Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2020 93
2021 196
2022 188
2023 124
2024 136
2025 25

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

697 results

Results by year

Filters applied: in the last 5 years. Clear all
Page 1
VITT-like Monoclonal Gammopathy of Thrombotic Significance.
Wang JJ, Warkentin TE, Schönborn L, Wheeler MB, Geerts WH, Costedoat-Chalumeau N, Gendron N, Ene G, Lozano M, Langer F, Lindhoff-Last E, Budde K, Chataway T, Troelnikov A, Sheppard JI, Zhang Y, Arnold DM, Gordon TP, Thiele T, Greinacher A, Nazy I. Wang JJ, et al. N Engl J Med. 2025 Feb 12. doi: 10.1056/NEJMoa2415930. Online ahead of print. N Engl J Med. 2025. PMID: 39938091
VITT antibodies are implicated in acute, transient prothrombotic disorders that are triggered by adenoviral vector vaccines against coronavirus disease 2019 or by adenovirus infection. We describe chronic prothrombotic disorders featuring anticoagulant-refractory thrombose …
VITT antibodies are implicated in acute, transient prothrombotic disorders that are triggered by adenoviral vector vaccines against coron
Host Response Stratification in Malarial and Non-malarial Sepsis: A Prospective, Multicenter Analysis From Uganda.
Cummings MJ, Lutwama JJ, Owor N, Tomoiaga AS, Ross JE, Muwanga M, Nsereko C, Nayiga I, Kyebambe S, Shinyale J, Ochar T, Nie K, Xie H, Miake-Lye S, Villagomez B, Qi J, Reynolds SJ, Nakibuuka MC, Lu X, Kayiwa J, Haumba M, Nakaseegu J, Che X, Byakika-Kibwika P, Wayengera M, Achan J, Kim-Schulze S, Lipkin WI, O'Donnell MR, Bakamutumaho B. Cummings MJ, et al. Crit Care Med. 2025 Feb 12. doi: 10.1097/CCM.0000000000006591. Online ahead of print. Crit Care Med. 2025. PMID: 39937058
DESIGN AND SETTING: Analysis of Olink proteomic data from prospective observational cohort studies of sepsis conducted at public hospitals in Uganda (discovery cohort [Entebbe, urban], n = 238; validation cohort [Tororo, rural], n = 253). PATIENTS: Adults (age 18 yr …
DESIGN AND SETTING: Analysis of Olink proteomic data from prospective observational cohort studies of sepsis conducted at public hosp …
APNet, an explainable sparse deep learning model to discover differentially active drivers of severe COVID-19.
Gavriilidis GI, Vasileiou V, Dimitsaki S, Karakatsoulis G, Giannakakis A, Pavlopoulos GA, Psomopoulos F. Gavriilidis GI, et al. Bioinformatics. 2025 Feb 8:btaf063. doi: 10.1093/bioinformatics/btaf063. Online ahead of print. Bioinformatics. 2025. PMID: 39921901
MOTIVATION: Computational analyses of bulk and single-cell omics provide translational insights into complex diseases, such as COVID-19, by revealing molecules, cellular phenotypes, and signalling patterns that contribute to unfavourable clinical outcomes. .. …
MOTIVATION: Computational analyses of bulk and single-cell omics provide translational insights into complex diseases, such as COVID- …
Clinical and Multiorgan Proteomics Characteristics of the Diverse Fatal Phase in Super Elderly Patients With SARS-CoV-2 Infection: A Descriptive Study.
Wang S, Sun J, Hu Y, Zhang W, Qin B, Li M, Zhang N, Wang S, Zhou T, Liu M, Ma C, Deng X, Bai Y, Qu G, Liu L, Shi H, Zhou B, Li K, Yang B, Li S, Wang F, Ma J, Zhang L, Wang Y, An L, Liu W, Chang Q, Zhang R, Yin X, Yang Y, Ao Q, Ma Q, Yan S, Huang H, Song P, Zhao S, Gao L, Lu W, Xu L, Lei L, Wang K, Song Q, Zhang Z, Fang X, He Y, Zhang Q, Jia J, Zhu P. Wang S, et al. J Med Virol. 2025 Feb;97(2):e70207. doi: 10.1002/jmv.70207. J Med Virol. 2025. PMID: 39921383
This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to fatal SARS-CoV-2 infection within the super-elderly population. ...Effective management of comorbidities may improve th …
This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to …
P.1 and P.2 SARS-CoV-2 Brazilian variants activate the unfolded protein response with a time and pathway specificity.
de Morais Gomes V, Santos DM, da Silva JM, Lazari LC, Machado RRG, Dos Santos AF, Araujo DB, Coutinho JVP, Arini GS, Angeli CB, de Souza EE, Marques RF, Boscardin SB, Wrenger C, Marinho CRF, Oliveira DBL, Durigon EL, Labriola L, Rosa-Fernandes L, Palmisano G. de Morais Gomes V, et al. J Proteomics. 2025 Feb 3:105397. doi: 10.1016/j.jprot.2025.105397. Online ahead of print. J Proteomics. 2025. PMID: 39909104
COVID-19 is a human respiratory syndrome caused by the infection of the SARS-CoV-2 virus that has a high rate of infection and mortality. ...This study elucidated an activation of a diversity of molecular mechanisms by Brazilian variants of S
COVID-19 is a human respiratory syndrome caused by the infection of the SARS-CoV-2 virus that has a high
HDL proteome and apolipoproteins concentrations in severe ICU COVID-19 patients.
Begue F, Veeren B, Rondeau P, Florence AM, Jamard S, Montravers P, Tanaka S, Meilhac O; French COVID Study Group. Begue F, et al. Lipids Health Dis. 2025 Jan 31;24(1):32. doi: 10.1186/s12944-024-02381-w. Lipids Health Dis. 2025. PMID: 39891286 Free PMC article.
Despite the crucial role that these nanoparticles play in SARS-CoV-2 infection, few studies have examined their structure during COVID-19 beyond HDL quantity. The study aimed to assess apolipoprotein levels in COVID-19 patients
Despite the crucial role that these nanoparticles play in SARS-CoV-2 infection, few studies have examined their structu …
Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis.
Canny SP, Stanaway IB, Holton SE, Mitchem M, O'Rourke AR, Pribitzer S, Baxter SK, Wurfel MM, Malhotra U, Buckner JH, Bhatraju PK, Morrell ED, Speake C, Mikacenic C, Hamerman JA. Canny SP, et al. Crit Care Explor. 2025 Jan 31;7(2):e1203. doi: 10.1097/CCE.0000000000001203. eCollection 2025 Feb 1. Crit Care Explor. 2025. PMID: 39888602 Free PMC article.
METHODS AND MODELS: We identified two cohorts of adult patients presenting with COVID-19 at two tertiary care hospitals in Seattle, Washington in 2020 and 2021. ...We identified 264 patients with COVID-19 of whom 24 met our sHLH definitio …
METHODS AND MODELS: We identified two cohorts of adult patients presenting with COVID-19 at two tertiary care hospitals …
Utility of Protein Markers in COVID-19 Patients.
Alicia LB, María Ángeles OG, Desirée MG, Maximino R, Marilina GA. Alicia LB, et al. Int J Mol Sci. 2025 Jan 14;26(2):653. doi: 10.3390/ijms26020653. Int J Mol Sci. 2025. PMID: 39859366 Free PMC article. Review.
COVID-19 has been a challenge at the healthcare level not only in the early stages of the pandemic, but also in the subsequent appearance of long-term COVID-19. Several investigations have attempted to identify proteomic biomarkers in an attempt
COVID-19 has been a challenge at the healthcare level not only in the early stages of the pandemic, but also in the subsequent
Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls.
Buonsenso D, Cotugno N, Amodio D, Pascucci GR, Di Sante G, Pighi C, Morrocchi E, Pucci A, Olivieri G, Colantoni N, Romani L, Rotili A, Neri A, Morello R, Sali M, Tremoulet A, Raffaelli F, Zampino G, Rossi P, Valentini P, Palma P. Buonsenso D, et al. Pediatr Res. 2025 Jan 24. doi: 10.1038/s41390-025-03837-0. Online ahead of print. Pediatr Res. 2025. PMID: 39849114
METHODS: We performed an extensive protein analysis of blood plasma from pediatric patients younger than 19 years of age Long COVID and a control group of children with acute COVID-19, MIS-C, and healthy controls resulted similar for sex distribution and age. …
METHODS: We performed an extensive protein analysis of blood plasma from pediatric patients younger than 19 years of age Long COVID a …
Proteomic, metabolomic and lipidomic profiles in community acquired pneumonia for differentiating viral and bacterial infections.
Rischke S, Gurke R, Zielbauer AS, Ziegler N, Hahnefeld L, Köhm M, Kannt A, Vehreschild MJ, Geisslinger G, Rohde G, Bellinghausen C, Behrens F, Study Group C. Rischke S, et al. Sci Rep. 2025 Jan 14;15(1):1922. doi: 10.1038/s41598-025-85229-2. Sci Rep. 2025. PMID: 39809876 Free PMC article.
Community-acquired pneumonia (CAP) has a significant impact on public health, especially in light of the recent SARS-CoV-2 pandemic. To enhance disease characterization and improve understanding of the underlying mechanisms, a comprehensive analysis of the pl …
Community-acquired pneumonia (CAP) has a significant impact on public health, especially in light of the recent SARS-CoV-2
4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection.
de Lima IL, Cataldi TR, Brites C, Labate MTV, Vaz SN, Deminco F, da Cunha GS, Labate CA, Eberlin MN. de Lima IL, et al. J Proteome Res. 2025 Feb 7;24(2):499-514. doi: 10.1021/acs.jproteome.4c00630. Epub 2025 Jan 13. J Proteome Res. 2025. PMID: 39803891 Free PMC article.
Since late 2021, Omicron variants have dominated the epidemiological scenario as the most successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sublineages, driving new and breakthrough infections gl …
Since late 2021, Omicron variants have dominated the epidemiological scenario as the most successful severe acute respirato
Proteomic and metabolomic profiling of plasma uncovers immune responses in patients with Long COVID-19.
Wei Y, Gu H, Ma J, Mao X, Wang B, Wu W, Yu S, Wang J, Zhao H, He Y. Wei Y, et al. Front Microbiol. 2024 Dec 27;15:1470193. doi: 10.3389/fmicb.2024.1470193. eCollection 2024. Front Microbiol. 2024. PMID: 39802657 Free PMC article.
This study included three age- and gender-matched cohorts: healthy controls (n = 18), COVID-19 recovered patients (n = 17), and Long COVID patients (n = 15). The proteomics results revealed significant differences in proteins between Long COV
This study included three age- and gender-matched cohorts: healthy controls (n = 18), COVID-19 recovered patients (n = …
Individual patient and donor seroprofiles in convalescent plasma treatment of COVID-19 in REMAP-CAP clinical trial.
Nurmi V, Mayne R, Knight C, Almonacid-Mendoza HL, Secret S, Estcourt L, Hepojoki J, Šuštić T, Lamikanra AA, Tsang HP, Menon DK, Shankar-Hari M, van der Schoot CE, Vidarsson G, Roberts DJ, Simmonds P, Hedman K, Harvala H. Nurmi V, et al. J Infect. 2025 Jan 9;90(2):106412. doi: 10.1016/j.jinf.2025.106412. Online ahead of print. J Infect. 2025. PMID: 39798805 Free article.
RESULTS: Most patients were SARS-CoV-2 seropositive pre-transfusion (72% nAb; 89% S-IgG seropositivity). ...Better outcomes, measured by organ support-free days, were associated with increase in S-IgM levels (p=0.007), decreased S-IgG fucosylation (p&l …
RESULTS: Most patients were SARS-CoV-2 seropositive pre-transfusion (72% nAb; 89% S-IgG seropositivity). ...Bett …
Assessment of Humoral Response at SARS-CoV-2 Infection by Multipronged Functional Proteomics Approaches.
Juanes-Velasco P, Pérez-Arévalo JC, Arias-Hidalgo C, Nuño-Soriano A, Landeira-Viñuela A, Corrales F, Bernardo D, Cuesta-Sancho S, Rojo-Rello S, Lécrevisse Q, Góngora R, Sánchez-Santos JM, De Las Rivas J, Hernández ÁP, Fuentes M. Juanes-Velasco P, et al. J Proteome Res. 2025 Feb 7;24(2):515-525. doi: 10.1021/acs.jproteome.4c00635. Epub 2025 Jan 7. J Proteome Res. 2025. PMID: 39772566
This study evaluates prior immunity as a prognostic factor in COVID-19 patients, crucial for understanding plasmatic signaling cascades in different disease stages and their impact on disease progression. COVID-19, caused by SARS-CoV
This study evaluates prior immunity as a prognostic factor in COVID-19 patients, crucial for understanding plasmatic si …
Proteomic Profile Regulated by the Immunomodulatory Jusvinza Drug in Neutrophils Isolated from Rheumatoid Arthritis Patients.
Hernández-Cedeño M, Rodríguez-Ulloa A, Ramos Y, González LJ, Serrano-Díaz A, Zettl K, Wiśniewski JR, Martinez-Donato G, Guillen-Nieto G, Besada V, Domínguez-Horta MDC. Hernández-Cedeño M, et al. Biomedicines. 2024 Nov 29;12(12):2740. doi: 10.3390/biomedicines12122740. Biomedicines. 2024. PMID: 39767648 Free PMC article.
The peptide induces regulatory T cells and decreases levels of TNF-alpha and IL-17; pre-clinical and phase I clinical studies support its use for the treatment of RA. This peptide was repositioned for the treatment of COVID-19 patients with sign …
The peptide induces regulatory T cells and decreases levels of TNF-alpha and IL-17; pre-clinical and phase I clinical studies …
In Search of Candidate Protein Biomarkers Related to COVID-19 in Solid Tissues and Non-Blood Fluids: An Update.
Alexovič M, Uličná C, Tabani H, Sabo J. Alexovič M, et al. Proteomics Clin Appl. 2024 Dec 30:e202400117. doi: 10.1002/prca.202400117. Online ahead of print. Proteomics Clin Appl. 2024. PMID: 39740114 Review.
The mass spectrometry-based proteomics of COVID-19-related biomarkers can help with the prognosis and diagnosis of this severe disease. DESIGN: Here, we surveyed scientific works in terms of proteomic analysis of solid tissues and non-blood fluids from …
The mass spectrometry-based proteomics of COVID-19-related biomarkers can help with the prognosis and diagnosis of this …
Proteomic profiling of peripheral blood mononuclear cells reveals immune dysregulation and metabolic alterations in kidney transplant recipients with COVID-19.
Leite GGF, Sousa MB, Rodrigues LOCP, Brunialti MKC, Medina-Pestana J, Butler JM, Peters-Sengers H, Requião-Moura L, Salomão R. Leite GGF, et al. Front Immunol. 2024 Dec 16;15:1508110. doi: 10.3389/fimmu.2024.1508110. eCollection 2024. Front Immunol. 2024. PMID: 39737170 Free PMC article.
Recently, mass spectrometry-based proteomics has emerged as a powerful tool to shed light on a broad spectrum of dysregulated biological processes in KTRs with COVID-19. ...Our results revealed significant proteomic alterations in COVID-19
Recently, mass spectrometry-based proteomics has emerged as a powerful tool to shed light on a broad spectrum of dysregulated biologi …
Viral infections in celiac disease: what should be considered for better management.
Asri N, Mohammadi S, Jahdkaran M, Rostami-Nejad M, Rezaei-Tavirani M, Mohebbi SR. Asri N, et al. Clin Exp Med. 2024 Dec 28;25(1):25. doi: 10.1007/s10238-024-01542-6. Clin Exp Med. 2024. PMID: 39731690 Free PMC article. Review.
Moreover, previous studies have shown that celiac patients, especially untreated subjects, are at increased risk of developing viral and bacterial infections, which can become a challenge for the clinician. Viruses, such as Rotavirus, Reovirus, Adenovirus, Enterovir …
Moreover, previous studies have shown that celiac patients, especially untreated subjects, are at increased risk of developing viral …
Self-Assembly of Human Fibrinogen into Microclot-Mimicking Antifibrinolytic Amyloid Fibrinogen Particles.
Mai X, Hu Y, Wu Z, Guo X, Dong M, Jia L, Ren J. Mai X, et al. ACS Appl Bio Mater. 2025 Jan 20;8(1):825-834. doi: 10.1021/acsabm.4c01651. Epub 2024 Dec 26. ACS Appl Bio Mater. 2025. PMID: 39723824
Recent clinical studies have highlighted the presence of microclots in the form of amyloid fibrinogen particles (AFPs) in plasma samples from Long COVID patients. ...Proteomic analysis suggests that AFPs interact with various components of human plasma and ha …
Recent clinical studies have highlighted the presence of microclots in the form of amyloid fibrinogen particles (AFPs) in plasma samp …
SARS-CoV-2 ORF8 drives osteoclastogenesis in preexisting immune-mediated inflammatory diseases.
Melano I, Azamor T, Caetano CC, Meyer NM, Onwubueke C, Visperas A, Familiar-Macedo D, Salem GM, Soos BL, Calabrese CM, Choi YJ, Chen S, Choi Y, Wu X, Vasconcelos Z, Comhair SA, Nielsen-Saines K, Calabrese LH, Husni ME, Jung JU, Piuzzi NS, Foo SS, Chen W. Melano I, et al. JCI Insight. 2024 Dec 20;9(24):e178820. doi: 10.1172/jci.insight.178820. JCI Insight. 2024. PMID: 39704167 Free PMC article.
This study sought to identify specific immune mediators that exacerbated preexisting IMIDs after SARS-CoV-2 exposure. Plasma samples from 4 groups were analyzed: healthy, IMID only, COVID-19 only, and COVID-19 + IMID. ...Long-term …
This study sought to identify specific immune mediators that exacerbated preexisting IMIDs after SARS-CoV-2 exposure. P …
Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV: A Secondary Analysis of the REPRIEVE Randomized Clinical Trial.
Kolossváry M, Schnittman SR, Zanni MV, Fitch KV, Fichtenbaum CJ, Aberg JA, Bloomfield GS, Malvestutto CD, Currier J, Diggs MR, deFilippi C, Eckard AR, Curran A, Centinbas M, Sadreyev R, Foldyna B, Mayrhofer T, Karady J, Taron J, McCallum S, Lu MT, Ribaudo HJ, Douglas PS, Grinspoon SK. Kolossváry M, et al. JAMA Cardiol. 2024 Dec 11:e244115. doi: 10.1001/jamacardio.2024.4115. Online ahead of print. JAMA Cardiol. 2024. PMID: 39661372
MAIN OUTCOMES AND MEASURES: Relative change in plasma proteomics, transcriptomics, and noncalcified plaque volume among those receiving treatment vs placebo. ...TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02344290....
MAIN OUTCOMES AND MEASURES: Relative change in plasma proteomics, transcriptomics, and noncalcified plaque volume among those receivi …
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19.
Rong Z, Mai H, Ebert G, Kapoor S, Puelles VG, Czogalla J, Hu S, Su J, Prtvar D, Singh I, Schädler J, Delbridge C, Steinke H, Frenzel H, Schmidt K, Braun C, Bruch G, Ruf V, Ali M, Sühs KW, Nemati M, Hopfner F, Ulukaya S, Jeridi D, Mistretta D, Caliskan ÖS, Wettengel JM, Cherif F, Kolabas ZI, Molbay M, Horvath I, Zhao S, Krahmer N, Yildirim AÖ, Ussar S, Herms J, Huber TB, Tahirovic S, Schwarzmaier SM, Plesnila N, Höglinger G, Ondruschka B, Bechmann I, Protzer U, Elsner M, Bhatia HS, Hellal F, Ertürk A. Rong Z, et al. Cell Host Microbe. 2024 Dec 11;32(12):2112-2130.e10. doi: 10.1016/j.chom.2024.11.007. Epub 2024 Nov 29. Cell Host Microbe. 2024. PMID: 39615487 Free article.
SARS-CoV-2 infection is associated with long-lasting neurological symptoms, although the underlying mechanisms remain unclear. Using optical clearing and imaging, we observed the accumulation of SARS-CoV-2 spike protein in the skull-menin
SARS-CoV-2 infection is associated with long-lasting neurological symptoms, although the underlying mechanisms remain u
Rapid diagnosis and severity scale of post-COVID condition using advanced spectroscopy.
Antelo-Riveiro P, Vázquez M, Domínguez-Santalla MJ, Rodríguez-Ruiz E, Piñeiro Á, Garcia-Fandino R. Antelo-Riveiro P, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2025 Mar 5;328:125474. doi: 10.1016/j.saa.2024.125474. Epub 2024 Nov 24. Spectrochim Acta A Mol Biomol Spectrosc. 2025. PMID: 39615091 Free article.
The COVID-19 pandemic has resulted in a persistent health challenge known as Post-COVID Condition (PCC), characterized by symptoms lasting at least three months after the initial SARS-CoV-2 infection and potentially persisting for several years. …
The COVID-19 pandemic has resulted in a persistent health challenge known as Post-COVID Condition (PCC), characterized by symp …
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19.
Maguire C, Chen J, Rouphael N, Pickering H, Phan HV, Glascock A, Chu V, Dandekar R, Corry D, Kheradmand F, Baden LR, Selaky R, McComsey GA, Haddad EK, Cairns CB, Pulendran B, Fernandez-Sesma A, Simon V, Metcalf JP, Higuita NIA, Messer WB, David MM, Nadeau KC, Kraft M, Bime C, Schaenman J, Erle D, Calfee CS, Atkinson MA, Brackenridge SC, Ehrlich LIR, Montgomery RR, Shaw AC, Hough CL, Geng LN, Hafler DA, Augustine AD, Becker PM, Peters B, Ozonoff A, Kim-Schulze SH, Krammer F, Bosinger S, Eckalbar W, Altman MC, Wilson M, Guan L, Kleinstein SH; IMPACC Network; Smolen KK, Reed EF, Levy O, Maecker H, Hunt P, Steen H, Diray-Arce J, Langelier CR, Melamed E. Maguire C, et al. bioRxiv [Preprint]. 2024 Nov 16:2024.11.14.622799. doi: 10.1101/2024.11.14.622799. bioRxiv. 2024. PMID: 39605478 Free PMC article. Preprint.
We also show that viral reactivation correlated with COVID-19 severity, demographic characteristics, and clinical outcomes, including mortality. ...IL-6, CXCL10, and TNF), increased activated CD4+ and CD8+ T-cells, and upregulation of cellular replication gen …
We also show that viral reactivation correlated with COVID-19 severity, demographic characteristics, and clinical outco …
iTRAQ-Based Proteomic Analysis of Spontaneous Achilles Tendon Rupture.
Qianman B, Jiasharete T, Badalihan A, Mamately A, Yeerbo N, Bahesutihan Y, Wupuer A, Aisaiding A, Wuerliebieke J, Jialihasi A, Li P, Jielile J. Qianman B, et al. J Proteome Res. 2025 Jan 3;24(1):65-76. doi: 10.1021/acs.jproteome.4c00357. Epub 2024 Nov 27. J Proteome Res. 2025. PMID: 39601082
The present study aimed to uncover the key pathological molecules by using iTRAQ proteomics. The results identified 2432 candidate proteins in SATR patients using iTRAQ proteomic analysis. A total of 307 differentially expressed proteins (DEPs) were identifie …
The present study aimed to uncover the key pathological molecules by using iTRAQ proteomics. The results identified 2432 candidate pr …
Dynamic Cellular Proteome Remodeling during SARS-CoV-2 Infection. Identification of Plasma Protein Readouts.
Dos Santos FM, Vindel-Alfageme J, Ciordia S, Castro V, Orera I, Garaigorta U, Gastaminza P, Corrales F. Dos Santos FM, et al. J Proteome Res. 2025 Jan 3;24(1):171-188. doi: 10.1021/acs.jproteome.4c00566. Epub 2024 Nov 26. J Proteome Res. 2025. PMID: 39593238 Free PMC article.
From this perspective, proteomics could help to understand the mechanisms associated with SARS-CoV-2 infection and to identify new therapeutic options. A TMT-based quantitative proteomics and phosphoproteomics analysis was performed to study the …
From this perspective, proteomics could help to understand the mechanisms associated with SARS-CoV-2 infection a …
Indeterminate Result of Interferon-gamma Release Assay-A Risk Factor of Mortality for COVID-19 and Non-COVID-19 Respiratory Infections.
Tian W, Han Z, Shi D, Wang H, Tang H, Wu Z, Zhang Y, Cui L, Shen N, Zheng J, Chen Y. Tian W, et al. J Med Virol. 2024 Nov;96(11):e70058. doi: 10.1002/jmv.70058. J Med Virol. 2024. PMID: 39588785 Free PMC article.
Toward the end of 2022, the cessation of China's "dynamic zero-COVID policy" had led to a notable outbreak of SARS-CoV-2 infections and a substantial number of severe cases and deaths were reported, which raised serious concerns. ...This indeterminate IGRA re …
Toward the end of 2022, the cessation of China's "dynamic zero-COVID policy" had led to a notable outbreak of SARS-CoV-2
Different dynamics of soluble inflammatory mediators after clearance of respiratory SARS-CoV-2 versus blood-borne hepatitis C virus infections.
Zeuzem A, Kumar SD, Oltmanns C, Witte M, Mischke J, Drick N, Fuge J, Pink I, Tauwaldt J, Debarry J, Illig T, Wedemeyer H, Maasoumy B, Li Y, Kraft ARM, Cornberg M. Zeuzem A, et al. Sci Rep. 2024 Nov 22;14(1):29013. doi: 10.1038/s41598-024-79909-8. Sci Rep. 2024. PMID: 39578604 Free PMC article.
Most SIM in the SARS-CoV-2 cohort normalized within 3 months. In chronic HCV, SIM were higher in cirrhotic than noncirrhotic patients post-HCV elimination. Dynamics of SIM after viral elimination vary between blood-borne acute and chronic HCV infection …
Most SIM in the SARS-CoV-2 cohort normalized within 3 months. In chronic HCV, SIM were higher in cirrhotic than noncirr …
Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.
Gualdrón-López M, Ayllon-Hermida A, Cortes-Serra N, Resa-Infante P, Bech-Serra JJ, Aparici-Herraiz I, Nicolau-Fernandez M, Erkizia I, Gutierrez-Chamorro L, Marfil S, Pradenas E, Ávila Nieto C, Cucurull B, Montaner-Tarbés S, Muelas M, Sotil R, Ballana E, Urrea V, Fraile L, Montoya M, Vergara J, Segales J, Carrillo J, Izquierdo-Useros N, Blanco J, Fernandez-Becerra C, de La Torre C, Pinazo MJ, Martinez-Picado J, Del Portillo HA. Gualdrón-López M, et al. Front Cell Infect Microbiol. 2024 Nov 6;14:1442743. doi: 10.3389/fcimb.2024.1442743. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 39569406 Free PMC article.
We hypothesized that molecular characterization of EVs isolated from COVID-19 patients would reveal peptides suitable for vaccine development. Blood samples were collected from three cohorts: severe COVID-19 patients (G1), mild/asymptomat …
We hypothesized that molecular characterization of EVs isolated from COVID-19 patients would reveal peptides suitable f …
Serum proteomics identifies biomarkers for predicting non-survivors in elderly COVID-19 patients.
Wang L, Tian W, Wang S, Liu Y, Wang H, Xiao J, Yu Z, Xie L, Chen Y. Wang L, et al. J Proteomics. 2025 Jan 16;311:105356. doi: 10.1016/j.jprot.2024.105356. Epub 2024 Nov 14. J Proteomics. 2025. PMID: 39547396 Free article.
In December 2022, China ceased the zero-COVID-19 policy, resulting in an increase in hospitalizations and deaths due to COVID-19, particularly among the elderly population. ...Our study elucidated that immune disorders, lung damage, and cardiovascular …
In December 2022, China ceased the zero-COVID-19 policy, resulting in an increase in hospitalizations and deaths due to COV
Insights into Acinetobacter baumannii AMA205's Unprecedented Antibiotic Resistance.
Traglia GM, Pasteran F, Moheb S, Akhtar U, Gonzalez S, Maldonado C, Furtado N, Mohamed A, Escalante J, Tuttobene MR, Quillen A, Fontan C, Albornoz E, Corso A, Bonomo RA, Rao GG, Tolmasky ME, Ramirez MS. Traglia GM, et al. Int J Mol Sci. 2024 Oct 24;25(21):11424. doi: 10.3390/ijms252111424. Int J Mol Sci. 2024. PMID: 39518977 Free PMC article.
The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, Acinetobacter baumannii stands out due to its remarkable ability to acquire resistance genes and persist in hospital environments, leading to some …
The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, Acineto …
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion.
Christ W, Kapell S, Sobkowiak MJ, Mermelekas G, Evertsson B, Sork H, Saher O, Bazaz S, Gustafsson O, Cardenas EI, Villa V, Ricciarelli R, Sandberg JK, Bergquist J, Sturchio A, Svenningsson P, Malm T, Espay AJ, Pernemalm M, Lindén A, Klingström J, El Andaloussi S, Ezzat K. Christ W, et al. ACS Chem Neurosci. 2024 Nov 20;15(22):4095-4104. doi: 10.1021/acschemneuro.4c00636. Epub 2024 Nov 7. ACS Chem Neurosci. 2024. PMID: 39510798
The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological complications in patients, known as long COVID, have renewed interest in the correlation between viral infections and neurodegenerative brain disorders. ...Importantly, UV- …
The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological complications in patients, known …
Serum proteomics for the identification of biomarkers to flag predilection of COVID19 patients to various organ morbidities.
Rajan MV, Sharma V, Upadhyay N, Murali A, Bandyopadhyay S, Hariprasad G. Rajan MV, et al. Clin Proteomics. 2024 Nov 1;21(1):61. doi: 10.1186/s12014-024-09512-6. Clin Proteomics. 2024. PMID: 39487396 Free PMC article.
This heterogeneity in the clinical presentation of COVID19 infection has posed a challenge to clinicians around the world. It is therefore crucial to identify specific organ-related morbidity for effective treatment and better patient outcomes. We have …
This heterogeneity in the clinical presentation of COVID19 infection has posed a challenge to clinicians around the wor …
Serum proteome reveals distinctive molecular features of H7N9- and SARS-CoV-2-infected patients.
Wang Y, Song Z, Ran P, Xiang H, Xu Z, Xu N, Deng M, Zhu L, Yin Y, Feng J, Ding C, Yang W. Wang Y, et al. Cell Rep. 2024 Nov 26;43(11):114900. doi: 10.1016/j.celrep.2024.114900. Epub 2024 Nov 1. Cell Rep. 2024. PMID: 39487987 Free article.
Here, we performed a proteomic approach on sera samples from patients with H7N9-virus or SARS-CoV-2-virus infection and healthy controls. Compared to SARS-CoV-2, H7N9-virus infection caused elevated neutrophil concentrations …
Here, we performed a proteomic approach on sera samples from patients with H7N9-virus or SARS-CoV-2-virus …
Proteomic analysis of post-COVID condition: Insights from plasma and pellet blood fractions.
Seco-González A, Antelo-Riveiro P, Bravo SB, Garrido PF, Domínguez-Santalla MJ, Rodríguez-Ruiz E, Piñeiro Á, Garcia-Fandino R. Seco-González A, et al. J Infect Public Health. 2024 Dec;17(12):102571. doi: 10.1016/j.jiph.2024.102571. Epub 2024 Oct 23. J Infect Public Health. 2024. PMID: 39486386 Free article.
BACKGROUND: Persistent symptoms extending beyond the acute phase of SARS-CoV-2 infection, known as Post-COVID condition (PCC), continue to impact many individuals years after the COVID-19 pandemic began. ...While significant progress has been ma …
BACKGROUND: Persistent symptoms extending beyond the acute phase of SARS-CoV-2 infection, known as Post-COVID condition …
Proteomic Signatures of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Narrative Review.
Dourdouna MM, Tatsi EB, Syriopoulou V, Michos A. Dourdouna MM, et al. Children (Basel). 2024 Sep 26;11(10):1174. doi: 10.3390/children11101174. Children (Basel). 2024. PMID: 39457139 Free PMC article. Review.
RESULTS: We identified 15 studies and summarized their key proteomic findings. These studies investigated the serum or plasma proteome of MIS-C patients using MS, Proximity Extension, or Aptamer-based assays. The studies associated the proteomic profil …
RESULTS: We identified 15 studies and summarized their key proteomic findings. These studies investigated the serum or plasma prot
Reactive Astrocytosis-A Potential Contributor to Increased Suicide in Long COVID-19 Patients?
Costanza A, Amerio A, Aguglia A, Rossi M, Parise A, Magnani L, Serafini G, Amore M, Martins D, Nguyen KD. Costanza A, et al. Brain Sci. 2024 Sep 27;14(10):973. doi: 10.3390/brainsci14100973. Brain Sci. 2024. PMID: 39451987 Free PMC article. Review.
Astrocyte-related circulating markers were increased in depressed subjects and, to a less consistent extent, in COVID-19 patients. Furthermore, reactive astrocytosis was observed in subjects with SI/SB and those with COVID-19. ...As such, the fo …
Astrocyte-related circulating markers were increased in depressed subjects and, to a less consistent extent, in COVID-19 pa
Type 2 Diabetes Mellitus Aggravates Complement Dysregulation and Affects Cortisol Response in Patients with Post-COVID-19.
Ji W, Xie X, Bai G, Fan Y, He Y, Zhang L, Zhou H, Li L, Qiang D, Li H. Ji W, et al. Diabetes Metab Syndr Obes. 2024 Oct 19;17:3849-3861. doi: 10.2147/DMSO.S480457. eCollection 2024. Diabetes Metab Syndr Obes. 2024. PMID: 39449862 Free PMC article.
PURPOSE: COVID-19 viral infection results in dysregulation of the complement system and a decrease in cortisol and adrenocorticotropin hormone (ACTH) levels. This study aimed to explore the complement system, as well as cortisol and ACTH responses in patients
PURPOSE: COVID-19 viral infection results in dysregulation of the complement system and a decrease in cortisol and adrenocorti …
Deep phenotyping of pulmonary edema and pulmonary vascular permeability in COVID-19 ARDS.
Schippers JR, Atmowihardjo LN, Duijvelaar E, Knaap LG, Netea MG, Meijboom LJ, Bos LDJ, Bogaard HJ, Aman J. Schippers JR, et al. Am J Physiol Lung Cell Mol Physiol. 2025 Jan 1;328(1):L30-L40. doi: 10.1152/ajplung.00196.2024. Epub 2024 Oct 22. Am J Physiol Lung Cell Mol Physiol. 2025. PMID: 39437755 Free article.
Our aim was to phenotype pulmonary edema and pulmonary vascular permeability in patients with coronavirus disease 2019 (COVID-19) ARDS. Transpulmonary thermodilution measurements were conducted in 65 patients with COVID-19 ARDS on …
Our aim was to phenotype pulmonary edema and pulmonary vascular permeability in patients with coronavirus disease 2019 (COV
Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19.
Jernbom AF, Skoglund L, Pin E, Sjöberg R, Tegel H, Hober S, Rostami E, Rasmusson A, Cunningham JL, Havervall S, Thålin C, Månberg A, Nilsson P. Jernbom AF, et al. Nat Commun. 2024 Oct 17;15(1):8941. doi: 10.1038/s41467-024-53356-5. Nat Commun. 2024. PMID: 39414823 Free PMC article.
Autoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. We investigated the new-onset autoantibody repertoire in 525 healthcare workers and hospitalized COVID-19 patients at f …
Autoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. …
Unveiling unique effector function-related bulk antibody profiles in long-term hemodialysis patients following COVID-19 mRNA booster vaccination.
Chou CY, Cheng CY, Lee CH, Kuro-O M, Chen TH, Wang SY, Chuang YK, Yang YJ, Lin YH, Tsai IL. Chou CY, et al. J Microbiol Immunol Infect. 2025 Feb;58(1):27-37. doi: 10.1016/j.jmii.2024.09.007. Epub 2024 Oct 1. J Microbiol Immunol Infect. 2025. PMID: 39395903 Free article.
BACKGROUND: Hemodialysis patients exhibit a reduced response to vaccination and have different vaccine dose regimens. ...Therefore, we aimed to analyze the antibody glycosylation profiles in hemodialysis patients who were vaccinated against severe acute
BACKGROUND: Hemodialysis patients exhibit a reduced response to vaccination and have different vaccine dose regimens. ...Therefore, w …
Synergistic evolution: The dynamic adaptation of SARS-CoV-2 and human protective immunity in the real world.
Li Y, Zhang X, Yi J, Chen Y, Liang J, Wang L, Ma J, Zhu R, Zhang X, Hu D, Jia Y, Yu X, Wang Y. Li Y, et al. J Infect. 2024 Dec;89(6):106310. doi: 10.1016/j.jinf.2024.106310. Epub 2024 Oct 10. J Infect. 2024. PMID: 39393556 Free article.
OBJECTIVES: SARS-CoV-2 is continually evolving with new variants to evade protective immunity and cause new infections. ...RESULTS: In the initial wave of the COVID-19 pandemic, >75% of the patients demonstrated robust NAb responses ag …
OBJECTIVES: SARS-CoV-2 is continually evolving with new variants to evade protective immunity and cause new infections. …
Peculiarities of Hemostasis and Proteomics in Patients With Acute Myocardial Infarction and Healthy Volunteers After SARS-CV-2 Infection.
Kalinskaya AI, Elizarova AK, Anisimova AS, Vorobyeva DA, Rusakovich GI, Maryukhnich EV, Dukhin OA, Ivanova OI, Bugrova AE, Brzhozovskiy AG, Indeykina MI, Kononikhin AS, Nikolaev EN, Vasilieva EY. Kalinskaya AI, et al. Kardiologiia. 2024 Sep 30;64(9):58-69. doi: 10.18087/cardio.2024.9.n2752. Kardiologiia. 2024. PMID: 39392268 English, Russian.
MATERIAL AND METHODS: The study included patients with AMI who have recently had COVID-19 (AMI-post-COVID, n=56) and patients with AMI who have not recently had COVID-19 (AMI-control, n=141). ...This may be due to long-term chronic inflam …
MATERIAL AND METHODS: The study included patients with AMI who have recently had COVID-19 (AMI-post-COVID, n=56) and …
Circulating Proteins Associated with Anti-IL6 Receptor Therapeutic Resistance in the Sera of Patients with Severe COVID-19.
Michot JM, Dozio V, Rohmer J, Pommeret F, Roumier M, Yu H, Sklodowki K, Danlos FX, Ouali K, Kishazi E, Naigeon M, Griscelli F, Gachot B, Groh M, Bacciarello G, Stoclin A, Willekens C, Sakkal M, Bayle A, Zitvogel L, Silvin A, Soria JC, Barlesi F, Beeler K, André F, Vasse M, Chaput N, Ackermann F, Escher C, Marabelle A. Michot JM, et al. J Proteome Res. 2024 Nov 1;23(11):5001-5015. doi: 10.1021/acs.jproteome.2c00422. Epub 2024 Oct 1. J Proteome Res. 2024. PMID: 39352225
The outcomes of patients with COVID-19 and acute respiratory distress syndrome triggered by the SARS-CoV2 virus remain uncertain. Tocilizumab is an anti-interleukin-6 treatment that exerts encouraging clinical activity by controlling the …
The outcomes of patients with COVID-19 and acute respiratory distress syndrome triggered by the SARS-CoV2
Cerebral small vessel injury in mice with damage to ACE2-expressing cerebral vascular endothelial cells and post COVID-19 patients.
Lu J, Zuo X, Cai A, Xiao F, Xu Z, Wang R, Miao C, Yang C, Zheng X, Wang J, Ding X, Xiong W. Lu J, et al. Alzheimers Dement. 2024 Nov;20(11):7971-7988. doi: 10.1002/alz.14279. Epub 2024 Oct 1. Alzheimers Dement. 2024. PMID: 39352003 Free PMC article.
DISCUSSION: Our findings suggest that SARS-CoV-2 may induce cerebral small vessel damage with persistent sequelae, underscoring the imperative for heightened clinical vigilance in mitigating or treating SARS-CoV-2-mediated cerebral …
DISCUSSION: Our findings suggest that SARS-CoV-2 may induce cerebral small vessel damage with persistent sequelae, unde …
Acute estradiol and progesterone therapy in hospitalized adults to reduce COVID-19 severity: a randomized control trial.
Lovre D, Qadir MMF, Bateman K, Saltzman LY, Sherman M, Mauvais-Jarvis F. Lovre D, et al. Sci Rep. 2024 Sep 30;14(1):22732. doi: 10.1038/s41598-024-73263-5. Sci Rep. 2024. PMID: 39349554 Free PMC article. Clinical Trial.
COVID-19 outcomes are less severe in women than men suggesting that female sex is protective. ...The E2P4 group exhibited a decrease in biomarker pathways of respiratory and gastrointestinal disease inflammation, infection by coronavirus, and immune cell traf
COVID-19 outcomes are less severe in women than men suggesting that female sex is protective. ...The E2P4 group exhibited a de
Mortality Risk and Urinary Proteome Changes in Acute COVID-19 Survivors in the Multinational CRIT-COV-U Study.
Siwy J, Keller F, Banasik M, Peters B, Dudoignon E, Mebazaa A, Gülmez D, Spasovski G, Lazo MS, Rajzer MW, Fuławka Ł, Dzitkowska-Zabielska M, Mischak H, Hecking M, Beige J, Wendt R, UriCoV Working Group. Siwy J, et al. Biomedicines. 2024 Sep 13;12(9):2090. doi: 10.3390/biomedicines12092090. Biomedicines. 2024. PMID: 39335603 Free PMC article.
Therefore, within this study, the mortality risk post-acute COVID-19 in the CRIT-COV-U cohort was investigated. METHODS: Survival data from 651 patients that survived an acute phase of COVID-19 were retrieved and the association between u …
Therefore, within this study, the mortality risk post-acute COVID-19 in the CRIT-COV-U cohort was investigated. METHODS …
Potential Plasma Proteins (LGALS9, LAMP3, PRSS8 and AGRN) as Predictors of Hospitalisation Risk in COVID-19 Patients.
McLarnon T, McDaid D, Lynch SM, Cooper E, McLaughlin J, McGilligan VE, Watterson S, Shukla P, Zhang SD, Bucholc M, English A, Peace A, O'Kane M, Kelly M, Bhavsar M, Murray EK, Gibson DS, Walsh CP, Bjourson AJ, Rai TS. McLarnon T, et al. Biomolecules. 2024 Sep 17;14(9):1163. doi: 10.3390/biom14091163. Biomolecules. 2024. PMID: 39334929 Free PMC article.
Background: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has posed unprecedented challenges to healthcare systems worldwide. ...Methods: We investigated the proteomic and genomic profile of COVID-19
Background: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has posed unprecede …
Sulfated Bile Acids in Serum as Potential Biomarkers of Disease Severity and Mortality in COVID-19.
Porru E, Comito R, Interino N, Cerrato A, Contoli M, Rizzo P, Conti M, Campo G, Spadaro S, Caliceti C, Marini F, Capriotti AL, Laganà A, Roda A. Porru E, et al. Cells. 2024 Sep 19;13(18):1576. doi: 10.3390/cells13181576. Cells. 2024. PMID: 39329758 Free PMC article.
The fight against coronavirus disease 2019 (COVID-19) continues. Since the pandemic's onset, several biomarkers have been proposed to assess the diagnosis and prognosis of this disease. This research aimed to identify potential disease severity biomarkers in …
The fight against coronavirus disease 2019 (COVID-19) continues. Since the pandemic's onset, several biomarkers have be …
Alterations in the plasma proteome persist ten months after recovery from mild to moderate SARS-CoV-2 infection.
Huapaya JA, Gairhe S, Kanth S, Tian X, Demirkale CY, Regenold D, Sun J, Lynch NF, Luo R, Forsberg A, Dewar R, Rehman T, Li W, Krack J, Kuruppu J, Aboye EA, Barnett C, Strich JR, Davey R, Childs R, Chertow D, Kovacs JA, Torabi-Parizi P, Suffredini AF. Huapaya JA, et al. Front Immunol. 2024 Sep 11;15:1448780. doi: 10.3389/fimmu.2024.1448780. eCollection 2024. Front Immunol. 2024. PMID: 39324144 Free PMC article.
BACKGROUND: Limited data are available describing the effects of SARS-CoV-2 breakthrough infections on the plasma proteome. METHODS: PCR-positive SARS-CoV-2 patients, enrolled in a natural history study, underwent analysis o …
BACKGROUND: Limited data are available describing the effects of SARS-CoV-2 breakthrough infections on the plasma pr
Targeted MRM-analysis of plasma proteins in frozen whole blood samples from patients with COVID-19: a retrospective study.
Bugrova AE, Strelnikova PA, Kononikhin AS, Zakharova NV, Diyachkova EO, Brzhozovskiy AG, Indeykina MI, Kurochkin IN, Averyanov AV, Nikolaev EN. Bugrova AE, et al. Clin Chem Lab Med. 2024 Sep 26. doi: 10.1515/cclm-2024-0800. Online ahead of print. Clin Chem Lab Med. 2024. PMID: 39321553 Free article.
A total of 131 samples (FRCC, Russia) from patients with mild (n=41), moderate (n=39) and severe (n=19) COVID-19 infection and healthy controls (n=32) were analyzed. ...The best-performing classifier built with 10 proteins achieved the best combination of ROC …
A total of 131 samples (FRCC, Russia) from patients with mild (n=41), moderate (n=39) and severe (n=19) COVID-19 infect …
Proteomics of blood extracellular vesicles in inflammatory respiratory diseases for biomarker discovery and new insights into pathophysiology.
Kawasaki T, Takeda Y, Kumanogoh A. Kawasaki T, et al. Inflamm Regen. 2024 Sep 18;44(1):38. doi: 10.1186/s41232-024-00351-4. Inflamm Regen. 2024. PMID: 39294831 Free PMC article. Review.
Blood EVs offer advantages over traditional serum or plasma samples. Proteomic analyses of blood EVs have revealed numerous biomarkers that can be used to stratify patients, predict disease progression, and identify candidate therapeutic targets. ...Moreover, EVs pl …
Blood EVs offer advantages over traditional serum or plasma samples. Proteomic analyses of blood EVs have revealed numerous biomarker …
Monitoring SARS-CoV-2 IgA, IgM and IgG antibodies in dried blood and saliva samples using antibody proximity extension assays (AbPEA).
Wang M, Kamali-Moghaddam M, Löf L, Cortabarría Fernandez M, Díaz Codina R, Sterky FH, Åberg M, Landegren U, Zhao H. Wang M, et al. Sci Rep. 2024 Sep 17;14(1):21655. doi: 10.1038/s41598-024-72453-5. Sci Rep. 2024. PMID: 39289450 Free PMC article.
Using a modified proximity extension assay, total and immunoglobulin (Ig) class-specific anti-SARS-CoV-2 antibodies were sensitively and conveniently detected directly from o1.2 mm discs cut from dried blood and saliva spots (DBS and DSS) without the need for …
Using a modified proximity extension assay, total and immunoglobulin (Ig) class-specific anti-SARS-CoV-2 antibodies wer …
No signs of mast cell involvement in long-COVID: A case-control study.
Lenning OB, Jonsson G, Grimstad T, Janssen EAM, Braut GS, Berven F, Omdal R. Lenning OB, et al. Scand J Immunol. 2024 Nov;100(5):e13407. doi: 10.1111/sji.13407. Epub 2024 Sep 16. Scand J Immunol. 2024. PMID: 39285602
Long-COVID caused by SARS-CoV-2 infection has significant and increasing effects on human health worldwide. ...Involvement of mast cells-evolutionary old "multipurpose" innate immune cells-was reported recently in studies of acute infection and post-acute- …
Long-COVID caused by SARS-CoV-2 infection has significant and increasing effects on human health worldwide. ...Involvem …
Molecular targets in SARS-CoV-2 infection: An update on repurposed drug candidates.
Rahmani D, Jafari A, Kesharwani P, Sahebkar A. Rahmani D, et al. Pathol Res Pract. 2024 Nov;263:155589. doi: 10.1016/j.prp.2024.155589. Epub 2024 Sep 8. Pathol Res Pract. 2024. PMID: 39276508 Review.
The 2019 widespread contagion of the human coronavirus novel type (SARS-CoV-2) led to a pandemic declaration by the World Health Organization. A daily increase in patient numbers has formed an urgent necessity to find suitable targets and treatm …
The 2019 widespread contagion of the human coronavirus novel type (SARS-CoV-2) led to a pandemic declaration by …
Potential immunomodulatory effects of CAS+IMD monoclonal antibody cocktail in hospitalized patients with COVID-19.
Wang B, Golubov J, Oswald EM, Poon P, Wei Q, Lett C, Shehadeh F, Kaczynski M, Felix LO, Mishra B, Mylona EK, Wipperman MF, Chio E, Hamon SC, Hooper AT, Somersan-Karakaya S, Musser BJ, Petro CD, Hamilton JD, Sleeman MA, Kalliolias GD, Mylonakis E, Skokos D. Wang B, et al. EBioMedicine. 2024 Oct;108:105334. doi: 10.1016/j.ebiom.2024.105334. Epub 2024 Sep 12. EBioMedicine. 2024. PMID: 39270622 Free PMC article.
BACKGROUND: Passive administration of SARS-CoV-2 neutralizing monoclonal antibodies (mAbs), such as CAS + IMD (Casirivimab + Imdevimab) antibody cocktail demonstrated beneficial effects on clinical outcomes in hospitalized patients with COVID
BACKGROUND: Passive administration of SARS-CoV-2 neutralizing monoclonal antibodies (mAbs), such as CAS + IMD (Casirivi …
Increased mortality in hospital- compared to community-onset carbapenem-resistant enterobacterales infections.
Boutzoukas AE, Mackow N, Giri A, Komarow L, Hill C, Chen L, Doi Y, Satlin MJ, Arias C, Wang M, Mora Moreo L, Herc E, Cober E, Weston G, Patel R, Bonomo RA, Fowler V, van Duin D. Boutzoukas AE, et al. J Antimicrob Chemother. 2024 Nov 4;79(11):2916-2922. doi: 10.1093/jac/dkae306. J Antimicrob Chemother. 2024. PMID: 39236214
BACKGROUND: The CDC reported a 35% increase in hospital-onset (HO) carbapenem-resistant Enterobacterales (CRE) infections during the COVID-19 pandemic. We evaluated patient outcomes following HO and community-onset (CO) CRE bloodstream infections (BSI). ...Th …
BACKGROUND: The CDC reported a 35% increase in hospital-onset (HO) carbapenem-resistant Enterobacterales (CRE) infections during the COVI
Molecular fingerprint by omics-based approaches in saliva from patients affected by SARS-CoV-2 infection.
Pinto G, Gelzo M, Cernera G, Esposito M, Illiano A, Serpico S, Pinchera B, Gentile I, Castaldo G, Amoresano A. Pinto G, et al. J Mass Spectrom. 2024 Sep;59(9):e5082. doi: 10.1002/jms.5082. J Mass Spectrom. 2024. PMID: 39228271
Clinical expression of coronavirus disease 2019 (COVID-19) infectionis widely variable including fatal cases and patients with mild symptoms and a rapid resolution. ...In fact, on a total of 28 peptides, 22 (80%) were differently expressed in
Clinical expression of coronavirus disease 2019 (COVID-19) infectionis widely variable including fatal cases and
Plasma proteomics of acute tubular injury.
Schmidt IM, Surapaneni AL, Zhao R, Upadhyay D, Yeo WJ, Schlosser P, Huynh C, Srivastava A, Palsson R, Kim T, Stillman IE, Barwinska D, Barasch J, Eadon MT, El-Achkar TM, Henderson J, Moledina DG, Rosas SE, Claudel SE, Verma A, Wen Y, Lindenmayer M, Huber TB, Parikh SV, Shapiro JP, Rovin BH, Stanaway IB, Sathe NA, Bhatraju PK, Coresh J; Kidney Precision Medicine Project; Rhee EP, Grams ME, Waikar SS. Schmidt IM, et al. Nat Commun. 2024 Aug 27;15(1):7368. doi: 10.1038/s41467-024-51304-x. Nat Commun. 2024. PMID: 39191768 Free PMC article.
Non-invasive biomarkers of ATI may allow for early detection and drug development. Using the SomaScan proteomics platform on 434 patients with biopsy-confirmed kidney disease, we here identify plasma biomarkers associated with ATI severity. ...Additionally, we exami …
Non-invasive biomarkers of ATI may allow for early detection and drug development. Using the SomaScan proteomics platform on 434 p
Multi-modal immune dynamics of pre-COVID-19 Kawasaki Disease following intravenous immunoglobulin.
Cotugno N, Olivieri G, Pascucci GR, Amodio D, Morrocchi E, Pighi C, Manno EC, Rotulo GA, D'Anna C, Chinali M, Tarissi de Jacobis I, Buonsenso D, Villani A, Rossi P, Marchesi A, Palma P. Cotugno N, et al. Clin Immunol. 2024 Oct;267:110349. doi: 10.1016/j.clim.2024.110349. Epub 2024 Aug 24. Clin Immunol. 2024. PMID: 39186994 Free article.
To characterize this condition, plasma proteomic profiles, flow cytometry, and gene expression of T cell subsets were investigated in longitudinal samples from KD patients and compared with two control groups. ...APBB1IP demonstrated an association with coronary art …
To characterize this condition, plasma proteomic profiles, flow cytometry, and gene expression of T cell subsets were investigated in …
Identification of biomarkers for COVID-19 associated secondary hemophagocytic lymphohistiocytosis.
Canny SP, Stanaway IB, Holton SE, Mitchem M, O'Rourke AR, Pribitzer S, Baxter SK, Wurfel MM, Malhotra U, Buckner JH, Bhatraju PK, Morrell ED, Speake C, Mikacenic C, Hamerman JA. Canny SP, et al. bioRxiv [Preprint]. 2024 Aug 15:2024.08.13.607855. doi: 10.1101/2024.08.13.607855. bioRxiv. 2024. Update in: Crit Care Explor. 2025 Jan 31;7(2):e1203. doi: 10.1097/CCE.0000000000001203. PMID: 39185173 Free PMC article. Updated. Preprint.
DESIGN: In two cohorts of adult patients presenting with COVID-19 in 2020 and 2021, clinical lab values and serum proteomics were assessed. ...SETTING: Two tertiary care hospitals in Seattle, Washington (Virginia Mason Medical Center and Harborv …
DESIGN: In two cohorts of adult patients presenting with COVID-19 in 2020 and 2021, clinical lab values and seru …
Alterations in plasma proteome during acute COVID-19 and recovery.
Suski M, Olszanecka A, Stachowicz A, Kiepura A, Terlecki M, Madej J, Rajzer M, Olszanecki R. Suski M, et al. Mol Med. 2024 Aug 25;30(1):131. doi: 10.1186/s10020-024-00898-5. Mol Med. 2024. PMID: 39183264 Free PMC article.
METHODS: The presented study investigates temporal changes in plasma proteins in COVID-19 patients during hospitalization due to SARS-CoV-2 infection and six months after recovery by targeted SureQuant acquisition using PQ500 panel. ...Fu …
METHODS: The presented study investigates temporal changes in plasma proteins in COVID-19 patients during hospitalizati …
Interferon gene expression declines over time post-COVID infection and in long COVID patients.
Gómez-Carballa A, Pischedda S, Pardo-Seco J, Gómez-Rial J, Martinón-Torres F, Salas A. Gómez-Carballa A, et al. Infect Dis (Lond). 2025 Jan;57(1):35-48. doi: 10.1080/23744235.2024.2389481. Epub 2024 Aug 20. Infect Dis (Lond). 2025. PMID: 39163143 Free article.
It has been shown that an impaired and uncontrolled release of these glycoproteins can result in tissue damage and explain severe progression of coronavirus disease 2019 (COVID-19). However, their potential role in Long-COVID syndrome (LC) remains debateable. …
It has been shown that an impaired and uncontrolled release of these glycoproteins can result in tissue damage and explain severe progressio …
Deep Plasma Proteomics with Data-Independent Acquisition: Clinical Study Protocol Optimization with a COVID-19 Cohort.
Ward B, Pyr Dit Ruys S, Balligand JL, Belkhir L, Cani PD, Collet JF, De Greef J, Dewulf JP, Gatto L, Haufroid V, Jodogne S, Kabamba B, Lingurski M, Yombi JC, Vertommen D, Elens L. Ward B, et al. J Proteome Res. 2024 Sep 6;23(9):3806-3822. doi: 10.1021/acs.jproteome.4c00104. Epub 2024 Aug 19. J Proteome Res. 2024. PMID: 39159935 Free PMC article.
Here, we highlight the efficacy of combining moderate plasma prefractionation and data-independent acquisition (DIA) to significantly improve proteome coverage and depth while remaining cost-efficient. Using human plasma collected from a 20-patient COVID-1
Here, we highlight the efficacy of combining moderate plasma prefractionation and data-independent acquisition (DIA) to significantly improv …
High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases.
Jia X, Crawford JC, Gebregzabher D, Monson EA, Mettelman RC, Wan Y, Ren Y, Chou J, Novak T, McQuilten HA, Clarke M, Bachem A, Foo IJ, Fritzlar S, Carrera Montoya J, Trenerry AM, Nie S, Leeming MG, Nguyen THO, Kedzierski L, Littler DR, Kueh A, Cardamone T, Wong CY, Hensen L, Cabug A, Laguna JG, Agrawal M, Flerlage T, Boyd DF, Van de Velde LA, Habel JR, Loh L, Koay HF, van de Sandt CE, Konstantinov IE, Berzins SP, Flanagan KL, Wakim LM, Herold MJ, Green AM, Smallwood HS, Rossjohn J, Thwaites RS, Chiu C, Scott NE, Mackenzie JM, Bedoui S, Reading PC, Londrigan SL, Helbig KJ, Randolph AG, Thomas PG, Xu J, Wang Z, Chua BY, Kedzierska K. Jia X, et al. Cell. 2024 Aug 22;187(17):4586-4604.e20. doi: 10.1016/j.cell.2024.07.026. Epub 2024 Aug 12. Cell. 2024. PMID: 39137778 Free article.
Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized with avian A(H7N9) influenza, we investigated early drivers underpinning fatal disease. Transcriptomics strongly lin …
Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In pa
Molecular mimicry in multisystem inflammatory syndrome in children.
Bodansky A, Mettelman RC, Sabatino JJ Jr, Vazquez SE, Chou J, Novak T, Moffitt KL, Miller HS, Kung AF, Rackaityte E, Zamecnik CR, Rajan JV, Kortbawi H, Mandel-Brehm C, Mitchell A, Wang CY, Saxena A, Zorn K, Yu DJL, Pogorelyy MV, Awad W, Kirk AM, Asaki J, Pluvinage JV, Wilson MR, Zambrano LD, Campbell AP; Overcoming COVID-19 Network Investigators; Thomas PG, Randolph AG, Anderson MS, DeRisi JL. Bodansky A, et al. Nature. 2024 Aug;632(8025):622-629. doi: 10.1038/s41586-024-07722-4. Epub 2024 Aug 7. Nature. 2024. PMID: 39112696 Free PMC article.
In parallel, we also probed antibody responses from patients with MIS-C to the complete SARS-CoV-2 proteome and found enriched reactivity against a distinct domain of the SARS-CoV-2 nucleocapsid protein. ...Consequently, we …
In parallel, we also probed antibody responses from patients with MIS-C to the complete SARS-CoV-2 proteome
Association of caffeine consumption with cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease: A BALTAZAR cohort study.
Blum D, Cailliau E, Béhal H, Vidal JS, Delaby C, Buée L, Allinquant B, Gabelle A, Bombois S, Lehmann S, Schraen-Maschke S, Hanon O; BALTAZAR study group. Blum D, et al. Alzheimers Dement. 2024 Oct;20(10):6948-6959. doi: 10.1002/alz.14169. Epub 2024 Aug 4. Alzheimers Dement. 2024. PMID: 39099181 Free PMC article.
INTRODUCTION: We investigated the link between habitual caffeine intake with memory impairments and cerebrospinal fluid (CSF) biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. METHODS: MCI (N = 147) and AD (N = 116) patients of the …
INTRODUCTION: We investigated the link between habitual caffeine intake with memory impairments and cerebrospinal fluid (CSF) biomarkers in …
Clinical Characteristics and Comparative Proteomics Analysis of COVID-19-Related Atrioventricular Block.
Gao Y, Chen Z, Wu S, Chen R, Dai Y, Zhang S, Chen K. Gao Y, et al. Rev Cardiovasc Med. 2024 May 28;25(6):195. doi: 10.31083/j.rcm2506195. eCollection 2024 Jun. Rev Cardiovasc Med. 2024. PMID: 39076308 Free PMC article.
We aim to describe the baseline characteristics, proteomics profile, and outcomes for patients with COVID-19-related AVB. METHODS: We prospectively recruited patients diagnosed with COVID-19-related AVB between November 2022 and Ma …
We aim to describe the baseline characteristics, proteomics profile, and outcomes for patients with COVID-19-rel …
Pulmonary and renal long COVID at two-year revisit.
Wang J, Liang X, Zheng Y, Zhu Y, Zhou K, Wu X, Sun R, Hu Y, Zhu X, Chi H, Chen S, Lyu M, Xie Y, Yi X, Liu W, Cai X, Li S, Zhang Q, Wu C, Shi Y, Wang D, Peng M, Zhang Y, Liu H, Zhang C, Quan S, Kong Z, Kang Z, Zhu G, Zhu H, Chen S, Liang J, Yang H, Pang J, Fang Y, Chen H, Li J, Xu J, Guo T, Shen B. Wang J, et al. iScience. 2024 Jun 21;27(7):110344. doi: 10.1016/j.isci.2024.110344. eCollection 2024 Jul 19. iScience. 2024. PMID: 39055942 Free PMC article.
Pulmonary long COVID, characterized by fibrous stripes, was observed in 8.7% and 17.8% of patients at the 1-year and 2-year revisits, respectively, while renal long COVID was present in 15.2% and 23.9% of patients, respectively. ...This study provides a longitudinal …
Pulmonary long COVID, characterized by fibrous stripes, was observed in 8.7% and 17.8% of patients at the 1-year and 2-year revisits, …
Increased adrenal steroidogenesis and suppressed corticosteroid responsiveness in critical COVID-19.
Wen TZ, Li TR, Chen XY, Chen HY, Wang S, Fu WJ, Xiao SQ, Luo J, Tang R, Ji JL, Huang JF, He ZC, Luo T, Zhao HL, Chen C, Miao JY, Niu Q, Wang Y, Bian XW, Yao XH. Wen TZ, et al. Metabolism. 2024 Nov;160:155980. doi: 10.1016/j.metabol.2024.155980. Epub 2024 Jul 23. Metabolism. 2024. PMID: 39053691 Free article.
BACKGROUND: The effect of coronavirus disease 2019 (COVID-19) on adrenal endocrine metabolism in critically ill patients remains unclear. ...FINDINGS: The demographic characteristics of COVID-19 patients were comparable with those …
BACKGROUND: The effect of coronavirus disease 2019 (COVID-19) on adrenal endocrine metabolism in critically ill pati
Unbiased plasma profiling using pre-selected RNA aptamer pools predicts mortality in COVID-19 and identifies protein risk factors.
Jørgensen AG, Dupont DM, Fjelstrup S, Bus C, Hansen CB, Benfield T, Garred P, Heegaard PMH, Kjems J. Jørgensen AG, et al. Mol Ther Nucleic Acids. 2024 Jun 15;35(3):102253. doi: 10.1016/j.omtn.2024.102253. eCollection 2024 Sep 10. Mol Ther Nucleic Acids. 2024. PMID: 39049875 Free PMC article.
The impact of the COVID-19 pandemic demands effective prognostic tools for precise risk evaluation and timely intervention. This study utilized the APTASHAPE technology to profile plasma proteins in COVID-19 patient samples. Employing a highly d …
The impact of the COVID-19 pandemic demands effective prognostic tools for precise risk evaluation and timely intervention. Th …
Anti-TNF therapy impairs both short- and long-term IgG responses after repeated vaccination.
Buhre JS, Pongracz T, Geisen UM, Schubert M, Wang W, Nouta J, Obara M, Lehrian S, Rahmöller J, Petry J, Tran F, Schreiber S, Sümbül M, Berner D, Gerdes S, Schirmer J, Longardt AC, Hoff P, Kalinke U, Ludwig RJ, Bartsch YC, Hoyer BF, Wuhrer M, Ehlers M. Buhre JS, et al. Allergy. 2025 Feb;80(2):423-439. doi: 10.1111/all.16241. Epub 2024 Jul 25. Allergy. 2025. PMID: 39049686 Free PMC article.
Using TriNetX, a global healthcare database, we determined the risk of SARS-CoV-2 breakthrough infections in vaccinated patients treated with anti-TNF or other immunosuppressive drugs. ...Re-activation of potential memory B cells initially generated hi …
Using TriNetX, a global healthcare database, we determined the risk of SARS-CoV-2 breakthrough infections in vaccinated …
Network-based integrative multi-omics approach reveals biosignatures specific to COVID-19 disease phases.
Agamah FE, Ederveen THA, Skelton M, Martin DP, Chimusa ER, 't Hoen PAC. Agamah FE, et al. Front Mol Biosci. 2024 Jul 8;11:1393240. doi: 10.3389/fmolb.2024.1393240. eCollection 2024. Front Mol Biosci. 2024. PMID: 39040605 Free PMC article.
BACKGROUND: COVID-19 disease is characterized by a spectrum of disease phases (mild, moderate, and severe). ...The World Health Organization Ordinal Scale WHO Ordinal Scale was used as a disease severity reference to harmonize COVID-19 patient m …
BACKGROUND: COVID-19 disease is characterized by a spectrum of disease phases (mild, moderate, and severe). ...The World Healt …
Blood proteomics of COVID-19 infection: An update.
Alexovič M, Bondarchuk T, Uličná C, Sabo J. Alexovič M, et al. Clin Chim Acta. 2024 Aug 15;562:119881. doi: 10.1016/j.cca.2024.119881. Epub 2024 Jul 19. Clin Chim Acta. 2024. PMID: 39033952 Review.
Despite significant progress in understanding SARS-CoV-2 and its impact, a deeper comprehension of the molecular changes in the host following infection is still lacking. Proteomic analysis of COVID-19 infected patients can provide …
Despite significant progress in understanding SARS-CoV-2 and its impact, a deeper comprehension of the molecular change …
Molecular overlaps of neurological manifestations of COVID-19 and schizophrenia from a proteomic perspective.
Antunes ASLM, Reis-de-Oliveira G, Martins-de-Souza D. Antunes ASLM, et al. Eur Arch Psychiatry Clin Neurosci. 2025 Feb;275(1):109-122. doi: 10.1007/s00406-024-01842-8. Epub 2024 Jul 19. Eur Arch Psychiatry Clin Neurosci. 2025. PMID: 39028452
In addition, clinical evidence indicates that a diagnosis of a schizophrenia spectrum disorder is a risk factor for mortality in patients with COVID-19. ...Specifically, the COVID-19 brain proteome enriches processes that are hallm …
In addition, clinical evidence indicates that a diagnosis of a schizophrenia spectrum disorder is a risk factor for mortality in p
Changes in neuroinflammatory biomarkers correlate with disease severity and neuroimaging alterations in patients with COVID-19 neurological complications.
Barros-Aragão FGQ, Pinto TP, Carregari VC, Rezende NBS, Pinheiro TL, Reis-de-Oliveira G, Cabral-Castro MJ, Queiroz DC, Fonseca PLC, Gonçalves AL, de Freitas GR, Sudo FK, Mattos P, Bozza FA, Rodrigues EC, Aguiar RS, Rodrigues RS, Brandão CO, Souza AS, Martins-de-Souza D, De Felice FG, Tovar-Moll F. Barros-Aragão FGQ, et al. Brain Behav Immun Health. 2024 Jun 13;39:100805. doi: 10.1016/j.bbih.2024.100805. eCollection 2024 Aug. Brain Behav Immun Health. 2024. PMID: 39022627 Free PMC article.
To illuminate possible mechanisms leading to COVID-19 neurological disease, we retrospectively investigated in detail a cohort of 35 COVID-19 mild and severe hospitalized patients presenting neurological alterations subject to clinically
To illuminate possible mechanisms leading to COVID-19 neurological disease, we retrospectively investigated in detail a cohort …
Polymyalgia Rheumatica Following Respiratory Syncytial Virus (RSV) Vaccination.
El Labban M, Oluic S, Guleid H, Hassan M, Diab R, Rida MA. El Labban M, et al. Eur J Case Rep Intern Med. 2024 Jun 27;11(7):004636. doi: 10.12890/2024_004636. eCollection 2024. Eur J Case Rep Intern Med. 2024. PMID: 38984193 Free PMC article.
Studies have previously linked the onset and relapse of polymyalgia rheumatica symptoms to the influenza and COVID-19 vaccines. The Food and Drug Administration approved the respiratory syncytial virus (RSV) vaccine, which is a recombinant protein vaccine for …
Studies have previously linked the onset and relapse of polymyalgia rheumatica symptoms to the influenza and COVID-19 vacci
Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19.
Kanth SM, Huapaya JA, Gairhe S, Wang H, Tian X, Demirkale CY, Hou C, Ma J, Kuhns DB, Fink DL, Malayeri A, Turkbey E, Harmon SA, Chen MY, Regenold D, Lynch NF, Ramelli S, Li W, Krack J, Kuruppu J, Lionakis MS, Strich JR, Davey R, Childs R, Chertow DS, Kovacs JA, Parizi PT, Suffredini AF; COVID-ARC Study Group. Kanth SM, et al. Cell Rep Med. 2024 Jul 16;5(7):101642. doi: 10.1016/j.xcrm.2024.101642. Epub 2024 Jul 8. Cell Rep Med. 2024. PMID: 38981485 Free PMC article.
In order to assess homeostatic mechanisms in the lung after COVID-19, changes in the protein signature of bronchoalveolar lavage from 45 patients with mild to moderate disease at three phases (acute, recovery, and convalescent) are evaluated over a year. ...W …
In order to assess homeostatic mechanisms in the lung after COVID-19, changes in the protein signature of bronchoalveolar lava …
Clinical features and multiomics profiles indicate coagulation and platelet dysfunction in COVID-19 viral sepsis.
Xiao Z, Lin M, Song N, Wu X, Hou J, Wang L, Tian X, An C, Dela Cruz CS, Sharma L, Chang D. Xiao Z, et al. iScience. 2024 May 25;27(6):110110. doi: 10.1016/j.isci.2024.110110. eCollection 2024 Jun 21. iScience. 2024. PMID: 38974472 Free PMC article.
Increased cases of sepsis during COVID-19 in the absence of known bacterial pathogens highlighted role of viruses as causative agents of sepsis. In this study, we investigated clinical, laboratory, proteomic, and metabolomic characteristics of viral se …
Increased cases of sepsis during COVID-19 in the absence of known bacterial pathogens highlighted role of viruses as causative …
Extracellular matrix remodelling pathway in peripheral blood mononuclear cells from severe COVID-19 patients: an explorative study.
Murphy SL, Balzer NR, Ranheim T, Sagen EL, Huse C, Bjerkeli V, Michelsen AE, Finbråten AK, Heggelund L, Dyrhol-Riise AM, Tveita A, Holten AR, Trøseid M, Ueland T, Ulas T, Aukrust P, Barratt-Due A, Halvorsen B, Dahl TB. Murphy SL, et al. Front Immunol. 2024 Jun 18;15:1379570. doi: 10.3389/fimmu.2024.1379570. eCollection 2024. Front Immunol. 2024. PMID: 38957465 Free PMC article.
There is a reciprocal relationship between extracellular matrix (ECM) remodelling and inflammation that could be operating in the progression of severe COVID-19. To explore the immune-driven ECM remodelling in COVID-19, we in this explorative study ana …
There is a reciprocal relationship between extracellular matrix (ECM) remodelling and inflammation that could be operating in the progressio …
Sex differences and immune correlates of Long COVID development, persistence, and resolution.
Hamlin RE, Pienkos SM, Chan L, Stabile MA, Pinedo K, Rao M, Grant P, Bonilla H, Holubar M, Singh U, Jacobson KB, Jagannathan P, Maldonado Y, Holmes SP, Subramanian A, Blish CA. Hamlin RE, et al. bioRxiv [Preprint]. 2024 Jun 19:2024.06.18.599612. doi: 10.1101/2024.06.18.599612. bioRxiv. 2024. Update in: Sci Transl Med. 2024 Nov 13;16(773):eadr1032. doi: 10.1126/scitranslmed.adr1032. PMID: 38948732 Free PMC article. Updated. Preprint.
Sex differences have been observed in acute COVID-19 and Long COVID (LC) outcomes, with greater disease severity and mortality during acute infection in males and a greater proportion of females developing LC. ...To investigate the immunologic underpinnings of LC de …
Sex differences have been observed in acute COVID-19 and Long COVID (LC) outcomes, with greater disease severity and mortality …
Molecular mimicry of SARS-COV-2 antigens as a possible natural anti-cancer preventive immunization.
Ragone C, Mauriello A, Cavalluzzo B, Cavalcanti E, Russo L, Manolio C, Mangano S, Cembrola B, Tagliamonte M, Buonaguro L. Ragone C, et al. Front Immunol. 2024 Jun 14;15:1398002. doi: 10.3389/fimmu.2024.1398002. eCollection 2024. Front Immunol. 2024. PMID: 38947322 Free PMC article.
BACKGROUND: In the present study we investigated whether peptides derived from the entire SARS-CoV-2 proteome share homology to TAAs (tumor-associated antigens) and cross-reactive CD8+ T cell can be elicited by the BNT162b2 preventive vaccine or the …
BACKGROUND: In the present study we investigated whether peptides derived from the entire SARS-CoV-2 proteome sh …
An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy.
Pechous RD, Malaviarachchi PA, Banerjee SK, Byrum SD, Alkam DH, Ghaffarieh A, Kurten RC, Kennedy JL, Zhang X. Pechous RD, et al. J Virol. 2024 Jul 23;98(7):e0079424. doi: 10.1128/jvi.00794-24. Epub 2024 Jun 28. J Virol. 2024. PMID: 38940558 Free PMC article.
Coronavirus disease 2019 (COVID-19) has claimed millions of lives since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and lung disease appears the primary cause of
Coronavirus disease 2019 (COVID-19) has claimed millions of lives since the emergence of severe acute
Value of a secretomic approach for distinguishing patients with COVID-19 viral pneumonia among patients with respiratory distress admitted to intensive care unit.
Blangy-Letheule A, Vergnaud A, Dupas T, Habert D, Montnach J, Oulehri W, Hassoun D, Denis M, Lecomte J, Persello A, Roquilly A, Courty J, Seve M, Leroux AA, Rozec B, Bourgoin-Voillard S, De Waard M, Lauzier B. Blangy-Letheule A, et al. J Med Virol. 2024 Jun;96(6):e29756. doi: 10.1002/jmv.29756. J Med Virol. 2024. PMID: 38899468
In intensive care units, COVID-19 viral pneumonia patients (VPP) present symptoms similar to those of other patients with Nonviral infection (NV-ICU). ...The objective of this study is to identify the secretomic signatures of VPP with those of NV-ICU. …
In intensive care units, COVID-19 viral pneumonia patients (VPP) present symptoms similar to those of other patients
A Targeted LC-MRM(3) Proteomic Approach for the Diagnosis of SARS-CoV-2 Infection in Nasopharyngeal Swabs.
Drouin N, Elfrink HL, Boers SA, van Hugten S, Wessels E, de Vries JJC, Groeneveld GH, Miggiels P, Van Puyvelde B, Dhaenens M, Budding AE, Ran L, Masius R, Takats Z, Boogaerds A, Bulters M, Muurlink W, Oostvogel P, Harms AC, van der Lubben M, Hankemeier T. Drouin N, et al. Mol Cell Proteomics. 2024 Jul;23(7):100805. doi: 10.1016/j.mcpro.2024.100805. Epub 2024 Jun 17. Mol Cell Proteomics. 2024. PMID: 38897290 Free PMC article.
Since its first appearance, severe acute respiratory syndrome coronavirus 2 quickly spread around the world and the lack of adequate PCR testing capacities, especially during the early pandemic, led the scientific community to explore new …
Since its first appearance, severe acute respiratory syndrome coronavirus 2 quickly spread around …
Activation of the MAPK network provides a survival advantage during the course of COVID-19-induced sepsis: a real-world evidence analysis of a multicenter COVID-19 Sepsis Cohort.
Witowski A, Palmowski L, Rahmel T, Nowak H, Ehrentraut SF, Putensen C, von Groote T, Zarbock A, Babel N, Anft M, Sitek B, Bracht T, Bayer M, Weber M, Weisheit C, Pfänder S, Eisenacher M, Adamzik M, Katharina R, Koos B, Ziehe D; CovidDataNet.NRW research group. Witowski A, et al. Infection. 2024 Jun 19. doi: 10.1007/s15010-024-02325-7. Online ahead of print. Infection. 2024. PMID: 38896372
PURPOSE: There is evidence that lower activity of the RAF/MEK/ERK network is associated with positive outcomes in mild and moderate courses of COVID-19. The effect of this cascade in COVID-19 sepsis is still undetermined. Therefore, we tested the hypot …
PURPOSE: There is evidence that lower activity of the RAF/MEK/ERK network is associated with positive outcomes in mild and moderate courses …
Proteomic lung analysis revealed hyper-activation of neutrophil extracellular trap formation in cases of fatal COVID-19.
Song S, Zeng L, Xu J, Shi L, Lu L, Ling Y, Zhang L. Song S, et al. Heliyon. 2024 May 24;10(11):e31878. doi: 10.1016/j.heliyon.2024.e31878. eCollection 2024 Jun 15. Heliyon. 2024. PMID: 38882332 Free PMC article.
The molecular pathology of lung injury in patients with Corona Virus Disease 2019 (COVID-19) remain unclear. In this study, we performed a proteomic study of lung tissues from seven patients with COVID-19, and eight without. ...Fur …
The molecular pathology of lung injury in patients with Corona Virus Disease 2019 (COVID-19) remain unclear. In this st …
Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants.
Maaß H, Ynga-Durand M, Milošević M, Krstanović F, Matešić MP, Žuža I, Jonjić S, Brizić I, Šustić A, Bloos F; SepNet Critical Care Trials Group; Protić A, Čičin-Šain L. Maaß H, et al. Sci Rep. 2024 Jun 13;14(1):13605. doi: 10.1038/s41598-024-64384-y. Sci Rep. 2024. PMID: 38871772 Free PMC article.
The aim of this study was to characterize the systemic cytokine signature of critically ill COVID-19 patients in a high mortality setting aiming to identify biomarkers of severity, and to explore their associations with viral loads and clinical charact …
The aim of this study was to characterize the systemic cytokine signature of critically ill COVID-19 patients in a high …
Long-lasting, biochemically modified mRNA, and its frameshifted recombinant spike proteins in human tissues and circulation after COVID-19 vaccination.
Boros LG, Kyriakopoulos AM, Brogna C, Piscopo M, McCullough PA, Seneff S. Boros LG, et al. Pharmacol Res Perspect. 2024 Jun;12(3):e1218. doi: 10.1002/prp2.1218. Pharmacol Res Perspect. 2024. PMID: 38867495 Free PMC article. Review.
According to the CDC, both Pfizer and Moderna COVID-19 vaccines contain nucleoside-modified messenger RNA (mRNA) encoding the viral spike glycoprotein of severe acute respiratory syndrome caused by corona virus (SARS-CoV-2), administered …
According to the CDC, both Pfizer and Moderna COVID-19 vaccines contain nucleoside-modified messenger RNA (mRNA) encodi …
Plasma taurine level is linked to symptom burden and clinical outcomes in post-COVID condition.
Khoramjoo M, Wang K, Srinivasan K, Gheblawi M, Mandal R, Rousseau S, Wishart D, Prasad V, Richer L, Cheung AM, Oudit GY. Khoramjoo M, et al. PLoS One. 2024 Jun 5;19(6):e0304522. doi: 10.1371/journal.pone.0304522. eCollection 2024. PLoS One. 2024. PMID: 38837993 Free PMC article.
BACKGROUND: A subset of individuals (10-20%) experience post-COVID condition (PCC) subsequent to initial SARS-CoV-2 infection, which lacks effective treatment. PCC carries a substantial global burden associated with negative economic and health impacts. This …
BACKGROUND: A subset of individuals (10-20%) experience post-COVID condition (PCC) subsequent to initial SARS-CoV-2 inf …
Potential Immune-Inflammatory Proteome Biomarkers for Guiding the Treatment of Patients with Primary Acute Angle-Closure Glaucoma Caused by COVID-19.
Gong Q, Fu M, Wang J, Zhao S, Wang H. Gong Q, et al. J Proteome Res. 2024 Jul 5;23(7):2587-2597. doi: 10.1021/acs.jproteome.4c00325. Epub 2024 Jun 5. J Proteome Res. 2024. PMID: 38836775 Free PMC article.
This is the first study to explore the specific inflammatory proteomic landscape in SARS-CoV-2-induced PAACG. The expression of 92 inflammation-related proteins in 19 aqueous humor samples from PAACGs or cataract patients was detected using the …
This is the first study to explore the specific inflammatory proteomic landscape in SARS-CoV-2-induced PAACG. Th …
Exploring the relationship between HCMV serostatus and outcomes in COVID-19 sepsis.
Ziehe D, Wolf A, Rahmel T, Nowak H, Haberl H, Bergmann L, Rump K, Dyck B, Palmowski L, Marko B, Witowski A, Willemsen KM, Pfaender S, Eisenacher M, Anft M, Babel N, Bracht T, Sitek B, Bayer M, Zarbock A, von Groote T, Putensen C, Ehrentraut SF, Weisheit C, Adamzik M, Unterberg M, Koos B. Ziehe D, et al. Front Immunol. 2024 May 8;15:1386586. doi: 10.3389/fimmu.2024.1386586. eCollection 2024. Front Immunol. 2024. PMID: 38779663 Free PMC article.
However, among patients aged 60 years, HCMV seropositivity was significantly higher in COVID-19 sepsis patients compared to controls (86% vs 61%, respectively; p = 0.030). ...DISCUSSION: These findings confirm the association between HCMV seropositivit …
However, among patients aged 60 years, HCMV seropositivity was significantly higher in COVID-19 sepsis patients
Proteomic snapshot of saliva samples predicts new pathways implicated in SARS-CoV-2 pathogenesis.
Moreno E, Ciordia S, Fátima SM, Jiménez D, Martínez-Sanz J, Vizcarra P, Ron R, Sánchez-Conde M, Bargiela R, Sanchez-Carrillo S, Moreno S, Corrales F, Ferrer M, Serrano-Villar S. Moreno E, et al. Clin Proteomics. 2024 May 22;21(1):37. doi: 10.1186/s12014-024-09482-9. Clin Proteomics. 2024. PMID: 38778280 Free PMC article.
BACKGROUND: Information on the microbiome's human pathways and active members that can affect SARS-CoV-2 susceptibility and pathogenesis in the salivary proteome is very scarce. Here, we studied a unique collection of samples harvested from April to Ju …
BACKGROUND: Information on the microbiome's human pathways and active members that can affect SARS-CoV-2 susceptibility …
A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learning.
Patel MA, Daley M, Van Nynatten LR, Slessarev M, Cepinskas G, Fraser DD. Patel MA, et al. Clin Proteomics. 2024 May 17;21(1):33. doi: 10.1186/s12014-024-09488-3. Clin Proteomics. 2024. PMID: 38760690 Free PMC article.
BACKGROUND: COVID-19 is a complex, multi-system disease with varying severity and symptoms. Identifying changes in critically ill COVID-19 patients' proteomes enables a better understanding of markers associated with susceptibility, sympt …
BACKGROUND: COVID-19 is a complex, multi-system disease with varying severity and symptoms. Identifying changes in critically …
Serum proteomics reveals hemophagocytic lymphohistiocytosis-like phenotype in a subset of patients with multisystem inflammatory syndrome in children.
Tulling AJ, Holierhoek MG, Jansen-Hoogendijk AM, Hoste L, Haerynck F, Tavernier SJ, Oostenbrink R, Buysse CMP, Bannier MAGE, Bekhof J, Breukels M, Hammer SC, Jacobs MAM, Kamps AWA, van der Linden JW, Lebon A, Oudshoorn JH, Tramper-Stranders GA, Vastert SJ, Wieringa JW, Terheggen-Lagro SWJ, Wildenbeest JG, von Asmuth EGJ, van den Akker EB, van Gijn ME, Lugthart G, Buddingh EP. Tulling AJ, et al. Clin Immunol. 2024 Jul;264:110252. doi: 10.1016/j.clim.2024.110252. Epub 2024 May 12. Clin Immunol. 2024. PMID: 38744408 Free article.
We hypothesized that thrombocytopenic MIS-C patients have more features of HLH. Clinical characteristics and routine laboratory parameters were collected from 228 MIS-C patients, of whom 85 (37%) were thrombocytopenic. Thrombocytopenic patients had inc …
We hypothesized that thrombocytopenic MIS-C patients have more features of HLH. Clinical characteristics and routine laborator …
Bioinformation Analysis of Differential Expression Proteins in Different Processes of COVID-19.
Guo N, Han X, Han G, Dai M, Han Z, Li Q. Guo N, et al. Viral Immunol. 2024 May;37(4):194-201. doi: 10.1089/vim.2023.0094. Viral Immunol. 2024. PMID: 38717820
COVID-19 is a highly infectious respiratory disease whose progression has been associated with multiple factors. From SARS-CoV-2 infection to death, biomarkers capable of predicting different disease processes are needed to help us further under
COVID-19 is a highly infectious respiratory disease whose progression has been associated with multiple factors. From SARS
Multi-cohort study on cytokine and chemokine profiles in the progression of COVID-19.
Huang C, Hu X, Wang D, Gong R, Wang Q, Ren F, Wu Y, Chen J, Xiong X, Li H, Wang Q, Long G, Zhang D, Han Y. Huang C, et al. Sci Rep. 2024 May 6;14(1):10324. doi: 10.1038/s41598-024-61133-z. Sci Rep. 2024. PMID: 38710800 Free PMC article.
Various substances in the blood plasma serve as prognostic indicators of the progression of COVID-19. Consequently, multi-omics studies, such as proteomic and metabolomics, are ongoing to identify accurate biomarkers. ...To determine the relationship between …
Various substances in the blood plasma serve as prognostic indicators of the progression of COVID-19. Consequently, multi-omic …
Development and assessment of a multiepitope synthetic antigen for the diagnosis of Dengue virus infection.
da Silva IBN, de Moraes Rodrigues J, Batista RCG, Gomes VDS, Chacon CS, Almeida MDS, de Araujo TS, Ortiz da Silva B, Castiñeiras TMPP, Ferreira Junior ODC, Carneiro FA, Montero-Lomeli M. da Silva IBN, et al. Braz J Infect Dis. 2024 May-Jun;28(3):103746. doi: 10.1016/j.bjid.2024.103746. Epub 2024 May 1. Braz J Infect Dis. 2024. PMID: 38703788 Free PMC article.
The distinguishing factor between the two proteins lies in the origin of their epitope sequences, where rDME-C is based on the reference dengue proteome, while rDME-BR utilizes sequences from prevalent Dengue genotypes in Brazil from 2008 to 2019. ...No cross-reactivity wa …
The distinguishing factor between the two proteins lies in the origin of their epitope sequences, where rDME-C is based on the reference den …
SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9.
Luo Y, Zhang Z, Ren J, Dou C, Wen J, Yang Y, Li X, Yan Z, Han Y. Luo Y, et al. Front Immunol. 2024 Apr 15;15:1303356. doi: 10.3389/fimmu.2024.1303356. eCollection 2024. Front Immunol. 2024. PMID: 38686388 Free PMC article.
BACKGROUND: Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), as a typical tumor marker, has been found to exert immunomodulatory effects in many diseases. We previously reported the clinical and molecular evidences supporting that SARS-Cov
BACKGROUND: Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), as a typical tumor marker, has been found to exert immunomo …
Proteomics validate circulating GDF-15 as an independent biomarker for COVID-19 severity.
Bu S, Royston L, Mabanga T, Berini CA, Tremblay C, Lebouché B, Cox J, Costiniuk CT, Durand M, Isnard S, Routy JP. Bu S, et al. Front Immunol. 2024 Apr 15;15:1377126. doi: 10.3389/fimmu.2024.1377126. eCollection 2024. Front Immunol. 2024. PMID: 38686386 Free PMC article.
METHODS: Blood samples were collected from 926 COVID-19 adult patients and from 285 hospitalized controls from the Biobanque Quebecoise de la COVID-19 (BQC19). ...No association was established between anti-SARS-CoV-2 IgG le …
METHODS: Blood samples were collected from 926 COVID-19 adult patients and from 285 hospitalized controls from the Biob …
Protocol to identify biomarkers in patients with post-COVID condition using multi-omics and machine learning analysis of human plasma.
Khoramjoo M, Srinivasan K, Wang K, Wishart D, Prasad V, Oudit GY. Khoramjoo M, et al. STAR Protoc. 2024 Jun 21;5(2):103041. doi: 10.1016/j.xpro.2024.103041. Epub 2024 Apr 27. STAR Protoc. 2024. PMID: 38678567 Free PMC article.
Here, we present a workflow for analyzing multi-omics data of plasma samples in patients with post-COVID condition (PCC). Applicable to various diseases, we outline steps for data preprocessing and integrating diverse assay datasets. Then, we detail statistical analysis to …
Here, we present a workflow for analyzing multi-omics data of plasma samples in patients with post-COVID condition (PCC). Applicable …
Targeting the High-Density Lipoprotein Proteome for the Treatment of Post-Acute Sequelae of SARS-CoV-2.
Grote K, Schaefer AC, Soufi M, Ruppert V, Linne U, Mukund Bhagwat A, Szymanski W, Graumann J, Gercke Y, Aldudak S, Hilfiker-Kleiner D, Schieffer E, Schieffer B. Grote K, et al. Int J Mol Sci. 2024 Apr 20;25(8):4522. doi: 10.3390/ijms25084522. Int J Mol Sci. 2024. PMID: 38674105 Free PMC article.
Here, we target the high-density lipoprotein (HDL) proteome in a case series of 16 patients with post-COVID-19 symptoms treated with HMG-Co-A reductase inhibitors (statin) plus angiotensin II type 1 receptor blockers (ARBs) for 6 weeks. Patients
Here, we target the high-density lipoprotein (HDL) proteome in a case series of 16 patients with post-COVID-19 s …
Plasma Proteomics Elucidated a Protein Signature in COVID-19 Patients with Comorbidities and Early-Diagnosis Biomarkers.
Urbiola-Salvador V, Lima de Souza S, Macur K, Czaplewska P, Chen Z. Urbiola-Salvador V, et al. Biomedicines. 2024 Apr 10;12(4):840. doi: 10.3390/biomedicines12040840. Biomedicines. 2024. PMID: 38672194 Free PMC article.
Pre-existing comorbidities increase the mortality rate and aggravate the exacerbated immune response against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, which can result in more severe …
Pre-existing comorbidities increase the mortality rate and aggravate the exacerbated immune response against the severe acute
How PBPK Can Help to Understand Old Drugs and Inform their Dosing in Elderly: Amantadine Case Study.
Shuklinova O, Neuhoff S, Polak S. Shuklinova O, et al. Clin Pharmacol Ther. 2024 Jul;116(1):225-234. doi: 10.1002/cpt.3276. Epub 2024 Apr 26. Clin Pharmacol Ther. 2024. PMID: 38666589
The model performance was verified against plasma and urine data reported after single and multiple dose administration in healthy volunteers and elderly patients from 18 independent studies. The ratios of predicted vs. observed maximal plasma concentration and area under …
The model performance was verified against plasma and urine data reported after single and multiple dose administration in healthy volunteer …
Construction and efficacy testing of DNA vaccines containing HLA-A*02:01-restricted SARS-CoV-2 T-cell epitopes predicted by immunoinformatics.
Tan D, Kang N, Zhu Y, Hou J, Wang H, Xu H, Zu C, Gao Z, Liu M, Liu N, Deng Q, Lu H, Liu J, Xie Y. Tan D, et al. Acta Biochim Biophys Sin (Shanghai). 2024 Apr 24;56(7):986-996. doi: 10.3724/abbs.2024039. Acta Biochim Biophys Sin (Shanghai). 2024. PMID: 38655616 Free PMC article.
Vaccines play essential roles in the fight against the COVID-19 pandemic. The development and assessment of COVID-19 vaccines have generally focused on the induction and boosting of neutralizing antibodies targeting the SARS-CoV- …
Vaccines play essential roles in the fight against the COVID-19 pandemic. The development and assessment of COVID-19
Temporal associations of plasma levels of the secreted phospholipase A(2) family and mortality in severe COVID-19.
Lu E, Hara A, Sun S, Hallmark B, Snider JM, Seeds MC, Watkins JC, McCall CE, Zhang HH, Yao G, Chilton FH. Lu E, et al. Eur J Immunol. 2024 Jun;54(6):e2350721. doi: 10.1002/eji.202350721. Epub 2024 Apr 23. Eur J Immunol. 2024. PMID: 38651231
Previous research suggests that group IIA-secreted phospholipase A(2) (sPLA(2)-IIA) plays a role in and predicts lethal COVID-19 disease. The current study reanalyzed a longitudinal proteomic data set to determine the temporal relationship between levels of s …
Previous research suggests that group IIA-secreted phospholipase A(2) (sPLA(2)-IIA) plays a role in and predicts lethal COVID-19
COVID-19 increases extracorporeal coagulation during hemodialysis associated with upregulation of vWF/FBLN5 signaling in patients with severe/critical symptoms.
Yang G, Shan H, Wu D, Li S, Lai Z, Zheng F, Xiong Z, Xiong Z, Diao Y, Shan Y, Chen Y, Wang A, Liang W, Yin Y. Yang G, et al. BMC Infect Dis. 2024 Apr 22;24(1):427. doi: 10.1186/s12879-024-09245-9. BMC Infect Dis. 2024. PMID: 38649864 Free PMC article.
BACKGROUND: COVID-19 has been shown to increase the risk of extracorporeal coagulation during hemodialysis in patients, but the underlying mechanism remains unclear. ...Post-infection blood composition was analyzed by protein spectrometry and ELISA. RESULTS: …
BACKGROUND: COVID-19 has been shown to increase the risk of extracorporeal coagulation during hemodialysis in patients, …
Proteomic and Cellular Characterization of Omicron Breakthrough Infections and a Third Homologous or Heterologous Boosting Vaccination in a Longitudinal Cohort.
Zhang Y, Fu Z, Zhang H, Lin K, Song J, Guo J, Zhang Q, Yuan G, Wang H, Fan M, Zhao Y, Sun R, Guo T, Jiang N, Qiu C, Zhang W, Ai J. Zhang Y, et al. Mol Cell Proteomics. 2024 Jun;23(6):100769. doi: 10.1016/j.mcpro.2024.100769. Epub 2024 Apr 18. Mol Cell Proteomics. 2024. PMID: 38641227 Free PMC article.
The understanding of dynamic plasma proteome features in hybrid immunity and breakthrough infection is limited. A deeper understanding of the immune differences between heterologous and homologous immunization could assist in the future establishment of vaccination strateg …
The understanding of dynamic plasma proteome features in hybrid immunity and breakthrough infection is limited. A deeper understandin …
The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis.
Patel MA, Fraser DD, Daley M, Cepinskas G, Veraldi N, Grazioli S. Patel MA, et al. Mol Med. 2024 Apr 17;30(1):51. doi: 10.1186/s10020-024-00806-x. Mol Med. 2024. PMID: 38632526 Free PMC article.
BACKGROUND: The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct treatment protocol. Distinguishing MIS-C from SARS-CoV-2 negative sepsis (SCNS) patient
BACKGROUND: The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infec …
Comprehensive overview of the anesthesiology research landscape: A machine Learning Analysis of 737 NIH-funded anesthesiology primary Investigator's publication trends.
Ghanem M, Espinosa C, Chung P, Reincke M, Harrison N, Phongpreecha T, Shome S, Saarunya G, Berson E, James T, Xie F, Shu CH, Hazra D, Mataraso S, Kim Y, Seong D, Chakraborty D, Studer M, Xue L, Marić I, Chang AL, Tjoa E, Gaudillière B, Tawfik VL, Mackey S, Aghaeepour N. Ghanem M, et al. Heliyon. 2024 Apr 3;10(7):e29050. doi: 10.1016/j.heliyon.2024.e29050. eCollection 2024 Apr 15. Heliyon. 2024. PMID: 38623206 Free PMC article.
BACKGROUND: Anesthesiology plays a crucial role in perioperative care, critical care, and pain management, impacting patient experiences and clinical outcomes. However, our understanding of the anesthesiology research landscape is limited. ...However, when focusing …
BACKGROUND: Anesthesiology plays a crucial role in perioperative care, critical care, and pain management, impacting patient experien …
IgG1 glycosylation highlights premature aging in Down syndrome.
Streng BMM, Van Coillie J, Wildenbeest JG, Binnendijk RS, Smits G, den Hartog G, Wang W, Nouta J, Linty F, Visser R, Wuhrer M, Vidarsson G, Bont LJ; PRIDE study group. Streng BMM, et al. Aging Cell. 2024 Jul;23(7):e14167. doi: 10.1111/acel.14167. Epub 2024 Apr 15. Aging Cell. 2024. PMID: 38616780 Free PMC article.
We previously showed decreased antibody response following SARS-CoV-2 vaccination in adults with DS. IgG1 Fc glycosylation patterns are known to affect the effector function of IgG and are associated with aging. Here, we compare total and anti-spike (S) IgG1 …
We previously showed decreased antibody response following SARS-CoV-2 vaccination in adults with DS. IgG1 Fc glycosylat …
Multi-Omics Profiling Reveals Phenotypic and Functional Heterogeneity of Neutrophils in COVID-19.
Zhang L, Nishi H, Kinoshita K. Zhang L, et al. Int J Mol Sci. 2024 Mar 29;25(7):3841. doi: 10.3390/ijms25073841. Int J Mol Sci. 2024. PMID: 38612651 Free PMC article.
We analyzed public single-cell RNA-seq, bulk RNA-seq, and proteome data from healthy donors and patients with COVID-19 to investigate neutrophil subpopulations and their response to disease pathogenesis. ...Further investigation into transcription fact …
We analyzed public single-cell RNA-seq, bulk RNA-seq, and proteome data from healthy donors and patients with COVID- …
Impaired retinal oxygen metabolism and perfusion are accompanied by plasma protein and lipid alterations in recovered COVID-19 patients.
Pai V, Bileck A, Hommer N, Janku P, Lindner T, Kauer V, Rumpf B, Haslacher H, Hagn G, Meier-Menches SM, Schmetterer L, Schmidl D, Gerner C, Garhöfer G. Pai V, et al. Sci Rep. 2024 Apr 10;14(1):8395. doi: 10.1038/s41598-024-56834-4. Sci Rep. 2024. PMID: 38600099 Free PMC article.
Blood plasma samples underwent mass spectrometry-based multi-omics profiling, including proteomics, metabolomics and eicosadomics. A total of 40 subjects were included in the present study, of which 29 had recovered from moderate to severe COVID-19 within 2 t …
Blood plasma samples underwent mass spectrometry-based multi-omics profiling, including proteomics, metabolomics and eicosadomics. A …
Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity.
Glitza IC, Seo YD, Spencer CN, Wortman JR, Burton EM, Alayli FA, Loo CP, Gautam S, Damania A, Densmore J, Fairchild J, Cabanski CR, Wong MC, Peterson CB, Weiner B, Hicks N, Aunins J, McChalicher C, Walsh E, Tetzlaff MT, Hamid O, Ott PA, Boland GM, Sullivan RJ, Grossmann KF, Ajami NJ, LaVallee T, Henn MR, Tawbi HA, Wargo JA. Glitza IC, et al. Cancer Discov. 2024 Jul 1;14(7):1161-1175. doi: 10.1158/2159-8290.CD-24-0066. Cancer Discov. 2024. PMID: 38588588 Free PMC article. Clinical Trial.
We performed a multicenter, randomized placebo-controlled, biomarker-stratified phase I trial in patients with ICB-naive metastatic melanoma using SER-401, an orally delivered Firmicutesenriched spore formulation. ...Analysis of 14 accrued patients demonstrated that …
We performed a multicenter, randomized placebo-controlled, biomarker-stratified phase I trial in patients with ICB-naive metastatic m …
Integration of metalloproteome and immunoproteome reveals a tight link of iron-related proteins with COVID-19 pathogenesis and immunity.
Zhou Y, Cheng T, Tang K, Li H, Luo C, Yu F, Xiao F, Jin L, Hung IF, Lu L, Yuen KY, Chan JF, Yuan S, Sun H. Zhou Y, et al. Clin Immunol. 2024 Jun;263:110205. doi: 10.1016/j.clim.2024.110205. Epub 2024 Apr 2. Clin Immunol. 2024. PMID: 38575044
In this study, we build up a metal-coding assisted multiplexed proteome assay platform for serum metalloproteomic and immunoproteomic profiling. By taking COVID-19 as a showcase, we unbiasedly uncovered the most evident modulation of iron-related proteins, i. …
In this study, we build up a metal-coding assisted multiplexed proteome assay platform for serum metalloproteomic and immunoproteomic …
Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections.
Fredolini C, Dodig-Crnković T, Bendes A, Dahl L, Dale M, Albrecht V, Mattsson C, Thomas CE, Torinsson Naluai Å, Gisslen M, Beck O, Roxhed N, Schwenk JM. Fredolini C, et al. Commun Med (Lond). 2024 Apr 2;4(1):55. doi: 10.1038/s43856-024-00480-4. Commun Med (Lond). 2024. PMID: 38565620 Free PMC article.
BACKGROUND: Self-sampling of dried blood spots (DBS) offers new routes to gather valuable health-related information from the general population. Yet, the utility of using deep proteome profiling from home-sampled DBS to obtain clinically relevant insights about …
BACKGROUND: Self-sampling of dried blood spots (DBS) offers new routes to gather valuable health-related information from the general popula …
Integrated multiomics implicates dysregulation of ECM and cell adhesion pathways as drivers of severe COVID-associated kidney injury.
Anandakrishnan N, Yi Z, Sun Z, Liu T, Haydak J, Eddy S, Jayaraman P, DeFronzo S, Saha A, Sun Q, Yang D, Mendoza A, Mosoyan G, Wen HH, Schaub JA, Fu J, Kehrer T, Menon R, Otto EA, Godfrey B, Suarez-Farinas M, Leffters S, Twumasi A, Meliambro K, Charney AW, García-Sastre A, Campbell KN, Gusella GL, He JC, Miorin L, Nadkarni GN, Wisnivesky J, Li H, Kretzler M, Coca SG, Chan L, Zhang W, Azeloglu EU. Anandakrishnan N, et al. medRxiv [Preprint]. 2024 Mar 19:2024.03.18.24304401. doi: 10.1101/2024.03.18.24304401. medRxiv. 2024. PMID: 38562892 Free PMC article. Preprint.
In this multicenter study, we combined quantitative deep urinary proteomics and machine learning to predict severe acute outcomes in hospitalized COVID-19 patients. ...Further, single-cell transcriptomic analysis of kidney organoids infected with SA
In this multicenter study, we combined quantitative deep urinary proteomics and machine learning to predict severe acute outcomes in …
Proteomic characteristics of the treatment trajectory of patients with COVID-19.
Li X, Ding G, Li S, Liu C, Zheng X, Luo J, He S, Zeng F, Huang X, Zeng F. Li X, et al. Arch Virol. 2024 Mar 27;169(4):84. doi: 10.1007/s00705-024-05991-y. Arch Virol. 2024. PMID: 38532129
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has prompted global concern due to its profound impact on public health and the economy. ...Our study revealed the infection profiles of SARS-CoV-2 at the protein expression …
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has prompted global concern due to its profound impact …
SARS-CoV-2 infection triggers more potent antibody-dependent cellular cytotoxicity (ADCC) responses than mRNA-, vector-, and inactivated virus-based COVID-19 vaccines.
Zedan HT, Smatti MK, Al-Sadeq DW, Al Khatib HA, Nicolai E, Pieri M, Bernardini S, Hssain AA, Taleb S, Qotba H, Issa K, Abu Raddad LJ, Althani AA, Nasrallah GK, Yassine HM. Zedan HT, et al. J Med Virol. 2024 Mar;96(3):e29527. doi: 10.1002/jmv.29527. J Med Virol. 2024. PMID: 38511514
Here, we investigated ADCC activity in convalescent sera from infected patients with wild-type (WT) severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) or omicron variant compared with three coronav
Here, we investigated ADCC activity in convalescent sera from infected patients with wild-type (WT) severe acute res
Microclots, as defined by amyloid-fibrinogen aggregates, predict risks of disseminated intravascular coagulation and mortality.
Schofield J, Abrams ST, Jenkins R, Lane S, Wang G, Toh CH. Schofield J, et al. Blood Adv. 2024 May 28;8(10):2499-2508. doi: 10.1182/bloodadvances.2023012473. Blood Adv. 2024. PMID: 38507683 Free PMC article.
Microclots have been associated with various conditions, including postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection. They have been postulated to be amyloid-fibrin(ogen) aggregates, but their role as a progn …
Microclots have been associated with various conditions, including postacute sequelae of severe acute respiratory sy
Human umbilical cord mesenchymal stem cell therapy for renal dysfunction in Alport syndrome: protocol for an open-label, single-arm trial in China.
Huang L, Zou J, Zhang Y, Gu J, Wu J, Zhang C. Huang L, et al. BMJ Open. 2024 Mar 15;14(3):e075138. doi: 10.1136/bmjopen-2023-075138. BMJ Open. 2024. PMID: 38490657 Free PMC article.
However, the safety and therapeutic potential of MSC transfusion for patients with AS are still need to be confirmed. Therefore, we have designed a clinical trial to evaluate the hypothesis that intravenous infusion of human umbilical cord-derived MSC (hUC-MSC) is s …
However, the safety and therapeutic potential of MSC transfusion for patients with AS are still need to be confirmed. Therefore, we h …
Identification of biomarkers and pathways for the SARS-CoV-2 infections in obstructive sleep apnea patients based on machine learning and proteomic analysis.
Luo H, Yan J, Gong R, Zhang D, Zhou X, Wang X. Luo H, et al. BMC Pulm Med. 2024 Mar 5;24(1):112. doi: 10.1186/s12890-024-02921-1. BMC Pulm Med. 2024. PMID: 38443855 Free PMC article.
Subsequently, the expression levels of pivotal genes were validated through proteomics data from COVID-19 cases. RESULTS: Fourteen feature genes shared between OSA and COVID-19 were selected for further investigation. ...Subsequently, employing …
Subsequently, the expression levels of pivotal genes were validated through proteomics data from COVID-19 cases. RESULT …
Imatinib treatment improves hyperglycaemic dysregulation in severe COVID-19: a secondary analysis of blood biomarkers in a randomised controlled trial.
Duijvelaar E, Pan X, Bogaard HJ, Eringa EC, Aman J. Duijvelaar E, et al. Crit Care. 2024 Feb 29;28(1):65. doi: 10.1186/s13054-024-04829-y. Crit Care. 2024. PMID: 38424569 Free PMC article. Clinical Trial.
SARS-CoV-2 can induce insulin resistance, which is, among others, mediated by adipose tissue dysfunction and reduced angiotensin-converting enzyme 2 (ACE2) enzymatic activity. In SARS-CoV-2-infected mice, the tyrosine kinase inhibitor ima
SARS-CoV-2 can induce insulin resistance, which is, among others, mediated by adipose tissue dysfunction and reduced an
Deciphering the omicron variant: integrated omics analysis reveals critical biomarkers and pathophysiological pathways.
Yang Q, Lin Z, Xue M, Jiang Y, Chen L, Chen J, Liao Y, Lv J, Guo B, Zheng P, Huang H, Sun B. Yang Q, et al. J Transl Med. 2024 Feb 29;22(1):219. doi: 10.1186/s12967-024-05022-z. J Transl Med. 2024. PMID: 38424541 Free PMC article.
BACKGROUND: The rapid emergence and global dissemination of the Omicron variant of SARS-CoV-2 have posed formidable challenges in public health. This scenario underscores the urgent need for an enhanced understanding of Omicron's pathophysiological mechanisms …
BACKGROUND: The rapid emergence and global dissemination of the Omicron variant of SARS-CoV-2 have posed formidable cha …
The free plasma amyloid Aβ1-42/Aβ1-40 ratio predicts conversion to dementia for subjects with mild cognitive impairment with performance equivalent to that of the total plasma Aβ1-42/Aβ1-40 ratio. The BALTAZAR study.
Schraen-Maschke S, Duhamel A, Vidal JS, Ramdane N, Vaudran L, Dussart C, Buée L, Sablonnière B, Delaby C, Allinquant B, Gabelle A, Bombois S, Lehmann S, Hanon O; BALTAZAR study group. Schraen-Maschke S, et al. Neurobiol Dis. 2024 Apr;193:106459. doi: 10.1016/j.nbd.2024.106459. Epub 2024 Feb 27. Neurobiol Dis. 2024. PMID: 38423192 Free article.
This was comparable to the risk of conversion in the highest quartile of total plasma Abeta(1)(-)(42)/Abeta(1)(-)(40): hazard ratio = 0.37 (95% confidence interval [0.16-0.89], p-value = 0.027). However, while patients in the highest quartile of total plasma Abeta(1)(-)(42 …
This was comparable to the risk of conversion in the highest quartile of total plasma Abeta(1)(-)(42)/Abeta(1)(-)(40): hazard ratio = 0.37 ( …
Proteome analysis develops novel plasma proteins classifier in predicting the mortality of COVID-19.
Zeng Y, Li Y, Zhang W, Lu H, Lin S, Zhang W, Xia L, Hu H, Song Y, Xu F. Zeng Y, et al. Cell Prolif. 2024 Jul;57(7):e13617. doi: 10.1111/cpr.13617. Epub 2024 Feb 25. Cell Prolif. 2024. PMID: 38403992 Free PMC article.
Then, we used machine learning to develop a protein classifier which can predict the clinical outcomes of the patients with COVID-19 and help identify the high-risk patients. ...In total, this work revealed a potential protein classifier which c …
Then, we used machine learning to develop a protein classifier which can predict the clinical outcomes of the patients with …
Correlation of Myeloid-Derived Suppressor Cell Expansion with Upregulated Transposable Elements in Severe COVID-19 Unveiled in Single-Cell RNA Sequencing Reanalysis.
Farahmandnejad M, Mosaddeghi P, Dorvash M, Sakhteman A, Negahdaripour M, Faridi P. Farahmandnejad M, et al. Biomedicines. 2024 Jan 29;12(2):315. doi: 10.3390/biomedicines12020315. Biomedicines. 2024. PMID: 38397917 Free PMC article.
In this study, we reanalyzed single-cell RNA seq data of bronchoalveolar lavage (BAL) samples obtained from six severe COVID-19 patients and three healthy donors to assess the probable correlation of TE expression with the immune responses induced by the s
In this study, we reanalyzed single-cell RNA seq data of bronchoalveolar lavage (BAL) samples obtained from six severe COVID-19
Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients.
Kaneko T, Ezra S, Abdo R, Voss C, Zhong S, Liu X, Hovey O, Slessarev M, Van Nynatten LR, Ye M, Fraser DD, Li SS. Kaneko T, et al. Clin Proteomics. 2024 Feb 22;21(1):13. doi: 10.1186/s12014-024-09457-w. Clin Proteomics. 2024. PMID: 38389037 Free PMC article.
SARS-CoV-2 infection triggers extensive host immune reactions, leading to severe diseases in certain individuals. However, the molecular basis underlying the excessive yet non-productive immune responses in severe COVID-19 remains incompletely u
SARS-CoV-2 infection triggers extensive host immune reactions, leading to severe diseases in certain individuals. Howev
COVID-19 immune signatures in Uganda persist in HIV co-infection and diverge by pandemic phase.
Cummings MJ, Bakamutumaho B, Lutwama JJ, Owor N, Che X, Astorkia M, Postler TS, Kayiwa J, Kiconco J, Muwanga M, Nsereko C, Rwamutwe E, Nayiga I, Kyebambe S, Haumba M, Bosa HK, Ocom F, Watyaba B, Kikaire B, Tomoiaga AS, Kisaka S, Kiwanuka N, Lipkin WI, O'Donnell MR; Collaboration for Clinical and Laboratory Characterization of COVID-19 in Uganda. Cummings MJ, et al. Nat Commun. 2024 Feb 17;15(1):1475. doi: 10.1038/s41467-024-45204-3. Nat Commun. 2024. PMID: 38368384 Free PMC article.
In a prospective cohort study of 306 adults encompassing the entire clinical spectrum of SARS-CoV-2 infection in Uganda, we profile the peripheral blood proteome and transcriptome to characterize the immunopathology of COVID-19 acr …
In a prospective cohort study of 306 adults encompassing the entire clinical spectrum of SARS-CoV-2 infection in …
Proteomics of serum-derived extracellular vesicles are associated with the severity and different clinical profiles of patients with COVID-19: An exploratory secondary analysis.
Paes Leme AF, Yokoo S, Normando AGC, Ormonde JVS, Domingues RR, Cruz FF, Silva PL, Souza BSF, Dos Santos CC, Castro-Faria-Neto H, Martins CM, Lopes-Pacheco M, Rocco PRM. Paes Leme AF, et al. Cytotherapy. 2024 May;26(5):444-455. doi: 10.1016/j.jcyt.2024.02.001. Epub 2024 Feb 15. Cytotherapy. 2024. PMID: 38363248
BACKGROUND AIMS: Coronavirus disease 2019 (COVID-19) is characterized by a broad spectrum of clinical manifestations with the potential to progress to multiple organ dysfunction in severe cases. ...METHODS: An exploratory secondary analysis of the SARI …
BACKGROUND AIMS: Coronavirus disease 2019 (COVID-19) is characterized by a broad spectrum of clinical manifestat …
MicroRNA-guided drug discovery for mitigating persistent pulmonary complications in critical COVID-19 survivors: A longitudinal pilot study.
García-Hidalgo MC, Benítez ID, Perez-Pons M, Molinero M, Belmonte T, Rodríguez-Muñoz C, Aguilà M, Santisteve S, Torres G, Moncusí-Moix A, Gort-Paniello C, Peláez R, Larráyoz IM, Caballero J, Barberà C, Nova-Lamperti E, Torres A, González J, Barbé F, de Gonzalo-Calvo D. García-Hidalgo MC, et al. Br J Pharmacol. 2025 Jan;182(2):380-395. doi: 10.1111/bph.16330. Epub 2024 Feb 15. Br J Pharmacol. 2025. PMID: 38359818
BACKGROUND AND PURPOSE: The post-acute sequelae of SARS-CoV-2 infection pose a significant global challenge, with nearly 50% of critical COVID-19 survivors manifesting persistent lung abnormalities. ...CONCLUSION AND IMPLICATIONS: Our study reve …
BACKGROUND AND PURPOSE: The post-acute sequelae of SARS-CoV-2 infection pose a significant global challenge, with nearl …
Genomic, Proteomic, and Phenotypic Biomarkers of COVID-19 Severity: Protocol for a Retrospective Observational Study.
English A, McDaid D, Lynch SM, McLaughlin J, Cooper E, Wingfield B, Kelly M, Bhavsar M, McGilligan V, Irwin RE, Bucholc M, Zhang SD, Shukla P, Rai TS, Bjourson AJ, Murray E, Gibson DS, Walsh C. English A, et al. JMIR Res Protoc. 2024 Feb 14;13:e50733. doi: 10.2196/50733. JMIR Res Protoc. 2024. PMID: 38354037 Free PMC article.
Although a targeted approach highlights key pathways, a multiomics approach will provide a clearer and more comprehensive picture of severe COVID-19 etiology and progression. OBJECTIVE: The COVID-19 Response Study aims to carry out an integrated multio …
Although a targeted approach highlights key pathways, a multiomics approach will provide a clearer and more comprehensive picture of severe …
Excretion of SARS-CoV-2 RNA in feces has no prognostic benefit in the outcome of COVID-19: A clinical and immunological study.
Šušak B, Dalmatin-Dragišić M, Laura L, Mikulić V, Nakić K, Mikulić I, Brizić I, Arapović J, Arapović M. Šušak B, et al. Biomol Biomed. 2024 Feb 10;24(4):1016-1027. doi: 10.17305/bb.2024.10176. Biomol Biomed. 2024. PMID: 38340324 Free PMC article.
This study explores the correlation between immunological and clinical characteristics in coronavirus disease 2019 (COVID-19) patients with detectable severe acute respiratory syndrome coronavirus 2 ( …
This study explores the correlation between immunological and clinical characteristics in coronavirus disease 2019 (COVID
Longitudinal plasma proteomics reveals biomarkers of alveolar-capillary barrier disruption in critically ill COVID-19 patients.
Duijvelaar E, Gisby J, Peters JE, Bogaard HJ, Aman J. Duijvelaar E, et al. Nat Commun. 2024 Jan 25;15(1):744. doi: 10.1038/s41467-024-44986-w. Nat Commun. 2024. PMID: 38272877 Free PMC article.
Imatinib treatment attenuates protein perturbations associated with inflammation and extracellular matrix turnover. These proteomic alterations are contextualised using external pulmonary RNA-sequencing data of deceased COVID-19 patients and imatinib-t …
Imatinib treatment attenuates protein perturbations associated with inflammation and extracellular matrix turnover. These proteomic a …
A high throughput immuno-affinity mass spectrometry method for detection and quantitation of SARS-CoV-2 nucleoprotein in human saliva and its comparison with RT-PCR, RT-LAMP, and lateral flow rapid antigen test.
Lane D, Allsopp R, Holmes CW, Slingsby OC, Jukes-Jones R, Bird P, Anderson NL, Razavi M, Yip R, Pearson TW, Pope M, Khunti K, Doykov I, Hällqvist J, Mills K, Skipp P, Carling R, Ng L, Shaw J, Gupta P, Jones DJL. Lane D, et al. Clin Chem Lab Med. 2024 Jan 23;62(6):1206-1216. doi: 10.1515/cclm-2023-0243. Print 2024 May 27. Clin Chem Lab Med. 2024. PMID: 38253336 Free article.
OBJECTIVES: Many reverse transcription polymerase chain reaction (RT-PCR) methods exist that can detect SARS-CoV-2 RNA in different matrices. RT-PCR is highly sensitive, although viral RNA may be detected long after active infection has taken place. SARS
OBJECTIVES: Many reverse transcription polymerase chain reaction (RT-PCR) methods exist that can detect SARS-CoV-2 RNA …
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid.
Cervia-Hasler C, Brüningk SC, Hoch T, Fan B, Muzio G, Thompson RC, Ceglarek L, Meledin R, Westermann P, Emmenegger M, Taeschler P, Zurbuchen Y, Pons M, Menges D, Ballouz T, Cervia-Hasler S, Adamo S, Merad M, Charney AW, Puhan M, Brodin P, Nilsson J, Aguzzi A, Raeber ME, Messner CB, Beckmann ND, Borgwardt K, Boyman O. Cervia-Hasler C, et al. Science. 2024 Jan 19;383(6680):eadg7942. doi: 10.1126/science.adg7942. Epub 2024 Jan 19. Science. 2024. PMID: 38236961
Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after confirmed severe acute respiratory syndrome coro
Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses of blood serum from COVID
Impaired humoral immunity following COVID-19 vaccination in HTLV-1 carriers.
Kameda T, Utsunomiya A, Otsuka N, Kubuki Y, Uchida T, Shide K, Kamiunten A, Nakano N, Tokunaga M, Miyazono T, Ito Y, Yonekura K, Kawakita T, Akizuki K, Tahira Y, Karasawa M, Hidaka T, Konagata A, Taniguchi N, Nagatomo Y, Kogo F, Shimizu K, Ueno H, Ishizaki J, Takahashi N, Ikei Y, Hidaka M, Yamaguchi H, Shimoda K. Kameda T, et al. BMC Infect Dis. 2024 Jan 17;24(1):96. doi: 10.1186/s12879-024-09001-z. BMC Infect Dis. 2024. PMID: 38233756 Free PMC article.
BACKGROUND: Whether human T-lymphotropic virus type 1 (HTLV-1) carriers can develop sufficient humoral immunity after coronavirus disease 2019 (COVID-19) vaccination is unknown. METHODS: To investigate humoral immunity after COVID-19 vaccination …
BACKGROUND: Whether human T-lymphotropic virus type 1 (HTLV-1) carriers can develop sufficient humoral immunity after coronavirus dis …
CoVProt: Toward a Mass Spectrometry Data Portal for COVID-19 Proteomics Research and Development.
Rajoria S, Kavuru SR, Pyda HS, Bihani S, Borishetty D, Biswas D, Prajapati J, Paladi H, Srivastava S. Rajoria S, et al. OMICS. 2024 Jan;28(1):24-31. doi: 10.1089/omi.2023.0274. Epub 2024 Jan 9. OMICS. 2024. PMID: 38193774
The coronavirus disease 2019 (COVID-19) pandemic has wreaked havoc globally. Beyond the pandemic, the long-term effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in …
The coronavirus disease 2019 (COVID-19) pandemic has wreaked havoc globally. Beyond the pandemic, the long-term effects …
Association of COVID-19 coinfection with increased mortality among patients with Pseudomonas aeruginosa bloodstream infection in the Veterans Health Administration system.
Hojat LS, Wilson BM, Perez F, Mojica MF, Singer ME, Bonomo RA, Epstein LH. Hojat LS, et al. Antimicrob Steward Healthc Epidemiol. 2023 Dec 15;3(1):e237. doi: 10.1017/ash.2023.455. eCollection 2023. Antimicrob Steward Healthc Epidemiol. 2023. PMID: 38156202 Free PMC article.
Patients in the COVID-19 period were further stratified by the presence or absence of concomitant COVID-19 infection. ...CONCLUSIONS: Higher mortality was observed in patients with COVID-19 coinfection among patients
Patients in the COVID-19 period were further stratified by the presence or absence of concomitant COVID-19
Perturbations of the T-cell receptor repertoire in response to SARS-CoV-2 in immunocompetent and immunocompromised individuals.
Delmonte OM, Oguz C, Dobbs K, Myint-Hpu K, Palterer B, Abers MS, Draper D, Truong M, Kaplan IM, Gittelman RM, Zhang Y, Rosen LB, Snow AL, Dalgard CL, Burbelo PD, Imberti L, Sottini A, Quiros-Roldan E, Castelli F, Rossi C, Brugnoni D, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Anderson MV, Saracino A, Chironna M, Di Stefano M, Fiore JR, Santantonio T, Castagnoli R, Marseglia GL, Magliocco M, Bosticardo M, Pala F, Shaw E, Matthews H, Weber SE, Xirasagar S, Barnett J, Oler AJ, Dimitrova D, Bergerson JRE, McDermott DH, Rao VK, Murphy PM, Holland SM, Lisco A, Su HC, Lionakis MS, Cohen JI, Freeman AF, Snyder TM, Lack J, Notarangelo LD. Delmonte OM, et al. J Allergy Clin Immunol. 2024 Jun;153(6):1655-1667. doi: 10.1016/j.jaci.2023.12.011. Epub 2023 Dec 27. J Allergy Clin Immunol. 2024. PMID: 38154666
BACKGROUND: Functional T-cell responses are essential for virus clearance and long-term protection after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, whereas certain clinical factors, …
BACKGROUND: Functional T-cell responses are essential for virus clearance and long-term protection after severe acute respi
Crowdsourcing temporal transcriptomic coronavirus host infection data: Resources, guide, and novel insights.
Flynn J, Ahmadi MM, McFarland CT, Kubal MD, Taylor MA, Cheng Z, Torchia EC, Edwards MG. Flynn J, et al. Biol Methods Protoc. 2023 Nov 14;8(1):bpad033. doi: 10.1093/biomethods/bpad033. eCollection 2023. Biol Methods Protoc. 2023. PMID: 38107402 Free PMC article.
The lack of existing data on SARS-CoV-2 hampered early attempts to treat severe forms of coronavirus disease-2019 (COVID-19) during the pandemic. ...The circulatory hormone adrenomedullin was observed as maximally elevated in elderly p
The lack of existing data on SARS-CoV-2 hampered early attempts to treat severe forms of coronavirus disease-201 …
Extensive acute and sustained changes to neutrophil proteomes post-SARS-CoV-2 infection.
Long MB, Howden AJM, Keir HR, Rollings CM, Giam YH, Pembridge T, Delgado L, Abo-Leyah H, Lloyd AF, Sollberger G, Hull R, Gilmour A, Hughes C, New BJM, Cassidy D, Shoemark A, Richardson H, Lamond AI, Cantrell DA, Chalmers JD, Brenes AJ. Long MB, et al. Eur Respir J. 2024 Mar 7;63(3):2300787. doi: 10.1183/13993003.00787-2023. Print 2024 Mar. Eur Respir J. 2024. PMID: 38097207 Free PMC article.
BACKGROUND: Neutrophils are important in the pathophysiology of coronavirus disease 2019 (COVID-19), but the molecular changes contributing to altered neutrophil phenotypes following severe acute respiratory syndrome coronavirus
BACKGROUND: Neutrophils are important in the pathophysiology of coronavirus disease 2019 (COVID-19), but the molecular …
SARS-CoV-2-infected hiPSC-derived cardiomyocytes reveal dynamic changes in the COVID-19 hearts.
Li X, Hu H, Liu W, Zhang Q, Wang Y, Chen X, Zhu Y, Hu Z, Wang M, Ma J, Leng L. Li X, et al. Stem Cell Res Ther. 2023 Dec 12;14(1):361. doi: 10.1186/s13287-023-03603-1. Stem Cell Res Ther. 2023. PMID: 38087340 Free PMC article.
BACKGROUND: The ongoing coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on our societies. ...In this respect, data indicate that heart failure is one of the most common readmission diagnoses among COVID-19 patients
BACKGROUND: The ongoing coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on our societies. ...In …
Plasma proteomics-based biomarkers for predicting response to mesenchymal stem cell therapy in severe COVID-19.
Li TT, Yao WQ, Dong HB, Wang ZR, Zhang ZY, Yuan MQ, Shi L, Wang FS. Li TT, et al. Stem Cell Res Ther. 2023 Dec 10;14(1):350. doi: 10.1186/s13287-023-03573-4. Stem Cell Res Ther. 2023. PMID: 38072927 Free PMC article.
BACKGROUND: The objective of this study was to identify potential biomarkers for predicting response to MSC therapy by pre-MSC treatment plasma proteomic profile in severe COVID-19 in order to optimize treatment choice. METHODS: A total of 58 patients
BACKGROUND: The objective of this study was to identify potential biomarkers for predicting response to MSC therapy by pre-MSC treatment pla …
Into the Dark Serum Proteome: Personalized Features of IgG1 and IgA1 Repertoires in Severe COVID-19 Patients.
Bondt A, Hoek M, Dingess K, Tamara S, de Graaf B, Peng W, den Boer MA, Damen M, Zwart C, Barendregt A, van Rijswijck DMH, Schulte D, Grobben M, Tejjani K, van Rijswijk J, Völlmy F, Snijder J, Fortini F, Papi A, Volta CA, Campo G, Contoli M, van Gils MJ, Spadaro S, Rizzo P, Heck AJR. Bondt A, et al. Mol Cell Proteomics. 2024 Jan;23(1):100690. doi: 10.1016/j.mcpro.2023.100690. Epub 2023 Dec 6. Mol Cell Proteomics. 2024. PMID: 38065436 Free PMC article.
Here, we focus exclusively on these personalized features in the serum proteome and distinctively chose to study individual samples from a low diversity population: elderly donors infected by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2
Here, we focus exclusively on these personalized features in the serum proteome and distinctively chose to study individual samples f …
Proteomic Evolution from Acute to Post-COVID-19 Conditions.
Mohammed Y, Tran K, Carlsten C, Ryerson C, Wong A, Lee T, Cheng MP, Vinh DC, Lee TC, Winston BW, Sweet D, Boyd JH, Walley KR, Haljan G, McGeer A, Lamontagne F, Fowler R, Maslove D, Singer J, Patrick DM, Marshall JC, Murthy S, Jain F, Borchers CH, Goodlett DR, Levin A, Russell JA; ARBs CORONA I Consortium. Mohammed Y, et al. J Proteome Res. 2024 Jan 5;23(1):52-70. doi: 10.1021/acs.jproteome.3c00324. Epub 2023 Dec 4. J Proteome Res. 2024. PMID: 38048423 Free PMC article.
Many COVID-19 survivors have post-COVID-19 conditions, and females are at a higher risk. We sought to determine (1) how protein levels change from acute to post-COVID-19 conditions, (2) whether females have a plasma protein signature diff …
Many COVID-19 survivors have post-COVID-19 conditions, and females are at a higher risk. We sought to determine …
Omics-CNN: A comprehensive pipeline for predictive analytics in quantitative omics using one-dimensional convolutional neural networks.
Zompola A, Korfiati A, Theofilatos K, Mavroudi S. Zompola A, et al. Heliyon. 2023 Oct 28;9(11):e21165. doi: 10.1016/j.heliyon.2023.e21165. eCollection 2023 Nov. Heliyon. 2023. PMID: 38027840 Free PMC article.
The developed tool has the potential to classify patients depending on the expression of genetic and clinical factors and identify features that can act as diagnostic biomarkers. ...RESULTS: The newly introduced pipeline was applied to one transcriptomics and one …
The developed tool has the potential to classify patients depending on the expression of genetic and clinical factors and iden …
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization.
Bejaoui Y, Humaira Amanullah F, Saad M, Taleb S, Bradic M, Megarbane A, Ait Hssain A, Abi Khalil C, El Hajj N. Bejaoui Y, et al. Clin Epigenetics. 2023 Nov 28;15(1):186. doi: 10.1186/s13148-023-01597-4. Clin Epigenetics. 2023. PMID: 38017502 Free PMC article.
Previous reports have shown accelerated biological aging and telomere attrition acceleration following SARS-CoV-2 infection. However, the effect of accelerated epigenetic aging on outcome (death/recovery) in COVID-19 patients with acute r …
Previous reports have shown accelerated biological aging and telomere attrition acceleration following SARS-CoV-2 infec …
Dysregulations in hemostasis, metabolism, immune response, and angiogenesis in post-acute COVID-19 syndrome with and without postural orthostatic tachycardia syndrome: a multi-omic profiling study.
Mahdi A, Zhao A, Fredengren E, Fedorowski A, Braunschweig F, Nygren-Bonnier M, Runold M, Bruchfeld J, Nickander J, Deng Q, Checa A, Desta L, Pernow J, Ståhlberg M. Mahdi A, et al. Sci Rep. 2023 Nov 19;13(1):20230. doi: 10.1038/s41598-023-47539-1. Sci Rep. 2023. PMID: 37981644 Free PMC article.
Post-acute COVID-19 (PACS) are associated with cardiovascular dysfunction, especially postural orthostatic tachycardia syndrome (POTS). ...Twenty-one healthy subjects without a prior COVID-19 infection (mean age 43 years, 95% females), 20 non-hospitali …
Post-acute COVID-19 (PACS) are associated with cardiovascular dysfunction, especially postural orthostatic tachycardia syndrom …
Circulating monocytes expressing senescence-associated features are enriched in COVID-19 patients with severe disease.
Lin Y, Postma DF, Steeneken LS, Melo Dos Santos LS, Kirkland JL, Espindola-Netto JM, Tchkonia T, Borghesan M, Bouma HR, Demaria M. Lin Y, et al. Aging Cell. 2023 Dec;22(12):e14011. doi: 10.1111/acel.14011. Epub 2023 Nov 15. Aging Cell. 2023. PMID: 37969056 Free PMC article.
Here, we measured the abundance of senescence-associated signatures in whole blood, plasma and peripheral blood mononuclear cells (PBMCs) of COVID-19 patients and patients without an infection. Bulk transcriptomic and targeted proteomic assays r …
Here, we measured the abundance of senescence-associated signatures in whole blood, plasma and peripheral blood mononuclear cells (PBMCs) of …
Frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in Mexico City.
Nieto-Rivera B, Saldaña-Ahuactzi Z, Parra-Ortega I, Flores-Alanis A, Carbajal-Franco E, Cruz-Rangel A, Galaviz-Hernández S, Romero-Navarro B, de la Rosa-Zamboni D, Salazar-García M, Contreras CA, Ortega-Riosvelasco F, López-Martínez I, Barrera-Badillo G, Diaz-Garcia H, Romo-Castillo M, Moreno-Espinosa S, Luna-Pineda VM. Nieto-Rivera B, et al. Sci Rep. 2023 Nov 13;13(1):19763. doi: 10.1038/s41598-023-47035-6. Sci Rep. 2023. PMID: 37957308 Free PMC article.
Of the 797 patients, 632 were infected with one CRP and 165 with > 2 CRPs. Deaths occurred only in SARS-CoV-2-infected patients. ...Age, cyanosis (symptom), and immunosuppression (comorbidity) were found to differentiate between SARS- …
Of the 797 patients, 632 were infected with one CRP and 165 with > 2 CRPs. Deaths occurred only in SARS-CoV-2
Protocol of the Berlin Long-term Observation of Vascular Events (BeLOVE): a prospective cohort study with deep phenotyping and long-term follow up of cardiovascular high-risk patients.
Weber JE, Ahmadi M, Boldt LH, Eckardt KU, Edelmann F, Gerhardt H, Grittner U, Haubold K, Hübner N, Kollmus-Heege J, Landmesser U, Leistner DM, Mai K, Müller DN, Nolte CH, Pieske B, Piper SK, Rattan S, Rauch G, Schmidt S, Schmidt-Ott KM, Schönrath K, Schulz-Menger J, Schweizerhof O, Siegerink B, Spranger J, Ramachandran VS, Witzenrath M, Endres M, Pischon T. Weber JE, et al. BMJ Open. 2023 Oct 31;13(10):e076415. doi: 10.1136/bmjopen-2023-076415. BMJ Open. 2023. PMID: 37907297 Free PMC article.
Deep phenotyping is then performed after ~90 days and includes assessments of the patient's medical history, health status and behaviour, cardiovascular, nutritional, metabolic, and anthropometric parameters, and patient-related outcome measures. ...All parti …
Deep phenotyping is then performed after ~90 days and includes assessments of the patient's medical history, health status and …
A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study.
Jackson HR, Zandstra J, Menikou S, Hamilton MS, McArdle AJ, Fischer R, Thorne AM, Huang H, Tanck MW, Jansen MH, De T, Agyeman PKA, Von Both U, Carrol ED, Emonts M, Eleftheriou I, Van der Flier M, Fink C, Gloerich J, De Groot R, Moll HA, Pokorn M, Pollard AJ, Schlapbach LJ, Tsolia MN, Usuf E, Wright VJ, Yeung S, Zavadska D, Zenz W, Coin LJM, Casals-Pascual C, Cunnington AJ, Martinon-Torres F, Herberg JA, de Jonge MI, Levin M, Kuijpers TW, Kaforou M; PERFORM consortium. Jackson HR, et al. Lancet Digit Health. 2023 Nov;5(11):e774-e785. doi: 10.1016/S2589-7500(23)00149-8. Lancet Digit Health. 2023. PMID: 37890901 Free article.
METHODS: In this multi-cohort machine learning study, patient data were taken from EUCLIDS, the Swiss Pediatric Sepsis study, the GENDRES study, and the PERFORM study, which were all based in Europe. We generated three high-dimensional proteomic datasets (SomaScan a …
METHODS: In this multi-cohort machine learning study, patient data were taken from EUCLIDS, the Swiss Pediatric Sepsis study, the GEN …
Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID.
Wang K, Khoramjoo M, Srinivasan K, Gordon PMK, Mandal R, Jackson D, Sligl W, Grant MB, Penninger JM, Borchers CH, Wishart DS, Prasad V, Oudit GY. Wang K, et al. Cell Rep Med. 2023 Nov 21;4(11):101254. doi: 10.1016/j.xcrm.2023.101254. Epub 2023 Oct 26. Cell Rep Med. 2023. PMID: 37890487 Free PMC article.
The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adverse multisystem consequences. ...Our study reveals pertinent biological processes during convalescence that differ from acute infection, and …
The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adver …
Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque quebecoise de la COVID-19 (BQC-19).
Yamga E, Soulé A, Piché A, Emad A, Durand M, Rousseau S. Yamga E, et al. Clin Proteomics. 2023 Oct 24;20(1):44. doi: 10.1186/s12014-023-09436-7. Clin Proteomics. 2023. PMID: 37875801 Free PMC article.
The quest for understanding and managing the long-term effects of COVID-19, often referred to as Long COVID or post-COVID-19 condition (PCC), remains an active research area. Recent findings highlighted angiopoietin-1 (ANG-1) and p-selectin (P-SEL) as …
The quest for understanding and managing the long-term effects of COVID-19, often referred to as Long COVID or post-COVID
Clinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome.
Sanhueza S, Vidal MA, Hernandez MA, Henriquez-Beltran ME, Cabrera C, Quiroga R, Antilef BE, Aguilar KP, Castillo DA, Llerena FJ, Fraga Figueroa M, Nazal M, Castro E, Lagos P, Moreno A, Lastra JJ, Gajardo J, Garcés P, Riffo B, Buchert J, Sanhueza R, Ormazába V, Saldivia P, Vargas C, Nourdin G, Koch E, Zuñiga FA, Lamperti L, Bustos P, Guzmán-Gutiérrez E, Tapia CA, Ferrada L, Cerda G, Woehlbier U, Riquelme E, Yuseff MI, Muñoz Ramirez BA, Lombardi G, De Gonzalo-Calvo D, Salomon C, Verdugo RA, Quiñones LA, Colombo A, Barría MI, Labarca G, Nova-Lamperti E. Sanhueza S, et al. Front Med (Lausanne). 2023 Oct 6;10:1271863. doi: 10.3389/fmed.2023.1271863. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37869162 Free PMC article.
The aim of this study was to identify and characterize L-TPD in patients with long-COVID and elucidate the main pathways and long-term consequences attributed to this condition by analyzing clinical parameters and functional tests supported by machine learning and s …
The aim of this study was to identify and characterize L-TPD in patients with long-COVID and elucidate the main pathways and long-ter …
Short-term predictor for COVID-19 severity from a longitudinal multi-omics study for practical application in intensive care units.
Kugler S, Hahnefeld L, Kloka JA, Ginzel S, Nürenberg-Goloub E, Zinn S, Vehreschild MJ, Zacharowski K, Lindau S, Ullrich E, Burmeister J, Kohlhammer J, Schwäble J, Gurke R, Dorochow E, Bennett A, Dauth S, Campe J, Knape T, Laux V, Kannt A, Köhm M, Geisslinger G, Resch E, Behrens F. Kugler S, et al. Talanta. 2024 Feb 1;268(Pt 1):125295. doi: 10.1016/j.talanta.2023.125295. Epub 2023 Oct 9. Talanta. 2024. PMID: 37866305 Free article.
A workflow was established to identify a predictor for short-term COVID-19 disease progression in the acute phase of intensive care patients to support clinical decision-making. METHODS: Thirty-two patients with SARS-CoV-2 i …
A workflow was established to identify a predictor for short-term COVID-19 disease progression in the acute phase of intensive …
Cerebrospinal fluid metabolomic and proteomic characterization of neurologic post-acute sequelae of SARS-CoV-2 infection.
Chen S, Liang J, Chen D, Huang Q, Sun K, Zhong Y, Lin B, Kong J, Sun J, Gong C, Wang J, Gao Y, Zhang Q, Sun H. Chen S, et al. Brain Behav Immun. 2024 Jan;115:209-222. doi: 10.1016/j.bbi.2023.10.016. Epub 2023 Oct 17. Brain Behav Immun. 2024. PMID: 37858739
The mechanism by which SARS-CoV-2 causes neurological post-acute sequelae of SARS-CoV-2 (neuro-PASC) remains unclear. Herein, we conducted proteomic and metabolomic analyses of cerebrospinal fluid (CSF) samples from 21 neuro-PASC …
The mechanism by which SARS-CoV-2 causes neurological post-acute sequelae of SARS-CoV-2 (neuro-PAS …
ERC-BiP Functional Protein Pathway for Assessing Endoplasmic Reticulum Stress Induced by SARS-CoV-2 Replication after Cell Invasion.
Xue M, Lin Z, Zhang T, Cheng ZJ, Lin R, Guo B, Zeng Y, Hu F, Li F, Zheng P, Huang H, Li N, Zhao Q, Sun B, Tang X. Xue M, et al. Can J Infect Dis Med Microbiol. 2023 Oct 9;2023:7253779. doi: 10.1155/2023/7253779. eCollection 2023. Can J Infect Dis Med Microbiol. 2023. PMID: 37849973 Free PMC article.
This study aimed to establish a protein-metabolic pathway associated with ER dysfunction based on the invasion mechanism of SARS-CoV-2. METHODS: This study included 17 healthy people and 46 COVID-19 patients, including 38 mild patients
This study aimed to establish a protein-metabolic pathway associated with ER dysfunction based on the invasion mechanism of SARS-C
BNT162b2 versus mRNA-1273 Third Dose COVID-19 Vaccine in Patients with CKD and Maintenance Dialysis Patients.
Yau K, Tam P, Chan CT, Hu Q, Qi F, Abe KT, Kurtesi A, Jiang Y, Estrada-Codecido J, Brown T, Liu L, Siwakoti A, Leis JA, Levin A, Oliver MJ, Colwill K, Gingras AC, Hladunewich MA. Yau K, et al. Clin J Am Soc Nephrol. 2024 Jan 1;19(1):85-97. doi: 10.2215/CJN.0000000000000328. Epub 2023 Oct 17. Clin J Am Soc Nephrol. 2024. PMID: 37847518 Free PMC article. Clinical Trial.
BACKGROUND: There is a lack of randomized controlled trial data regarding differences in immunogenicity of varying coronavirus disease 2019 (COVID-19) mRNA vaccine regimens in CKD populations. METHODS: We conducted a randomized controlled trial at three kidne …
BACKGROUND: There is a lack of randomized controlled trial data regarding differences in immunogenicity of varying coronavirus diseas …
[The Swecrit Biobank, associated clinical registries, and machine learning (artificial intelligence) improve critical care knowledge].
Frigyesi A, Lengquist M, Johnsson P, Lybeck A, Spångfors M, Helena L, Jakobsson A, Friberg H. Frigyesi A, et al. Lakartidningen. 2023 Oct 16;120:23078. Lakartidningen. 2023. PMID: 37846149 Free article. Swedish.
The unique Swecrit Biobank and its associated clinical registries for sepsis, ARDS, cardiac arrest, trauma, and COVID-19 include more than 150,000 blood samples and descriptions of critically ill patients. These assets provide a unique opportunity to r …
The unique Swecrit Biobank and its associated clinical registries for sepsis, ARDS, cardiac arrest, trauma, and COVID-19
Multi-Omic Candidate Screening for Markers of Severe Clinical Courses of COVID-19.
Dutsch A, Uhlig C, Bock M, Graesser C, Schuchardt S, Uhlig S, Schunkert H, Joner M, Holdenrieder S, Lechner K. Dutsch A, et al. J Clin Med. 2023 Sep 27;12(19):6225. doi: 10.3390/jcm12196225. J Clin Med. 2023. PMID: 37834869 Free PMC article.
BACKGROUND: Severe coronavirus disease 2019 (COVID-19) disease courses are characterized by immuno-inflammatory, thrombotic, and parenchymal alterations. Prediction of individual COVID-19 disease courses to guide targeted prevention remains chal …
BACKGROUND: Severe coronavirus disease 2019 (COVID-19) disease courses are characterized by immuno-inflammatory, thromb …
Age-related influence on DNA damage, proteomic inflammatory markers and oxidative stress in hospitalized COVID-19 patients compared to healthy controls.
Draxler A, Blaschke A, Binar J, Weber M, Haslacher M, Bartak V, Bragagna L, Mare G, Maqboul L, Klapp R, Herzog T, Széll M, Petrera A, Laky B, Wagner KH, Thell R. Draxler A, et al. Redox Biol. 2023 Nov;67:102914. doi: 10.1016/j.redox.2023.102914. Epub 2023 Oct 3. Redox Biol. 2023. PMID: 37832397 Free PMC article.

Hospitalized COVID-19 patients (n = 48) demonstrated higher serum levels of 55 inflammatory proteins (p < 0.001), including hs-C-reactive protein levels (p < 0.05), compared to healthy controls (n = 48). ...UCB levels were significantly lower in individ

Hospitalized COVID-19 patients (n = 48) demonstrated higher serum levels of 55 inflammatory proteins (p < 0.001), in

Short Survey on the Protein Modifications in Plasma during SARS-CoV-2 Infection.
Gęgotek A, Zarkovic N, Orehovec B, Jaganjac M, Sunjic SB, Skrzydlewska E. Gęgotek A, et al. Int J Mol Sci. 2023 Sep 14;24(18):14109. doi: 10.3390/ijms241814109. Int J Mol Sci. 2023. PMID: 37762413 Free PMC article.
Although the COVID-19 pandemic has ended, it is important to understand the pathology of severe SARS-CoV-2 infection associated with respiratory failure and high mortality. ...This study for the first time demonstrates the formation of lipid met …
Although the COVID-19 pandemic has ended, it is important to understand the pathology of severe SARS-CoV-2
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets.
Haas KM, McGregor MJ, Bouhaddou M, Polacco BJ, Kim EY, Nguyen TT, Newton BW, Urbanowski M, Kim H, Williams MAP, Rezelj VV, Hardy A, Fossati A, Stevenson EJ, Sukerman E, Kim T, Penugonda S, Moreno E, Braberg H, Zhou Y, Metreveli G, Harjai B, Tummino TA, Melnyk JE, Soucheray M, Batra J, Pache L, Martin-Sancho L, Carlson-Stevermer J, Jureka AS, Basler CF, Shokat KM, Shoichet BK, Shriver LP, Johnson JR, Shaw ML, Chanda SK, Roden DM, Carter TC, Kottyan LC, Chisholm RL, Pacheco JA, Smith ME, Schrodi SJ, Albrecht RA, Vignuzzi M, Zuliani-Alvarez L, Swaney DL, Eckhardt M, Wolinsky SM, White KM, Hultquist JF, Kaake RM, García-Sastre A, Krogan NJ. Haas KM, et al. Nat Commun. 2023 Sep 27;14(1):6030. doi: 10.1038/s41467-023-41442-z. Nat Commun. 2023. PMID: 37758692 Free PMC article.
Using affinity purification-mass spectrometry and global phosphoproteomic and protein abundance analyses using three IAV strains (pH1N1, H3N2, H5N1) in three human cell types (A549, NHBE, THP-1), we map 332 IAV-human protein-protein interactions and identify 13 IAV-modulated kina …
Using affinity purification-mass spectrometry and global phosphoproteomic and protein abundance analyses using three IAV strains (pH1N1, H3N …
Comprehensive proteomics and meta-analysis of COVID-19 host response.
Babačić H, Christ W, Araújo JE, Mermelekas G, Sharma N, Tynell J, García M, Varnaite R, Asgeirsson H, Glans H, Lehtiö J, Gredmark-Russ S, Klingström J, Pernemalm M. Babačić H, et al. Nat Commun. 2023 Sep 22;14(1):5921. doi: 10.1038/s41467-023-41159-z. Nat Commun. 2023. PMID: 37739942 Free PMC article.
Therefore, to better understand the systemic host response to SARS-CoV-2 infection, we performed systematic analyses of the circulating, soluble proteins in the blood through global proteomics by mass-spectrometry (MS) proteomics. ...Some protei …
Therefore, to better understand the systemic host response to SARS-CoV-2 infection, we performed systematic analyses of …
Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time.
Figueirêdo Leite GG, Colo Brunialti MK, Peçanha-Pietrobom PM, Abrão Ferreira PR, Ota-Arakaki JS, Cunha-Neto E, Ferreira BL, Ronsein GE, Tashima AK, Salomão R. Figueirêdo Leite GG, et al. iScience. 2023 Sep 2;26(10):107824. doi: 10.1016/j.isci.2023.107824. eCollection 2023 Oct 20. iScience. 2023. PMID: 37736053 Free PMC article.
The clinical presentation of COVID-19 is highly variable, and understanding the underlying biological processes is crucial. This study utilized a proteomic analysis to investigate dysregulated processes in the peripheral blood mononuclear cells of p
The clinical presentation of COVID-19 is highly variable, and understanding the underlying biological processes is cruc …
Plasma proteomics show altered inflammatory and mitochondrial proteins in patients with neurologic symptoms of post-acute sequelae of SARS-CoV-2 infection.
Hanson BA, Visvabharathy L, Orban ZS, Jimenez M, Batra A, Liotta EM, DeLisle RK, Klausner JD, Cohen P, Padhye AS, Tachas G, Koralnik IJ. Hanson BA, et al. Brain Behav Immun. 2023 Nov;114:462-474. doi: 10.1016/j.bbi.2023.08.022. Epub 2023 Sep 11. Brain Behav Immun. 2023. PMID: 37704012 Free PMC article.
Persistent symptoms of COVID-19 survivors constitute long COVID syndrome, also called post-acute sequelae of SARS-CoV-2 infection (PASC). ...To gain insight into the pathogenesis of PASC, we leveraged a well-characterized group of Neuro-PASC (NP …
Persistent symptoms of COVID-19 survivors constitute long COVID syndrome, also called post-acute sequelae of SARS-Co
Transcriptomic and proteomic assessment of tocilizumab response in a randomized controlled trial of patients hospitalized with COVID-19.
Shivram H, Hackney JA, Rosenberger CM, Teterina A, Qamra A, Onabajo O, McBride J, Cai F, Bao M, Tsai L, Regev A, Rosas IO, Bauer RN. Shivram H, et al. iScience. 2023 Aug 11;26(9):107597. doi: 10.1016/j.isci.2023.107597. eCollection 2023 Sep 15. iScience. 2023. PMID: 37664617 Free PMC article.
High interleukin (IL)-6 levels are associated with greater COVID-19 severity. IL-6 receptor blockade by tocilizumab (anti-IL6R; Actemra) is used globally for the treatment of severe COVID-19, yet a molecular understanding of the therapeutic benefit rem …
High interleukin (IL)-6 levels are associated with greater COVID-19 severity. IL-6 receptor blockade by tocilizumab (anti-IL6R …
Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children.
Amodio D, Pascucci GR, Cotugno N, Rossetti C, Manno EC, Pighi C, Morrocchi E, D'Alessandro A, Perrone MA, Valentini A, Franceschini A, Chinali M, Deodati A, Azzari C, Rossi P, Cianfarani S, Andreani M, Porzio O, Palma P. Amodio D, et al. Clin Immunol. 2023 Oct;255:109751. doi: 10.1016/j.clim.2023.109751. Epub 2023 Sep 3. Clin Immunol. 2023. PMID: 37660743 Free article.
Despite the multiple benefits of vaccination, cardiac adverse Events Following COVID-19 Immunization (c-AEFI) have been reported. These events as well as the severe cardiac involvement reported in Multisystem inflammatory syndrome in children (MIS-C) appear more fre …
Despite the multiple benefits of vaccination, cardiac adverse Events Following COVID-19 Immunization (c-AEFI) have been report …
Distinct subsets of anti-pulmonary autoantibodies correlate with disease severity and survival in severe COVID-19 patients.
Tóth E, Fagyas M, Nagy B Jr, Siket IM, Szőke B, Mártha L, Mahdi M, Erdősi G, Pólik Z, Kappelmayer J, Papp Z, Borbély A, Szabó T, Balla J, Balla G, Bácsi A, Szekanecz Z, Bai P, Tóth A. Tóth E, et al. Geroscience. 2024 Apr;46(2):1561-1574. doi: 10.1007/s11357-023-00887-2. Epub 2023 Sep 1. Geroscience. 2024. PMID: 37656328 Free PMC article.
Autoantibodies targeting the lung tissue were identified in severe COVID-19 patients in this retrospective study. Fifty-three percent of 104 patients developed anti-pulmonary antibodies, the majority of which were IgM class, suggesting that they develo …
Autoantibodies targeting the lung tissue were identified in severe COVID-19 patients in this retrospective study. Fifty …
Colostrum Features of Active and Recovered COVID-19 Patients Revealed Using Next-Generation Proteomics Technique, SWATH-MS.
Hernández-Caravaca I, Moros-Nicolás C, González-Brusi L, Romero de Ávila MJ, De Paco Matallana C, Pelegrín P, Castaño-Molina MÁ, Díaz-Meca L, Sánchez-Romero J, Martínez-Alarcón L, Avilés M, Izquierdo-Rico MJ. Hernández-Caravaca I, et al. Children (Basel). 2023 Aug 21;10(8):1423. doi: 10.3390/children10081423. Children (Basel). 2023. PMID: 37628421 Free PMC article.
The samples were analyzed by means of RT-qPCR to determine presence of the virus and using SWATH-MS for proteomic analysis. Proteomic results were then analyzed using bioinformatic methods. The viral tests were negative for SARS-CoV-2 in the col …
The samples were analyzed by means of RT-qPCR to determine presence of the virus and using SWATH-MS for proteomic analysis. Proteo
Dexamethasone attenuates interferon-related cytokine hyperresponsiveness in COVID-19 patients.
Engel JJ, van der Made CI, Keur N, Setiabudiawan T, Röring RJ, Damoraki G, Dijkstra H, Lemmers H, Ioannou S, Poulakou G, van der Meer JWM, Giamarellos-Bourboulis EJ, Kumar V, van de Veerdonk FL, Netea MG, Ziogas A. Engel JJ, et al. Front Immunol. 2023 Aug 8;14:1233318. doi: 10.3389/fimmu.2023.1233318. eCollection 2023. Front Immunol. 2023. PMID: 37614228 Free PMC article.
BACKGROUND: Dexamethasone improves the survival of COVID-19 patients in need of supplemental oxygen therapy. Although its broad immunosuppressive effects are well-described, the immunological mechanisms modulated by dexamethasone in patients hospitaliz …
BACKGROUND: Dexamethasone improves the survival of COVID-19 patients in need of supplemental oxygen therapy. Although i …
Elevation of IL-17 Cytokines Distinguishes Kawasaki Disease From Other Pediatric Inflammatory Disorders.
Brodeur KE, Liu M, Ibanez D, de Groot MJ, Chen L, Du Y, Seyal E, Laza-Briviesca R, Baker A, Chang JC, Chang MH, Day-Lewis M, Dedeoglu F, Dionne A, de Ferranti SD, Friedman KG, Halyabar O, Lo MS, Meidan E, Sundel RP, Henderson LA, Nigrovic PA, Newburger JW, Son MB, Lee PY. Brodeur KE, et al. Arthritis Rheumatol. 2024 Feb;76(2):285-292. doi: 10.1002/art.42680. Epub 2023 Nov 20. Arthritis Rheumatol. 2024. PMID: 37610270 Free PMC article.
We validated the key findings using serum samples from additional patients with KD (n = 37) and febrile controls (n = 28). RESULTS: High-fidelity proteomic profiling revealed distinct patterns of cytokine and chemokine expression across pediatric inflammatory diseas …
We validated the key findings using serum samples from additional patients with KD (n = 37) and febrile controls (n = 28). RESULTS: H …
Rare genetic variants involved in multisystem inflammatory syndrome in children: a multicenter Brazilian cohort study.
Reis BCSD, Soares Faccion R, de Carvalho FAA, Moore DCBC, Zuma MCC, Plaça DR, Salerno Filgueiras I, Leandro Mathias Fonseca D, Cabral-Marques O, Bonomo AC, Savino W, Freitas FCP, Faoro H, Passetti F, Robaina JR, de Oliveira FRC, Novaes Bellinat AP, Zeitel RS, Salú MDS, de Oliveira MBG, Rodrigues-Santos G, Prata-Barbosa A, de Vasconcelos ZFM. Reis BCSD, et al. Front Cell Infect Microbiol. 2023 Jul 31;13:1182257. doi: 10.3389/fcimb.2023.1182257. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37588055 Free PMC article.
INTRODUCTION: Despite the existing data on the Multisystem Inflammatory Syndrome in Children (MIS-C), the factors that determine these patients evolution remain elusive. Answers may lie, at least in part, in genetics. It is currently under investigation that MIS-C patie
INTRODUCTION: Despite the existing data on the Multisystem Inflammatory Syndrome in Children (MIS-C), the factors that determine these pa
COVIDpro: Database for Mining Protein Dysregulation in Patients with COVID-19.
Zhang F, Luna A, Tan T, Chen Y, Sander C, Guo T. Zhang F, et al. J Proteome Res. 2023 Sep 1;22(9):2847-2859. doi: 10.1021/acs.jproteome.3c00092. Epub 2023 Aug 9. J Proteome Res. 2023. PMID: 37555633
The ongoing pandemic of the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 still has limited treatment options. ...COVIDpro serves as a valuable resource for testing …
The ongoing pandemic of the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
Identification of SARS-CoV-2 biomarkers in saliva by transcriptomic and proteomics analysis.
Marin LM, Katselis GS, Chumala P, Sanche S, Julseth L, Penz E, Skomro R, Siqueira WL. Marin LM, et al. Clin Proteomics. 2023 Aug 3;20(1):30. doi: 10.1186/s12014-023-09417-w. Clin Proteomics. 2023. PMID: 37537537 Free PMC article.
The qualitative detection of SARS-CoV-2 specific RNA was done by rRT-PCR. SARS-CoV-2 proteins were identified in all COVID-19 samples (100%), while viral RNA was detected in only 24 out of 42 COVID-19 samples ( …
The qualitative detection of SARS-CoV-2 specific RNA was done by rRT-PCR. SARS-CoV-2 proteins were …
Identification of cuproptosis-related molecular subtypes and a novel predictive model of COVID-19 based on machine learning.
Luo H, Yan J, Zhang D, Zhou X. Luo H, et al. Front Immunol. 2023 Jul 17;14:1152223. doi: 10.3389/fimmu.2023.1152223. eCollection 2023. Front Immunol. 2023. PMID: 37533853 Free PMC article.
BACKGROUND: To explicate the pathogenic mechanisms of cuproptosis, a newly observed copper induced cell death pattern, in Coronavirus disease 2019 (COVID-19). METHODS: Cuproptosis-related subtypes were distinguished in COVID-19 patients a …
BACKGROUND: To explicate the pathogenic mechanisms of cuproptosis, a newly observed copper induced cell death pattern, in Coronavirus
Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system.
Schmidt F, Abdesselem HB, Suhre K, Vaikath NN, Sohail MU, Al-Nesf M, Bensmail I, Mashod F, Sarwath H, Bernhardt J, Schaefer-Ramadan S, Tan TM, Morris PE, Schenck EJ, Price D, Mohamed-Ali V, Al-Maadheed M, Arredouani A, Decock J, Blackburn JM, Choi AMK, El-Agnaf OM. Schmidt F, et al. Front Physiol. 2023 Jul 14;14:1203723. doi: 10.3389/fphys.2023.1203723. eCollection 2023. Front Physiol. 2023. PMID: 37520825 Free PMC article.
Background: Coronavirus disease (COVID-19) manifests many clinical symptoms, including an exacerbated immune response and cytokine storm. ...Results and conclusion: Autoantibody responses to 57 proteins were significantly altered in the COVID- …
Background: Coronavirus disease (COVID-19) manifests many clinical symptoms, including an exacerbated immune res …
Clinical and humoral immune response characterization of SARS-CoV-2 Omicron BA.2.38 infection in pediatric patients.
Liu Y, Zhao L, Wang L, Li Y, Wang L, Yu B, Hu D, Weng H, Guo J, Yang J, Yang J, Yu X. Liu Y, et al. Heliyon. 2023 Jul 11;9(7):e18093. doi: 10.1016/j.heliyon.2023.e18093. eCollection 2023 Jul. Heliyon. 2023. PMID: 37519697 Free PMC article.
Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a health concern for both unvaccinated and vaccinated individuals against coronavirus disease 2019 (COVID-19). . …
Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2
Identification of Immunodominant Proteins of the Leishmania (Viannia) naiffi SubProteome as Pan-Specific Vaccine Targets against Leishmaniasis.
Jesus-Oliveira P, Silva-Couto L, Pinho N, Da Silva-Ferreira AT, Saboia-Vahia L, Cuervo P, Da-Cruz AM, Gomes-Silva A, Pinto EF. Jesus-Oliveira P, et al. Vaccines (Basel). 2023 Jun 21;11(7):1129. doi: 10.3390/vaccines11071129. Vaccines (Basel). 2023. PMID: 37514945 Free PMC article.
In this work we aimed to identify the immunodominant proteins present in the soluble extract of L. naiffi (sLnAg) as candidates for composing a pan-specific anti-leishmaniasis vaccine. After immunoblotting using cured patients of cutaneous leishmaniasis sera and proteom
In this work we aimed to identify the immunodominant proteins present in the soluble extract of L. naiffi (sLnAg) as candidates for composin …
The Renin-Angiotensin System in COVID-19: Can Long COVID Be Predicted?
König S, Vollenberg R, Tepasse PR. König S, et al. Life (Basel). 2023 Jun 28;13(7):1462. doi: 10.3390/life13071462. Life (Basel). 2023. PMID: 37511837 Free PMC article.
(1) Background: Co-morbidities such as hypertension and cardiovascular disease are major risk factors for severe COVID-19. The renin-angiotensin system (RAS) is critically involved in their pathophysiology and is counter-balanced by both angiotensin-converting enzym …
(1) Background: Co-morbidities such as hypertension and cardiovascular disease are major risk factors for severe COVID-19. The …
Association of ABO blood types and clinical variables with COVID-19 infection severity in Libya.
Abdulla SA, Elawamy HA, Mohamed NA, Abduallah EH, Amshahar HA, Abuzaeid NK, Eisa MA, Osman MEM, Konozy EHE. Abdulla SA, et al. SAGE Open Med. 2023 Jul 21;11:20503121231187736. doi: 10.1177/20503121231187736. eCollection 2023. SAGE Open Med. 2023. PMID: 37489137 Free PMC article.
OBJECTIVE: The continuing COVID-19 pandemic is a coronavirus-related health emergency (severe acute respiratory syndrome coronavirus 2). ...METHODS: This study is a retrospective case-control study conducted online am …
OBJECTIVE: The continuing COVID-19 pandemic is a coronavirus-related health emergency (severe acute re