep Disturbances in School-Aged Children: An Interrupted Time-Series Analysis in France, 2016-2023.
Valtuille Z, Acquaviva E, Trebossen V, Ouldali N, Bourmaud A, Sclison S, Gomez A, Revet A, Peyre H, Delorme R, Kaguelidou F. Valtuille Z, et al. J Pediatr. 2025 May;280:114502. doi: 10.1016/j.jpeds.2025.114502. Epub 2025 Feb 5. J Pediatr. 2025. PMID: 39921118 Free article.
Prescriptions of hypnotic medications (hydroxyzine, alimemazine, melatonin, and Z-drugs) dispensed to children aged 6-17 years were analyzed. Monthly rates of hypnotic prescriptions per 1000 children were modeled before and after the pandemic onset (March 2020) to assess r …
Prescriptions of hypnotic medications (hydroxyzine, alimemazine, melatonin, and Z-drugs) dispensed to children aged 6-17 years were a …
Olfactory and Gustatory Disturbances as Early Indicators of Lung Cancer in Patients with Sleep Disorders: A Retrospective Cohort Study from the TriNetX US Collaborative Networks.
Tsai RY, Ho CC, Hu JY, Hsiao Y, Huang HE, Wei JC. Tsai RY, et al. Int J Med Sci. 2025 Jan 13;22(3):723-731. doi: 10.7150/ijms.106014. eCollection 2025. Int J Med Sci. 2025. PMID: 39898247 Free PMC article.
Subgroup analysis indicated that the risk was particularly elevated in patients over 50, males, and those with dorsalgia. COVID-19 infection did not have a significant impact on lung cancer risk in this population. ...
Subgroup analysis indicated that the risk was particularly elevated in patients over 50, males, and those with dorsalgia. COVID-19 …
Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective.
Sanduzzi Zamparelli S, Sanduzzi Zamparelli A, Bocchino M. Sanduzzi Zamparelli S, et al. Life (Basel). 2025 Jan 16;15(1):113. doi: 10.3390/life15010113. Life (Basel). 2025. PMID: 39860053 Free PMC article. Review.
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has profoundly impacted global health, with pneumonia emerging as a major complication in severe cases. ...Fur …
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 ( …
Comprehensive list of preventative migraine headache medications without significant drug-drug interactions.
Dave J, Hakkinen I, Zhang P. Dave J, et al. Front Neurol. 2024 Dec 12;15:1527897. doi: 10.3389/fneur.2024.1527897. eCollection 2024. Front Neurol. 2024. PMID: 39734637 Free PMC article.
METHODS: We compiled a list of prevention medications from Szperka et al.'s "Migraine Care in the Era of COVID-19" as well as American Headache Society's 2018 and 2021 "Consensus Statements on Integrating New Migraine Treatments into Clinical Practice." ...The resul …
METHODS: We compiled a list of prevention medications from Szperka et al.'s "Migraine Care in the Era of COVID-19" as well as …
Melatonin's Impact on Cytokine Storm and Modulation of Purinergic Receptors for COVID-19 Prognosis: A Mental Health Perspective.
Bertollo AG, Dalazen JB, Cassol JV, Hellmann MB, Mota TL, Ignácio ZM, Bagatini MD. Bertollo AG, et al. J Mol Neurosci. 2024 Dec 5;74(4):113. doi: 10.1007/s12031-024-02292-6. J Mol Neurosci. 2024. PMID: 39636363 Review.
In 2019, coronavirus disease 2019 (COVID-19) started a global health crisis and was associated with high rates of depression and anxiety. ...Recent studies suggest melatonin's anti-inflammatory and antioxidant properties may benefit COVID …
In 2019, coronavirus disease 2019 (COVID-19) started a global health crisis and was associated with high rates of depre …
Efficacy of Melatonin as a Promising Intervention for Migraine Prevention: A Systematic Review of Randomized Control Trials.
Nelakuditi B, Dandamudi BJ, Dimaano KAM, Shah N, AlQassab O, Al-Sulaitti Z, Khan S. Nelakuditi B, et al. Cureus. 2024 Oct 28;16(10):e72559. doi: 10.7759/cureus.72559. eCollection 2024 Oct. Cureus. 2024. PMID: 39606511 Free PMC article. Review.
The availability and use of melatonin as an over-the-counter supplement have surged significantly in recent years due to the increased prevalence of sleep-wake disorders, notably in the post-COVID-19 era. ...The aim of this systematic review is to evaluate th …
The availability and use of melatonin as an over-the-counter supplement have surged significantly in recent years due to the increase …
Heat Treatment of Saliva to Reduce Infectious Disease Contamination Does Not Impact the Analysis of Melatonin by Radioimmunoassay.
Salkeld MD, Kennaway DJ. Salkeld MD, et al. J Pineal Res. 2024 Nov;76(8):e70009. doi: 10.1111/jpi.70009. J Pineal Res. 2024. PMID: 39563175
Melatonin levels in saliva are typically determined in a laboratory setting by RIA or enzyme-linked immunosorbent assay and the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presente …
Melatonin levels in saliva are typically determined in a laboratory setting by RIA or enzyme-linked immunosorbent assay and the emerg …
Enhancing Sleep and Reducing Occupational Stress Through Forest Therapy: A Comparative Study Across Job Groups.
Kweon J, Kim Y, Choi H, Im W, Kim H. Kweon J, et al. Psychiatry Investig. 2024 Oct;21(10):1120-1128. doi: 10.30773/pi.2024.0118. Epub 2024 Oct 17. Psychiatry Investig. 2024. PMID: 39465238 Free PMC article.
OBJECTIVE: The coronavirus disease-2019 (COVID-19) pandemic radically shifted occupational patterns, leading to increased telecommuting and related stressors. ...Our study examined the efficacy of forest therapy in alleviating work-induced stress across vario …
OBJECTIVE: The coronavirus disease-2019 (COVID-19) pandemic radically shifted occupational patterns, leading to increas …
A double-blind, randomized, placebo-controlled trial of melatonin as an adjuvant agent for induction of labor: The MILO trial.
Quach D, Mol BW, Springer J, Tully E, Higgins C, Jones M, Hennes D, Pham Y, Swarnamani K, Palmer K, Davies-Tuck M. Quach D, et al. Acta Obstet Gynecol Scand. 2024 Dec;103(12):2442-2454. doi: 10.1111/aogs.14951. Epub 2024 Oct 24. Acta Obstet Gynecol Scand. 2024. PMID: 39446608 Free PMC article. Clinical Trial.
RESULTS: Between 2019 and 2021 we randomized 189 women (103 to melatonin and 86 to placebo). The study was prematurely terminated due to logistical complications resulting from the COVID-19 pandemic. ...CONCLUSIONS: In women undergoing induction of labor, …
RESULTS: Between 2019 and 2021 we randomized 189 women (103 to melatonin and 86 to placebo). The study was prematurely terminated due …
Investigating the Effectiveness of Melatonin in the Treatment of Critically Ill Patients with COVID-19 Hospitalized in the Intensive Care Unit: A Double-Blind Randomized Clinical Trial.
Tirkan A, Eskandari D, Roham M, Aloosh O, Ramim T, Afshar H. Tirkan A, et al. Med J Islam Repub Iran. 2024 Apr 15;38:41. doi: 10.47176/mjiri.38.41. eCollection 2024. Med J Islam Repub Iran. 2024. PMID: 39416373 Free PMC article.
BACKGROUND: Melatonin, a tryptophan product, has anti-inflammatory and virucidal effects. A study evaluated whether melatonin is more effective than placebo in critically ill COVID-19 patients. ...CONCLUSION: Melatonin can significantly reduce i …
BACKGROUND: Melatonin, a tryptophan product, has anti-inflammatory and virucidal effects. A study evaluated whether melatonin …
Assessment of Supplementation with Different Biomolecules in the Prevention and Treatment of COVID-19.
González-Acedo A, Manzano-Moreno FJ, García-Recio E, Ruiz C, Luna-Bertos E, Costela-Ruiz VJ. González-Acedo A, et al. Nutrients. 2024 Sep 11;16(18):3070. doi: 10.3390/nu16183070. Nutrients. 2024. PMID: 39339670 Free PMC article. Review.
Consequences of the disease produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have led to an urgent search for preventive and therapeutic strategies. ...The objective of this study was to re …
Consequences of the disease produced by the severe acute respiratory syndrome coronavirus 2 (SA …
Perceptions around sleep hygiene practices and beliefs among urban Black adolescents and their caregivers during the COVID-19 pandemic.
Adams EL, Estradé M, Lewis EC, Poirier-Barna L, Smith MT, Gittelsohn J. Adams EL, et al. Sleep Health. 2024 Dec;10(6):678-682. doi: 10.1016/j.sleh.2024.07.009. Epub 2024 Sep 26. Sleep Health. 2024. PMID: 39332925
METHODS: Semistructured interviews were conducted with adolescents (n = 9) and caregivers (n = 9) from January-March 2021, during the COVID-19 pandemic. Interview questions included adolescent's current sleep habits, barriers, and home and neighborhood influences. . …
METHODS: Semistructured interviews were conducted with adolescents (n = 9) and caregivers (n = 9) from January-March 2021, during the COV …
Unlocking the health benefits of melatonin supplementation: A promising preventative and therapeutic strategy.
Azzeh FS, Kamfar WW, Ghaith MM, Alsafi RT, Shamlan G, Ghabashi MA, Farrash WF, Alyamani RA, Alazzeh AY, Alkholy SO, Bakr EH, Qadhi AH, Arbaeen AF. Azzeh FS, et al. Medicine (Baltimore). 2024 Sep 20;103(38):e39657. doi: 10.1097/MD.0000000000039657. Medicine (Baltimore). 2024. PMID: 39312371 Free PMC article. Review.
Melatonin (MLT) is crucial in controlling human sleep-wake patterns. While it has long been recognized for regulating circadian rhythms, its demonstrated efficacy in managing various diseases has recently gained considerable attention. ...Several studies have focused on ex …
Melatonin (MLT) is crucial in controlling human sleep-wake patterns. While it has long been recognized for regulating circadian rhyth …
Investigating the efficacy of melatonin, topical sodium citrate, and multivitamin with zinc as a potential treatment for postinfectious loss of smell.
Garcia ECD, Rosa LR, Santos ACRD, Ishimatsu GKA, Lopes NMD, Fornazieri MA. Garcia ECD, et al. Braz J Otorhinolaryngol. 2024 Nov-Dec;90(6):101496. doi: 10.1016/j.bjorl.2024.101496. Epub 2024 Aug 31. Braz J Otorhinolaryngol. 2024. PMID: 39243697 Free PMC article.
The aim of study was evaluating the effectiveness of adding melatonin, multivitamin and sodium citrate to olfactory training for the treatment of olfactory loss caused by COVID-19. ...CONCLUSIONS: Olfactory training alone and olfactory training with associate …
The aim of study was evaluating the effectiveness of adding melatonin, multivitamin and sodium citrate to olfactory training for the …
Melatonin reverses EGFR-TKI therapeutic resistance by modulating crosstalk between circadian-related gene signature and immune infiltration patterns in patients with COVID-19 and lung adenocarcinoma.
Dai Z, Lin B, Cao Y, Wang L, Liao K, Guo L, Zhang J. Dai Z, et al. Comput Biol Med. 2024 Sep;180:108937. doi: 10.1016/j.compbiomed.2024.108937. Epub 2024 Jul 28. Comput Biol Med. 2024. PMID: 39074422
BACKGROUND: Patients with lung cancer exhibit the poorest outcomes when infected with coronavirus disease 2019 (COVID-19). However, the potential impact of COVID-19 on the tumor microenvironment (TME) of lung adenocarcinoma (LUAD) remains unknow …
BACKGROUND: Patients with lung cancer exhibit the poorest outcomes when infected with coronavirus disease 2019 (COVID-19 …
[Sleep disorders and oncological diseases].
Kolokolov OV, Salina EA, Lvova OI. Kolokolov OV, et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(5. Vyp. 2):125-131. doi: 10.17116/jnevro2024124052125. Zh Nevrol Psikhiatr Im S S Korsakova. 2024. PMID: 38934677 Review. Russian.
The study of neurological symptoms and signs connected with neoplasms and antitumor therapy is relevant in the context of an increasing prevalence of cancer. The COVID-19 pandemic and social factors have increased the number of patients suffering from insomnia. ...
The study of neurological symptoms and signs connected with neoplasms and antitumor therapy is relevant in the context of an increasing prev …
Fecal Microbiota Transplantation for Sleep Disturbance in Post-acute COVID-19 Syndrome.
Lau RI, Su Q, Ching JYL, Lui RN, Chan TT, Wong MTL, Lau LHS, Wing YK, Chan RNY, Kwok HYH, Ho AHY, Tse YK, Cheung CP, Li MKT, Siu WY, Liu C, Lu W, Wang Y, Chiu EOL, Cheong PK, Chan FKL, Ng SC. Lau RI, et al. Clin Gastroenterol Hepatol. 2024 Dec;22(12):2487-2496.e6. doi: 10.1016/j.cgh.2024.06.004. Epub 2024 Jun 20. Clin Gastroenterol Hepatol. 2024. PMID: 38908733
BACKGROUND & AIMS: Post-acute COVID-19 syndrome (PACS) is associated with sleep disturbance, but treatment options are limited. ...Secondary outcomes included changes in the Pittsburgh Sleep Quality Index, Generalized Anxiety Disorder-7 scale, Epworth Sleepiness …
BACKGROUND & AIMS: Post-acute COVID-19 syndrome (PACS) is associated with sleep disturbance, but treatment options are lim …
Potential Application of Modified mRNA in Cardiac Regeneration.
Wang AYL, Chang YC, Chen KH, Loh CYY. Wang AYL, et al. Cell Transplant. 2024 Jan-Dec;33:9636897241248956. doi: 10.1177/09636897241248956. Cell Transplant. 2024. PMID: 38715279 Free PMC article. Review.
In addition, the regenerative ability of the adult heart is limited after injury, partly due to cell-cycle arrest in cardiomyocytes. In the current post-COVID-19 era, urgently authorized modified mRNA (modRNA) vaccines have been widely used to prevent severe …
In addition, the regenerative ability of the adult heart is limited after injury, partly due to cell-cycle arrest in cardiomyocytes. In the …
Redox Homeostasis Alteration Is Restored through Melatonin Treatment in COVID-19 Patients: A Preliminary Study.
Soto ME, Pérez-Torres I, Manzano-Pech L, Palacios-Chavarría A, Valdez-Vázquez RR, Guarner-Lans V, Soria-Castro E, Díaz-Díaz E, Castrejón-Tellez V. Soto ME, et al. Int J Mol Sci. 2024 Apr 21;25(8):4543. doi: 10.3390/ijms25084543. Int J Mol Sci. 2024. PMID: 38674128 Free PMC article.
Type II pneumocytes are the target of the SARS-CoV-2 virus, which alters their redox homeostasis to increase reactive oxygen species (ROS). ...Thus, MT restores the redox homeostasis that is altered in COVID-19 patients and can be used as adjuva …
Type II pneumocytes are the target of the SARS-CoV-2 virus, which alters their redox homeostasis to increase reactive o …
Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration.
Yehia A, Abulseoud OA. Yehia A, et al. Mol Neurodegener. 2024 Apr 19;19(1):36. doi: 10.1186/s13024-024-00728-6. Mol Neurodegener. 2024. PMID: 38641847 Free PMC article. Review.
According to various studies, melatonin has proven efficacy in attenuating the severity of certain COVID-19 manifestations, validating its reputation as an anti-viral compound. ...Therefore, we propose ferroptosis as the culprit behind the post-COVID- …
According to various studies, melatonin has proven efficacy in attenuating the severity of certain COVID-19 manifestati …
Inhibitory effect of food-functioned phytochemicals on dysregulated inflammatory pathways triggered by SARS-CoV-2: a mechanistic review.
Jantan I, Norahmad NA, Yuandani, Haque MA, Mohamed-Hussein ZA, Mohd Abd Razak MR, Syed Mohamed AF, Lam KW, Ibrahim S. Jantan I, et al. Crit Rev Food Sci Nutr. 2025;65(13):2405-2430. doi: 10.1080/10408398.2024.2341266. Epub 2024 Apr 15. Crit Rev Food Sci Nutr. 2025. PMID: 38619217 Review.
Many plant extracts have been used clinically in the management of COVID-19, however, their immunosuppressive activities were mainly investigated based on in silico activity. ...The present review critically analyzes the anti-inflammatory effects and mechanisms of p …
Many plant extracts have been used clinically in the management of COVID-19, however, their immunosuppressive activities were …
COVID-19-Related Brief Insomnia in a 13-Year-Old Adolescent Girl.
Serdengeçti N, Tarakçıoğlu MC. Serdengeçti N, et al. Sleep Sci. 2024 Feb 29;17(1):e112-e114. doi: 10.1055/s-0043-1777780. eCollection 2024 Mar. Sleep Sci. 2024. PMID: 38545246 Free PMC article.
Neuropsychiatric manifestations that have developed after coronavirus disease 2019 (COVID-19) infection have not been fully clarified yet. Persistent insomnia and consequent significant impairment in daily functioning is an unexpected symptom of COVID- …
Neuropsychiatric manifestations that have developed after coronavirus disease 2019 (COVID-19) infection have not been f …
Melatonin Use in Pediatrics: A Clinical Review on Indications, Multisystem Effects, and Toxicity.
Shenoy P, Etcheverry A, Ia J, Witmans M, Tablizo MA. Shenoy P, et al. Children (Basel). 2024 Mar 9;11(3):323. doi: 10.3390/children11030323. Children (Basel). 2024. PMID: 38539358 Free PMC article. Review.
With increasing sleep disturbances and mental health problems after the COVID-19 pandemic, melatonin has become even more popular and studies have shown a dramatic increase in use as well as resulting side effects, including melatonin overdose. As m …
With increasing sleep disturbances and mental health problems after the COVID-19 pandemic, melatonin has become even mo …
Landau-Kleffner Syndrome, Attention-Deficit/Hyperactivity Disorder (ADHD), and Viral/Autoimmune Encephalitis: Challenges in the Diagnosis and Management of a Six-Year-Old Boy.
Althagafi L, Al Fuhayd R, Almeathem FK, Almeshal RA, Al-Amri LJ, Mustafa WA. Althagafi L, et al. Cureus. 2024 Jan 11;16(1):e52133. doi: 10.7759/cureus.52133. eCollection 2024 Jan. Cureus. 2024. PMID: 38344501 Free PMC article.
Methylphenidate was the prescribed starting at 5 mg, and the dose was gradually increased to 20 mg/day given separately as 10 mg twice a day. A week later, melatonin 2 mg was added. Three months, later the EEG was repeated and was normal, and sodium valproate was tapered o …
Methylphenidate was the prescribed starting at 5 mg, and the dose was gradually increased to 20 mg/day given separately as 10 mg twice a day …
A mid-pandemic night's dream: Melatonin, from harbinger of anti-inflammation to mitochondrial savior in acute and long COVID-19 (Review).
Lempesis IG, Georgakopoulou VE, Reiter RJ, Spandidos DA. Lempesis IG, et al. Int J Mol Med. 2024 Mar;53(3):28. doi: 10.3892/ijmm.2024.5352. Epub 2024 Feb 1. Int J Mol Med. 2024. PMID: 38299237 Free PMC article. Review.
Coronavirus disease 2019 (COVID-19), a systemic illness caused by severe acute respiratory distress syndrome 2 (SARS-CoV-2), has triggered a worldwide pandemic with symptoms ranging from asymptomatic to chronic, affecting practically ever …
Coronavirus disease 2019 (COVID-19), a systemic illness caused by severe acute respiratory distress syndrome 2 (SARS …
Melatonin Prevents Alcohol- and Metabolic Dysfunction- Associated Steatotic Liver Disease by Mitigating Gut Dysbiosis, Intestinal Barrier Dysfunction, and Endotoxemia.
LeFort KR, Rungratanawanich W, Song BJ. LeFort KR, et al. Antioxidants (Basel). 2023 Dec 25;13(1):43. doi: 10.3390/antiox13010043. Antioxidants (Basel). 2023. PMID: 38247468 Free PMC article. Review.
Melatonin (MT) has often been used to support good sleep quality, especially during the COVID-19 pandemic, as many have suffered from stress-related disrupted sleep patterns. ...
Melatonin (MT) has often been used to support good sleep quality, especially during the COVID-19 pandemic, as many have …
Assessing the antiviral potential of melatonin: A comprehensive systematic review.
Alomari T, Al-Abdallat H, Hamamreh R, Alomari O, Hos BH, Reiter RJ. Alomari T, et al. Rev Med Virol. 2024 Jan;34(1):e2499. doi: 10.1002/rmv.2499. Epub 2023 Dec 21. Rev Med Virol. 2024. PMID: 38126924 Review.
The findings highlight strong evidence supporting antiviral properties of melatonin. In silico studies identify melatonin as a candidate against SARS-CoV-2, reducing cytokine storm-related respiratory responses. ...In summary, our review highlig …
The findings highlight strong evidence supporting antiviral properties of melatonin. In silico studies identify melatonin as a …
Effects of the COVID-19 pandemic on the incidence of central precocious puberty; a narrative review.
Hoskyns RB, Howard SR. Hoskyns RB, et al. J Pediatr Endocrinol Metab. 2023 Dec 15;37(2):102-109. doi: 10.1515/jpem-2023-0507. Print 2024 Feb 26. J Pediatr Endocrinol Metab. 2023. PMID: 38097507 Review.
There are multiple theories potentially explaining this change in incidence of CPP over COVID-19. These include the direct effect of SARS-coV-2 infection, increasing body mass index of adolescents over sequential lockdowns, changes in sleep patt …
There are multiple theories potentially explaining this change in incidence of CPP over COVID-19. These include the direct eff …
The double burden of malnutrition and environmental enteric dysfunction as potential factors affecting gut-derived melatonin in children under adverse environments.
Bezerra AN, Peixoto CL, Lopes SC, Bruin VMS, Bruin PFC, Oriá RB. Bezerra AN, et al. Front Nutr. 2023 Nov 27;10:1217173. doi: 10.3389/fnut.2023.1217173. eCollection 2023. Front Nutr. 2023. PMID: 38089926 Free PMC article.
Poor environmental conditions combined with continuous unhealthy and unsafe diets may substantially increase the risk of a vicious cycle of enteric infections (EED-environmental enteric dysfunction) and malnutrition (DBM-double burden of malnutrition) in children. Gut melatoni …
Poor environmental conditions combined with continuous unhealthy and unsafe diets may substantially increase the risk of a vicious cycle of …
Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases.
Castillejos-López M, Romero Y, Varela-Ordoñez A, Flores-Soto E, Romero-Martinez BS, Velázquez-Cruz R, Vázquez-Pérez JA, Ruiz V, Gomez-Verjan JC, Rivero-Segura NA, Camarena Á, Torres-Soria AK, Gonzalez-Avila G, Sommer B, Solís-Chagoyán H, Jaimez R, Torres-Espíndola LM, Aquino-Gálvez A. Castillejos-López M, et al. Cells. 2023 Nov 29;12(23):2724. doi: 10.3390/cells12232724. Cells. 2023. PMID: 38067152 Free PMC article. Review.
Hypoxia is a condition in which the lack of adequate oxygenation promotes adaptation mechanisms and is related to several genes that regulate the circadian cycles, the latter because hypoxia alters the production of melatonin and brain physiology. Additionally, the lack of …
Hypoxia is a condition in which the lack of adequate oxygenation promotes adaptation mechanisms and is related to several genes that regulat …
Safety and efficacy of melatonin as an adjuvant therapy in COVID-19 patients: Systematic review and meta-analysis.
Mohamed Taha A, Adel Abdelkader Saed S, Hossam-Eldin Moawad M, Abd El-Tawab Moawad W, Al-Hejazi T, Mousa Y, Sharma R, Reiter RJ. Mohamed Taha A, et al. Adv Med Sci. 2023 Sep;68(2):341-352. doi: 10.1016/j.advms.2023.09.007. Epub 2023 Sep 22. Adv Med Sci. 2023. PMID: 37742478 Review.
BACKGROUND: Melatonin might be beneficial to coronavirus disease 2019 (COVID-19) patients in terms of both prevention and treatment. We investigated how melatonin affected various clinical and laboratory results in COVID-19 patient …
BACKGROUND: Melatonin might be beneficial to coronavirus disease 2019 (COVID-19) patients in terms of both preve …
Melatonin Supplementation for Cancer-Related Fatigue in Patients With Early Stage Breast Cancer Receiving Radiotherapy: A Double-Blind Placebo-Controlled Trial.
Mukhopadhyay ND, Khorasanchi A, Pandey S, Nemani S, Parker G, Deng X, Arthur DW, Urdaneta A, Del Fabbro E. Mukhopadhyay ND, et al. Oncologist. 2024 Feb 2;29(2):e206-e212. doi: 10.1093/oncolo/oyad250. Oncologist. 2024. PMID: 37699115 Free PMC article. Clinical Trial.
The purpose of this randomized double-blind placebo-controlled phase III trial was to assess the effects of melatonin for preventing fatigue and other symptoms in patients with breast cancer undergoing RT. ...Sixteen patients withdrew prior to study completion for various …
The purpose of this randomized double-blind placebo-controlled phase III trial was to assess the effects of melatonin for preventing …
The use of prescription drugs and health care services during the 6-month post-COVID-19 period.
Mooses K, Vesilind K, Oja M, Tamm S, Haug M, Kalda R, Suija K, Tisler A, Meister T, Malk M, Uusküla A, Kolde R. Mooses K, et al. Sci Rep. 2023 Jul 19;13(1):11638. doi: 10.1038/s41598-023-38691-9. Sci Rep. 2023. PMID: 37468497 Free PMC article.
The health impact of COVID-19 was more apparent among females and individuals with non-severe COVID-19. The increased risk of exacerbating pre-existing conditions was observed for the COVID-19 group. ...Compared with RESP, COVID- …
The health impact of COVID-19 was more apparent among females and individuals with non-severe COVID-19. The incr …
Melatonin, vitamins and minerals supplements for the treatment of Covid-19 and Covid-like illness: A prospective, randomized, double-blind multicenter study.
Mahjoub L, Youssef R, Yaakoubi H, Salah HB, Jaballah R, Mejri M, Sekma A, Trabelsi I, Nouira S, Khrouf M, Soltane HB, Mezgar Z, Boukadida L, Zorgati A, Boukef R. Mahjoub L, et al. Explore (NY). 2024 Jan-Feb;20(1):95-100. doi: 10.1016/j.explore.2023.06.009. Epub 2023 Jun 20. Explore (NY). 2024. PMID: 37419768 Free PMC article. Clinical Trial.
BACKGROUND: Melatonin, zinc, and multivitamins are among most recommended supplements in the fight against coronavirus disease 2019 (COVID-19). ...CONCLUSIONS: Our results showed that daily doses of Melatonin, zinc and vitamins did significantly …
BACKGROUND: Melatonin, zinc, and multivitamins are among most recommended supplements in the fight against coronavirus disease …
Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases of COVID-19: A Hypothetical Approach.
Taner N, Haskologlu IC, Erdag E, Mercan M, Chuckwunyere U, Ulker D, Sehirli AO, Abacioglu N. Taner N, et al. Adv Exp Med Biol. 2023;1412:427-442. doi: 10.1007/978-3-031-28012-2_23. Adv Exp Med Biol. 2023. PMID: 37378781 Review.
Since the outbreak of the first SARS-CoV-2 epidemic in China, pharmacists have rapidly engaged and developed strategies for pharmaceutical care and supply. ...In addition to its anti-inflammatory and antioxidant effects, melatonin plays a role in suppr …
Since the outbreak of the first SARS-CoV-2 epidemic in China, pharmacists have rapidly engaged and developed strategies …
Melatonin effects on sleep quality of COVID-19 patients: a protocol for systematic review and meta-analysis of randomised controlled trials with trial sequential analysis.
Zhang JJ, Sun R, Guo S, Zhang H. Zhang JJ, et al. BMJ Open. 2023 Jun 22;13(6):e068345. doi: 10.1136/bmjopen-2022-068345. BMJ Open. 2023. PMID: 37349103 Free PMC article.
INTRODUCTION: Sleep disturbance is one of the common complaints of patients with COVID-19 infection. Melatonin is a physiological indoleamine involved in circadian rhythm regulation and it is currently used for secondary sleep disorders caused by various dise …
INTRODUCTION: Sleep disturbance is one of the common complaints of patients with COVID-19 infection. Melatonin is a phy …
Therapeutic Benefits of Melatonin against COVID-19.
Mubashshir M, Ahmad N, Negi T, Rawal R, Singhvi N, Khatoon H, Laxmi V, Dubey O, Sharma RB, Negi G, Ovais M. Mubashshir M, et al. Neuroimmunomodulation. 2023;30(1):196-205. doi: 10.1159/000531550. Epub 2023 Jun 19. Neuroimmunomodulation. 2023. PMID: 37336193 Free PMC article. Review.
Moreover, melatonin does not seem to reduce the efficiency of approved vaccines against the SARS-CoV-2 virus. ...Hence, the novel use of melatonin along with other antivirals as an early treatment option against COVID-19 infection …
Moreover, melatonin does not seem to reduce the efficiency of approved vaccines against the SARS-CoV-2 virus. .. …
Variation in Twitter posts referencing pediatric sleep aids.
Carson M, Moore M, Cicalese O, Dunnewald M, Varker A, Mindell JA, Williamson AA. Carson M, et al. Sleep Health. 2023 Aug;9(4):451-459. doi: 10.1016/j.sleh.2023.04.009. Epub 2023 Jun 15. Sleep Health. 2023. PMID: 37330322 Free PMC article.
In addition, variation in tweets before and after the onset of the COVID-19 pandemic was examined. METHODS: Twitter was searched over a 25-month period using TweetDeck. ...Tweets about pediatric sleep aids increased during the pandemic, primarily those posts about …
In addition, variation in tweets before and after the onset of the COVID-19 pandemic was examined. METHODS: Twitter was search …
The inhibitory and inactivating effects of visible light on SARS-CoV-2: A narrative update.
Gorman S. Gorman S. J Photochem Photobiol. 2023 Jun;15:100187. doi: 10.1016/j.jpap.2023.100187. Epub 2023 May 24. J Photochem Photobiol. 2023. PMID: 37288364 Free PMC article.
Prior to the coronavirus disease-19 (COVID-19) pandemic, the germicidal effects of visible light (lambda = 400 - 700 nm) were well known. This review provides an overview of new findings that suggest there are direct inactivating effects of visible light - pa …
Prior to the coronavirus disease-19 (COVID-19) pandemic, the germicidal effects of visible light (lambda = 400 - 700 nm …
What a difference a year makes: Objective rest/activity patterns, circadian phase markers, and sleep quality before and during the COVID-19 pandemic.
Esquivel-Mendoza J, Burgess HJ, Gren LH, Shoaf K, Baron KG. Esquivel-Mendoza J, et al. Sleep Health. 2023 Aug;9(4):544-550. doi: 10.1016/j.sleh.2023.04.002. Epub 2023 Jun 1. Sleep Health. 2023. PMID: 37270395 Free PMC article.
OBJECTIVES: The COVID-19 pandemic led to numerous changes in sleep duration, quality, and timing. The goal of this study was to examine objective and self-reported changes in sleep and circadian timing before and during the pandemic. ...CONCLUSION: Our data demonstr …
OBJECTIVES: The COVID-19 pandemic led to numerous changes in sleep duration, quality, and timing. The goal of this study was t …
Bmal1 and Gut-lung axis in SARS-CoV-2 infection: New insight into the effects of melatonin on COVID-19 patients?
Khezri MR, Varzandeh R, Ghasemnejad-Berenji M. Khezri MR, et al. Biomed Pharmacother. 2023 Aug;164:114291. doi: 10.1016/j.biopha.2023.114291. Epub 2023 Jan 23. Biomed Pharmacother. 2023. PMID: 37257225 Free PMC article.
Numerous studies have tried to introduce different mechanisms involved in the pathophysiology of COVID-19 and efforts in this field are also ongoing. The presence of SARS-CoV-2 RNA in feces of COVID-19 patients along with a variety …
Numerous studies have tried to introduce different mechanisms involved in the pathophysiology of COVID-19 and efforts in this …
Mental health and drug use in college students: Should we take action?
Pérez T, Pardo MC, Cabellos Y, Peressini M, Ureña-Vacas I, Serrano DR, González-Burgos E. Pérez T, et al. J Affect Disord. 2023 Oct 1;338:32-40. doi: 10.1016/j.jad.2023.05.080. Epub 2023 May 27. J Affect Disord. 2023. PMID: 37245551 Free article.
The perception of these symptoms did not change after returning to face-to-face university classes in the post-COVID19 era. Despite the high percentage of cases with clear symptoms of anxiety and depression, most students never had a diagnosis of mental illnesses [anxiety …
The perception of these symptoms did not change after returning to face-to-face university classes in the post-COVID19 era. Despite t …
Melatonin and Cytokines Modulate Daily Instrumental Activities of Elderly People with SARS-CoV-2 Infection.
França DCH, Fujimori M, de Queiroz AA, Borges MD, Magalhães Neto AM, de Camargos PJV, Ribeiro EB, França EL, Honorio-França AC, Fagundes-Triches DLG. França DCH, et al. Int J Mol Sci. 2023 May 12;24(10):8647. doi: 10.3390/ijms24108647. Int J Mol Sci. 2023. PMID: 37239991 Free PMC article.
Thus, this study aimed to analyze cytokine and melatonin levels in serum and correlate the Comprehensive Geriatric Assessment in elderly patients with SARS-CoV-2 infection. ...There was an increase in IL-6, IL-17, and melatonin in the group of e …
Thus, this study aimed to analyze cytokine and melatonin levels in serum and correlate the Comprehensive Geriatric Assessment in elde …
Angiotensin converting enzyme 2 gene expression and markers of oxidative stress are correlated with disease severity in patients with COVID-19.
Alobaidy ASH, Elhelaly M, Amer ME, Shemies RS, Othman AI, El-Missiry MA. Alobaidy ASH, et al. Mol Biol Rep. 2023 Jul;50(7):5827-5836. doi: 10.1007/s11033-023-08515-0. Epub 2023 May 24. Mol Biol Rep. 2023. PMID: 37222866 Free PMC article.
BACKGROUND: Oxidative stress is thought to play a significant role in the pathogenesis and severity of COVID-19. Additionally, angiotensin converting enzyme 2 (ACE2) expression may predict the severity and clinical course of COVID-19. ...Melatonin …
BACKGROUND: Oxidative stress is thought to play a significant role in the pathogenesis and severity of COVID-19. Additionally, …
The clinical efficacy of melatonin in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.
Huang PY, Wu JY, Liu TH, Tsai YW, Chen PT, Liao CT, Toh HS. Huang PY, et al. Front Med (Lausanne). 2023 Apr 25;10:1171294. doi: 10.3389/fmed.2023.1171294. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37181363 Free PMC article.
Melatonin has been shown to have anti-inflammatory and immunomodulatory effects and its effect on COVID-19 clinical outcomes is controversial. ...With a very low certainty of evidence, we found no significant difference in the recovery rate of COVID- …
Melatonin has been shown to have anti-inflammatory and immunomodulatory effects and its effect on COVID-19 clinical out …
ROLE OF GUT MICROBIOME HOMEOSTASIS, INTEGRITY OF THE INTESTINAL EPITHELIAL CELLS, AND THE (ENDOGENOUS) BUTYRATE IN ENDURING A HEALTHY LONG LIFE.
Preethy S, Yamamoto N, Liem N, Bharatidasan S, Iwasaki M, Abraham S. Preethy S, et al. Georgian Med News. 2023 Mar;(336):73-78. Georgian Med News. 2023. PMID: 37166884
In this background, a black yeast Aureobasidium pullulans produced biological response modifier beta glucans (BRMGs) has shown beneficial outcome (anti-inflammatory: decrease in IL-6, Ferritin, C-reactive protein in COVID-19, D-Dimer; anti-fibrotic in fatty liver di …
In this background, a black yeast Aureobasidium pullulans produced biological response modifier beta glucans (BRMGs) has shown beneficial ou …
[Mental disorders associated with acute COVID-19: clinical picture, therapy approaches].
Samushiya MA, Chorbinskaya SA, Kolpakov EA, Shmyrev VI, Kryzhanovskiy SM, Baranovskaya OP, Trifonova EV, Devyatkin AV, Kydryavtseva NA, Maeva VO, Schepkina EV. Samushiya MA, et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(4. Vyp. 2):52-59. doi: 10.17116/jnevro202312304252. Zh Nevrol Psikhiatr Im S S Korsakova. 2023. PMID: 37141129 Russian.
BACKGROUND: The purpose is to study the structure of clinical manifestations of mental disorders in the acute period of COVID-19 among patients, who were hospitalized with a new coronavirus infection and their relations with the severity of the immune respons …
BACKGROUND: The purpose is to study the structure of clinical manifestations of mental disorders in the acute period of COVID-19 …
Melatonin and Aging.
Bondy SC. Bondy SC. Subcell Biochem. 2023;103:291-307. doi: 10.1007/978-3-031-26576-1_13. Subcell Biochem. 2023. PMID: 37120473 Review.
The utility of incurring appropriate changes in lifestyle is generally not confined to a single organ system but has a broadly positive systemic effect.Among one of the most potent means of slowing down age-related changes is the use of melatonin, a widely distributed biol …
The utility of incurring appropriate changes in lifestyle is generally not confined to a single organ system but has a broadly positive syst …
Pre-pandemic circadian phase predicts pandemic alcohol use among adolescents.
Hasler BP, Wallace ML, Graves JL, Witt R, Guo K, Buysse DJ, Siegle GJ, Clark DB. Hasler BP, et al. J Sleep Res. 2024 Feb;33(1):e13905. doi: 10.1111/jsr.13905. Epub 2023 Apr 11. J Sleep Res. 2024. PMID: 37039532 Free PMC article.
School schedules shifted later during the COVID-19 pandemic, ostensibly reducing circadian misalignment and potentially mitigating problems with depression and alcohol. ...We assessed circadian phase via dim light melatonin onset prior to the pandemic, then c …
School schedules shifted later during the COVID-19 pandemic, ostensibly reducing circadian misalignment and potentially mitiga …
Can melatonin reduce the severity of post-COVID-19 syndrome?
Souissi A, Dergaa I, Romdhani M, Ghram A, Irandoust K, Chamari K, Ben Saad H. Souissi A, et al. EXCLI J. 2023 Feb 2;22:173-187. doi: 10.17179/excli2023-5864. eCollection 2023. EXCLI J. 2023. PMID: 36998709 Free PMC article. Review.
This short review aimed at (i) providing an update on the health benefits associated with melatonin supplementation, while (ii) considering future potential research directions concerning melatonin supplementation use relative to Coronavirus disease of 2019 ( …
This short review aimed at (i) providing an update on the health benefits associated with melatonin supplementation, while (ii) consi …
[Appropriate Use and Abuse of Sedative-Hypnotic Drugs].
Zheng JW, Meng SQ, Liu WY, Chang XW, Shi J. Zheng JW, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 Mar;54(2):231-239. doi: 10.12182/20230260302. Sichuan Da Xue Xue Bao Yi Xue Ban. 2023. PMID: 36949678 Free PMC article. Review. Chinese.
The incidence of insomnia has been increasing in recent years. In addition, due to the impact of the COVID-19 pandemic, more and more people are experiencing a variety of insomniac problems, including having difficulty in sleep initation, waking up too early, and sh …
The incidence of insomnia has been increasing in recent years. In addition, due to the impact of the COVID-19 pandemic, more a …
Differences in the diurnal variation of salivary stress biomarkers during the coronavirus (COVID-19) pandemic between telecommuters and office workers.
Hasebe K, Watanabe D, Yamaguchi T, Hu A, Tabuchi M, Kuwashima Y, Watanabe A, Hikima N, Uehara Y, Mizushima S, Okuno S, Mizushima A. Hasebe K, et al. Neuro Endocrinol Lett. 2023 Mar 8;44(1):26-30. Neuro Endocrinol Lett. 2023. PMID: 36931224
OBJECTIVES: It is necessary to objectively assess the stress state of workers, from the standpoint of holistic palliative care, in order to determine how the rapid change in work styles in the "live with coronavirus era"-in which people will coexist and live with the co …
OBJECTIVES: It is necessary to objectively assess the stress state of workers, from the standpoint of holistic palliative care, in order to …
Role of Supplements in the Management of COVID-19 - A Comprehensive Review.
Balasubramanian R, Maideen NMP, Muthusamy S, Ramanathan S, Jahir Hussain MH. Balasubramanian R, et al. Infect Disord Drug Targets. 2023;23(5):e100323214544. doi: 10.2174/1871526523666230310094646. Infect Disord Drug Targets. 2023. PMID: 36896901 Review.
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) and patients with COVID-19 may be treated primarily with SARS …
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome c …
Potential of Nano-Antioxidants and Nanomedicine for Recovery from Neurological Disorders Linked to Long COVID Syndrome.
Akanchise T, Angelova A. Akanchise T, et al. Antioxidants (Basel). 2023 Feb 6;12(2):393. doi: 10.3390/antiox12020393. Antioxidants (Basel). 2023. PMID: 36829952 Free PMC article. Review.
Long-term neurological complications, persisting in patients who cannot fully recover several months after severe SARS-CoV-2 coronavirus infection, are referred to as neurological sequelae of the long COVID syndrome. Among the numerous clinical post-ac …
Long-term neurological complications, persisting in patients who cannot fully recover several months after severe SARS-CoV- …
Sleep, Dietary Melatonin Supplementation, and COVID-19.
Gasmi A, Semenova Y, Noor S, Benahmed AG, Bjørklund G. Gasmi A, et al. Curr Med Chem. 2024;31(11):1298-1314. doi: 10.2174/0929867330666230224093849. Curr Med Chem. 2024. PMID: 36825700 Review.
BACKGROUND: During the COVID-19 pandemic, people suffered from major mental health problems. These include stress, anxiety, and confusion about the existing situation of home confinement. ...OBJECTIVE: This review discusses the indications for using melatonin …
BACKGROUND: During the COVID-19 pandemic, people suffered from major mental health problems. These include stress, anxiety, an …
Computational medicinal chemistry role in clinical pharmacy education: Ingavirin for coronavirus disease 2019 (COVID-19) discovery model.
Saadah LM, Deiab GIA, Al-Balas QA, Basheti IA. Saadah LM, et al. Pharm Pract (Granada). 2022 Oct-Dec;20(4):2746. doi: 10.18549/PharmPract.2022.4.2746. Epub 2022 Nov 8. Pharm Pract (Granada). 2022. PMID: 36793906 Free PMC article.
OBJECTIVE: Given the major shift to patient-directed education, novel coronavirus (nCoV) provides a live example on how medicinal chemistry could be a key science to teach pharmacy students. ...CONCLUSION: Ingavirin has a promising inhibitory potential to host (ACE2 …
OBJECTIVE: Given the major shift to patient-directed education, novel coronavirus (nCoV) provides a live example on how medici …
Melatonin levels are low in COVID-19 positive patients and these levels are associated with depression, death anxiety and insomnia.
Yılmaz S, Öner P. Yılmaz S, et al. Scand J Clin Lab Invest. 2023 Apr;83(2):86-94. doi: 10.1080/00365513.2023.2175236. Epub 2023 Feb 8. Scand J Clin Lab Invest. 2023. PMID: 36752213
In addition, and the melatonin levels of COVID-19 positive patients at 02:00 h and at 06:00 h were lower than both the COVID-19 negative patient group and the control group. It was observed that the peak melatonin concentration of COVI …
In addition, and the melatonin levels of COVID-19 positive patients at 02:00 h and at 06:00 h were lower than both the …
Development of indolealkylamine derivatives as potential multi-target agents for COVID-19 treatment.
Chauhan J, Cecon E, Labani N, Gbahou F, Real F, Bomsel M, Dubey KD, Das R, Dam J, Jockers R, Sen S. Chauhan J, et al. Eur J Med Chem. 2023 Mar 5;249:115152. doi: 10.1016/j.ejmech.2023.115152. Epub 2023 Jan 27. Eur J Med Chem. 2023. PMID: 36724633 Free PMC article.
COVID-19 is a complex disease with short-term and long-term respiratory, inflammatory and neurological symptoms that are triggered by the infection with SARS-CoV-2. ...Both compounds inhibit SARS-CoV-2 entry into host cells …
COVID-19 is a complex disease with short-term and long-term respiratory, inflammatory and neurological symptoms that are trigg …
Endoplasmic Reticulum Stress in Elderly Patients with COVID-19: Potential of Melatonin Treatment.
Yiang GT, Wu CC, Lu CL, Hu WC, Tsai YJ, Huang YM, Su WL, Lu KC. Yiang GT, et al. Viruses. 2023 Jan 4;15(1):156. doi: 10.3390/v15010156. Viruses. 2023. PMID: 36680196 Free PMC article. Review.
Aging is associated with oxidative damage. Moreover, SARS-CoV-2 infections may increase the production of reactive oxygen species and such infections will disturb the Ca(++) balance via an endoplasmic reticulum (ER) stress-mediated unfolded protein response. …
Aging is associated with oxidative damage. Moreover, SARS-CoV-2 infections may increase the production of reactive oxyg …
Melatonin for prevention of acute kidney injury in patients treated with intravenous polymyxin B: a double-blind, placebo-controlled randomized clinical trial.
Rigatto MH, Bergo P, Baldissera G, Beck E, David L, Santoro L, Barros A, Zanin R, Budelon Gonçalves JI, Falci D, Caumo W, Zavascki AP. Rigatto MH, et al. Clin Microbiol Infect. 2023 May;29(5):623-628. doi: 10.1016/j.cmi.2022.12.017. Epub 2022 Dec 28. Clin Microbiol Infect. 2023. PMID: 36586514 Free article. Clinical Trial.
Melatonin or placebo pills were administered until the end of polymyxin B treatment or for a maximum of 14 days. ...RESULTS: Eighty-eight patients were randomized: 44 in the melatonin group and 44 in the placebo group. The study ended prematurely because of polymyxi …
Melatonin or placebo pills were administered until the end of polymyxin B treatment or for a maximum of 14 days. ...RESULTS: Eighty-e …
Melatonin-Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions.
Iesanu MI, Zahiu CDM, Dogaru IA, Chitimus DM, Pircalabioru GG, Voiculescu SE, Isac S, Galos F, Pavel B, O'Mahony SM, Zagrean AM. Iesanu MI, et al. Antioxidants (Basel). 2022 Nov 14;11(11):2244. doi: 10.3390/antiox11112244. Antioxidants (Basel). 2022. PMID: 36421432 Free PMC article. Review.
Melatonin is a pineal indolamine, allegedly known as a circadian rhythm regulator, and an antioxidative and immunomodulatory molecule. ...The gut represents one of melatonin's most abundant extra pineal sources, with a 400-times-higher concentration than the …
Melatonin is a pineal indolamine, allegedly known as a circadian rhythm regulator, and an antioxidative and immunomodulatory molecule …
Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial.
Ameri A, Frouz Asadi M, Ziaei A, Vatankhah M, Safa O, Kamali M, Fathalipour M, Mahmoodi M, Hassanipour S. Ameri A, et al. Inflammopharmacology. 2023 Feb;31(1):265-274. doi: 10.1007/s10787-022-01096-7. Epub 2022 Nov 19. Inflammopharmacology. 2023. PMID: 36401728 Free PMC article. Clinical Trial.
Patients with COVID-19 have shown melatonin deficiency. We evaluated the efficacy and safety of administration oral melatonin in patients with COVID-19-induced pneumonia. ...Melatonin significantly improved clinical status with a s …
Patients with COVID-19 have shown melatonin deficiency. We evaluated the efficacy and safety of administration oral …
Possible Application of Melatonin in Long COVID.
Cardinali DP, Brown GM, Pandi-Perumal SR. Cardinali DP, et al. Biomolecules. 2022 Nov 7;12(11):1646. doi: 10.3390/biom12111646. Biomolecules. 2022. PMID: 36358996 Free PMC article. Review.
Clinical sequelae and symptoms for a considerable number of COVID-19 patients can linger for months beyond the acute stage of SARS-CoV-2 infection, "long COVID". ...Further studies on the therapeutic use of melatonin in the neurological s …
Clinical sequelae and symptoms for a considerable number of COVID-19 patients can linger for months beyond the acute stage of …
Potential Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2.
Begum R, Mamun-Or-Rashid ANM, Lucy TT, Pramanik MK, Sil BK, Mukerjee N, Tagde P, Yagi M, Yonei Y. Begum R, et al. Molecules. 2022 Oct 16;27(20):6934. doi: 10.3390/molecules27206934. Molecules. 2022. PMID: 36296527 Free PMC article. Review.
We were motivated to consider melatonin as a defensive agent against SARS-CoV-2 because of its various unique properties. ...Melatonin has a high safety profile, but it needs further clinical trials and experiments for use as a therapeutic agent …
We were motivated to consider melatonin as a defensive agent against SARS-CoV-2 because of its various unique pr …
The role of melatonin as an adjuvant in the treatment of COVID-19: A systematic review.
Faridzadeh A, Tabashiri A, Miri HH, Mahmoudi M. Faridzadeh A, et al. Heliyon. 2022 Oct;8(10):e10906. doi: 10.1016/j.heliyon.2022.e10906. Epub 2022 Oct 7. Heliyon. 2022. PMID: 36254292 Free PMC article. Review.
INTRODUCTION: Since November 2019, the world has been grappling with the rapid spread of the Coronavirus disease 2019 (COVID-19). In response to this major health crisis, the first vaccination rollout was launched in December 2020. ...The use of melatonin …
INTRODUCTION: Since November 2019, the world has been grappling with the rapid spread of the Coronavirus disease 2019 (COVID- …
Is Melatonin the "Next Vitamin D"?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements.
Minich DM, Henning M, Darley C, Fahoum M, Schuler CB, Frame J. Minich DM, et al. Nutrients. 2022 Sep 22;14(19):3934. doi: 10.3390/nu14193934. Nutrients. 2022. PMID: 36235587 Free PMC article. Review.
Research over the last decade into cancer, Alzheimer's disease, multiple sclerosis, fertility, PCOS, and many other conditions, combined with the COVID-19 pandemic, has led to greater awareness of melatonin because of its ability to act as a potent antioxidan …
Research over the last decade into cancer, Alzheimer's disease, multiple sclerosis, fertility, PCOS, and many other conditions, combined wit …
Sleep During the COVID-19 Pandemic.
Papagiouvanni I, Kotoulas SC, Vettas C, Sourla E, Pataka A. Papagiouvanni I, et al. Curr Psychiatry Rep. 2022 Nov;24(11):635-643. doi: 10.1007/s11920-022-01371-y. Epub 2022 Oct 4. Curr Psychiatry Rep. 2022. PMID: 36192579 Free PMC article. Review.
PURPOSE OF REVIEW: We reviewed current evidence on the impact of coronavirus disease 2019 (COVID-19) pandemic on sleep of different populations. RECENT FINDINGS: Several studies demonstrated that sleep deprivation may cause immune system dysregulation, which …
PURPOSE OF REVIEW: We reviewed current evidence on the impact of coronavirus disease 2019 (COVID-19) pandemic on sleep …
The safety and efficacy of melatonin in the treatment of COVID-19: A systematic review and meta-analysis.
Wang XC, Wu GL, Cai YF, Zhang SJ. Wang XC, et al. Medicine (Baltimore). 2022 Sep 30;101(39):e30874. doi: 10.1097/MD.0000000000030874. Medicine (Baltimore). 2022. PMID: 36181086 Free PMC article.
BACKGROUND: As an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the common signs of coronavirus disease 2019 (COVID-19) are respiratory symptoms, f …
BACKGROUND: As an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 …
MEL-Index: Estimation of Tissue Melatonin Levels Using Gene Expression Data.
Fernandes PACM, Markus RP, Kinker GS. Fernandes PACM, et al. Methods Mol Biol. 2022;2550:29-32. doi: 10.1007/978-1-0716-2593-4_5. Methods Mol Biol. 2022. PMID: 36180674
As measuring locally produced melatonin in fresh tissues might be a challenge due to limited material availability, we created a simple predictive model, the MEL-Index, which infers the content of tissue melatonin using gene expression data. The MEL-Index can be a p …
As measuring locally produced melatonin in fresh tissues might be a challenge due to limited material availability, we created a simp …
Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?
Catalano A, Iacopetta D, Ceramella J, Maio AC, Basile G, Giuzio F, Bonomo MG, Aquaro S, Walsh TJ, Sinicropi MS, Saturnino C, Geronikaki A, Salzano G. Catalano A, et al. Foods. 2022 Sep 17;11(18):2884. doi: 10.3390/foods11182884. Foods. 2022. PMID: 36141012 Free PMC article. Review.
The beginning of the end or the end of the beginning? After two years mastered by coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. The reduction of severe cases and deaths from COVID-19 led to increasing importance …
The beginning of the end or the end of the beginning? After two years mastered by coronavirus disease 19 (COVID-19) pan …
[Autism Spectrum Disorders: What the COVID-19 Pandemic Has Taught Us].
Ionescu S, Jourdan-Ionescu C. Ionescu S, et al. Ann Med Psychol (Paris). 2022 Sep 6. doi: 10.1016/j.amp.2022.08.013. Online ahead of print. Ann Med Psychol (Paris). 2022. PMID: 36091091 Free PMC article. French.
The article is devoted to the consequences of the pandemic caused by SARS-CoV-2 and more particularly, of the preventive measures adopted during this period on people with autism spectrum disorders (ASD). ...This increased risk is explained by the presence of …
The article is devoted to the consequences of the pandemic caused by SARS-CoV-2 and more particularly, of the preventiv …
Autophagy Dysregulation in Metabolic Associated Fatty Liver Disease: A New Therapeutic Target.
Chen CL, Lin YC. Chen CL, et al. Int J Mol Sci. 2022 Sep 2;23(17):10055. doi: 10.3390/ijms231710055. Int J Mol Sci. 2022. PMID: 36077452 Free PMC article. Review.
Autophagy has also been reported to inhibit the production of pro-inflammatory cytokines and provide energy for the hepatic stellate cells activation during liver fibrosis. Thyroid hormone, irisin, melatonin, hydrogen sulfide, sulforaphane, DA-1241, vacuole membrane protei …
Autophagy has also been reported to inhibit the production of pro-inflammatory cytokines and provide energy for the hepatic stellate cells a …
Transcutaneous auricular vagal nerve stimulation releases extrapineal melatonin and reduces thermal hypersensitivity in Zucker diabetic fatty rats.
Wang S, Li S, Zhai X, Rong P, He J, Liu L, He X, Liu W. Wang S, et al. Front Neurosci. 2022 Aug 11;16:916822. doi: 10.3389/fnins.2022.916822. eCollection 2022. Front Neurosci. 2022. PMID: 36033612 Free PMC article.
Type 2 diabetes (T2D) is the most common comorbidity of COVID-19, and both are related to the lack of circulating melatonin. In addition, chronic pain is a common sequela of both COVID-19 and T2D. ...In conclusion, the mechanism of the therapeut …
Type 2 diabetes (T2D) is the most common comorbidity of COVID-19, and both are related to the lack of circulating melatonin …
Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19.
Hosseinzadeh A, Bagherifard A, Koosha F, Amiri S, Karimi-Behnagh A, Reiter RJ, Mehrzadi S. Hosseinzadeh A, et al. Life Sci. 2022 Oct 15;307:120866. doi: 10.1016/j.lfs.2022.120866. Epub 2022 Aug 6. Life Sci. 2022. PMID: 35944663 Free PMC article. Review.
Severe COVID-19 is associated with the dynamic changes in coagulation parameters. Coagulopathy is considered as a major extra-pulmonary risk factor for severity and mortality of COVID-19; patients with elevated levels of coagulation biomarkers have poo …
Severe COVID-19 is associated with the dynamic changes in coagulation parameters. Coagulopathy is considered as a major extra- …
Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19.
Loh D, Reiter RJ. Loh D, et al. Int J Mol Sci. 2022 Jul 23;23(15):8122. doi: 10.3390/ijms23158122. Int J Mol Sci. 2022. PMID: 35897696 Free PMC article. Review.
The relentless, protracted evolution of the SARS-CoV-2 virus imposes tremendous pressure on herd immunity and demands versatile adaptations by the human host genome to counter transcriptomic and epitranscriptomic alterations associated with a wide range of sh …
The relentless, protracted evolution of the SARS-CoV-2 virus imposes tremendous pressure on herd immunity and demands v …
A Pilot of a Randomized Control Trial of Melatonin and Vitamin C for Mild-to-Moderate COVID-19.
Fogleman C, Cohen D, Mercier A, Farrell D, Rutz J, Bresz K, Vernon T. Fogleman C, et al. J Am Board Fam Med. 2022 Jul-Aug;35(4):695-707. doi: 10.3122/jabfm.2022.04.210529. J Am Board Fam Med. 2022. PMID: 35896462 Free article. Clinical Trial.
This study aimed to help determine the effect of dietary supplements on symptom course and quality of life in patients with mild-to-moderate COVID-19 infection. DESIGN: We modified the Wisconsin Upper Respiratory Symptom Survey (WURSS) to conduct a 3 arm, parallel, …
This study aimed to help determine the effect of dietary supplements on symptom course and quality of life in patients with mild-to-moderate …
The impact of COVID-19 on sleep and circadian rhythm.
Lins-Filho O, Pedrosa RP. Lins-Filho O, et al. J Bras Pneumol. 2022 Jul 8;48(3):e20220191. doi: 10.36416/1806-3756/e20220191. J Bras Pneumol. 2022. PMID: 35830058 Free PMC article. No abstract available.
The use of dietary supplements for mental health among the Saudi population: A cross-sectional survey.
Alateeq D, Alsubaie MA, Alsafi FA, Alsulaiman SH, Korayem GB. Alateeq D, et al. Saudi Pharm J. 2022 Jun;30(6):742-749. doi: 10.1016/j.jsps.2022.03.017. Epub 2022 Mar 29. Saudi Pharm J. 2022. PMID: 35812149 Free PMC article.
INTRODUCTION: Despite limited evidence about the efficacy and safety of dietary supplements (DSs) for improving mental health, people with or without mental disorders often tend to use them, especially during the ongoing COVID-19 pandemic. Previous studies focused o …
INTRODUCTION: Despite limited evidence about the efficacy and safety of dietary supplements (DSs) for improving mental health, people with o …
A Review of the Potential Effects of Melatonin in Compromised Mitochondrial Redox Activities in Elderly Patients With COVID-19.
Su WL, Wu CC, Wu SV, Lee MC, Liao MT, Lu KC, Lu CL. Su WL, et al. Front Nutr. 2022 Jun 20;9:865321. doi: 10.3389/fnut.2022.865321. eCollection 2022. Front Nutr. 2022. PMID: 35795579 Free PMC article. Review.
The signs of aging, including immune aging, increased basal inflammation, mitochondrial dysfunction, significant telomeric abrasion, and disrupted autophagy, contribute to the increased severity of severe acute respiratory syndrome coronavirus …
The signs of aging, including immune aging, increased basal inflammation, mitochondrial dysfunction, significant telomeric abrasion, and dis …
Could melatonin have a potential adjuvant role in the treatment of the lasting anosmia associated with COVID-19? A review.
Xerfan EMS, Morelhao PK, Arakaki FH, Facina ADS, Tomimori J, Xavier SD, Tufik S, Andersen ML. Xerfan EMS, et al. Int J Dev Neurosci. 2022 Oct;82(6):465-470. doi: 10.1002/jdn.10208. Epub 2022 Jul 23. Int J Dev Neurosci. 2022. PMID: 35766866 Free PMC article. Review.
INTRODUCTION: Anosmia, the loss of the sense of smell, is usually associated with rhinopathies and has been reported as a common symptom of COVID-19. There is no specific drug to treat this condition, although some evidence suggests that melatonin could promo …
INTRODUCTION: Anosmia, the loss of the sense of smell, is usually associated with rhinopathies and has been reported as a common symptom of …
Protective Effect of Melatonin Administration against SARS-CoV-2 Infection: A Systematic Review.
Molina-Carballo A, Palacios-López R, Jerez-Calero A, Augustín-Morales MC, Agil A, Muñoz-Hoyos A, Muñoz-Gallego A. Molina-Carballo A, et al. Curr Issues Mol Biol. 2021 Dec 22;44(1):31-45. doi: 10.3390/cimb44010003. Curr Issues Mol Biol. 2021. PMID: 35723382 Free PMC article. Review.
according to the World Health Organization (WHO), COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, responsible for an increasing number of cases and deaths. ...Results: once the selection process was completed, and after an in-d …
according to the World Health Organization (WHO), COVID-19 is an infectious disease caused by the SARS-CoV-2 …
Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels.
Cecon E, Fernandois D, Renault N, Coelho CFF, Wenzel J, Bedart C, Izabelle C, Gallet S, Le Poder S, Klonjkowski B, Schwaninger M, Prevot V, Dam J, Jockers R. Cecon E, et al. Cell Mol Life Sci. 2022 Jun 13;79(7):361. doi: 10.1007/s00018-022-04390-3. Cell Mol Life Sci. 2022. PMID: 35697820 Free PMC article.
COVID-19 is a complex disease with short- and long-term respiratory, inflammatory and neurological symptoms that are triggered by the infection with SARS-CoV-2. ...Our findings open new perspectives for the repurposing of melatonergic drugs and …
COVID-19 is a complex disease with short- and long-term respiratory, inflammatory and neurological symptoms that are triggered …
Infections, Pandemics, and Sleep Disorders.
Kolokolov OV, Salina EA, Yudina VV, Shuldyakov AA, Runnova AE. Kolokolov OV, et al. Neurosci Behav Physiol. 2022;52(3):319-325. doi: 10.1007/s11055-022-01242-2. Epub 2022 Jun 7. Neurosci Behav Physiol. 2022. PMID: 35692961 Free PMC article.
Studies of the neurological symptoms and signs associated with the acute and late phases of infectious diseases are important in pandemic conditions. The novel coronavirus infection (COVID-19) pandemic has increased the number of patients with sleeplessness, …
Studies of the neurological symptoms and signs associated with the acute and late phases of infectious diseases are important in pandemic co …
Digital Addiction and Sleep.
Dresp-Langley B, Hutt A. Dresp-Langley B, et al. Int J Environ Res Public Health. 2022 Jun 5;19(11):6910. doi: 10.3390/ijerph19116910. Int J Environ Res Public Health. 2022. PMID: 35682491 Free PMC article. Review.
Recent studies have shown that the problem has increased in magnitude worldwide during the COVID-19 pandemic. The extent to which dysfunctional sleep is a consequence of altered motivation, memory function, mood, diet, and other lifestyle variables or results from e …
Recent studies have shown that the problem has increased in magnitude worldwide during the COVID-19 pandemic. The extent to wh …
Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action.
Muñoz-Jurado A, Escribano BM, Caballero-Villarraso J, Galván A, Agüera E, Santamaría A, Túnez I. Muñoz-Jurado A, et al. Inflammopharmacology. 2022 Oct;30(5):1569-1596. doi: 10.1007/s10787-022-01011-0. Epub 2022 Jun 5. Inflammopharmacology. 2022. PMID: 35665873 Free PMC article. Review.
RESULTS: Melatonin causes a significant increase in the levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione and can counteract and inhibit the effects of the NLRP3 inflammasome, which would also be beneficial during SARS-CoV-2 …
RESULTS: Melatonin causes a significant increase in the levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione …
A comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID-19 patients by phytotherapeutic melatonin and epigallocatechin-3-gallate.
Chattree V, Singh K, Singh K, Goel A, Maity A, Lone A. Chattree V, et al. J Food Biochem. 2022 Dec;46(12):e14259. doi: 10.1111/jfbc.14259. Epub 2022 Jun 3. J Food Biochem. 2022. PMID: 35662052 Free PMC article. Review.
SARS-CoV-2 infection has now become the world's most significant health hazard, with the World Health Organization declaring a pandemic on March 11, 2020. COVID-19 enters the lungs through angiotensin-converting enzyme 2 (ACE2) receptors, alters …
SARS-CoV-2 infection has now become the world's most significant health hazard, with the World Health Organization decl …
SARS-CoV-2 Infection Dysregulates Host Iron (Fe)-Redox Homeostasis (Fe-R-H): Role of Fe-Redox Regulators, Ferroptosis Inhibitors, Anticoagulants, and Iron-Chelators in COVID-19 Control.
Naidu SAG, Clemens RA, Naidu AS. Naidu SAG, et al. J Diet Suppl. 2023;20(2):312-371. doi: 10.1080/19390211.2022.2075072. Epub 2022 May 22. J Diet Suppl. 2023. PMID: 35603834
Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in every symptomatic (mild, moderate to severe) clinical phase of COVID-19. ...Therefore, Fe-R-H restoration is a host biomarker-driven potential combat strategy …
Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in every symptomatic (mild, moderat …
Does melatonin reduce mortality in COVID-19?
Pilia E, Alborino E, Covello RD. Pilia E, et al. Ann Med Surg (Lond). 2022 Jun;78:103817. doi: 10.1016/j.amsu.2022.103817. Epub 2022 May 18. Ann Med Surg (Lond). 2022. PMID: 35603098 Free PMC article. No abstract available.
Potential of Endogenous Oxytocin in Endocrine Treatment and Prevention of COVID-19.
Wang SC, Zhang F, Zhu H, Yang H, Liu Y, Wang P, Parpura V, Wang YF. Wang SC, et al. Front Endocrinol (Lausanne). 2022 May 3;13:799521. doi: 10.3389/fendo.2022.799521. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35592777 Free PMC article. Review.
Coronavirus disease 2019 or COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a significant threat to the health of human beings. ...Meanwhile, blocking …
Coronavirus disease 2019 or COVID-19 caused by severe acute respiratory syndrome coronav …
High dose melatonin as an adjuvant therapy in intubated patients with COVID-19: A randomized clinical trial.
Alizadeh N, Dianatkhah M, Alimohamadi Y, Moradi H, Akbarpour S, Akrami M, Mansouri F, Faraji N, Rezaie Z, Alizadeh M, Hosamirudsari H. Alizadeh N, et al. J Taibah Univ Med Sci. 2022 Jun;17(3):454-460. doi: 10.1016/j.jtumed.2022.04.012. Epub 2022 May 13. J Taibah Univ Med Sci. 2022. PMID: 35581997 Free PMC article.
OBJECTIVE: In the COVID-19 pandemic, the SARS-CoV-2 virus has infected millions of people worldwide. Mortality primarily results from the inflammation state and its complications. High-dose melatonin has been established as an anti-inflam …
OBJECTIVE: In the COVID-19 pandemic, the SARS-CoV-2 virus has infected millions of people worldwide. Mort …
Melatonin as a complementary and prophylactic agent against COVID-19 in high-risk populations: A narrative review of recent findings from clinical and preclinical studies.
Hosseini A, Badri T, Esmaeili Gouvarchin Ghaleh H, Hassanpour K, Alishiri G, Akbariqomi M, Farnoosh G. Hosseini A, et al. Fundam Clin Pharmacol. 2022 Dec;36(6):918-929. doi: 10.1111/fcp.12805. Epub 2022 May 31. Fundam Clin Pharmacol. 2022. PMID: 35567287 Review.
Search terms "melatonin" and "COVID-19" were manually searched on PubMed or other electronic database and relevant articles were included. ...These beneficial effects highlight the impact of melatonin as an adjuvant and a potential alternative for the …
Search terms "melatonin" and "COVID-19" were manually searched on PubMed or other electronic database and relevant arti …
The CLASS Study (Circadian Light in Adolescence, Sleep and School): protocol for a prospective, longitudinal cohort to assess sleep, light, circadian timing and academic performance in adolescence.
Stone JE, Wiley J, Chachos E, Hand AJ, Lu S, Raniti M, Klerman E, Lockley SW, Carskadon MA, Phillips AJK, Bei B, Rajaratnam SMW; CLASS Study Team. Stone JE, et al. BMJ Open. 2022 May 10;12(5):e055716. doi: 10.1136/bmjopen-2021-055716. BMJ Open. 2022. PMID: 35537785 Free PMC article.
We also describe protocol adaptations to enable remote data collection when required during the COVID-19 pandemic. METHODS: Approximately 220 healthy adolescents aged 12-13 years (school Year 7) will be recruited from the general community in Melbourne, Australia. . …
We also describe protocol adaptations to enable remote data collection when required during the COVID-19 pandemic. METHODS: Ap …
How Are the Sleep Problems of Children in the US Foster Care System Addressed?
Alfano CA, Valentine M, Nogales JM, Kim J, Kim JS, Rigos P, McGlinchey EL, Ripple CH, Wolfson AR. Alfano CA, et al. J Dev Behav Pediatr. 2022 Oct-Nov 01;43(8):e525-e532. doi: 10.1097/DBP.0000000000001090. Epub 2022 May 4. J Dev Behav Pediatr. 2022. PMID: 35507424
Nearly half of all caregivers (46%) reported giving their child melatonin. Caregivers reported that a bedtime routine/consistency, reassurance of safety/love, and a calming environment were most important for helping their child sleep well. ...As these data were collected …
Nearly half of all caregivers (46%) reported giving their child melatonin. Caregivers reported that a bedtime routine/consistency, re …
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