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Page 1
Longitudinal clinical proteomics reveals pneumonia type-specific protein biomarkers and autoantibodies.
Semenova A, Poor TA, Müller-Reif JB, Prakki SRS, Geyer P, Mück-Häusl M, Holdt LM, Teupser D, Mann M, Yildirim AÖ, Wunderink RG, Misharin AV, Singer BD, Budinger GRS, Kapellos TS, Schiller HB. Semenova A, et al. medRxiv [Preprint]. 2026 Jan 13:2026.01.12.26343938. doi: 10.64898/2026.01.12.26343938. medRxiv. 2026. PMID: 41646792 Free PMC article. Preprint.
Specific molecular endotypes are currently not well defined and different viral or bacterial pathogens may trigger specific host responses and pathogenic mechanisms. We performed longitudinal proteomic profiling of bronchoalveolar lavage fluid and plasma from bacterial, in …
Specific molecular endotypes are currently not well defined and different viral or bacterial pathogens may trigger specific host responses a …
Exploration of immune phenotypes in self-sampling citizens.
Dahl L, Bendes A, Álvez MB, Albrecht V, Aghelpasand H, Björkander S, Merid SK, Mezger A, Käller M, Fredolini C, Naluai ÅT, Beck O, Melén E, Bauer S, Gisslén M, Roxhed N, Schwenk JM. Dahl L, et al. iScience. 2026 Jan 3;29(2):114611. doi: 10.1016/j.isci.2025.114611. eCollection 2026 Feb 20. iScience. 2026. PMID: 41630906 Free PMC article.
With self-sampled dried blood spots (DBS) and health information from 437 (22%) volunteers, we performed multi-analyte COVID-19 serology, measured autoantibodies (AAbs) against 22 interferons, and quantified 502 circulating low-abundant immune-related blood proteins …
With self-sampled dried blood spots (DBS) and health information from 437 (22%) volunteers, we performed multi-analyte COVID-19 …
Iparomlimab and tuvonralimab (QL1706) combined definitive chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma (QL1706-IIT-02): a single arm, phase 2 trial.
Zhang W, Zhang T, Chen X, Li J, Gao L, Jiang S, Wang Y, Zheng Z, Dong J, Li Z, Zhao G, Cao F, Bai N, Wang P, Yan C, Pang Q. Zhang W, et al. EClinicalMedicine. 2026 Jan 21;92:103758. doi: 10.1016/j.eclinm.2026.103758. eCollection 2026 Feb. EClinicalMedicine. 2026. PMID: 41623855 Free PMC article.
The primary endpoint was progression-free survival (PFS). This study is registered with ClinicalTrials.gov (NCT05490719). FINDINGS: 20 patients (51.3%) completed the full cycles of QL-1706. Reasons for the premature cessation of QL1706 were disease progression (n = …
The primary endpoint was progression-free survival (PFS). This study is registered with ClinicalTrials.gov (NCT05490719). FINDINGS: 2 …
Antibodies Against SARS-CoV-2 Nucleocapsid Protein Possess Autoimmune Properties.
Rak A, Zabrodskaya Y, Wong PF, Isakova-Sivak I. Rak A, et al. Antibodies (Basel). 2025 Dec 22;15(1):2. doi: 10.3390/antib15010002. Antibodies (Basel). 2025. PMID: 41562775 Free PMC article.
Contemporary SARS-CoV-2 variants, while associated with a reduced propensity for severe acute pathology, retain the capacity to induce long-term post-COVID syndrome, including in ambulatory patient populations. ...In the present study, we aim to identi …
Contemporary SARS-CoV-2 variants, while associated with a reduced propensity for severe acute pathology, retain the cap …
Tetrandrine-driven autophagy suppresses SARS-CoV-2 replication by modulating cholesterol and IGF signaling pathways.
Marchioro LO, De Stefanis S, Araújo BG, Mariotti D, Watanabe IKM, Stumpe M, Matusali G, Maggi F, Smaili SS, Dengjel J, Pereira GJS, Antonioli M. Marchioro LO, et al. Cell Death Discov. 2026 Jan 6;12(1):82. doi: 10.1038/s41420-025-02926-7. Cell Death Discov. 2026. PMID: 41495014 Free article.
SARS-CoV-2 exploits multiple host cellular processes, including autophagy, a critical intracellular degradation pathway, to facilitate viral replication and evade immune detection. ...In this study, we investigated the effects of Tetrandrine on SARS- …
SARS-CoV-2 exploits multiple host cellular processes, including autophagy, a critical intracellular degradation pathway …
Exploratory Research on the Urine Proteome in Patients With Diabetic Peripheral Neuropathy.
Wei L, Jiang Y, Wang H, Wu J, Han C, Zhan Y, Zhou Y, Cao Y, Gao Y. Wei L, et al. Int J Endocrinol. 2025 Dec 22;2025:6652078. doi: 10.1155/ije/6652078. eCollection 2025. Int J Endocrinol. 2025. PMID: 41476994 Free PMC article.
Urinary proteomics was used to analyze urine samples from patients with DPN and healthy individuals. ...The most significant KEGG signaling pathways were ribosome, coronavirus disease (COVID-19), and metabolic pathways. Furthermore, some differe …
Urinary proteomics was used to analyze urine samples from patients with DPN and healthy individuals. ...The most significant K …
Mapping Interactions Between Cytokines, Chemokines, Growth Factors, and Conventional Biomarkers in COVID-19 ICU-Patients.
Eriksson MB, Marks-Hultström M, Åberg M, Lipcsey M, Frithiof R, Larsson AO. Eriksson MB, et al. Int J Mol Sci. 2025 Nov 26;26(23):11419. doi: 10.3390/ijms262311419. Int J Mol Sci. 2025. PMID: 41373577 Free PMC article.
Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyperinflammation with cytokine and chemokine release, alongside elevations in conventional laboratory biomarkers such as C-reactive protein (CRP), ferritin, and procalcitonin (PCT). ...T …
Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyperinflammation with cytokine and chemokine r …
Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19.
Whitcomb LA, Berry K, LaVergne SM, Natter N, Baxter BA, Rao S, Tipton M, Gritsenko MA, Weitz KK, Gerbasi V, Bramer LM, Piehowski PD, Webb TL, Henao-Tamayo M, Chicco AJ, Dunn J, Dutt TS, Ryan EP. Whitcomb LA, et al. BMC Infect Dis. 2025 Dec 10;26(1):61. doi: 10.1186/s12879-025-11824-3. BMC Infect Dis. 2025. PMID: 41372813 Free PMC article.
Post-Acute Sequelae of COVID-19 (PASC), or "long COVID," describes persistent symptoms following recovery from SARS-CoV-2 infection. ...To address this gap, we conducted a longitudinal, multi-omics analysis of blood samples from COVID- …
Post-Acute Sequelae of COVID-19 (PASC), or "long COVID," describes persistent symptoms following recovery from SARS- …
Omics-based computational approaches for biomarker identification, prediction, and treatment of Long COVID.
Pinero S, Li X, Zhang J, Winter M, Lee SH, Nguyen T, Liu L, Li J, Le TD. Pinero S, et al. Crit Rev Clin Lab Sci. 2025 Dec 9:1-27. doi: 10.1080/10408363.2025.2583083. Online ahead of print. Crit Rev Clin Lab Sci. 2025. PMID: 41368891 Review.
Long COVID, or post-acute sequelae of COVID-19 (PASC), is a major global health problem, with cumulative estimates suggesting that around 400 million people worldwide have been affected. ...Using standardized criteria, we evaluated study design, statistical rigor, r …
Long COVID, or post-acute sequelae of COVID-19 (PASC), is a major global health problem, with cumulative estimates suggesting …
Plasma proteomic signatures in HIV-infected individuals post-SARS-CoV-2 infection.
Chanthara C, Khattiya J, Roytrakul S, Akekawatchai C, Phaonakrop N, Niyomdecha N. Chanthara C, et al. BMC Infect Dis. 2025 Dec 9;26(1):59. doi: 10.1186/s12879-025-12307-1. BMC Infect Dis. 2025. PMID: 41366310 Free PMC article.
The long-term immunological effects of prior Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in people living with Human Immunodeficiency Virus (HIV) remain poorly understood. This study aimed t …
The long-term immunological effects of prior Severe Acute Respiratory Syndrome Coronavirus 2 (S …
The seven enigmas of SARS-CoV-2: from the past to the future.
Andreakos E, Arkin L, Bastard P, Bolze A, Borghesi A, Brodin P, Casanova JL, Casari G, Cobat A, Drolet B, Fellay J, Hsieh E, Meyts I, Mogensen TH, Sancho-Shimizu V, Spaan AN, Su HC, Vinh DC, Yatim A, Zhang Q, Zhang SY; COVID Human Genetic Effort+. Andreakos E, et al. J Hum Immun. 2025 Nov 3;1(4):e20250149. doi: 10.70962/jhi.20250149. Epub 2025 Oct 24. J Hum Immun. 2025. PMID: 41347066 Free PMC article.
Five years ago, we launched the COVID Human Genetic Effort. Our goal was to explain the clinical variability among SARS-CoV-2-exposed individuals by searching for monogenic inborn errors of immunity (IEI) and their phenocopies. ...Understanding the hum …
Five years ago, we launched the COVID Human Genetic Effort. Our goal was to explain the clinical variability among SARS-CoV …
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
Slowikowski K, Sen P, Cosgriff CV, Tantivit J, Eisenhaure T, LaSalle TJ, Manakongtreecheep K, Tirard A, Arnold BY, Pacheco-Navarro A, Yang EY, Reyes M, Gonye A, Gushterova I, Russo B, Rojas-Lopez M, Sharma N, Thomas MF, Sharova T, Frederick D, Lavin-Parsons K, Lilley B, McKaig B, Lodenstein C, Khanna H, Kays K, Charland N, Smith N, Ramesh S, Delorey TM, Phillips D, Amir-Zilberstein L, Brown EM, Benson M, Park SM, Tusi BK, Pokatayev V, Hecht C, Pishesha N, Woolley AE, Cosimi L, Rozenblatt-Rosen O, Bod L, Blainey PC, Regev A, Deguine J, Xavier R, Hung D, Boland GM, Bhattacharyya RP, Utz PJ, Goldberg MB, Mansour MK, Filbin MR, Sade-Feldman M, Hacohen N, Villani AC. Slowikowski K, et al. medRxiv [Preprint]. 2025 Sep 21:2025.09.19.25334095. doi: 10.1101/2025.09.19.25334095. medRxiv. 2025. PMID: 41332837 Free PMC article. Preprint.
In this study, we analyzed 2.5 million circulating immune cells from 428 patients across time points (840 PBMC samples), encompassing three contemporaneous SARS-CoV-2 cohorts: acutely infected patients across five WHO disease severity levels and …
In this study, we analyzed 2.5 million circulating immune cells from 428 patients across time points (840 PBMC samples), encompassing …
Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ TIL.
Xie H, Jiang A, Dey A, Dean JW, Perera JJ, Smith NP, Chen ACY, Anderson S, Cicerchia AM, Sun Y, Michaud WA, Florentin M, Fang J, Revach OY, Sharova T, Lawless A, Xu KH, Song Y, Patel B, Stevens JD, Lane WJ, Keskin DB, Cohen S, Lawrence DP, Sullivan RJ, Flaherty KT, Boland GM, Nieman LT, Sade-Feldman M, Hacohen N, Sen DR, Wu C, Gastman B, Qi R, Yin H, Villani AC, Manguso RT, Jenkins RW. Xie H, et al. bioRxiv [Preprint]. 2025 Nov 20:2025.11.19.689204. doi: 10.1101/2025.11.19.689204. bioRxiv. 2025. PMID: 41332750 Free PMC article. Preprint.
Tumor-infiltrating lymphocyte (TIL) therapy is FDA-approved for patients with treatment-resistant advanced melanoma, but the TIL subpopulations critical for tumor eradication remains incompletely understood. Using patient-derived TIL-melanoma co-cultures, we identif …
Tumor-infiltrating lymphocyte (TIL) therapy is FDA-approved for patients with treatment-resistant advanced melanoma, but the TIL subp …
Neutralizing Antibody Response Characteristics in Elderly Patients with SARS-CoV-2 Infection and Their Association with Clinical Phenotypes.
Li Y, Wang L, Ma J, Geng W, Wang Y. Li Y, et al. Vaccines (Basel). 2025 Oct 29;13(11):1107. doi: 10.3390/vaccines13111107. Vaccines (Basel). 2025. PMID: 41295480 Free PMC article.
Background/Objectives: Although SARS-CoV-2 infection often follows a self-limiting course, its public health impact remains persistent. ...Based on NAb levels, SARS-CoV-2 strains were immunologically classified. Results: There was a posit …
Background/Objectives: Although SARS-CoV-2 infection often follows a self-limiting course, its public health impact rem …
Urinary Peptidomic Profiling In Post-Acute Sequelae of SARS-CoV-2 Infection: A Case-Control Study.
Gülmez D, Siwy J, Kurz K, Wendt R, Banasik M, Peters B, Dudoignon E, Depret F, Salgueira M, Nowacki E, Kurnikowski A, Mussnig S, Krenn S, Gonos S, Löffler-Ragg J, Weiss G, Mischak H, Hecking M, Schernhammer E, Beige J; UriCoV Working Group. Gülmez D, et al. Proteomics. 2026 Jan;26(1):32-43. doi: 10.1002/pmic.70074. Epub 2025 Nov 21. Proteomics. 2026. PMID: 41273049 Free PMC article.
Post-acute sequelae of severe acute respiratory syndrome coronavirus 2-infection (PASC) is challenging to diagnose and treat, and its molecular pathophysiology remains unclear. ...Using standardized capillary electrophoresis-MS, we examin …
Post-acute sequelae of severe acute respiratory syndrome coronavirus 2-infection (PASC) is challen …
Persistent renin-angiotensin system and inflammatory dysregulation following COVID-19 impairs ischemic stroke recovery.
Quek AML, Teng O, Park JH, Er BGC, Lim ECH, Seet RCS. Quek AML, et al. Exp Mol Pathol. 2025 Dec;144:105009. doi: 10.1016/j.yexmp.2025.105009. Epub 2025 Nov 20. Exp Mol Pathol. 2025. PMID: 41270326 Free article.
We conducted a prospective observational cohort study comparing clinical and molecular profiles of ischemic stroke patients with and without recent COVID-19 infection to age-matched healthy controls. ...Both stroke groups showed elevated angiotensin-(1 …
We conducted a prospective observational cohort study comparing clinical and molecular profiles of ischemic stroke patients wi …
Surface proteome of plasma extracellular vesicles differentiates between SARS-CoV-2 and influenza infection.
Bertrams W, Roessler FK, Bæk R, Jung AL, Laakmann K, Jørgensen MM, Lehmann M, Weckler B, Schulte LN, Rohde G, Bar N, Barten G, Schmeck B; CAPNETZ study group. Bertrams W, et al. Virulence. 2026 Dec;17(1):2590305. doi: 10.1080/21505594.2025.2590305. Epub 2025 Dec 16. Virulence. 2026. PMID: 41263641 Free PMC article.
Small extracellular vesicles (sEVs) play a role in the pathophysiology of viral respiratory infections and may be suitable biomarkers for COVID-19 and Influenza infections, or targets for treatment. We investigated differences in the surface proteome of plasm …
Small extracellular vesicles (sEVs) play a role in the pathophysiology of viral respiratory infections and may be suitable biomarkers for …
Proteomic and metabolomic profiling of plasma reveals physiologic changes in patients with convalescent COVID-19.
Wang L, Zhang Y, Bao L, Guo Y, Hai Q, Wu J, Wang T, Sun G, Liang X. Wang L, et al. Metabolomics. 2025 Nov 15;21(6):168. doi: 10.1007/s11306-025-02337-w. Metabolomics. 2025. PMID: 41241689 Free PMC article.
BACKGROUND: This study aimed to analyze the molecular composition and physiological changes in the plasma of patients with convalescent coronavirus disease 2019 (COVID-19). METHODS: Plasma samples from 29 hospitalized patients recovering from …
BACKGROUND: This study aimed to analyze the molecular composition and physiological changes in the plasma of patients with convalesce …
Leukocytic ADAM10 and ADAM17 modulate disease severity and systemic outcome in bacterial and viral pneumonia.
Aljohmani A, Herr C, Witzenrath M, Pätzold L, Bischoff M, Wartenberg P, Boehm U, Beisswenger C, Tian Q, Laschke MW, Hannig M, Lehr CM, Bals R, Schilling O, Yildiz D. Aljohmani A, et al. Eur Respir J. 2025 Nov 6:2402060. doi: 10.1183/13993003.02060-2024. Online ahead of print. Eur Respir J. 2025. PMID: 41198388 Free article.
BACKGROUND: Pneumonia caused by viral or bacterial pathogens such as SARS-CoV2 or Pseudomonas aeruginosa may result in life-threatening disease with a strong contribution of proteases' dysregulation. ...RESULTS: Hospitalized bacterial pneumonia and COVID-1 …
BACKGROUND: Pneumonia caused by viral or bacterial pathogens such as SARS-CoV2 or Pseudomonas aeruginosa may result in life-th …
Vaccination protects against COVID-associated pulmonary fibrin deposition.
Ireland J, Myers D, Huang C, Allen C, Roth G, Zou Z, Zhao M, Suzuki M, Olano L, Tan J, Kanth SM, Huapaya JA, Twigg H 3rd, Suffredini AF, Sun P. Ireland J, et al. J Virol. 2025 Nov 25;99(11):e0063325. doi: 10.1128/jvi.00633-25. Epub 2025 Nov 6. J Virol. 2025. PMID: 41196038 Free PMC article.
Understanding the protective mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines against severe COVID is important for therapeutic development to mitigate disease-associated lung patholo …
Understanding the protective mechanism of severe acute respiratory syndrome coronavirus 2 (SARS …
A Vascularized Human Organ Chip Reveals SARS-CoV-2 Susceptibility in Developmentally Guided Tissue Maturation.
Kalejaiye TD, Bhattacharya R, Musah S. Kalejaiye TD, et al. Cell Mol Bioeng. 2025 Jul 22;18(5):453-471. doi: 10.1007/s12195-025-00851-4. eCollection 2025 Oct. Cell Mol Bioeng. 2025. PMID: 41185630 Free PMC article.
This study aimed to develop mature visceral epithelial cells (podocytes) from human induced pluripotent stem (iPS) cells using a developmental approach and model severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 …
This study aimed to develop mature visceral epithelial cells (podocytes) from human induced pluripotent stem (iPS) cells using a development …
Tracking the soluble biomarkers of MIS-C and their association with clinical parameters and severity.
Pidkova T, Pino-Ramirez RM, Urrea V, Vidal M, Aguilar R, Moncunill G, Antón J, Clotet B, Dobaño C, Fortuny C, Blanco J, Trinité B. Pidkova T, et al. Pediatr Res. 2025 Oct 31. doi: 10.1038/s41390-025-04542-8. Online ahead of print. Pediatr Res. 2025. PMID: 41174152
METHODS: This study analyzed 92 inflammatory biomarkers in serum samples from 22 pediatric MIS-C patients and 17 convalescent COVID-19 children using Olink proteomics. MIS-C samples were taken at diagnosis, before treatment, and at follow-up. Convalesc …
METHODS: This study analyzed 92 inflammatory biomarkers in serum samples from 22 pediatric MIS-C patients and 17 convalescent COVI …
Blood diagnostic biomarkers for neurologic manifestations of long COVID.
Padhye AS, Koralnik IJ, Hanson BA, Visvabharathy L, DeLisle RK, Tachas G. Padhye AS, et al. Brain Behav Immun Health. 2025 Sep 25;49:101110. doi: 10.1016/j.bbih.2025.101110. eCollection 2025 Nov. Brain Behav Immun Health. 2025. PMID: 41146907 Free PMC article.
BACKGROUND: SARS-CoV-2 responsible for COVID-19 caused a global pandemic, with billions of infections, millions of deaths and ongoing manifestations post COVID-19. "Long Covid", a Post-Acute Sequelae of COVID-19 (PASC …
BACKGROUND: SARS-CoV-2 responsible for COVID-19 caused a global pandemic, with billions of infections, mi …
Liquid Biopsy-Multiomics Link Adhesion Pathway Dysregulation to Kidney Injury Severity.
Anandakrishnan N, Yi Z, Sun Z, Liu T, Haydak J, Eddy S, Jayaraman P, DeFronzo S, Saha A, Sun Q, Yang D, Mendoza A, Mosoyan G, Wen HH, Fu J, Kehrer T, Menon R, Otto EA, Godfrey B, Yang J, Suarez-Farinas M, Leffters S, Twumasi A, Meliambro K, Charney AW, García-Sastre A, Campbell KN, Gusella GL, He JC, Miorin L, Nadkarni GN, Wisnivesky J, Li H, Kretzler M, Coca SG, Chan L, Zhang W, Azeloglu EU. Anandakrishnan N, et al. Kidney Int Rep. 2025 Jul 24;10(10):3592-3610. doi: 10.1016/j.ekir.2025.07.021. eCollection 2025 Oct. Kidney Int Rep. 2025. PMID: 41141506 Free PMC article.
METHODS: In this multicenter observational study, we used clinically obtained liquid biopsy proteomics and machine learning (ML) to predict severe outcomes in patients with COVID-associated and non-COVID AKI. ...Single-cell transcriptomic analysis in the in v …
METHODS: In this multicenter observational study, we used clinically obtained liquid biopsy proteomics and machine learning (M …
Multi-omics and machine learning identify novel biomarkers and therapeutic targets of COVID-19.
Zhou Y, Fan P, Zhang H, Han S, Bai M, Wang J, Wang Q. Zhou Y, et al. Front Immunol. 2025 Oct 2;16:1671936. doi: 10.3389/fimmu.2025.1671936. eCollection 2025. Front Immunol. 2025. PMID: 41112249 Free PMC article.
RESULTS: Principal component analysis effectively grouped samples based on clinical characteristics. Using random forest and SVM-RFE models, we identified clinical indicators capable of accurately distinguishing COVID-19 patients. ...Correlation …
RESULTS: Principal component analysis effectively grouped samples based on clinical characteristics. Using random forest and SVM-RFE …
Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS.
Costa Monteiro AC, Pickering H, Sarma A, Taylor CS, Jenkins MM, Hsu FM, Nadel B, Levy O, Baden LR, Melamed E, Ehrlich LIR, McComsey GA, Sekaly RP, Cairns CB, Haddad EK, Shaw AC, Hafler DA, Montgomery RR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NIA, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Geng LN, Fernandez-Sesma A, Simon V, Krammer F, Kraft M, Bime C, Calfee CS, Erle DJ, Bosinger S, Eckalbar W, Maecker H, Rahman A, Guan L, Peters B, Kleinstein SH, Augustine AD, Diray-Arce J, Becker PM, Rouphael N; IMPACC Network; CAFPINT Site investigators of the PALISI Network; Agus M, Kulkarni H, Schaenmann JM, Salehi-Rad R, Matthay MA, Reed EF, Sapru A. Costa Monteiro AC, et al. Crit Care. 2025 Oct 14;29(1):432. doi: 10.1186/s13054-025-05596-0. Crit Care. 2025. PMID: 41088445 Free PMC article.
Our pilot analysis included pediatric patients requiring invasive mechanical ventilation (CAF-PINT, NCT01892969). Our validation cohort included adult hospitalized patients with COVID-19 (IMPACC, NCT04378777), testing the association of ECS% to outcome …
Our pilot analysis included pediatric patients requiring invasive mechanical ventilation (CAF-PINT, NCT01892969). Our validation coho …
Huashi Baidu granules alleviate LPS-induced endothelial injury by modulating the AKT1-FOXO3a signaling pathway.
Tian C, Zhao J, Lyu T, Hao R, Li J, Wan L, Kang M, Zhao S, Yang Z, Feng S, Wang Q, Li M. Tian C, et al. Phytomedicine. 2025 Nov 25;148:157372. doi: 10.1016/j.phymed.2025.157372. Epub 2025 Oct 4. Phytomedicine. 2025. PMID: 41076917 Free article.
BACKGROUND: Huashi Baidu granules (HSBD) are a proprietary Chinese medicine demonstrated to be effective in treating COVID-19 patients. Although HSBD has shown promising clinical efficacy, its mechanism of endothelial protection remains unclear. ...CON …
BACKGROUND: Huashi Baidu granules (HSBD) are a proprietary Chinese medicine demonstrated to be effective in treating COVID-19 …
Bioinformatics analysis of the proteome in the pathway of complement and coagulation cascades in COVID-19: discovering potential biomarkers of FGB and SERPINA5.
Liu S, Shi H, Yang Y, Zhu C, Zhou J, Jin W, Song S, Zhang L. Liu S, et al. BMC Infect Dis. 2025 Oct 8;25(1):1252. doi: 10.1186/s12879-025-11598-8. BMC Infect Dis. 2025. PMID: 41062954 Free PMC article.
The complement system, a key innate immunity component, is implicated in COVID-19 pathogenesis. Proteomic studies reveal dysregulated complement and coagulation cascades (CCC) proteins in COVID-19, yet comprehensive analyses remain limited. ...I …
The complement system, a key innate immunity component, is implicated in COVID-19 pathogenesis. Proteomic studies revea …
Aging and Host Responses to Severe Infection: Proteomic Analysis of a Prospective Multicenter Cohort From Uganda.
Conte Cortez Martins G, Lutwama JJ, Owor N, Tomoiaga AS, Ross JE, Lu X, Nsereko C, Nayiga I, Kyebambe S, Shinyale J, Ochar T, Kiwubeyi M, Nankwanga R, Nie K, Xie H, Miake-Lye S, Villagomez B, Qi J, Reynolds SJ, Nakibuuka MC, Kayiwa J, Haumba M, Nakaseegu J, Che X, Kim-Schulze S, Lipkin WI, O'Donnell MR, Bakamutumaho B, Cummings MJ. Conte Cortez Martins G, et al. Crit Care Explor. 2025 Oct 7;7(10):e1330. doi: 10.1097/CCE.0000000000001330. eCollection 2025 Oct 1. Crit Care Explor. 2025. PMID: 41060251 Free PMC article.
SETTING: Two public referral hospitals in Uganda. PATIENTS: Non-pregnant adults (18 yr old or older) hospitalized with severe, undifferentiated infection. ...MEASUREMENTS AND MAIN RESULTS: We analyzed clinical data and serum Olink proteomic profiles from 434 …
SETTING: Two public referral hospitals in Uganda. PATIENTS: Non-pregnant adults (18 yr old or older) hospitalized with severe, undiff …
Extracting a COVID-19 signature from a multi-omic dataset.
Bauvin B, Godon T, Bachelot G, Carpentier C, Huusaari R, Deraspe M, Rousu J, Quach C, Corbeil J. Bauvin B, et al. Front Bioinform. 2025 Sep 22;5:1645785. doi: 10.3389/fbinf.2025.1645785. eCollection 2025. Front Bioinform. 2025. PMID: 41059484 Free PMC article.
INTRODUCTION: The complexity of COVID-19 requires approaches that extend beyond symptom-based descriptors. Multi-omic data, combining clinical, proteomic, and metabolomic information, offer a more detailed view of disease mechanisms and biomarker disco …
INTRODUCTION: The complexity of COVID-19 requires approaches that extend beyond symptom-based descriptors. Multi-omic data, co …
Tracking down the origin and subsequent spread of SARS-CoV-2 lineage B.1.619.
Bollen N, Hong SL, Potter BI, Lienhard R, Tritten ML, Sierro N, Guedj E, Dulize R, Bornand D, Auberson M, Berthouzoz M, Duvoisin P, Ivanov NV, Peitsch MC, Hill V; Belgium Consortium COVID-19 Genomics; Matheeussen V, Bontems S, Verhasselt B, Degosserie J, Waumans L, Bayon-Vicente G, Reynders M, Cattoir L, Coste V, Valgaeren H, Van Weyenbergh J, Cuypers L, André E, Durkin K, Maes P, Khan K, Huber C, Suchard MA, Maidadi Foudi M, Godwe C, Moumbeket Yifomnjou MH, Landry M, Njouom R, Mbala Kingebeni P, Oluniyi P, Olawoye IB, Happi C, Ayouba A, Peeters M, Behillil S, Simon-Lorière E, Hölzer M, Dellicour S, Dudas G, Baele G. Bollen N, et al. Virus Evol. 2025 Sep 23;11(1):veaf017. doi: 10.1093/ve/veaf017. eCollection 2025. Virus Evol. 2025. PMID: 41031290 Free PMC article.
Since late 2020, the emergence of variants of concern (VOCs) of SARS-CoV-2 has been of concern to public health, researchers and policymakers. Mutations in the SARS-CoV-2 genome-for which clear evidence is available indicating a significa …
Since late 2020, the emergence of variants of concern (VOCs) of SARS-CoV-2 has been of concern to public health, resear …
Acute Respiratory Distress Syndrome Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes.
Sarma A, Christenson SA, Shoshana BZ, Oliveira AP, Neyton LPA, Mick E, Sinha P, Wilson JG, Moazed F, Leligdowicz A, Maddali MV, Siegel ER, Lyon ZM, Carrillo SH, Zhou H, Jauregui A, Ghale R, Caldera S, Hayakawa PS, Deiss T, Love C, Byrne A, Kalantar KL, DeRisi JL, Erle DJ, Krummel MF, Kangelaris KN, Hendrickson CM, Woodruff PG, Matthay MA, Bos LDJ, Langelier CR, Calfee CS; COMET Consortium. Sarma A, et al. Am J Respir Crit Care Med. 2025 Dec;211(12):2352-2362. doi: 10.1164/rccm.202407-1454OC. Am J Respir Crit Care Med. 2025. PMID: 40997225 Free PMC article.
Objectives: To identify differences in the pulmonary biology of ARDS molecular phenotypes Methods: We compared tracheal aspirate gene expression between hyperinflammatory and hypoinflammatory phenotypes in bulk RNA sequencing (RNASeq) from coronavirus disease (COVID …
Objectives: To identify differences in the pulmonary biology of ARDS molecular phenotypes Methods: We compared tracheal aspirate gene expres …
Multi-Omics Blood Atlas Reveals Host Immune Response Features of Immunocompromised Populations Following SARS-CoV-2 Infection.
Yang X, Shen Y, Tang B, Zhu J, Wang B, Wang Q, Tian W, Wuchty S, Zhang Z, Liang Z, Dong Y. Yang X, et al. Mol Cell Proteomics. 2025 Oct;24(10):101068. doi: 10.1016/j.mcpro.2025.101068. Epub 2025 Sep 10. Mol Cell Proteomics. 2025. PMID: 40939689 Free PMC article.
The dysregulation of human genes and proteins following SARS-CoV-2 infection significantly impacts the clinical symptoms and prognosis of COVID-19, particularly in immunocompromised individuals such as patients with hematological t …
The dysregulation of human genes and proteins following SARS-CoV-2 infection significantly impacts the clinical …
A High-Throughput Broad Neutralizing Antibody Assay for Detecting SARS-CoV-2 Variant Immunity in Population.
Zhang X, Wang Y, Li M, Li H, Zhang X, Xu X, Ma Q, Hu D, Jia Y, Liang T, Zhu Y, Bihani S, Srivastava S, Fuentes M, Li Y, Han X, Wang B, Yu X. Zhang X, et al. ACS Infect Dis. 2025 Oct 10;11(10):2766-2779. doi: 10.1021/acsinfecdis.5c00402. Epub 2025 Sep 12. ACS Infect Dis. 2025. PMID: 40939614
Detecting neutralizing antibodies (NAbs) to SARS-CoV-2 variants that are evolved is crucial to know the escape of host immunity to the newly arising variants. ...Altogether, our high-throughput proteomics platform represents a powerful tool for the det …
Detecting neutralizing antibodies (NAbs) to SARS-CoV-2 variants that are evolved is crucial to know the escape of host …
Deep learning integration of chest computed tomography and plasma proteomics to identify novel aspects of severe COVID-19 pneumonia.
Hong Y, Chen L, Yu Y, Zhao Z, Wu R, Gong R, Cheng Y, Yuan L, Zheng S, Zheng C, Lin R, Chen J, Sun K, Xu P, Ye L, Han C, Zhou X, Liu Y, Yu J, Zheng Y, Yang J, Huang J, Chen J, Fang J, Chen C, Fan B, Fang H, Ye B, Chen X, Qian X, Chen J, Yu H, Zhang J, Pan XM, Zhan YX, Zheng YH, Huang ZH, Zhong C, Liu N, Ni H, Zhang G, Zhang Z; Chinese Multi-omics Advances In Sepsis (CMAISE) Consortium. Hong Y, et al. J Intensive Med. 2024 Dec 16;5(3):252-261. doi: 10.1016/j.jointm.2024.11.001. eCollection 2025 Jul. J Intensive Med. 2024. PMID: 40933743 Free PMC article.
BACKGROUND: Heterogeneity is a critical characteristic of severe coronavirus disease 2019 (COVID-19) pneumonia. Integrating chest computed tomography (CT) imaging and plasma proteomics holds the potential to elucidate Image-Expression Axes (IEAs) that …
BACKGROUND: Heterogeneity is a critical characteristic of severe coronavirus disease 2019 (COVID-19) pneumonia. Integra …
Single-Cell and Plasma Proteomics Do Not Differentiate Patients With and Without SARS-CoV-2 Antigenemia in Convalescence in a Cohort of 100 Patients.
Pienkos S, Swank Z, Hamlin RE, Rao M, Grant P, Bonilla H, Jacobson K, Jagannathan P, Singh U, Walt DR, Subramanian A, Blish C. Pienkos S, et al. Open Forum Infect Dis. 2025 Aug 26;12(9):ofaf515. doi: 10.1093/ofid/ofaf515. eCollection 2025 Sep. Open Forum Infect Dis. 2025. PMID: 40926879 Free PMC article.
Plasma samples obtained approximately 3 (n = 100) and 12 months (n = 78) after acute SARS-CoV-2 infection were tested for S1, spike, and N antigens. There were no significant differences in plasma proteins or single-cell protein expression levels on immune ce …
Plasma samples obtained approximately 3 (n = 100) and 12 months (n = 78) after acute SARS-CoV-2 infection were tested f …
A multiomics recovery factor predicts long COVID in the IMPACC study.
Gabernet G, Maciuch J, Gygi JP, Moore JF, Hoch A, Syphurs C, Chu T, Doni Jayavelu N, Corry DB, Kheradmand F, Baden LR, Sekaly RP, McComsey GA, Haddad EK, Cairns CB, Rouphael N, Fernandez-Sesma A, Simon V, Metcalf JP, Agudelo Higuita NI, Hough CL, Messer WB, Davis MM, Nadeau KC, Pulendran B, Kraft M, Bime C, Reed EF, Schaenman J, Erle DJ, Calfee CS, Atkinson MA, Brakenridge SC, Melamed E, Shaw AC, Hafler DA, Augustine AD, Becker PM, Ozonoff A, Bosinger SE, Eckalbar W, Maecker HT, Kim-Schulze S, Steen H, Krammer F, Westendorf K; IMPACC Network; Peters B, Fourati S, Altman MC, Levy O, Smolen KK, Montgomery RR, Diray-Arce J, Kleinstein SH, Guan L, Ehrlich LI. Gabernet G, et al. J Clin Invest. 2025 Sep 9;135(21):e193698. doi: 10.1172/JCI193698. eCollection 2025 Nov 3. J Clin Invest. 2025. PMID: 40924481 Free PMC article.
BACKGROUNDFollowing SARS-CoV-2 infection, approximately 10%-35% of patients with COVID-19 experience long COVID (LC), in which debilitating symptoms persist for at least 3 months. Elucidating the biologic underpinnings of LC could identif …
BACKGROUNDFollowing SARS-CoV-2 infection, approximately 10%-35% of patients with COVID-19 experien …
Immune-coagulation dynamics in severe COVID-19 revealed by autoantibody profiling and multi-omics integration.
Ambikan AT, Cederholm A, Rezene S, Aranda-Guillén M, Nordqvist H, Treutiger CJ, Lira-Junior R, Landegren N, Gupta S. Ambikan AT, et al. Sci Rep. 2025 Sep 1;15(1):32149. doi: 10.1038/s41598-025-17054-6. Sci Rep. 2025. PMID: 40890263 Free PMC article.
Severe COVID-19 is characterized by immune-coagulation dysregulation, yet the contribution of related autoantibodies remains poorly understood. We investigated relationships between plasma autoantibody reactivities, whole-blood transcriptomics, plasma proteomics …
Severe COVID-19 is characterized by immune-coagulation dysregulation, yet the contribution of related autoantibodies remains p …
Divergent biological pathways distinguish community-acquired pneumonia from COVID-19 despite similar plasma cytokine profiles.
Fraser DD, Van Nynatten LR, Tweddell D, Daley M, Russell JA; CAPtivate Consortium. Fraser DD, et al. Respir Res. 2025 Aug 31;26(1):264. doi: 10.1186/s12931-025-03331-5. Respir Res. 2025. PMID: 40887575 Free PMC article.
METHODS: We conducted a novel case-control study to profile cytokine levels in patients with CAP and COVID-19. Age- and sex-matched cohorts included 39 patients with CAP, 39 with COVID-19, and 20 healthy controls. ...RESULTS: Median ages …
METHODS: We conducted a novel case-control study to profile cytokine levels in patients with CAP and COVID-19. Age- and …
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases.
Bhak Y, Raptis V, He Y, Nakanishi T, Macdonald-Dunlop E, Sagiya Y, Morisaki T, Matsuda K; BioBank Japan Project; Japan COVID-19 Task Force; Kanai A, Suzuki Y, Oda Y, Kamatani Y, Namkoong H, Saiki R, Kimura A, Koike R, Ogawa S, Miyano S, Imoto S, Kanai T, Fukunaga K, Okada Y, Mälarstig A, Tenesa A. Bhak Y, et al. Sci Rep. 2025 Aug 28;15(1):31721. doi: 10.1038/s41598-025-10031-z. Sci Rep. 2025. PMID: 40877285 Free PMC article.
Males and females exhibit differences in proteome profiles associated with disease risk. However, sex-dimorphic protein quantitative trait loci (SD-pQTL) and their effects on sex differences in health disorders have not been thoroughly investigated. ...
Males and females exhibit differences in proteome profiles associated with disease risk. However, sex-dimorphic protein quantitative …
Clinical and Proteomic Associations of SARS-CoV-2 Infection and COVID-19 Vaccination in Multimorbid Patients: A Cross-Sectional Observational Study.
Hudák A, Pettko-Szandtner A, Letoha A, Letoha T. Hudák A, et al. Int J Mol Sci. 2025 Aug 19;26(16):8007. doi: 10.3390/ijms26168007. Int J Mol Sci. 2025. PMID: 40869330 Free PMC article.
This study assessed clinical outcomes, comorbidities, and systemic biomarker and proteomic profiles in 366 multimorbid patients, stratified into four groups based on SARS-CoV-2 infection and vaccination status (COV+ vac+, COV …
This study assessed clinical outcomes, comorbidities, and systemic biomarker and proteomic profiles in 366 multimorbid pati …
Multiplex Targeted Proteomic Analysis of Cytokine Ratios for ICU Mortality in Severe COVID-19.
Araújo R, Von Rekowski CP, Fonseca TAH, Calado CRC, Ramalhete L, Bento L. Araújo R, et al. Proteomes. 2025 Aug 2;13(3):35. doi: 10.3390/proteomes13030035. Proteomes. 2025. PMID: 40843708 Free PMC article.
BACKGROUND: Accurate and timely prediction of mortality in intensive care unit (ICU) patients, particularly those with COVID-19, remains clinically challenging due to complex immune responses. Proteomic cytokine profiling holds promise for refin …
BACKGROUND: Accurate and timely prediction of mortality in intensive care unit (ICU) patients, particularly those with COVID- …
Integrated multi-omics characterization across clinically relevant subgroups of long COVID.
Ai J, Guo J, Lin K, Cai J, Zhang H, Zhu F, Sun G, Xue Q, Zhu K, Yang Y, Yuan G, Song J, Fu Z, Qi X, Sun Y, Lin W, Qiu C, Jiang N, Wang S, Zhang W. Ai J, et al. Natl Sci Rev. 2024 Nov 15;12(8):nwae410. doi: 10.1093/nsr/nwae410. eCollection 2025 Aug. Natl Sci Rev. 2024. PMID: 40842862 Free PMC article.
When SARS-CoV-2 became regional epidemics, a substantial number of patients suffered from post-acute sequelae of COVID-19 (PASC, aka long COVID). ...In this study, through integrative multi-omics analyses encompassing transcriptomics, …
When SARS-CoV-2 became regional epidemics, a substantial number of patients suffered from post-acute sequelae of …
Treatment with intravenous immunoglobulin modulates coagulation- and complement-related pathways in COVID-19 patients.
McGrosso D, Raygoza J, Kumar AJ, Lam MTY, Barnes LA, Karandashova S, Perryman A, Geriak M, Odish MF, Coufal NG, Lichtenstein B, Sakoulas G, Meier A, Nizet V, Masso-Silva JA. McGrosso D, et al. Front Immunol. 2025 Jul 31;16:1623309. doi: 10.3389/fimmu.2025.1623309. eCollection 2025. Front Immunol. 2025. PMID: 40821834 Free PMC article.
METHODS: We describe the first proteomic analysis from the plasma of COVID-19 patients treated with IVIG, as well as clinical outcomes. ...Proteomic analysis showed that serum from patients with COVID-19 has increased …
METHODS: We describe the first proteomic analysis from the plasma of COVID-19 patients treated with IVIG, as wel …
Preliminary Findings on Post-COVID Cardiovascular Risk: Transcriptional Regulation and Gene Expression Patterns.
Sharma V, Singh J, Kumar A, Jogpal V, Akhtar MS, Orayj K, Farooqui S, Khan A, Sharma G, Sharma AK. Sharma V, et al. J Cell Biochem. 2025 Aug;126(8):e70059. doi: 10.1002/jcb.70059. J Cell Biochem. 2025. PMID: 40819217
Survivors of COVID-19 are facing a new vulnerability of encountering post-COVID complications, including cardiovascular diseases (CVDs). ...However, some recent studies have begun to elucidate complex pathological signaling pathways in these conditions, further inve …
Survivors of COVID-19 are facing a new vulnerability of encountering post-COVID complications, including cardiovascular diseas …
Investigating the impact of dipeptidyl peptidase-1 inhibition in humans using multi-omics.
Long MB, Gilmour A, Hull RC, Giam YH, Richardson H, Hughes C, Abo-Leyah H, Keir HR, Alferes de Lima Headley D, Dowey R, Turton H, New BJM, Pembridge T, Delgado L, McIntosh E, Stobo J, Peh ZH, Band M, McLaren-Neil F, Singanayagam A, Sibila O, Thompson AAR, Gierlinski M, Dicker AJ, Condliffe AM, Chalmers JD. Long MB, et al. J Allergy Clin Immunol. 2025 Nov;156(5):1356-1367. doi: 10.1016/j.jaci.2025.07.016. Epub 2025 Aug 6. J Allergy Clin Immunol. 2025. PMID: 40780678 Free article. Clinical Trial.
OBJECTIVE: We sought to profile effects of DPP-1 inhibition using a secondary analysis of the STOP-COVID19 trial. METHODS: The STOP-COVID19 trial was a randomized placebo-controlled trial of brensocatib 25 mg in patients hospitalized for severe coronavirus …
OBJECTIVE: We sought to profile effects of DPP-1 inhibition using a secondary analysis of the STOP-COVID19 trial. METHODS: The STOP- …
Proteomic Profiling of Human Peripheral Blood Cell Targets of IgG Induced by SARS-CoV-2: Insights into Vaccine Safety.
Machado NR, do Nascimento LA, Fagundes BO, Borges JVDS, Sgnotto FDR, Bergamasco IS, Fernandes JR, Pinto TNC, Pietrobon AJ, Benard G, Sato MN, Victor JR. Machado NR, et al. Vaccines (Basel). 2025 Jun 27;13(7):694. doi: 10.3390/vaccines13070694. Vaccines (Basel). 2025. PMID: 40733671 Free PMC article.
This study investigates the IgG autoantibody responses in patients with varying severities of COVID-19 infection and compares these responses with vaccinated individuals. ...These findings align with the established safety profile of COVID-19 …
This study investigates the IgG autoantibody responses in patients with varying severities of COVID-19 infection and co …
Humoral Response Profile in SARS-CoV-2 Infection: Differences across Virus Strains and Influenza.
Arias-Hidalgo C, Juanes-Velasco P, Iglesia-Sánchez A, Nuño-Soriano A, Lecrevisse Q, Herrero R, Ferruelo A, Douhal Y, Wang H, Zhang X, Telleria P, K J Pieren D, van Els CACM, López-Parra M, Sánchez-Guijo F, Góngora R, Montalvillo E, Sánchez-Santos JM, De Las Rivas J, Bernardo D, Lorente JA, Wang Y, Yu X, Hernández ÁP, Fuentes M. Arias-Hidalgo C, et al. J Proteome Res. 2025 Sep 5;24(9):4347-4361. doi: 10.1021/acs.jproteome.4c00935. Epub 2025 Jul 29. J Proteome Res. 2025. PMID: 40728019
The clinical manifestation of COVID-19 after SARS-CoV-2 infection varies greatly, with many patients requiring intensive care due to complications like acute respiratory distress syndrome, reduced respiratory system compliance, and …
The clinical manifestation of COVID-19 after SARS-CoV-2 infection varies greatly, with many pat …
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution.
Edahiro R, Sato G, Naito T, Shirai Y, Saiki R, Sonehara K, Tomofuji Y, Yamamoto K, Namba S, Sasa N, Nagao G, Wang QS, Takahashi Y, Hasegawa T, Kishikawa T, Suzuki K, Liu YC, Motooka D, Takuwa A, Tanaka H, Azekawa S; Japan COVID-19 Task Force; Namkoong H, Koike R, Kimura A, Imoto S, Miyano S, Kanai T, Fukunaga K, Uemura M, Morita T, Kato Y, Hirata H, Takeda Y, Doki Y, Eguchi H, Okuzaki D, Sakakibara S, Ogawa S, Kumanogoh A, Okada Y. Edahiro R, et al. Nat Genet. 2025 Aug;57(8):1905-1921. doi: 10.1038/s41588-025-02266-3. Epub 2025 Jul 28. Nat Genet. 2025. PMID: 40721531 Free PMC article.
Here, we constructed an immune cell atlas with single-cell transcriptomics of >1.5 million peripheral blood mononuclear cells, host genetics, plasma proteomics and gut metagenomics from 235 Japanese persons, including patients with coronavirus disease 2019 …
Here, we constructed an immune cell atlas with single-cell transcriptomics of >1.5 million peripheral blood mononuclear cells, host genet …
Biological characteristics of SARS-CoV-2 resistant populations by integrated gut microbiota sequencing, metabolomics, and proteomics: a cohort comparison study.
Xu H, Li H, Xu J, Chen Y, Deng L, Chen X, Xu Y. Xu H, et al. Front Med (Lausanne). 2025 Jul 7;12:1593007. doi: 10.3389/fmed.2025.1593007. eCollection 2025. Front Med (Lausanne). 2025. PMID: 40692947 Free PMC article.
OBJECTIVE: Most research reports on COVID-19 infections have focused on the correlation between the severity of the disease symptoms and immune deficits, while the mechanisms affecting the susceptibility to SARS-CoV-2 remain largely unknown. The …
OBJECTIVE: Most research reports on COVID-19 infections have focused on the correlation between the severity of the disease sy …
Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study.
Hou J, Haslund-Gourley B, Diray-Arce J, Hoch A, Rouphael N, Becker PM, Augustine AD, Ozonoff A, Guan L, Kleinstein SH, Peters B, Reed E, Altman M, Langelier CR, Maecker H, Kim S, Montgomery RR, Krammer F, Wilson M, Eckalbar W, Bosinger SE, Levy O, Steen H, Rosen LB, Baden LR, Melamed E, Ehrlich LIR, McComsey GA, Sekaly RP, Schaenman J, Shaw AC, Hafler DA, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Agudelo Higuita NI, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Fernandez Sesma A, Simon V, Kraft M, Bime C, Calfee CS, Erle DJ, Impacc Network, Robinson LF, Cairns CB, Haddad EK, Comunale MA. Hou J, et al. Front Med (Lausanne). 2025 Jul 4;12:1604388. doi: 10.3389/fmed.2025.1604388. eCollection 2025. Front Med (Lausanne). 2025. PMID: 40687705 Free PMC article.
INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study collected clinical, demogra …
INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden …
Personalized serum proteome profiles of COVID-19-associated acute respiratory distress syndrome in response to mesenchymal stem cell therapy.
Putri DU, Chen MC, Weng CM, Kuo HP, Lee CH, Han CL. Putri DU, et al. J Microbiol Immunol Infect. 2026 Feb;59(1):35-44. doi: 10.1016/j.jmii.2025.07.004. Epub 2025 Jul 11. J Microbiol Immunol Infect. 2026. PMID: 40685278 Free article.
Herein, we aimed to elucidate the molecular response to MSC treatment in COVID-19-related ARDS, and proposed protein signature to advocate for patient selection to maximize the benefit. METHOD: Five COVID-19-related ARDS patients who cons …
Herein, we aimed to elucidate the molecular response to MSC treatment in COVID-19-related ARDS, and proposed protein signature …
Long COVID in Elderly COPD Patients: Clinical Features, Pulmonary Function Decline, and Proteomic Insights.
Li S, Zhao H, Zhang M, Yuan T, Chai D, Shen Z, Qin C, Li Y, Pan M. Li S, et al. Int J Chron Obstruct Pulmon Dis. 2025 Jul 8;20:2337-2347. doi: 10.2147/COPD.S520300. eCollection 2025. Int J Chron Obstruct Pulmon Dis. 2025. PMID: 40655185 Free PMC article.
METHODS: We enrolled 85 elderly COPD patients, of whom 43 reported newly onset persistent fatigue (the most dominant complaint of long COVID) within 1 year after severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
METHODS: We enrolled 85 elderly COPD patients, of whom 43 reported newly onset persistent fatigue (the most dominant complaint of lon …
Comprehensive molecular characterization of post-COVID condition: Immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers.
Seco-Gonzalez A, Antelo-Riveiro P, Bravo SB, Domínguez-Santalla MJ, Rodríguez-Ruiz E, Piñeiro Á, Garcia-Fandino R. Seco-Gonzalez A, et al. J Infect Public Health. 2025 Oct;18(10):102870. doi: 10.1016/j.jiph.2025.102870. Epub 2025 Jun 6. J Infect Public Health. 2025. PMID: 40618677 Free article.
METHODS: Plasma and pellet fractions from 65 PCC patients, classified as symptomatic or asymptomatic, were analyzed using SWATH-MS with updated SARS-CoV-2 protein libraries (v2022 and v2024), enabling a comprehensive profiling of immune- and viral-rela …
METHODS: Plasma and pellet fractions from 65 PCC patients, classified as symptomatic or asymptomatic, were analyzed using SWATH-MS wi …
The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine storm.
Wang Z, Lebedev D, Li S, Rao S, Wu K, Doyle L, Wynne K, Blanco A, Mysior MM, Simpson JC, Scholz D, Wülfroth P, Zacharowski K, Kolch W, Zhernovkov V, Eissner G. Wang Z, et al. Front Immunol. 2025 Jun 19;16:1591860. doi: 10.3389/fimmu.2025.1591860. eCollection 2025. Front Immunol. 2025. PMID: 40612940 Free PMC article.
INTRODUCTION: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a major health emergency since its emergence in late 2019. ...Th …
INTRODUCTION: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome …
Comprehensive clinical and metabolomics profiling of COVID-19 Mexican patients across three epidemiological waves.
García-López DA, Monárrez-Espino J, Borrego-Moreno JC, Zheng J, Mandal R, Torres-Calzada C, Oropeza-Valdez JJ, Tenório Nunes A, Sánchez Rodríguez SH, López JA, Calzada Rodríguez BE, Wishart DS, López-Hernández Y. García-López DA, et al. Front Mol Biosci. 2025 Jun 18;12:1607583. doi: 10.3389/fmolb.2025.1607583. eCollection 2025. Front Mol Biosci. 2025. PMID: 40607062 Free PMC article.
AIMS AND METHODS: In this study, we aimed to evaluate clinical, laboratory, and comprehensive metabolomic data from hospitalized COVID-19 patients during the second, third and fourth waves (Alpha, Delta, and Omicron). ...This is the most comprehensive …
AIMS AND METHODS: In this study, we aimed to evaluate clinical, laboratory, and comprehensive metabolomic data from hospitalized C …
The Plasma Proteome in Community-acquired Pneumonia: Pathophysiology, Outcome, and 10-Year Risk.
Michels EHA, Peters-Sengers H, de Brabander J, Schuurman AR, Reijnders TDY, Haak BW, Brands X, Joosten SCM, Faber DR, Cremer OL, Douma RA, de Vos AF, Wiersinga WJ, Butler JM, van der Poll T. Michels EHA, et al. Am J Respir Crit Care Med. 2025 Nov;211(11):2180-2190. doi: 10.1164/rccm.202502-0325OC. Am J Respir Crit Care Med. 2025. PMID: 40600965
Additional Olink measurements were performed in patients with CAP admitted to the ICU and patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia across care settings (valida …
Additional Olink measurements were performed in patients with CAP admitted to the ICU and patients with severe acute …
Cerebrospinal Fluid Proteomic Profiling Reveals Proteins Associated with Neuroinflammatory Response in COVID-19 Patients.
Ramos de Andrade J, de Farias JB, Vitorino MLL, Travassos FT, Afonso da Silva R, de Lima Filho JL, Valença MM. Ramos de Andrade J, et al. ACS Omega. 2025 Jun 11;10(24):25489-25497. doi: 10.1021/acsomega.5c00707. eCollection 2025 Jun 24. ACS Omega. 2025. PMID: 40584364 Free PMC article.
The COVID-19 pandemic has highlighted the diverse clinical manifestations of SARS-CoV-2 infection, including neurological complications. This study investigates cerebrospinal fluid (CSF) proteomic profiles to identify proteins asso …
The COVID-19 pandemic has highlighted the diverse clinical manifestations of SARS-CoV-2 infection, …
Diagnostic screening of COVID-19 based on multiomics data by high-resolution mass spectrometry (MALDI (+)-TOF MS and ESI()-Orbitrap MS).
de Almeida CM, Motta LC, Folli GS, de Mello do Carmo J, Chaves AR, Brango-Vanegas J, da Costa RA, Franco OL, Pinto FG, Endringer DC, Filgueiras PR, Barauna VG, Mill JG, Romão W. de Almeida CM, et al. Metabolomics. 2025 Jun 29;21(4):94. doi: 10.1007/s11306-025-02299-z. Metabolomics. 2025. PMID: 40581904
OBJECTIVE: this study aimed to devise an effective multiomic method for differentiating SARS-CoV-2-infected patients, leveraging serum lipid and proteomic profiles. METHOD: Electrospray ionization mass spectrometry (ESI-MS) with an Orbitrap anal …
OBJECTIVE: this study aimed to devise an effective multiomic method for differentiating SARS-CoV-2-infected patients …
Long COVID and Biomarker Dysregulation-A Shift Toward Immune Exhaustion?
Kallaste A, Kisand K, Aart A, Salumets A, Kisand K, Peterson P, Lember M. Kallaste A, et al. Medicina (Kaunas). 2025 May 28;61(6):996. doi: 10.3390/medicina61060996. Medicina (Kaunas). 2025. PMID: 40572685 Free PMC article.
Background: SARS-CoV-2 infection can lead to persistent or newly emerging symptoms lasting for months, a condition known as long COVID (LC). ...Results: We observed a general decline in inflammatory biomarkers in post-COVID-19 patients ov …
Background: SARS-CoV-2 infection can lead to persistent or newly emerging symptoms lasting for months, a condition know …
Plasma proteomic profiling of hospitalized patients co-infected with HIV and SARS-CoV-2.
Zhang X, Yan X, Sun J, Shao Y, Song W, Qi T, Wang Z, Tang Y, Sun J, Xun J, Song Z, Xu S, Yang J, Wang J, Chen J, Zhang R, Liu L, Shen Y. Zhang X, et al. Front Immunol. 2025 Jun 11;16:1601672. doi: 10.3389/fimmu.2025.1601672. eCollection 2025. Front Immunol. 2025. PMID: 40568587 Free PMC article.
BACKGROUND: The interaction between human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections presents a critical challenge to immunopathogenesis. ...We aimed to il …
BACKGROUND: The interaction between human immunodeficiency virus (HIV) and severe acute respiratory syndrome …
A multiplexed LC-MS/MS method to reveal changes in inflammatory and coagulation cascades induced by host infection.
Pinto G, Illiano A, Serpico S, Maurelli F, Scaglione E, Colicchio R, Vitiello M, Varelli M, Salvatore P, Amoresano A. Pinto G, et al. Anal Bioanal Chem. 2025 Jul;417(18):4015-4023. doi: 10.1007/s00216-025-05950-9. Epub 2025 Jun 25. Anal Bioanal Chem. 2025. PMID: 40562979
Above the immune system, abnormalities in coagulation parameters have been observed in COVID-19-affected subjects displaying an increased risk of a blood clot causing thromboembolic events. ...Among the proteins analyzed, 90% exhibited a good instrumental response, …
Above the immune system, abnormalities in coagulation parameters have been observed in COVID-19-affected subjects displaying a …
Protein profiling in intensive care unit-treated COVID-19 patients identifies biomarkers of residual lung abnormalities.
Kalafatis D, Björnson M, Svobodová B, Kistner A, Nygren-Bonnier M, Runold M, Bruchfeld J, Wheelock Å, Dellgren G, Elowsson L, Westergren-Thorsson G, Sköld M. Kalafatis D, et al. ERJ Open Res. 2025 Jun 23;11(3):00981-2024. doi: 10.1183/23120541.00981-2024. eCollection 2025 May. ERJ Open Res. 2025. PMID: 40551787 Free PMC article.
BACKGROUND: In this study, we combine proteomics with functional parameters and imaging to examine potential biomarkers that may identify patients at risk of developing persistent lung sequelae following coronavirus disease 2019 (COVID-19). METH …
BACKGROUND: In this study, we combine proteomics with functional parameters and imaging to examine potential biomarkers that may iden …
Plasma Proteomic Profiling Yields a High-Performance Biomarker Panel for Predicting a Poor Prognosis in Patients with COVID-19.
Zhang Z, Yang H, Gao L, Guan L, Li X, Li J, Tong Z. Zhang Z, et al. J Proteome Res. 2025 Jul 4;24(7):3160-3173. doi: 10.1021/acs.jproteome.4c00725. Epub 2025 Jun 23. J Proteome Res. 2025. PMID: 40549983 Free PMC article.
Background The coronavirus disease 2019 (COVID-19) pandemic increased the demand for reliable tests to predict disease severity and mortality. Methods In training cohort, we obtained traditional clinical data and plasma proteomics performed usin …
Background The coronavirus disease 2019 (COVID-19) pandemic increased the demand for reliable tests to predict disease …
Circulating histones as clinical biomarkers in critically ill conditions.
García-Gimenez JL, Ruiz-Rodríguez JC, Ferrer R, Durá R, Artigas A, Bajaña I, de Andujar DBL, Cánovas-Cervera I, Ceccato A, Chiscano-Camón L, Climent-Martinez E, García Fernández G, Goma G, Monforte V, Quevedo-Sánchez B, Ruiz-Sanmartín A, Sierra-Rivera A, Carbonell Monleón N. García-Gimenez JL, et al. FEBS Lett. 2025 Nov;599(22):3174-3195. doi: 10.1002/1873-3468.70093. Epub 2025 Jun 17. FEBS Lett. 2025. PMID: 40527588 Free PMC article. Review.
Given their strong association with disease severity and prognosis, circulating histones have gained attention as potential clinical biomarkers for early diagnosis, prognosis, and therapeutic monitoring in critically ill patients. ...Integrating quantitative prot …
Given their strong association with disease severity and prognosis, circulating histones have gained attention as potential clinical …
Da-yuan-yin decoction alleviates bleomycin-induced pulmonary injury by inhibiting epithelial-mesenchymal transition via E-cadherin/β-catenin complex restoration.
Lin J, Wang S, Li Z, Li J, Wang X, Wan X, Li C, Chu F, Gai C, Li Y, Ding X, Li Y. Lin J, et al. J Ethnopharmacol. 2025 Jul 24;351:120148. doi: 10.1016/j.jep.2025.120148. Epub 2025 Jun 14. J Ethnopharmacol. 2025. PMID: 40523450
ETHNOPHARMACOLOGICAL RELEVANCE: The Da-Yuan-Yin (DYY) decoction, a classical multi-herbal preparation documented in the Treatise on Pestilence (Wenyi Lun,), exhibits therapeutic potential in respiratory pathophysiology. Clinical studies during the COVID-19 pa …
ETHNOPHARMACOLOGICAL RELEVANCE: The Da-Yuan-Yin (DYY) decoction, a classical multi-herbal preparation documented in the Treatise on Pestilen …
Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes.
Lawler NG, Yonker LM, Lodge S, Nitschke P, Leonard MM, Gray N, Whiley L, Masuda R, Holmes E, Wist J, Fasano A, Nicholson JK. Lawler NG, et al. J Proteome Res. 2025 Jul 4;24(7):3470-3483. doi: 10.1021/acs.jproteome.5c00062. Epub 2025 Jun 9. J Proteome Res. 2025. PMID: 40490306 Free PMC article.
SARS-CoV-2 infections in children lead to symptoms from mild respiratory illness to severe postacute sequelae of COVID-19, including multisystem inflammatory syndrome in Children (MIS-C). ...Despite milder clinical respiratory symptoms, c …
SARS-CoV-2 infections in children lead to symptoms from mild respiratory illness to severe postacute sequelae of COV …
The protein interaction of mitochondrial transcription factors A and B2 is associated with 30-day survival in critical COVID-19.
Westhus B, Thon P, Palmowski L, Rump K, Koos B, Wiebel F, Dyck B, Eisenacher M, Sitek B, Pfaender S, Babel N, Anft M, Putensen C, Ehrentraut SF, Weisheit C, Zarbock A, von Groote T, Witowski A, Unterberg M, Nowak H, Wolf A, Bergmann L, Adamzik M, Ziehe D, Rahmel T. Westhus B, et al. Front Immunol. 2025 May 16;16:1445403. doi: 10.3389/fimmu.2025.1445403. eCollection 2025. Front Immunol. 2025. PMID: 40458415 Free PMC article.
INTRODUCTION: Repair of mitochondrial damage seems pivotal for clinical recovery and determining outcome in patients with critical COVID-19. However, reliable biomarkers for non-invasively assessing mitochondrial repair in peripheral blood of criticall …
INTRODUCTION: Repair of mitochondrial damage seems pivotal for clinical recovery and determining outcome in patients with crit …
Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis.
Moyadee W, Roytrakul S, Jaresitthikunchai J, Phaonakrop N, Choowongkomon K, Ploypetch S, Tansakul N, Rattanasrisomporn A, Rattanasrisomporn J. Moyadee W, et al. Sci Rep. 2025 May 29;15(1):18899. doi: 10.1038/s41598-025-03108-2. Sci Rep. 2025. PMID: 40442209 Free PMC article.
This study aims to assess the serum proteome and identify proteins that differentiate healthy cats from cats diagnosed with effusive FIP using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). A total of 30 cats diagnosed with effusive FIP and 27 c …
This study aims to assess the serum proteome and identify proteins that differentiate healthy cats from cats diagnosed with effusive …
Dynamic Molecular Changes in Brain, Lung, and Heart of Hamsters Infected With SARS-CoV-2: Insights From a Severe and Recovery Phase Model.
Peng W, Wei X, Wu Y, Shi C, Liu X, Wu J, Yang H, Rong N, Zhao B, Zhang G, Zhang W, Liu J, Liu J, Yang J. Peng W, et al. J Med Virol. 2025 Jun;97(6):e70410. doi: 10.1002/jmv.70410. J Med Virol. 2025. PMID: 40432336
The Global pandemic of coronavirus disease 2019 was initiated by the emergence of severe acute respiratory syndrome coronavirus 2. ...Syrian hamsters, which are highly susceptible to SARS-CoV-2 infection, exhib …
The Global pandemic of coronavirus disease 2019 was initiated by the emergence of severe acute respiratory sy …
Early Immunological and Inflammation Proteomic Changes in Elderly COVID-19 Patients Predict Severe Disease Progression.
Liu S, Xu W, Tu B, Xiao Z, Li X, Huang L, Yuan X, Zhou J, Yang X, Yang J, Chang D, Chen W, Wang FS. Liu S, et al. Biomedicines. 2025 May 10;13(5):1162. doi: 10.3390/biomedicines13051162. Biomedicines. 2025. PMID: 40426989 Free PMC article.
Background: Elderly patients infected with SARS-CoV-2 are at higher risk of developing cytokine storm and severe outcomes; however, specific immunological and proteomic biomarkers for early prediction remain unclear in this vulnerable group. ... …
Background: Elderly patients infected with SARS-CoV-2 are at higher risk of developing cytokine storm and severe …
Proteomic profiling of serum small extracellular vesicles predicts post-COVID syndrome development.
Dobra G, Gyukity-Sebestyen E, Bukva M, Boroczky T, Nyiraty S, Bordacs B, Varkonyi T, Kocsis A, Szabo Z, Kecskemeti G, Polgar TF, Szell M, Buzas K. Dobra G, et al. Clin Immunol. 2025 Sep;278:110532. doi: 10.1016/j.clim.2025.110532. Epub 2025 May 24. Clin Immunol. 2025. PMID: 40419011
Post-COVID syndrome affects 10-35 % of COVID-19 patients, and up to 85 % of hospitalized individuals, underscoring the need for early identification of high-risk cases. We hypothesized that the proteomic profile of serum small extracellular vesicles (s …
Post-COVID syndrome affects 10-35 % of COVID-19 patients, and up to 85 % of hospitalized individuals, underscoring the …
High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19.
Qualls AE, Tsao T, Lui I, Lim SA, Su Y, Chen E, Duchen D, Maecker HT, Kim-Schulze S, Montgomery RR, Krammer F, Langelier CR, Levy O, Baden LR, Melamed E, Ehrlich LI, McComsey GA, Sekaly RP, Cairns CB, Haddad EK, Shaw AC, Hafler DA, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NIA, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Fernandez-Sesma A, Simon V, Kraft M, Bime C, Calfee CS, Erle DJ, Schaenmann J, Ozonoff A, Peters B, Kleinstein SH, Augustine AD, Diray-Arce J, Becker PM, Rouphael N; IMPACC Network; Goldman JD, Calabrese DR, Heath JR, Wells JA, Reed EF, Lanier LL, Pickering H, Aguilar OA. Qualls AE, et al. JCI Insight. 2025 May 22;10(13):e191314. doi: 10.1172/jci.insight.191314. eCollection 2025 Jul 8. JCI Insight. 2025. PMID: 40402577 Free PMC article.
However, the role of NK cell-mediated ADCC in SARS-CoV-2 infection remains unclear, particularly whether it limits viral spread and disease severity or contributes to the immunopathogenesis of COVID-19. ...Using an in vitro reporter system, we d …
However, the role of NK cell-mediated ADCC in SARS-CoV-2 infection remains unclear, particularly whether it limits vira …
Plasma protein biomarkers for long COVID-19: Predictors of symptom severity and mortality risk.
Maqsood K, Ahmad S, Saeed A, Roohi N. Maqsood K, et al. Clin Chim Acta. 2025 Jul 15;575:120350. doi: 10.1016/j.cca.2025.120350. Epub 2025 May 14. Clin Chim Acta. 2025. PMID: 40379198
INTRODUCTION: Long COVID-19 is marked by persistent symptoms beyond the acute phase, necessitating a deeper understanding of mortality risk factors for effective management. ...These findings highlight their potential for prognostic applications, warranting further …
INTRODUCTION: Long COVID-19 is marked by persistent symptoms beyond the acute phase, necessitating a deeper understanding of m …
What Can Proteomics Tell us About COVID-19 Infections? Mass Spectrometry as a Tool to Find New Proteins as Biomarkers.
Brasil-Oliveira LL, Souza PFN, Paier CRK, Bandeira MGL, Motta LCB, Montenegro RC, de Moraes MEA. Brasil-Oliveira LL, et al. Curr Protein Pept Sci. 2025;26(9):712-729. doi: 10.2174/0113892037364237250402151440. Curr Protein Pept Sci. 2025. PMID: 40353410 Review.
The COVID-19 outbreak, caused by the SARS-CoV-2 coronavirus, has threatened and taken many lives since the end of 2019. ...Usually, those markers are proteins with a differential accumulation only during infection. Based on that, prote …
The COVID-19 outbreak, caused by the SARS-CoV-2 coronavirus, has threatened and taken many lives s …
Epitope mapping of SARS-CoV-2 Spike protein using naturally-acquired immune responses to develop monoclonal antibodies.
López-Aladid R, Bueno-Freire L, Farriol-Duran R, Porta-Pardo E, Aguilar R, Vidal M, Jiménez A, Cabrera R, Vázquez N, López-Gavín A, Moncunill G, Carrascal M, García T, Lozano M, García-Basteiro AL, Dobaño C, Pazos MD, Estevez MC, Lechuga LM, Torres A, Fernández-Barat L. López-Aladid R, et al. Sci Rep. 2025 May 9;15(1):16269. doi: 10.1038/s41598-025-00555-9. Sci Rep. 2025. PMID: 40346118 Free PMC article.
In this project, we predicted 25 B-cell epitopes in silico in the SARS-CoV-2 Spike (S) protein and screened these against serum and plasma samples from 509 COVID-19 convalescent patients. ...We mapped the SARS-CoV-2 S …
In this project, we predicted 25 B-cell epitopes in silico in the SARS-CoV-2 Spike (S) protein and screened these again …
Exhaled breath protein composition in patients hospitalised during the first wave of COVID-19.
Gade IL, Bodilsen J, Mariager T, Hertz S, Duerlund LS, Holm CK, Madsen PH, Bennike TB, Honoré B. Gade IL, et al. J Breath Res. 2025 May 16;19(3). doi: 10.1088/1752-7163/add617. J Breath Res. 2025. PMID: 40341493
Coronavirus 2019 (COVID-19) leads to substantial morbidity and excess mortality all over the world which may be aggravated by the propensity of Severe Acute Respiratory Syndrome Coronavirus 2 to mutate. ...In conclusi …
Coronavirus 2019 (COVID-19) leads to substantial morbidity and excess mortality all over the world which may be aggrava …
Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19.
Scott JM, Qiu Z, Rahman J, Moskowitz CS, Michalski MG, Lehman S, Lee CP, Harrison J, Yu AF, Marouf A, Vardhana S, Boutros PC, Jones LW. Scott JM, et al. Front Immunol. 2025 Apr 3;16:1529385. doi: 10.3389/fimmu.2025.1529385. eCollection 2025. Front Immunol. 2025. PMID: 40248705 Free PMC article. Clinical Trial.
We assessed the safety, tolerability, and effects of exercise therapy in three patients with cancer and hospitalization for SARS-CoV-2 infection in an early-phase prospective trial. ...Correlative proteomic and single-cell immune sequencing of p …
We assessed the safety, tolerability, and effects of exercise therapy in three patients with cancer and hospitalization for SARS …
Exploration of the plasma proteomic profile of patients at risk of thromboembolic events.
Smit ER, Kreft IC, Camilleri E, Burggraaf-van Delft JLI, van Rein N, van Vlijmen BJM, Hulshof AM, van Bussel BCT, van Rosmalen F, van der Zwaan C, van de Berg T, Henskens Y, Ten Cate H, Coutinho JM, Kruip MJHA, Eikenboom JJC, Hoogendijk AJ, Cannegieter SC, van den Biggelaar M; in collaboration with BEAT-COVID group and Dutch COVID & Thrombosis Coalition. Smit ER, et al. Res Pract Thromb Haemost. 2025 Feb 28;9(2):102713. doi: 10.1016/j.rpth.2025.102713. eCollection 2025 Feb. Res Pract Thromb Haemost. 2025. PMID: 40224277 Free PMC article.
METHODS: Utilizing a high-throughput, data-independent acquisition, discovery-based proteomics workflow, we analyzed 434 plasma proteomes from different groups of individuals with elevated risk of thromboembolic events, including individuals I) on vitamin K antagoni …
METHODS: Utilizing a high-throughput, data-independent acquisition, discovery-based proteomics workflow, we analyzed 434 plasma pr …
Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients Who Had COVID-19.
Liu J, Guo L, Zhong J, Wu Y, Wang X, Tang X, Min K, Yang Y, Peng W, Wang Q, Ding T, Gu X, Zhang H, Liu Y, Huang C, Cao B, Wang J, Ren L, Yang J. Liu J, et al. J Med Virol. 2025 Apr;97(4):e70203. doi: 10.1002/jmv.70203. J Med Virol. 2025. PMID: 40207927 Free PMC article.
After the coronavirus disease 2019 (COVID-19) pandemic, the postacute effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have gradually attracted attention. To preci …
After the coronavirus disease 2019 (COVID-19) pandemic, the postacute effects of severe acute respirat …
Heme-induced lung injury in human precision cut lung slices: a new model for acute lung injury.
Kewalramani N, Machahua C, Marti TM, Zandbergen C, Chortarea S, Beretta-Piccoli J, von Garnier C, Dorn P, Fytianos K, Funke-Chambour M. Kewalramani N, et al. Respir Res. 2025 Apr 2;26(1):124. doi: 10.1186/s12931-025-03191-z. Respir Res. 2025. PMID: 40176049 Free PMC article.
METHODS: We analysed heme and its degrading enzymes along with inflammatory cytokines in patients with coronavirus disease 2019 (COVID-19) and ARDS compared to healthy adult subjects. ...RESULTS: Patients with COVID-19 and ARDS had …
METHODS: We analysed heme and its degrading enzymes along with inflammatory cytokines in patients with coronavirus disease 201 …
Prediction of influenza virus infection based on deep learning and peripheral blood proteomics: A diagnostic study.
Zhou Y, Wang P, Zhang H, Wang T, Han S, Ma X, Liang S, Bai M, Fan P, Wang L, Wang J, Wang Q. Zhou Y, et al. J Adv Res. 2026 Jan;79:707-719. doi: 10.1016/j.jare.2025.03.051. Epub 2025 Mar 28. J Adv Res. 2026. PMID: 40158620 Free PMC article.
METHODS: This study used the testing data of 850 patients (including influenza, COVID-19 and mixed infections) and 265 healthy individuals, to establish and validate a diagnostic prediction model for influenza infection and verified the potential value of thi …
METHODS: This study used the testing data of 850 patients (including influenza, COVID-19 and mixed infections) and 265 …
Elevated neuroinflammation, autoimmunity, and altered IgG glycosylation profile in the cerebral spinal fluid of severe COVID-19 patients.
Shull T, Bhimalli P, Welninski S, Cho BK, Mattamana B, Arivalagan J, Tarhoni I, Goo YA, Schneider JA, Agrawal S, Bennett DA, Leurgans S, Patel MB, Ely EW, Kelleher NL, Borgia JA, Schneider JR, Al-Harthi L. Shull T, et al. Brain Behav Immun. 2025 Aug;128:289-302. doi: 10.1016/j.bbi.2025.03.031. Epub 2025 Mar 27. Brain Behav Immun. 2025. PMID: 40157461
BACKGROUND AND OBJECTIVES: A spectrum of neurologic complications associated with COVID-19 are well documented. While neuroinflammation in the brain of COVID-19 patients likely contributes to these complications, the mechanisms of neuroinflammat …
BACKGROUND AND OBJECTIVES: A spectrum of neurologic complications associated with COVID-19 are well documented. While neuroinf …
Recent advances in inhibitor development and metabolic targeting in tuberculosis therapy.
Patel RR, Vidyasagar, Singh SK, Singh M. Patel RR, et al. Microb Pathog. 2025 Jun;203:107515. doi: 10.1016/j.micpath.2025.107515. Epub 2025 Mar 26. Microb Pathog. 2025. PMID: 40154850 Review.
Despite being a preventable and treatable disease, tuberculosis (TB) remained the second leading infectious cause of death globally in 2022, surpassed only by COVID-19. The death rate from TB is influenced by numerous factors that include antibiotic drug resistance, …
Despite being a preventable and treatable disease, tuberculosis (TB) remained the second leading infectious cause of death globally in 2022, …
Omics for searching plasma biomarkers associated with unfavorable COVID-19 progression in hypertensive patients.
Sánchez A, García-Pardo G, Martí A, Gómez-Bertomeu F, Chafino S, Massanella M, Flores-Piñas M, Cedó L, Vidal F, Peraire J, Rull A. Sánchez A, et al. Sci Rep. 2025 Mar 25;15(1):10343. doi: 10.1038/s41598-025-94725-4. Sci Rep. 2025. PMID: 40133696 Free PMC article.
Hypertension is one of the most common risk factors for COVID-19 clinical progression. The identification of plasma biomarkers for anticipating worse clinical outcomes and to better understand the shared mechanisms between hypertension and COVID …
Hypertension is one of the most common risk factors for COVID-19 clinical progression. The identification of plasma bio …
Exploring autoantigens in autoimmune limbic encephalitis using phage immunoprecipitation sequencing.
Kherbek H, Paramasivan NK, Dasari S, Karsten C, Thakolwiboon S, Gilligan M, Knight AM, LaFrance-Corey RG, Losada V, McKeon A, Pittock SJ, Zekeridou A, Mills JR, Dubey D. Kherbek H, et al. J Neurol. 2025 Mar 25;272(4):292. doi: 10.1007/s00415-025-13039-7. J Neurol. 2025. PMID: 40133514
METHODS: We used PhIP-Seq to analyze cerebrospinal fluid (CSF) from patients with antibody-negative ALE evaluated in our lab with detailed clinical records available (2008-2023). ...No malignancy was detected, and although the patient was initiated on immunot …
METHODS: We used PhIP-Seq to analyze cerebrospinal fluid (CSF) from patients with antibody-negative ALE evaluated in our lab with det …
Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments.
Hansen CB, Møller MEE, Pérez-Alós L, Israelsen SB, Drici L, Ottenheijm ME, Nielsen AB, Wewer Albrechtsen NJ, Benfield T, Garred P. Hansen CB, et al. iScience. 2025 Feb 17;28(3):112046. doi: 10.1016/j.isci.2025.112046. eCollection 2025 Mar 21. iScience. 2025. PMID: 40124495 Free PMC article.
Prognostic biomarkers have been widely studied in COVID-19, but their levels may be influenced by treatment strategies. This study examined plasma biomarkers and proteomic survival prediction in two unvaccinated hospitalized COVID-19 cohorts rec …
Prognostic biomarkers have been widely studied in COVID-19, but their levels may be influenced by treatment strategies. This s …
Seminal plasma proteomics of asymptomatic COVID-19 patients reveals disruption of male reproductive function.
Huang J, Su Y, Wang J, Fang Z, Zhang Y, Chen H, Wan X, Xiong Y, Song N, Chen H, Wu X. Huang J, et al. BMC Genomics. 2025 Mar 21;26(1):281. doi: 10.1186/s12864-025-11473-5. BMC Genomics. 2025. PMID: 40119256 Free PMC article.
BACKGROUND: A considerable proportion of males suffer from asymptomatic SARS-CoV-2 infection, while the effect on reproductive function and underlying pathomechanisms remain unclear. RESULTS: The total sperm count decreased evidently after asymptomatic infect …
BACKGROUND: A considerable proportion of males suffer from asymptomatic SARS-CoV-2 infection, while the effect on repro …
In-house assays for detecting anti-SARS-CoV-2 antibodies in serum and urine: Correlation with COVID-19 severity from a cohort study in Qatar.
Vaikath NN, Al-Nesf MA, Majbour N, Abdesselem HB, Gupta V, Bensmail I, Abdi IY, Elmagarmid KA, Shabani S, Sudhakaran IP, Ghanem SS, Al-Maadheed M, Mohamed-Ali V, Blackburn JM, Decock J, El-Agnaf OMA. Vaikath NN, et al. J Infect Public Health. 2025 Jun;18(6):102744. doi: 10.1016/j.jiph.2025.102744. Epub 2025 Mar 9. J Infect Public Health. 2025. PMID: 40117875 Free article.
METHODS: ELISA-based assay was developed to detect IgG and IgM antibodies against SARS-CoV-2. The assay was examined in serum and urine samples of two different cohort of patients affected by COVID-19 disease with different severity and c …
METHODS: ELISA-based assay was developed to detect IgG and IgM antibodies against SARS-CoV-2. The assay was examined in …
The Omics Landscape of Long COVID-A Comprehensive Systematic Review to Advance Biomarker, Target and Drug Discovery.
Baalbaki N, Slob EMA, Kazer SW, I Abdel-Aziz M, Bogaard HJ, Golebski K, Maitland-van der Zee AH. Baalbaki N, et al. Allergy. 2025 Apr;80(4):932-948. doi: 10.1111/all.16526. Epub 2025 Mar 14. Allergy. 2025. PMID: 40084919 Free PMC article.
An estimated 10% of coronavirus disease (COVID-19) survivors suffer from persisting symptoms referred to as long COVID (LC), a condition for which approved treatment options are still lacking. ...The synthesis of omics data, including genomics, transcriptomic …
An estimated 10% of coronavirus disease (COVID-19) survivors suffer from persisting symptoms referred to as long COVID …
Deciphering the IgG Idiotype Network Through Proteomic Analysis of Potential Targets in SARS-CoV-2-Induced Immune Responses.
Machado NR, Fagundes BO, do Nascimento LA, Bergamasco IS, Sgnotto FDR, Fernandes IG, Fernandes JR, Pinto TNC, da Borges JVS, Benard G, Sato MN, Victor JR. Machado NR, et al. Immunology. 2025 Jun;175(2):226-239. doi: 10.1111/imm.13919. Epub 2025 Mar 12. Immunology. 2025. PMID: 40077865
The association between COVID-19 and autoimmune diseases has gained increasing recognition, yet the specific targets of SARS-CoV-2-induced IgG are currently in focus for several studies. ...Serum samples were analysed from four groups: healthy c …
The association between COVID-19 and autoimmune diseases has gained increasing recognition, yet the specific targets of SAR …
Novel Methods for the Analysis of Serum NET Remnants: Evaluation in Patients with Severe COVID-19.
Pisani F, Porciani C, Croia C, Pucino V, Virdis A, Puxeddu I, Migliorini P, Pratesi F. Pisani F, et al. Int J Mol Sci. 2025 Feb 28;26(5):2221. doi: 10.3390/ijms26052221. Int J Mol Sci. 2025. PMID: 40076841 Free PMC article.
Several studies highlight the heterogeneity of NETs, underscoring the challenges associated with their detection. In patients with COVID-19, high levels of NET fragments, called NET remnants, are detected in the circulation but also in alveoli and bronchioles …
Several studies highlight the heterogeneity of NETs, underscoring the challenges associated with their detection. In patients with …
Decreased levels and function of dendritic cells in blood and airways predict COVID-19 severity.
Österberg B, Falck-Jones S, Vangeti S, Åhlberg E, Yu M, Granja D, Snik ME, Falck-Jones R, Barros GW, Charles A, Lepzien R, Johansson N, Holmes TH, Maecker H, Czarnewski P, Bell M, Färnert A, Smed-Sörensen A. Österberg B, et al. Clin Transl Immunology. 2025 Mar 3;14(3):e70026. doi: 10.1002/cti2.70026. eCollection 2025. Clin Transl Immunology. 2025. PMID: 40041475 Free PMC article.
However, a complete understanding of their specific roles in respiratory infections, including SARS-CoV-2, remains elusive. METHODS: To investigate the dynamics of monocytes and DCs in blood as well as the upper and lower airways, we sampled 147 patients …
However, a complete understanding of their specific roles in respiratory infections, including SARS-CoV-2, remains elus …
Metabolomic and lipoproteomic differences and similarities between COVID-19 and other types of pneumonia.
Ghini V, Pecchioli V, Celli T, Boccia N, Bertini L, Veneziani F, Vannucchi V, Turano P. Ghini V, et al. Sci Rep. 2025 Mar 3;15(1):7507. doi: 10.1038/s41598-025-91965-2. Sci Rep. 2025. PMID: 40032933 Free PMC article.
COVID-19 infection has revealed significant effects on the human blood metabolome and lipoproteome, which have been coherently observed in different cohorts worldwide and across the various waves of SARS-CoV-2 pandemic. ...To this purpose we are …
COVID-19 infection has revealed significant effects on the human blood metabolome and lipoproteome, which have been coherently …
Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID.
Hansen KS, Jørgensen SE, Cömert C, Schiøttz-Christensen B, Bross P, Agergaard J, Leth S, Østergaard L, Palmfeldt J, Olsen RKJ, Mogensen TH. Hansen KS, et al. J Med Virol. 2025 Mar;97(3):e70275. doi: 10.1002/jmv.70275. J Med Virol. 2025. PMID: 40025839 Free PMC article.
Alongside accumulating evidence of mitochondrial dysfunction in patients with acute SARS-CoV-2 infection, a symptomatic overlap exists between long COVID and mitochondrial disorders. ...We employed whole genome sequencing to analyze 13 patients …
Alongside accumulating evidence of mitochondrial dysfunction in patients with acute SARS-CoV-2 infection, a symp …
A detailed examination of coronavirus disease 2019 (COVID-19): Covering past and future perspectives.
Yasmin S, Ansari MY. Yasmin S, et al. Microb Pathog. 2025 Jun;203:107398. doi: 10.1016/j.micpath.2025.107398. Epub 2025 Feb 20. Microb Pathog. 2025. PMID: 39986548
There are a variety of computational repurposing methodologies, and some of them have been used to counter the coronavirus disease pandemic of 2019 (COVID-19). This review article compiles recently published data on the origin, transmission, pathogenesis, dia …
There are a variety of computational repurposing methodologies, and some of them have been used to counter the coronavirus disease pa …
Autoinflammatory encephalopathy due to PTPN1 haploinsufficiency: a case series.
Zhu G, Didry-Barca B, Seabra L, Rice GI, Uggenti C, Touimy M, Rodero MP, Trapero RH, Bondet V, Duffy D, Gautier P, Livingstone K, Sutherland FJH, Lebon P, Parisot M, Bole-Feysot C, Masson C, Cagnard N, Nitschké P, Anderson G, Assmann B, Barth M, Boespflug-Tanguy O, D'Arco F, Dorboz I, Giese T, Hacohen Y, Hancarova M, Husson M, Lepine A, Lim M, Mancardi MM, Melki I, Neubauer D, Sa M, Sedlacek Z, Seitz A, Rottman MS, Sanquer S, Straussberg R, Vlčková M, Villéga F, Wagner M, Zerem A, Marsh JA, Frémond ML, Kaliakatsos M, Crow YJ, El-Daher MT, Lepelley A. Zhu G, et al. Lancet Neurol. 2025 Mar;24(3):218-229. doi: 10.1016/S1474-4422(24)00526-X. Lancet Neurol. 2025. PMID: 39986310 Free PMC article.
We aimed to describe the clinical phenotype and molecular and cellular pathology of this new disease. METHODS: In this case series, we identified patients and collected clinical and neuroradiological data through collaboration with paediatric neurology and …
We aimed to describe the clinical phenotype and molecular and cellular pathology of this new disease. METHODS: In this case series, w …
Proteomics Reveals That Vitamin D Deficiency Leads to Immunoglobulin Abnormalities and Immune Dysregulation in Patients with Post-COVID-19 Condition.
Ji W, Xie X, Bai G, Fan Y, He Y, Zhang L, Zhou H, Li L, Li H. Ji W, et al. J Proteome Res. 2025 Mar 7;24(3):1449-1461. doi: 10.1021/acs.jproteome.4c01120. Epub 2025 Feb 20. J Proteome Res. 2025. PMID: 39979118
Vitamin D (VD) levels are closely related to the occurrence of post-COVID-19 conditions (PCCs), but the specific mechanism is still unclear. Here, a total of 50 PCC patient serum samples were divided into the VD sufficient group (VD 30 ng/mL), the VD insuffic …
Vitamin D (VD) levels are closely related to the occurrence of post-COVID-19 conditions (PCCs), but the specific mechanism is …
VITT-like Monoclonal Gammopathy of Thrombotic Significance.
Wang JJ, Warkentin TE, Schönborn L, Wheeler MB, Geerts WH, Costedoat-Chalumeau N, Gendron N, Ene G, Lozano M, Langer F, Lindhoff-Last E, Budde K, Chataway T, Troelnikov A, Sheppard JI, Zhang Y, Arnold DM, Gordon TP, Thiele T, Greinacher A, Nazy I. Wang JJ, et al. N Engl J Med. 2025 Mar 6;392(10):995-1005. doi: 10.1056/NEJMoa2415930. Epub 2025 Feb 12. N Engl J Med. 2025. PMID: 39938091
VITT antibodies are implicated in acute, transient prothrombotic disorders that are triggered by adenoviral vector vaccines against coronavirus disease 2019 or by adenovirus infection. We describe chronic prothrombotic disorders featuring anticoagulant-refractory thrombose …
VITT antibodies are implicated in acute, transient prothrombotic disorders that are triggered by adenoviral vector vaccines against coron …
Host Response Stratification in Malarial and Non-malarial Sepsis: A Prospective, Multicenter Analysis From Uganda.
Cummings MJ, Lutwama JJ, Owor N, Tomoiaga AS, Ross JE, Muwanga M, Nsereko C, Nayiga I, Kyebambe S, Shinyale J, Ochar T, Nie K, Xie H, Miake-Lye S, Villagomez B, Qi J, Reynolds SJ, Nakibuuka MC, Lu X, Kayiwa J, Haumba M, Nakaseegu J, Che X, Byakika-Kibwika P, Wayengera M, Achan J, Kim-Schulze S, Lipkin WI, O'Donnell MR, Bakamutumaho B. Cummings MJ, et al. Crit Care Med. 2025 Apr 1;53(4):e984-e991. doi: 10.1097/CCM.0000000000006591. Epub 2025 Feb 12. Crit Care Med. 2025. PMID: 39937058
DESIGN AND SETTING: Analysis of Olink proteomic data from prospective observational cohort studies of sepsis conducted at public hospitals in Uganda (discovery cohort [Entebbe, urban], n = 238; validation cohort [Tororo, rural], n = 253). PATIENTS: Adults (age 18 yr …
DESIGN AND SETTING: Analysis of Olink proteomic data from prospective observational cohort studies of sepsis conducted at public hosp …
APNet, an explainable sparse deep learning model to discover differentially active drivers of severe COVID-19.
Gavriilidis GI, Vasileiou V, Dimitsaki S, Karakatsoulis G, Giannakakis A, Pavlopoulos GA, Psomopoulos F. Gavriilidis GI, et al. Bioinformatics. 2025 Mar 4;41(3):btaf063. doi: 10.1093/bioinformatics/btaf063. Bioinformatics. 2025. PMID: 39921901 Free PMC article.
MOTIVATION: Computational analyses of bulk and single-cell omics provide translational insights into complex diseases, such as COVID-19, by revealing molecules, cellular phenotypes, and signalling patterns that contribute to unfavourable clinical outcomes. .. …
MOTIVATION: Computational analyses of bulk and single-cell omics provide translational insights into complex diseases, such as COVID- …
Clinical and Multiorgan Proteomics Characteristics of the Diverse Fatal Phase in Super Elderly Patients With SARS-CoV-2 Infection: A Descriptive Study.
Wang S, Sun J, Hu Y, Zhang W, Qin B, Li M, Zhang N, Wang S, Zhou T, Liu M, Ma C, Deng X, Bai Y, Qu G, Liu L, Shi H, Zhou B, Li K, Yang B, Li S, Wang F, Ma J, Zhang L, Wang Y, An L, Liu W, Chang Q, Zhang R, Yin X, Yang Y, Ao Q, Ma Q, Yan S, Huang H, Song P, Zhao S, Gao L, Lu W, Xu L, Lei L, Wang K, Song Q, Zhang Z, Fang X, He Y, Zhang Q, Jia J, Zhu P. Wang S, et al. J Med Virol. 2025 Feb;97(2):e70207. doi: 10.1002/jmv.70207. J Med Virol. 2025. PMID: 39921383
This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to fatal SARS-CoV-2 infection within the super-elderly population. ...Effective management of comorbidities may improve th …
This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to …
P.1 and P.2 SARS-CoV-2 Brazilian variants activate the unfolded protein response with a time and pathway specificity.
de Morais Gomes V, Santos DM, Macedo-da-Silva J, Lazari LC, Machado RRG, Dos Santos AF, Araujo DB, Coutinho JVP, Arini GS, Angeli CB, de Souza EE, Marques RF, Boscardin SB, Wrenger C, Marinho CRF, Oliveira DBL, Durigon EL, Labriola L, Rosa-Fernandes L, Palmisano G. de Morais Gomes V, et al. J Proteomics. 2025 May 15;315:105397. doi: 10.1016/j.jprot.2025.105397. Epub 2025 Feb 3. J Proteomics. 2025. PMID: 39909104
COVID-19 is a human respiratory syndrome caused by the infection of the SARS-CoV-2 virus that has a high rate of infection and mortality. ...This study elucidated an activation of a diversity of molecular mechanisms by Brazilian variants of S …
COVID-19 is a human respiratory syndrome caused by the infection of the SARS-CoV-2 virus that has a high …
HDL proteome and apolipoproteins concentrations in severe ICU COVID-19 patients.
Begue F, Veeren B, Rondeau P, Florence AM, Jamard S, Montravers P, Tanaka S, Meilhac O; French COVID Study Group. Begue F, et al. Lipids Health Dis. 2025 Jan 31;24(1):32. doi: 10.1186/s12944-024-02381-w. Lipids Health Dis. 2025. PMID: 39891286 Free PMC article.
Despite the crucial role that these nanoparticles play in SARS-CoV-2 infection, few studies have examined their structure during COVID-19 beyond HDL quantity. The study aimed to assess apolipoprotein levels in COVID-19 patients …
Despite the crucial role that these nanoparticles play in SARS-CoV-2 infection, few studies have examined their structu …
Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis.
Canny SP, Stanaway IB, Holton SE, Mitchem M, O'Rourke AR, Pribitzer S, Baxter SK, Wurfel MM, Malhotra U, Buckner JH, Bhatraju PK, Morrell ED, Speake C, Mikacenic C, Hamerman JA. Canny SP, et al. Crit Care Explor. 2025 Jan 31;7(2):e1203. doi: 10.1097/CCE.0000000000001203. eCollection 2025 Feb 1. Crit Care Explor. 2025. PMID: 39888602 Free PMC article.
METHODS AND MODELS: We identified two cohorts of adult patients presenting with COVID-19 at two tertiary care hospitals in Seattle, Washington in 2020 and 2021. ...We identified 264 patients with COVID-19 of whom 24 met our sHLH definitio …
METHODS AND MODELS: We identified two cohorts of adult patients presenting with COVID-19 at two tertiary care hospitals …
Utility of Protein Markers in COVID-19 Patients.
Alicia LB, María Ángeles OG, Desirée MG, Maximino R, Marilina GA. Alicia LB, et al. Int J Mol Sci. 2025 Jan 14;26(2):653. doi: 10.3390/ijms26020653. Int J Mol Sci. 2025. PMID: 39859366 Free PMC article. Review.
COVID-19 has been a challenge at the healthcare level not only in the early stages of the pandemic, but also in the subsequent appearance of long-term COVID-19. Several investigations have attempted to identify proteomic biomarkers in an attempt …
COVID-19 has been a challenge at the healthcare level not only in the early stages of the pandemic, but also in the subsequent …
Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls.
Buonsenso D, Cotugno N, Amodio D, Pascucci GR, Di Sante G, Pighi C, Morrocchi E, Pucci A, Olivieri G, Colantoni N, Romani L, Rotili A, Neri A, Morello R, Sali M, Tremoulet A, Raffaelli F, Zampino G, Rossi P, Valentini P, Palma P. Buonsenso D, et al. Pediatr Res. 2025 Sep;98(3):928-935. doi: 10.1038/s41390-025-03837-0. Epub 2025 Jan 24. Pediatr Res. 2025. PMID: 39849114
METHODS: We performed an extensive protein analysis of blood plasma from pediatric patients younger than 19 years of age Long COVID and a control group of children with acute COVID-19, MIS-C, and healthy controls resulted similar for sex distribution and age. …
METHODS: We performed an extensive protein analysis of blood plasma from pediatric patients younger than 19 years of age Long COVID a …
Proteomic, metabolomic and lipidomic profiles in community acquired pneumonia for differentiating viral and bacterial infections.
Rischke S, Gurke R, Zielbauer AS, Ziegler N, Hahnefeld L, Köhm M, Kannt A, Vehreschild MJ, Geisslinger G, Rohde G, Bellinghausen C, Behrens F, Study Group C. Rischke S, et al. Sci Rep. 2025 Jan 14;15(1):1922. doi: 10.1038/s41598-025-85229-2. Sci Rep. 2025. PMID: 39809876 Free PMC article.
Community-acquired pneumonia (CAP) has a significant impact on public health, especially in light of the recent SARS-CoV-2 pandemic. To enhance disease characterization and improve understanding of the underlying mechanisms, a comprehensive analysis of the pl …
Community-acquired pneumonia (CAP) has a significant impact on public health, especially in light of the recent SARS-CoV-2 …
4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection.
de Lima IL, Cataldi TR, Brites C, Labate MTV, Vaz SN, Deminco F, da Cunha GS, Labate CA, Eberlin MN. de Lima IL, et al. J Proteome Res. 2025 Feb 7;24(2):499-514. doi: 10.1021/acs.jproteome.4c00630. Epub 2025 Jan 13. J Proteome Res. 2025. PMID: 39803891 Free PMC article.
Since late 2021, Omicron variants have dominated the epidemiological scenario as the most successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sublineages, driving new and breakthrough infections gl …
Since late 2021, Omicron variants have dominated the epidemiological scenario as the most successful severe acute respirato …
Proteomic and metabolomic profiling of plasma uncovers immune responses in patients with Long COVID-19.
Wei Y, Gu H, Ma J, Mao X, Wang B, Wu W, Yu S, Wang J, Zhao H, He Y. Wei Y, et al. Front Microbiol. 2024 Dec 27;15:1470193. doi: 10.3389/fmicb.2024.1470193. eCollection 2024. Front Microbiol. 2024. PMID: 39802657 Free PMC article.
This study included three age- and gender-matched cohorts: healthy controls (n = 18), COVID-19 recovered patients (n = 17), and Long COVID patients (n = 15). The proteomics results revealed significant differences in proteins between Long COV …
This study included three age- and gender-matched cohorts: healthy controls (n = 18), COVID-19 recovered patients (n = …
Individual patient and donor seroprofiles in convalescent plasma treatment of COVID-19 in REMAP-CAP clinical trial.
Nurmi V, Mayne R, Knight C, Almonacid-Mendoza HL, Secret S, Estcourt L, Hepojoki J, Šuštić T, Lamikanra AA, Tsang HP, Menon DK, Shankar-Hari M, van der Schoot CE, Vidarsson G, Roberts DJ, Simmonds P, Hedman K, Harvala H. Nurmi V, et al. J Infect. 2025 Feb;90(2):106412. doi: 10.1016/j.jinf.2025.106412. Epub 2025 Jan 9. J Infect. 2025. PMID: 39798805 Free article.
RESULTS: Most patients were SARS-CoV-2 seropositive pre-transfusion (72% nAb; 89% S-IgG seropositivity). ...Better outcomes, measured by organ support-free days, were associated with increase in S-IgM levels (p=0.007), decreased S-IgG fucosylation (p&l …
RESULTS: Most patients were SARS-CoV-2 seropositive pre-transfusion (72% nAb; 89% S-IgG seropositivity). ...Bett …
Assessment of Humoral Response at SARS-CoV-2 Infection by Multipronged Functional Proteomics Approaches.
Juanes-Velasco P, Pérez-Arévalo JC, Arias-Hidalgo C, Nuño-Soriano A, Landeira-Viñuela A, Corrales F, Bernardo D, Cuesta-Sancho S, Rojo-Rello S, Lécrevisse Q, Góngora R, Sánchez-Santos JM, De Las Rivas J, Hernández ÁP, Fuentes M. Juanes-Velasco P, et al. J Proteome Res. 2025 Feb 7;24(2):515-525. doi: 10.1021/acs.jproteome.4c00635. Epub 2025 Jan 7. J Proteome Res. 2025. PMID: 39772566
This study evaluates prior immunity as a prognostic factor in COVID-19 patients, crucial for understanding plasmatic signaling cascades in different disease stages and their impact on disease progression. COVID-19, caused by SARS-CoV …
This study evaluates prior immunity as a prognostic factor in COVID-19 patients, crucial for understanding plasmatic si …
Proteomic Profile Regulated by the Immunomodulatory Jusvinza Drug in Neutrophils Isolated from Rheumatoid Arthritis Patients.
Hernández-Cedeño M, Rodríguez-Ulloa A, Ramos Y, González LJ, Serrano-Díaz A, Zettl K, Wiśniewski JR, Martinez-Donato G, Guillen-Nieto G, Besada V, Domínguez-Horta MDC. Hernández-Cedeño M, et al. Biomedicines. 2024 Nov 29;12(12):2740. doi: 10.3390/biomedicines12122740. Biomedicines. 2024. PMID: 39767648 Free PMC article.
The peptide induces regulatory T cells and decreases levels of TNF-alpha and IL-17; pre-clinical and phase I clinical studies support its use for the treatment of RA. This peptide was repositioned for the treatment of COVID-19 patients with sign …
The peptide induces regulatory T cells and decreases levels of TNF-alpha and IL-17; pre-clinical and phase I clinical studies …
In Search of Candidate Protein Biomarkers Related to COVID-19 in Solid Tissues and Non-Blood Fluids: An Update.
Alexovič M, Uličná C, Tabani H, Sabo J. Alexovič M, et al. Proteomics Clin Appl. 2025 Mar;19(2):e202400117. doi: 10.1002/prca.202400117. Epub 2024 Dec 30. Proteomics Clin Appl. 2025. PMID: 39740114 Review.
The mass spectrometry-based proteomics of COVID-19-related biomarkers can help with the prognosis and diagnosis of this severe disease. DESIGN: Here, we surveyed scientific works in terms of proteomic analysis of solid tissues and non-blood fluids from …
The mass spectrometry-based proteomics of COVID-19-related biomarkers can help with the prognosis and diagnosis of this …
Proteomic profiling of peripheral blood mononuclear cells reveals immune dysregulation and metabolic alterations in kidney transplant recipients with COVID-19.
Leite GGF, Sousa MB, Rodrigues LOCP, Brunialti MKC, Medina-Pestana J, Butler JM, Peters-Sengers H, Requião-Moura L, Salomão R. Leite GGF, et al. Front Immunol. 2024 Dec 16;15:1508110. doi: 10.3389/fimmu.2024.1508110. eCollection 2024. Front Immunol. 2024. PMID: 39737170 Free PMC article.
Recently, mass spectrometry-based proteomics has emerged as a powerful tool to shed light on a broad spectrum of dysregulated biological processes in KTRs with COVID-19. ...Our results revealed significant proteomic alterations in COVID-19 …
Recently, mass spectrometry-based proteomics has emerged as a powerful tool to shed light on a broad spectrum of dysregulated biologi …
Viral infections in celiac disease: what should be considered for better management.
Asri N, Mohammadi S, Jahdkaran M, Rostami-Nejad M, Rezaei-Tavirani M, Mohebbi SR. Asri N, et al. Clin Exp Med. 2024 Dec 28;25(1):25. doi: 10.1007/s10238-024-01542-6. Clin Exp Med. 2024. PMID: 39731690 Free PMC article. Review.
Moreover, previous studies have shown that celiac patients, especially untreated subjects, are at increased risk of developing viral and bacterial infections, which can become a challenge for the clinician. Viruses, such as Rotavirus, Reovirus, Adenovirus, Enterovir …
Moreover, previous studies have shown that celiac patients, especially untreated subjects, are at increased risk of developing viral …
Self-Assembly of Human Fibrinogen into Microclot-Mimicking Antifibrinolytic Amyloid Fibrinogen Particles.
Mai X, Hu Y, Wu Z, Guo X, Dong M, Jia L, Ren J. Mai X, et al. ACS Appl Bio Mater. 2025 Jan 20;8(1):825-834. doi: 10.1021/acsabm.4c01651. Epub 2024 Dec 26. ACS Appl Bio Mater. 2025. PMID: 39723824
Recent clinical studies have highlighted the presence of microclots in the form of amyloid fibrinogen particles (AFPs) in plasma samples from Long COVID patients. ...Proteomic analysis suggests that AFPs interact with various components of human plasma and ha …
Recent clinical studies have highlighted the presence of microclots in the form of amyloid fibrinogen particles (AFPs) in plasma samp …
SARS-CoV-2 ORF8 drives osteoclastogenesis in preexisting immune-mediated inflammatory diseases.
Melano I, Azamor T, Caetano CC, Meyer NM, Onwubueke C, Visperas A, Familiar-Macedo D, Salem GM, Soos BL, Calabrese CM, Choi YJ, Chen S, Choi Y, Wu X, Vasconcelos Z, Comhair SA, Nielsen-Saines K, Calabrese LH, Husni ME, Jung JU, Piuzzi NS, Foo SS, Chen W. Melano I, et al. JCI Insight. 2024 Dec 20;9(24):e178820. doi: 10.1172/jci.insight.178820. JCI Insight. 2024. PMID: 39704167 Free PMC article.
This study sought to identify specific immune mediators that exacerbated preexisting IMIDs after SARS-CoV-2 exposure. Plasma samples from 4 groups were analyzed: healthy, IMID only, COVID-19 only, and COVID-19 + IMID. ...Long-term …
This study sought to identify specific immune mediators that exacerbated preexisting IMIDs after SARS-CoV-2 exposure. P …
Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV: A Secondary Analysis of the REPRIEVE Randomized Clinical Trial.
Kolossváry M, Schnittman SR, Zanni MV, Fitch KV, Fichtenbaum CJ, Aberg JA, Bloomfield GS, Malvestutto CD, Currier J, Diggs MR, deFilippi C, Eckard AR, Curran A, Centinbas M, Sadreyev R, Foldyna B, Mayrhofer T, Karady J, Taron J, McCallum S, Lu MT, Ribaudo HJ, Douglas PS, Grinspoon SK. Kolossváry M, et al. JAMA Cardiol. 2025 Mar 1;10(3):254-264. doi: 10.1001/jamacardio.2024.4115. JAMA Cardiol. 2025. PMID: 39661372 Free PMC article. Clinical Trial.
MAIN OUTCOMES AND MEASURES: Relative change in plasma proteomics, transcriptomics, and noncalcified plaque volume among those receiving treatment vs placebo. ...TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02344290....
MAIN OUTCOMES AND MEASURES: Relative change in plasma proteomics, transcriptomics, and noncalcified plaque volume among those receivi …
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19.
Rong Z, Mai H, Ebert G, Kapoor S, Puelles VG, Czogalla J, Hu S, Su J, Prtvar D, Singh I, Schädler J, Delbridge C, Steinke H, Frenzel H, Schmidt K, Braun C, Bruch G, Ruf V, Ali M, Sühs KW, Nemati M, Hopfner F, Ulukaya S, Jeridi D, Mistretta D, Caliskan ÖS, Wettengel JM, Cherif F, Kolabas ZI, Molbay M, Horvath I, Zhao S, Krahmer N, Yildirim AÖ, Ussar S, Herms J, Huber TB, Tahirovic S, Schwarzmaier SM, Plesnila N, Höglinger G, Ondruschka B, Bechmann I, Protzer U, Elsner M, Bhatia HS, Hellal F, Ertürk A. Rong Z, et al. Cell Host Microbe. 2024 Dec 11;32(12):2112-2130.e10. doi: 10.1016/j.chom.2024.11.007. Epub 2024 Nov 29. Cell Host Microbe. 2024. PMID: 39615487 Free article.
SARS-CoV-2 infection is associated with long-lasting neurological symptoms, although the underlying mechanisms remain unclear. Using optical clearing and imaging, we observed the accumulation of SARS-CoV-2 spike protein in the skull-menin …
SARS-CoV-2 infection is associated with long-lasting neurological symptoms, although the underlying mechanisms remain u …
Rapid diagnosis and severity scale of post-COVID condition using advanced spectroscopy.
Antelo-Riveiro P, Vázquez M, Domínguez-Santalla MJ, Rodríguez-Ruiz E, Piñeiro Á, Garcia-Fandino R. Antelo-Riveiro P, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2025 Mar 5;328:125474. doi: 10.1016/j.saa.2024.125474. Epub 2024 Nov 24. Spectrochim Acta A Mol Biomol Spectrosc. 2025. PMID: 39615091 Free article.
The COVID-19 pandemic has resulted in a persistent health challenge known as Post-COVID Condition (PCC), characterized by symptoms lasting at least three months after the initial SARS-CoV-2 infection and potentially persisting for several years. …
The COVID-19 pandemic has resulted in a persistent health challenge known as Post-COVID Condition (PCC), characterized by symp …
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19.
Maguire C, Chen J, Rouphael N, Pickering H, Phan HV, Glascock A, Chu V, Dandekar R, Corry D, Kheradmand F, Baden LR, Selaky R, McComsey GA, Haddad EK, Cairns CB, Pulendran B, Fernandez-Sesma A, Simon V, Metcalf JP, Higuita NIA, Messer WB, David MM, Nadeau KC, Kraft M, Bime C, Schaenman J, Erle D, Calfee CS, Atkinson MA, Brackenridge SC, Ehrlich LIR, Montgomery RR, Shaw AC, Hough CL, Geng LN, Hafler DA, Augustine AD, Becker PM, Peters B, Ozonoff A, Kim-Schulze SH, Krammer F, Bosinger S, Eckalbar W, Altman MC, Wilson M, Guan L, Kleinstein SH; IMPACC Network; Smolen KK, Reed EF, Levy O, Maecker H, Hunt P, Steen H, Diray-Arce J, Langelier CR, Melamed E. Maguire C, et al. bioRxiv [Preprint]. 2024 Nov 16:2024.11.14.622799. doi: 10.1101/2024.11.14.622799. bioRxiv. 2024. PMID: 39605478 Free PMC article. Preprint.
We also show that viral reactivation correlated with COVID-19 severity, demographic characteristics, and clinical outcomes, including mortality. ...IL-6, CXCL10, and TNF), increased activated CD4+ and CD8+ T-cells, and upregulation of cellular replication gen …
We also show that viral reactivation correlated with COVID-19 severity, demographic characteristics, and clinical outco …
iTRAQ-Based Proteomic Analysis of Spontaneous Achilles Tendon Rupture.
Qianman B, Jiasharete T, Badalihan A, Mamately A, Yeerbo N, Bahesutihan Y, Wupuer A, Aisaiding A, Wuerliebieke J, Jialihasi A, Li P, Jielile J. Qianman B, et al. J Proteome Res. 2025 Jan 3;24(1):65-76. doi: 10.1021/acs.jproteome.4c00357. Epub 2024 Nov 27. J Proteome Res. 2025. PMID: 39601082
The present study aimed to uncover the key pathological molecules by using iTRAQ proteomics. The results identified 2432 candidate proteins in SATR patients using iTRAQ proteomic analysis. A total of 307 differentially expressed proteins (DEPs) were identifie …
The present study aimed to uncover the key pathological molecules by using iTRAQ proteomics. The results identified 2432 candidate pr …
Dynamic Cellular Proteome Remodeling during SARS-CoV-2 Infection. Identification of Plasma Protein Readouts.
Dos Santos FM, Vindel-Alfageme J, Ciordia S, Castro V, Orera I, Garaigorta U, Gastaminza P, Corrales F. Dos Santos FM, et al. J Proteome Res. 2025 Jan 3;24(1):171-188. doi: 10.1021/acs.jproteome.4c00566. Epub 2024 Nov 26. J Proteome Res. 2025. PMID: 39593238 Free PMC article.
From this perspective, proteomics could help to understand the mechanisms associated with SARS-CoV-2 infection and to identify new therapeutic options. A TMT-based quantitative proteomics and phosphoproteomics analysis was performed to study the …
From this perspective, proteomics could help to understand the mechanisms associated with SARS-CoV-2 infection a …
Indeterminate Result of Interferon-gamma Release Assay-A Risk Factor of Mortality for COVID-19 and Non-COVID-19 Respiratory Infections.
Tian W, Han Z, Shi D, Wang H, Tang H, Wu Z, Zhang Y, Cui L, Shen N, Zheng J, Chen Y. Tian W, et al. J Med Virol. 2024 Nov;96(11):e70058. doi: 10.1002/jmv.70058. J Med Virol. 2024. PMID: 39588785 Free PMC article.
Toward the end of 2022, the cessation of China's "dynamic zero-COVID policy" had led to a notable outbreak of SARS-CoV-2 infections and a substantial number of severe cases and deaths were reported, which raised serious concerns. ...This indeterminate IGRA re …
Toward the end of 2022, the cessation of China's "dynamic zero-COVID policy" had led to a notable outbreak of SARS-CoV-2 …
Different dynamics of soluble inflammatory mediators after clearance of respiratory SARS-CoV-2 versus blood-borne hepatitis C virus infections.
Zeuzem A, Kumar SD, Oltmanns C, Witte M, Mischke J, Drick N, Fuge J, Pink I, Tauwaldt J, Debarry J, Illig T, Wedemeyer H, Maasoumy B, Li Y, Kraft ARM, Cornberg M. Zeuzem A, et al. Sci Rep. 2024 Nov 22;14(1):29013. doi: 10.1038/s41598-024-79909-8. Sci Rep. 2024. PMID: 39578604 Free PMC article.
Most SIM in the SARS-CoV-2 cohort normalized within 3 months. In chronic HCV, SIM were higher in cirrhotic than noncirrhotic patients post-HCV elimination. Dynamics of SIM after viral elimination vary between blood-borne acute and chronic HCV infection …
Most SIM in the SARS-CoV-2 cohort normalized within 3 months. In chronic HCV, SIM were higher in cirrhotic than noncirr …
Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.
Gualdrón-López M, Ayllon-Hermida A, Cortes-Serra N, Resa-Infante P, Bech-Serra JJ, Aparici-Herraiz I, Nicolau-Fernandez M, Erkizia I, Gutierrez-Chamorro L, Marfil S, Pradenas E, Ávila Nieto C, Cucurull B, Montaner-Tarbés S, Muelas M, Sotil R, Ballana E, Urrea V, Fraile L, Montoya M, Vergara J, Segales J, Carrillo J, Izquierdo-Useros N, Blanco J, Fernandez-Becerra C, de La Torre C, Pinazo MJ, Martinez-Picado J, Del Portillo HA. Gualdrón-López M, et al. Front Cell Infect Microbiol. 2024 Nov 6;14:1442743. doi: 10.3389/fcimb.2024.1442743. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 39569406 Free PMC article.
We hypothesized that molecular characterization of EVs isolated from COVID-19 patients would reveal peptides suitable for vaccine development. Blood samples were collected from three cohorts: severe COVID-19 patients (G1), mild/asymptomat …
We hypothesized that molecular characterization of EVs isolated from COVID-19 patients would reveal peptides suitable f …
Serum proteomics identifies biomarkers for predicting non-survivors in elderly COVID-19 patients.
Wang L, Tian W, Wang S, Liu Y, Wang H, Xiao J, Yu Z, Xie L, Chen Y. Wang L, et al. J Proteomics. 2025 Jan 16;311:105356. doi: 10.1016/j.jprot.2024.105356. Epub 2024 Nov 14. J Proteomics. 2025. PMID: 39547396 Free article.
In December 2022, China ceased the zero-COVID-19 policy, resulting in an increase in hospitalizations and deaths due to COVID-19, particularly among the elderly population. ...Our study elucidated that immune disorders, lung damage, and cardiovascular …
In December 2022, China ceased the zero-COVID-19 policy, resulting in an increase in hospitalizations and deaths due to COV …
Insights into Acinetobacter baumannii AMA205's Unprecedented Antibiotic Resistance.
Traglia GM, Pasteran F, Moheb S, Akhtar U, Gonzalez S, Maldonado C, Furtado N, Mohamed A, Escalante J, Tuttobene MR, Quillen A, Fontan C, Albornoz E, Corso A, Bonomo RA, Rao GG, Tolmasky ME, Ramirez MS. Traglia GM, et al. Int J Mol Sci. 2024 Oct 24;25(21):11424. doi: 10.3390/ijms252111424. Int J Mol Sci. 2024. PMID: 39518977 Free PMC article.
The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, Acinetobacter baumannii stands out due to its remarkable ability to acquire resistance genes and persist in hospital environments, leading to some …
The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, Acineto …
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion.
Christ W, Kapell S, Sobkowiak MJ, Mermelekas G, Evertsson B, Sork H, Saher O, Bazaz S, Gustafsson O, Cardenas EI, Villa V, Ricciarelli R, Sandberg JK, Bergquist J, Sturchio A, Svenningsson P, Malm T, Espay AJ, Pernemalm M, Lindén A, Klingström J, El Andaloussi S, Ezzat K. Christ W, et al. ACS Chem Neurosci. 2024 Nov 20;15(22):4095-4104. doi: 10.1021/acschemneuro.4c00636. Epub 2024 Nov 7. ACS Chem Neurosci. 2024. PMID: 39510798
The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological complications in patients, known as long COVID, have renewed interest in the correlation between viral infections and neurodegenerative brain disorders. ...Importantly, UV- …
The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological complications in patients, known …
Serum proteomics for the identification of biomarkers to flag predilection of COVID19 patients to various organ morbidities.
Rajan MV, Sharma V, Upadhyay N, Murali A, Bandyopadhyay S, Hariprasad G. Rajan MV, et al. Clin Proteomics. 2024 Nov 1;21(1):61. doi: 10.1186/s12014-024-09512-6. Clin Proteomics. 2024. PMID: 39487396 Free PMC article.
This heterogeneity in the clinical presentation of COVID19 infection has posed a challenge to clinicians around the world. It is therefore crucial to identify specific organ-related morbidity for effective treatment and better patient outcomes. We have …
This heterogeneity in the clinical presentation of COVID19 infection has posed a challenge to clinicians around the wor …
Serum proteome reveals distinctive molecular features of H7N9- and SARS-CoV-2-infected patients.
Wang Y, Song Z, Ran P, Xiang H, Xu Z, Xu N, Deng M, Zhu L, Yin Y, Feng J, Ding C, Yang W. Wang Y, et al. Cell Rep. 2024 Nov 26;43(11):114900. doi: 10.1016/j.celrep.2024.114900. Epub 2024 Nov 1. Cell Rep. 2024. PMID: 39487987 Free article.
Here, we performed a proteomic approach on sera samples from patients with H7N9-virus or SARS-CoV-2-virus infection and healthy controls. Compared to SARS-CoV-2, H7N9-virus infection caused elevated neutrophil concentrations …
Here, we performed a proteomic approach on sera samples from patients with H7N9-virus or SARS-CoV-2-virus …
Proteomic analysis of post-COVID condition: Insights from plasma and pellet blood fractions.
Seco-González A, Antelo-Riveiro P, Bravo SB, Garrido PF, Domínguez-Santalla MJ, Rodríguez-Ruiz E, Piñeiro Á, Garcia-Fandino R. Seco-González A, et al. J Infect Public Health. 2024 Dec;17(12):102571. doi: 10.1016/j.jiph.2024.102571. Epub 2024 Oct 23. J Infect Public Health. 2024. PMID: 39486386 Free article.
BACKGROUND: Persistent symptoms extending beyond the acute phase of SARS-CoV-2 infection, known as Post-COVID condition (PCC), continue to impact many individuals years after the COVID-19 pandemic began. ...While significant progress has been ma …
BACKGROUND: Persistent symptoms extending beyond the acute phase of SARS-CoV-2 infection, known as Post-COVID condition …
Proteomic Signatures of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Narrative Review.
Dourdouna MM, Tatsi EB, Syriopoulou V, Michos A. Dourdouna MM, et al. Children (Basel). 2024 Sep 26;11(10):1174. doi: 10.3390/children11101174. Children (Basel). 2024. PMID: 39457139 Free PMC article. Review.
RESULTS: We identified 15 studies and summarized their key proteomic findings. These studies investigated the serum or plasma proteome of MIS-C patients using MS, Proximity Extension, or Aptamer-based assays. The studies associated the proteomic profil …
RESULTS: We identified 15 studies and summarized their key proteomic findings. These studies investigated the serum or plasma prot …
Reactive Astrocytosis-A Potential Contributor to Increased Suicide in Long COVID-19 Patients?
Costanza A, Amerio A, Aguglia A, Rossi M, Parise A, Magnani L, Serafini G, Amore M, Martins D, Nguyen KD. Costanza A, et al. Brain Sci. 2024 Sep 27;14(10):973. doi: 10.3390/brainsci14100973. Brain Sci. 2024. PMID: 39451987 Free PMC article. Review.
Astrocyte-related circulating markers were increased in depressed subjects and, to a less consistent extent, in COVID-19 patients. Furthermore, reactive astrocytosis was observed in subjects with SI/SB and those with COVID-19. ...As such, the fo …
Astrocyte-related circulating markers were increased in depressed subjects and, to a less consistent extent, in COVID-19 pa …
Type 2 Diabetes Mellitus Aggravates Complement Dysregulation and Affects Cortisol Response in Patients with Post-COVID-19.
Ji W, Xie X, Bai G, Fan Y, He Y, Zhang L, Zhou H, Li L, Qiang D, Li H. Ji W, et al. Diabetes Metab Syndr Obes. 2024 Oct 19;17:3849-3861. doi: 10.2147/DMSO.S480457. eCollection 2024. Diabetes Metab Syndr Obes. 2024. PMID: 39449862 Free PMC article.
PURPOSE: COVID-19 viral infection results in dysregulation of the complement system and a decrease in cortisol and adrenocorticotropin hormone (ACTH) levels. This study aimed to explore the complement system, as well as cortisol and ACTH responses in patients …
PURPOSE: COVID-19 viral infection results in dysregulation of the complement system and a decrease in cortisol and adrenocorti …
Deep phenotyping of pulmonary edema and pulmonary vascular permeability in COVID-19 ARDS.
Schippers JR, Atmowihardjo LN, Duijvelaar E, Knaap LG, Netea MG, Meijboom LJ, Bos LDJ, Bogaard HJ, Aman J. Schippers JR, et al. Am J Physiol Lung Cell Mol Physiol. 2025 Jan 1;328(1):L30-L40. doi: 10.1152/ajplung.00196.2024. Epub 2024 Oct 22. Am J Physiol Lung Cell Mol Physiol. 2025. PMID: 39437755 Free article.
Our aim was to phenotype pulmonary edema and pulmonary vascular permeability in patients with coronavirus disease 2019 (COVID-19) ARDS. Transpulmonary thermodilution measurements were conducted in 65 patients with COVID-19 ARDS on …
Our aim was to phenotype pulmonary edema and pulmonary vascular permeability in patients with coronavirus disease 2019 (COV …
Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19.
Jernbom AF, Skoglund L, Pin E, Sjöberg R, Tegel H, Hober S, Rostami E, Rasmusson A, Cunningham JL, Havervall S, Thålin C, Månberg A, Nilsson P. Jernbom AF, et al. Nat Commun. 2024 Oct 17;15(1):8941. doi: 10.1038/s41467-024-53356-5. Nat Commun. 2024. PMID: 39414823 Free PMC article.
Autoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. We investigated the new-onset autoantibody repertoire in 525 healthcare workers and hospitalized COVID-19 patients at f …
Autoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. …
Unveiling unique effector function-related bulk antibody profiles in long-term hemodialysis patients following COVID-19 mRNA booster vaccination.
Chou CY, Cheng CY, Lee CH, Kuro-O M, Chen TH, Wang SY, Chuang YK, Yang YJ, Lin YH, Tsai IL. Chou CY, et al. J Microbiol Immunol Infect. 2025 Feb;58(1):27-37. doi: 10.1016/j.jmii.2024.09.007. Epub 2024 Oct 1. J Microbiol Immunol Infect. 2025. PMID: 39395903 Free article.
BACKGROUND: Hemodialysis patients exhibit a reduced response to vaccination and have different vaccine dose regimens. ...Therefore, we aimed to analyze the antibody glycosylation profiles in hemodialysis patients who were vaccinated against severe acute …
BACKGROUND: Hemodialysis patients exhibit a reduced response to vaccination and have different vaccine dose regimens. ...Therefore, w …
Synergistic evolution: The dynamic adaptation of SARS-CoV-2 and human protective immunity in the real world.
Li Y, Zhang X, Yi J, Chen Y, Liang J, Wang L, Ma J, Zhu R, Zhang X, Hu D, Jia Y, Yu X, Wang Y. Li Y, et al. J Infect. 2024 Dec;89(6):106310. doi: 10.1016/j.jinf.2024.106310. Epub 2024 Oct 10. J Infect. 2024. PMID: 39393556 Free article.
OBJECTIVES: SARS-CoV-2 is continually evolving with new variants to evade protective immunity and cause new infections. ...RESULTS: In the initial wave of the COVID-19 pandemic, >75% of the patients demonstrated robust NAb responses ag …
OBJECTIVES: SARS-CoV-2 is continually evolving with new variants to evade protective immunity and cause new infections. …
Peculiarities of Hemostasis and Proteomics in Patients With Acute Myocardial Infarction and Healthy Volunteers After SARS-CV-2 Infection.
Kalinskaya AI, Elizarova AK, Anisimova AS, Vorobyeva DA, Rusakovich GI, Maryukhnich EV, Dukhin OA, Ivanova OI, Bugrova AE, Brzhozovskiy AG, Indeykina MI, Kononikhin AS, Nikolaev EN, Vasilieva EY. Kalinskaya AI, et al. Kardiologiia. 2024 Sep 30;64(9):58-69. doi: 10.18087/cardio.2024.9.n2752. Kardiologiia. 2024. PMID: 39392268 English, Russian.
MATERIAL AND METHODS: The study included patients with AMI who have recently had COVID-19 (AMI-post-COVID, n=56) and patients with AMI who have not recently had COVID-19 (AMI-control, n=141). ...This may be due to long-term chronic inflam …
MATERIAL AND METHODS: The study included patients with AMI who have recently had COVID-19 (AMI-post-COVID, n=56) and …
Circulating Proteins Associated with Anti-IL6 Receptor Therapeutic Resistance in the Sera of Patients with Severe COVID-19.
Michot JM, Dozio V, Rohmer J, Pommeret F, Roumier M, Yu H, Sklodowki K, Danlos FX, Ouali K, Kishazi E, Naigeon M, Griscelli F, Gachot B, Groh M, Bacciarello G, Stoclin A, Willekens C, Sakkal M, Bayle A, Zitvogel L, Silvin A, Soria JC, Barlesi F, Beeler K, André F, Vasse M, Chaput N, Ackermann F, Escher C, Marabelle A. Michot JM, et al. J Proteome Res. 2024 Nov 1;23(11):5001-5015. doi: 10.1021/acs.jproteome.2c00422. Epub 2024 Oct 1. J Proteome Res. 2024. PMID: 39352225
The outcomes of patients with COVID-19 and acute respiratory distress syndrome triggered by the SARS-CoV2 virus remain uncertain. Tocilizumab is an anti-interleukin-6 treatment that exerts encouraging clinical activity by controlling the …
The outcomes of patients with COVID-19 and acute respiratory distress syndrome triggered by the SARS-CoV2 …
Cerebral small vessel injury in mice with damage to ACE2-expressing cerebral vascular endothelial cells and post COVID-19 patients.
Lu J, Zuo X, Cai A, Xiao F, Xu Z, Wang R, Miao C, Yang C, Zheng X, Wang J, Ding X, Xiong W. Lu J, et al. Alzheimers Dement. 2024 Nov;20(11):7971-7988. doi: 10.1002/alz.14279. Epub 2024 Oct 1. Alzheimers Dement. 2024. PMID: 39352003 Free PMC article.
DISCUSSION: Our findings suggest that SARS-CoV-2 may induce cerebral small vessel damage with persistent sequelae, underscoring the imperative for heightened clinical vigilance in mitigating or treating SARS-CoV-2-mediated cerebral …
DISCUSSION: Our findings suggest that SARS-CoV-2 may induce cerebral small vessel damage with persistent sequelae, unde …
Acute estradiol and progesterone therapy in hospitalized adults to reduce COVID-19 severity: a randomized control trial.
Lovre D, Qadir MMF, Bateman K, Saltzman LY, Sherman M, Mauvais-Jarvis F. Lovre D, et al. Sci Rep. 2024 Sep 30;14(1):22732. doi: 10.1038/s41598-024-73263-5. Sci Rep. 2024. PMID: 39349554 Free PMC article. Clinical Trial.
COVID-19 outcomes are less severe in women than men suggesting that female sex is protective. ...The E2P4 group exhibited a decrease in biomarker pathways of respiratory and gastrointestinal disease inflammation, infection by coronavirus, and immune cell traf …
COVID-19 outcomes are less severe in women than men suggesting that female sex is protective. ...The E2P4 group exhibited a de …
Mortality Risk and Urinary Proteome Changes in Acute COVID-19 Survivors in the Multinational CRIT-COV-U Study.
Siwy J, Keller F, Banasik M, Peters B, Dudoignon E, Mebazaa A, Gülmez D, Spasovski G, Lazo MS, Rajzer MW, Fuławka Ł, Dzitkowska-Zabielska M, Mischak H, Hecking M, Beige J, Wendt R, UriCoV Working Group. Siwy J, et al. Biomedicines. 2024 Sep 13;12(9):2090. doi: 10.3390/biomedicines12092090. Biomedicines. 2024. PMID: 39335603 Free PMC article.
Therefore, within this study, the mortality risk post-acute COVID-19 in the CRIT-COV-U cohort was investigated. METHODS: Survival data from 651 patients that survived an acute phase of COVID-19 were retrieved and the association between u …
Therefore, within this study, the mortality risk post-acute COVID-19 in the CRIT-COV-U cohort was investigated. METHODS …
Potential Plasma Proteins (LGALS9, LAMP3, PRSS8 and AGRN) as Predictors of Hospitalisation Risk in COVID-19 Patients.
McLarnon T, McDaid D, Lynch SM, Cooper E, McLaughlin J, McGilligan VE, Watterson S, Shukla P, Zhang SD, Bucholc M, English A, Peace A, O'Kane M, Kelly M, Bhavsar M, Murray EK, Gibson DS, Walsh CP, Bjourson AJ, Rai TS. McLarnon T, et al. Biomolecules. 2024 Sep 17;14(9):1163. doi: 10.3390/biom14091163. Biomolecules. 2024. PMID: 39334929 Free PMC article.
Background: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has posed unprecedented challenges to healthcare systems worldwide. ...Methods: We investigated the proteomic and genomic profile of COVID-19 …
Background: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has posed unprecede …
Sulfated Bile Acids in Serum as Potential Biomarkers of Disease Severity and Mortality in COVID-19.
Porru E, Comito R, Interino N, Cerrato A, Contoli M, Rizzo P, Conti M, Campo G, Spadaro S, Caliceti C, Marini F, Capriotti AL, Laganà A, Roda A. Porru E, et al. Cells. 2024 Sep 19;13(18):1576. doi: 10.3390/cells13181576. Cells. 2024. PMID: 39329758 Free PMC article.
The fight against coronavirus disease 2019 (COVID-19) continues. Since the pandemic's onset, several biomarkers have been proposed to assess the diagnosis and prognosis of this disease. This research aimed to identify potential disease severity biomarkers in …
The fight against coronavirus disease 2019 (COVID-19) continues. Since the pandemic's onset, several biomarkers have be …
Alterations in the plasma proteome persist ten months after recovery from mild to moderate SARS-CoV-2 infection.
Huapaya JA, Gairhe S, Kanth S, Tian X, Demirkale CY, Regenold D, Sun J, Lynch NF, Luo R, Forsberg A, Dewar R, Rehman T, Li W, Krack J, Kuruppu J, Aboye EA, Barnett C, Strich JR, Davey R, Childs R, Chertow D, Kovacs JA, Torabi-Parizi P, Suffredini AF. Huapaya JA, et al. Front Immunol. 2024 Sep 11;15:1448780. doi: 10.3389/fimmu.2024.1448780. eCollection 2024. Front Immunol. 2024. PMID: 39324144 Free PMC article.
BACKGROUND: Limited data are available describing the effects of SARS-CoV-2 breakthrough infections on the plasma proteome. METHODS: PCR-positive SARS-CoV-2 patients, enrolled in a natural history study, underwent analysis o …
BACKGROUND: Limited data are available describing the effects of SARS-CoV-2 breakthrough infections on the plasma pr …
Targeted MRM-analysis of plasma proteins in frozen whole blood samples from patients with COVID-19: a retrospective study.
Bugrova AE, Strelnikova PA, Kononikhin AS, Zakharova NV, Diyachkova EO, Brzhozovskiy AG, Indeykina MI, Kurochkin IN, Averyanov AV, Nikolaev EN. Bugrova AE, et al. Clin Chem Lab Med. 2024 Sep 26. doi: 10.1515/cclm-2024-0800. Online ahead of print. Clin Chem Lab Med. 2024. PMID: 39321553 Free article.
A total of 131 samples (FRCC, Russia) from patients with mild (n=41), moderate (n=39) and severe (n=19) COVID-19 infection and healthy controls (n=32) were analyzed. ...The best-performing classifier built with 10 proteins achieved the best combination of ROC …
A total of 131 samples (FRCC, Russia) from patients with mild (n=41), moderate (n=39) and severe (n=19) COVID-19 infect …
Proteomics of blood extracellular vesicles in inflammatory respiratory diseases for biomarker discovery and new insights into pathophysiology.
Kawasaki T, Takeda Y, Kumanogoh A. Kawasaki T, et al. Inflamm Regen. 2024 Sep 18;44(1):38. doi: 10.1186/s41232-024-00351-4. Inflamm Regen. 2024. PMID: 39294831 Free PMC article. Review.
Blood EVs offer advantages over traditional serum or plasma samples. Proteomic analyses of blood EVs have revealed numerous biomarkers that can be used to stratify patients, predict disease progression, and identify candidate therapeutic targets. ...Moreover, EVs pl …
Blood EVs offer advantages over traditional serum or plasma samples. Proteomic analyses of blood EVs have revealed numerous biomarker …
Monitoring SARS-CoV-2 IgA, IgM and IgG antibodies in dried blood and saliva samples using antibody proximity extension assays (AbPEA).
Wang M, Kamali-Moghaddam M, Löf L, Cortabarría Fernandez M, Díaz Codina R, Sterky FH, Åberg M, Landegren U, Zhao H. Wang M, et al. Sci Rep. 2024 Sep 17;14(1):21655. doi: 10.1038/s41598-024-72453-5. Sci Rep. 2024. PMID: 39289450 Free PMC article.
Using a modified proximity extension assay, total and immunoglobulin (Ig) class-specific anti-SARS-CoV-2 antibodies were sensitively and conveniently detected directly from o1.2 mm discs cut from dried blood and saliva spots (DBS and DSS) without the need for …
Using a modified proximity extension assay, total and immunoglobulin (Ig) class-specific anti-SARS-CoV-2 antibodies wer …
No signs of mast cell involvement in long-COVID: A case-control study.
Lenning OB, Jonsson G, Grimstad T, Janssen EAM, Braut GS, Berven F, Omdal R. Lenning OB, et al. Scand J Immunol. 2024 Nov;100(5):e13407. doi: 10.1111/sji.13407. Epub 2024 Sep 16. Scand J Immunol. 2024. PMID: 39285602 Free article.
Long-COVID caused by SARS-CoV-2 infection has significant and increasing effects on human health worldwide. ...Involvement of mast cells-evolutionary old "multipurpose" innate immune cells-was reported recently in studies of acute infection and post-acute- …
Long-COVID caused by SARS-CoV-2 infection has significant and increasing effects on human health worldwide. ...Involvem …
Molecular targets in SARS-CoV-2 infection: An update on repurposed drug candidates.
Rahmani D, Jafari A, Kesharwani P, Sahebkar A. Rahmani D, et al. Pathol Res Pract. 2024 Nov;263:155589. doi: 10.1016/j.prp.2024.155589. Epub 2024 Sep 8. Pathol Res Pract. 2024. PMID: 39276508 Review.
The 2019 widespread contagion of the human coronavirus novel type (SARS-CoV-2) led to a pandemic declaration by the World Health Organization. A daily increase in patient numbers has formed an urgent necessity to find suitable targets and treatm …
The 2019 widespread contagion of the human coronavirus novel type (SARS-CoV-2) led to a pandemic declaration by …
Potential immunomodulatory effects of CAS+IMD monoclonal antibody cocktail in hospitalized patients with COVID-19.
Wang B, Golubov J, Oswald EM, Poon P, Wei Q, Lett C, Shehadeh F, Kaczynski M, Felix LO, Mishra B, Mylona EK, Wipperman MF, Chio E, Hamon SC, Hooper AT, Somersan-Karakaya S, Musser BJ, Petro CD, Hamilton JD, Sleeman MA, Kalliolias GD, Mylonakis E, Skokos D. Wang B, et al. EBioMedicine. 2024 Oct;108:105334. doi: 10.1016/j.ebiom.2024.105334. Epub 2024 Sep 12. EBioMedicine. 2024. PMID: 39270622 Free PMC article.
BACKGROUND: Passive administration of SARS-CoV-2 neutralizing monoclonal antibodies (mAbs), such as CAS + IMD (Casirivimab + Imdevimab) antibody cocktail demonstrated beneficial effects on clinical outcomes in hospitalized patients with COVID …
BACKGROUND: Passive administration of SARS-CoV-2 neutralizing monoclonal antibodies (mAbs), such as CAS + IMD (Casirivi …
Increased mortality in hospital- compared to community-onset carbapenem-resistant enterobacterales infections.
Boutzoukas AE, Mackow N, Giri A, Komarow L, Hill C, Chen L, Doi Y, Satlin MJ, Arias C, Wang M, Mora Moreo L, Herc E, Cober E, Weston G, Patel R, Bonomo RA, Fowler V, van Duin D. Boutzoukas AE, et al. J Antimicrob Chemother. 2024 Nov 4;79(11):2916-2922. doi: 10.1093/jac/dkae306. J Antimicrob Chemother. 2024. PMID: 39236214 Free PMC article.
BACKGROUND: The CDC reported a 35% increase in hospital-onset (HO) carbapenem-resistant Enterobacterales (CRE) infections during the COVID-19 pandemic. We evaluated patient outcomes following HO and community-onset (CO) CRE bloodstream infections (BSI). ...Th …
BACKGROUND: The CDC reported a 35% increase in hospital-onset (HO) carbapenem-resistant Enterobacterales (CRE) infections during the COVI …
Molecular fingerprint by omics-based approaches in saliva from patients affected by SARS-CoV-2 infection.
Pinto G, Gelzo M, Cernera G, Esposito M, Illiano A, Serpico S, Pinchera B, Gentile I, Castaldo G, Amoresano A. Pinto G, et al. J Mass Spectrom. 2024 Sep;59(9):e5082. doi: 10.1002/jms.5082. J Mass Spectrom. 2024. PMID: 39228271
Clinical expression of coronavirus disease 2019 (COVID-19) infectionis widely variable including fatal cases and patients with mild symptoms and a rapid resolution. ...In fact, on a total of 28 peptides, 22 (80%) were differently expressed in …
Clinical expression of coronavirus disease 2019 (COVID-19) infectionis widely variable including fatal cases and …
Plasma proteomics of acute tubular injury.
Schmidt IM, Surapaneni AL, Zhao R, Upadhyay D, Yeo WJ, Schlosser P, Huynh C, Srivastava A, Palsson R, Kim T, Stillman IE, Barwinska D, Barasch J, Eadon MT, El-Achkar TM, Henderson J, Moledina DG, Rosas SE, Claudel SE, Verma A, Wen Y, Lindenmayer M, Huber TB, Parikh SV, Shapiro JP, Rovin BH, Stanaway IB, Sathe NA, Bhatraju PK, Coresh J; Kidney Precision Medicine Project; Rhee EP, Grams ME, Waikar SS. Schmidt IM, et al. Nat Commun. 2024 Aug 27;15(1):7368. doi: 10.1038/s41467-024-51304-x. Nat Commun. 2024. PMID: 39191768 Free PMC article.
Non-invasive biomarkers of ATI may allow for early detection and drug development. Using the SomaScan proteomics platform on 434 patients with biopsy-confirmed kidney disease, we here identify plasma biomarkers associated with ATI severity. ...Additionally, we exami …
Non-invasive biomarkers of ATI may allow for early detection and drug development. Using the SomaScan proteomics platform on 434 p …
Multi-modal immune dynamics of pre-COVID-19 Kawasaki Disease following intravenous immunoglobulin.
Cotugno N, Olivieri G, Pascucci GR, Amodio D, Morrocchi E, Pighi C, Manno EC, Rotulo GA, D'Anna C, Chinali M, Tarissi de Jacobis I, Buonsenso D, Villani A, Rossi P, Marchesi A, Palma P. Cotugno N, et al. Clin Immunol. 2024 Oct;267:110349. doi: 10.1016/j.clim.2024.110349. Epub 2024 Aug 24. Clin Immunol. 2024. PMID: 39186994 Free article.
To characterize this condition, plasma proteomic profiles, flow cytometry, and gene expression of T cell subsets were investigated in longitudinal samples from KD patients and compared with two control groups. ...APBB1IP demonstrated an association with coronary art …
To characterize this condition, plasma proteomic profiles, flow cytometry, and gene expression of T cell subsets were investigated in …
Identification of biomarkers for COVID-19 associated secondary hemophagocytic lymphohistiocytosis.
Canny SP, Stanaway IB, Holton SE, Mitchem M, O'Rourke AR, Pribitzer S, Baxter SK, Wurfel MM, Malhotra U, Buckner JH, Bhatraju PK, Morrell ED, Speake C, Mikacenic C, Hamerman JA. Canny SP, et al. bioRxiv [Preprint]. 2024 Aug 15:2024.08.13.607855. doi: 10.1101/2024.08.13.607855. bioRxiv. 2024. Update in: Crit Care Explor. 2025 Jan 31;7(2):e1203. doi: 10.1097/CCE.0000000000001203. PMID: 39185173 Free PMC article. Updated. Preprint.
DESIGN: In two cohorts of adult patients presenting with COVID-19 in 2020 and 2021, clinical lab values and serum proteomics were assessed. ...SETTING: Two tertiary care hospitals in Seattle, Washington (Virginia Mason Medical Center and Harborv …
DESIGN: In two cohorts of adult patients presenting with COVID-19 in 2020 and 2021, clinical lab values and seru …
Alterations in plasma proteome during acute COVID-19 and recovery.
Suski M, Olszanecka A, Stachowicz A, Kiepura A, Terlecki M, Madej J, Rajzer M, Olszanecki R. Suski M, et al. Mol Med. 2024 Aug 25;30(1):131. doi: 10.1186/s10020-024-00898-5. Mol Med. 2024. PMID: 39183264 Free PMC article.
METHODS: The presented study investigates temporal changes in plasma proteins in COVID-19 patients during hospitalization due to SARS-CoV-2 infection and six months after recovery by targeted SureQuant acquisition using PQ500 panel. ...Fu …
METHODS: The presented study investigates temporal changes in plasma proteins in COVID-19 patients during hospitalizati …
Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation.
Cieri N, Hookeri N, Stromhaug K, Li L, Keating J, Díaz-Fernández P, Gómez-García de Soria V, Stevens J, Kfuri-Rubens R, Shao Y, Kooshesh KA, Powell K, Ji H, Hernandez GM, Abelin J, Klaeger S, Forman C, Clauser KR, Sarkizova S, Braun DA, Penter L, Kim HT, Lane WJ, Oliveira G, Kean LS, Li S, Livak KJ, Carr SA, Keskin DB, Muñoz-Calleja C, Ho VT, Ritz J, Soiffer RJ, Neuberg D, Stewart C, Getz G, Wu CJ. Cieri N, et al. Nat Biotechnol. 2025 Jun;43(6):971-982. doi: 10.1038/s41587-024-02348-3. Epub 2024 Aug 21. Nat Biotechnol. 2025. PMID: 39169264
Despite the crucial role of mHAgs in graft-versus-leukemia (GvL) and graft-versus-host disease (GvHD) reactions, it remains challenging to consistently link patient-specific mHAg repertoires to clinical outcomes. Here we devise an analytic framework to systematicall …
Despite the crucial role of mHAgs in graft-versus-leukemia (GvL) and graft-versus-host disease (GvHD) reactions, it remains challenging to c …
Interferon gene expression declines over time post-COVID infection and in long COVID patients.
Gómez-Carballa A, Pischedda S, Pardo-Seco J, Gómez-Rial J, Martinón-Torres F, Salas A. Gómez-Carballa A, et al. Infect Dis (Lond). 2025 Jan;57(1):35-48. doi: 10.1080/23744235.2024.2389481. Epub 2024 Aug 20. Infect Dis (Lond). 2025. PMID: 39163143 Free article.
It has been shown that an impaired and uncontrolled release of these glycoproteins can result in tissue damage and explain severe progression of coronavirus disease 2019 (COVID-19). However, their potential role in Long-COVID syndrome (LC) remains debateable. …
It has been shown that an impaired and uncontrolled release of these glycoproteins can result in tissue damage and explain severe progressio …
Deep Plasma Proteomics with Data-Independent Acquisition: Clinical Study Protocol Optimization with a COVID-19 Cohort.
Ward B, Pyr Dit Ruys S, Balligand JL, Belkhir L, Cani PD, Collet JF, De Greef J, Dewulf JP, Gatto L, Haufroid V, Jodogne S, Kabamba B, Lingurski M, Yombi JC, Vertommen D, Elens L. Ward B, et al. J Proteome Res. 2024 Sep 6;23(9):3806-3822. doi: 10.1021/acs.jproteome.4c00104. Epub 2024 Aug 19. J Proteome Res. 2024. PMID: 39159935 Free PMC article.
Here, we highlight the efficacy of combining moderate plasma prefractionation and data-independent acquisition (DIA) to significantly improve proteome coverage and depth while remaining cost-efficient. Using human plasma collected from a 20-patient COVID-1 …
Here, we highlight the efficacy of combining moderate plasma prefractionation and data-independent acquisition (DIA) to significantly improv …
High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases.
Jia X, Crawford JC, Gebregzabher D, Monson EA, Mettelman RC, Wan Y, Ren Y, Chou J, Novak T, McQuilten HA, Clarke M, Bachem A, Foo IJ, Fritzlar S, Carrera Montoya J, Trenerry AM, Nie S, Leeming MG, Nguyen THO, Kedzierski L, Littler DR, Kueh A, Cardamone T, Wong CY, Hensen L, Cabug A, Laguna JG, Agrawal M, Flerlage T, Boyd DF, Van de Velde LA, Habel JR, Loh L, Koay HF, van de Sandt CE, Konstantinov IE, Berzins SP, Flanagan KL, Wakim LM, Herold MJ, Green AM, Smallwood HS, Rossjohn J, Thwaites RS, Chiu C, Scott NE, Mackenzie JM, Bedoui S, Reading PC, Londrigan SL, Helbig KJ, Randolph AG, Thomas PG, Xu J, Wang Z, Chua BY, Kedzierska K. Jia X, et al. Cell. 2024 Aug 22;187(17):4586-4604.e20. doi: 10.1016/j.cell.2024.07.026. Epub 2024 Aug 12. Cell. 2024. PMID: 39137778 Free article.
Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized with avian A(H7N9) influenza, we investigated early drivers underpinning fatal disease. Transcriptomics strongly lin …
Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In pa …
Molecular mimicry in multisystem inflammatory syndrome in children.
Bodansky A, Mettelman RC, Sabatino JJ Jr, Vazquez SE, Chou J, Novak T, Moffitt KL, Miller HS, Kung AF, Rackaityte E, Zamecnik CR, Rajan JV, Kortbawi H, Mandel-Brehm C, Mitchell A, Wang CY, Saxena A, Zorn K, Yu DJL, Pogorelyy MV, Awad W, Kirk AM, Asaki J, Pluvinage JV, Wilson MR, Zambrano LD, Campbell AP; Overcoming COVID-19 Network Investigators; Thomas PG, Randolph AG, Anderson MS, DeRisi JL. Bodansky A, et al. Nature. 2024 Aug;632(8025):622-629. doi: 10.1038/s41586-024-07722-4. Epub 2024 Aug 7. Nature. 2024. PMID: 39112696 Free PMC article.
In parallel, we also probed antibody responses from patients with MIS-C to the complete SARS-CoV-2 proteome and found enriched reactivity against a distinct domain of the SARS-CoV-2 nucleocapsid protein. ...Consequently, we …
In parallel, we also probed antibody responses from patients with MIS-C to the complete SARS-CoV-2 proteome …
Association of caffeine consumption with cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease: A BALTAZAR cohort study.
Blum D, Cailliau E, Béhal H, Vidal JS, Delaby C, Buée L, Allinquant B, Gabelle A, Bombois S, Lehmann S, Schraen-Maschke S, Hanon O; BALTAZAR study group. Blum D, et al. Alzheimers Dement. 2024 Oct;20(10):6948-6959. doi: 10.1002/alz.14169. Epub 2024 Aug 4. Alzheimers Dement. 2024. PMID: 39099181 Free PMC article.
INTRODUCTION: We investigated the link between habitual caffeine intake with memory impairments and cerebrospinal fluid (CSF) biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. METHODS: MCI (N = 147) and AD (N = 116) patients of the …
INTRODUCTION: We investigated the link between habitual caffeine intake with memory impairments and cerebrospinal fluid (CSF) biomarkers in …
Clinical Characteristics and Comparative Proteomics Analysis of COVID-19-Related Atrioventricular Block.
Gao Y, Chen Z, Wu S, Chen R, Dai Y, Zhang S, Chen K. Gao Y, et al. Rev Cardiovasc Med. 2024 May 28;25(6):195. doi: 10.31083/j.rcm2506195. eCollection 2024 Jun. Rev Cardiovasc Med. 2024. PMID: 39076308 Free PMC article.
We aim to describe the baseline characteristics, proteomics profile, and outcomes for patients with COVID-19-related AVB. METHODS: We prospectively recruited patients diagnosed with COVID-19-related AVB between November 2022 and Ma …
We aim to describe the baseline characteristics, proteomics profile, and outcomes for patients with COVID-19-rel …
Coronavirus disease 2019-related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac magnetic resonance imaging abnormalities.
Ćorović A, Zhao X, Huang Y, Newland SR, Gopalan D, Harrison J, Giakomidi D, Chen S, Yarkoni NS, Wall C, Peverelli M, Sriranjan R, Gallo A, Graves MJ, Sage A, Lyons PA, Sithole N, Bennett MR, Rudd JHF, Mallat Z, Zhao TX, Nus M, Tarkin JM. Ćorović A, et al. Cardiovasc Res. 2024 Nov 25;120(14):1752-1767. doi: 10.1093/cvr/cvae159. Cardiovasc Res. 2024. PMID: 39073768 Free PMC article.
AIMS: While acute cardiovascular complications of coronavirus disease 2019 (COVID-19) are well described, less is known about longer-term cardiac sequelae. For many individuals with cardiac signs or symptoms arising after COVID-19 infection, the …
AIMS: While acute cardiovascular complications of coronavirus disease 2019 (COVID-19) are well described, less is known …
Pulmonary and renal long COVID at two-year revisit.
Wang J, Liang X, Zheng Y, Zhu Y, Zhou K, Wu X, Sun R, Hu Y, Zhu X, Chi H, Chen S, Lyu M, Xie Y, Yi X, Liu W, Cai X, Li S, Zhang Q, Wu C, Shi Y, Wang D, Peng M, Zhang Y, Liu H, Zhang C, Quan S, Kong Z, Kang Z, Zhu G, Zhu H, Chen S, Liang J, Yang H, Pang J, Fang Y, Chen H, Li J, Xu J, Guo T, Shen B. Wang J, et al. iScience. 2024 Jun 21;27(7):110344. doi: 10.1016/j.isci.2024.110344. eCollection 2024 Jul 19. iScience. 2024. PMID: 39055942 Free PMC article.
Pulmonary long COVID, characterized by fibrous stripes, was observed in 8.7% and 17.8% of patients at the 1-year and 2-year revisits, respectively, while renal long COVID was present in 15.2% and 23.9% of patients, respectively. ...This study provides a longitudinal …
Pulmonary long COVID, characterized by fibrous stripes, was observed in 8.7% and 17.8% of patients at the 1-year and 2-year revisits, …
Increased adrenal steroidogenesis and suppressed corticosteroid responsiveness in critical COVID-19.
Wen TZ, Li TR, Chen XY, Chen HY, Wang S, Fu WJ, Xiao SQ, Luo J, Tang R, Ji JL, Huang JF, He ZC, Luo T, Zhao HL, Chen C, Miao JY, Niu Q, Wang Y, Bian XW, Yao XH. Wen TZ, et al. Metabolism. 2024 Nov;160:155980. doi: 10.1016/j.metabol.2024.155980. Epub 2024 Jul 23. Metabolism. 2024. PMID: 39053691 Free article.
BACKGROUND: The effect of coronavirus disease 2019 (COVID-19) on adrenal endocrine metabolism in critically ill patients remains unclear. ...FINDINGS: The demographic characteristics of COVID-19 patients were comparable with those …
BACKGROUND: The effect of coronavirus disease 2019 (COVID-19) on adrenal endocrine metabolism in critically ill pati …
Unbiased plasma profiling using pre-selected RNA aptamer pools predicts mortality in COVID-19 and identifies protein risk factors.
Jørgensen AG, Dupont DM, Fjelstrup S, Bus C, Hansen CB, Benfield T, Garred P, Heegaard PMH, Kjems J. Jørgensen AG, et al. Mol Ther Nucleic Acids. 2024 Jun 15;35(3):102253. doi: 10.1016/j.omtn.2024.102253. eCollection 2024 Sep 10. Mol Ther Nucleic Acids. 2024. PMID: 39049875 Free PMC article.
The impact of the COVID-19 pandemic demands effective prognostic tools for precise risk evaluation and timely intervention. This study utilized the APTASHAPE technology to profile plasma proteins in COVID-19 patient samples. Employing a highly d …
The impact of the COVID-19 pandemic demands effective prognostic tools for precise risk evaluation and timely intervention. Th …
Anti-TNF therapy impairs both short- and long-term IgG responses after repeated vaccination.
Buhre JS, Pongracz T, Geisen UM, Schubert M, Wang W, Nouta J, Obara M, Lehrian S, Rahmöller J, Petry J, Tran F, Schreiber S, Sümbül M, Berner D, Gerdes S, Schirmer J, Longardt AC, Hoff P, Kalinke U, Ludwig RJ, Bartsch YC, Hoyer BF, Wuhrer M, Ehlers M. Buhre JS, et al. Allergy. 2025 Feb;80(2):423-439. doi: 10.1111/all.16241. Epub 2024 Jul 25. Allergy. 2025. PMID: 39049686 Free PMC article.
Using TriNetX, a global healthcare database, we determined the risk of SARS-CoV-2 breakthrough infections in vaccinated patients treated with anti-TNF or other immunosuppressive drugs. ...Re-activation of potential memory B cells initially generated hi …
Using TriNetX, a global healthcare database, we determined the risk of SARS-CoV-2 breakthrough infections in vaccinated …
Network-based integrative multi-omics approach reveals biosignatures specific to COVID-19 disease phases.
Agamah FE, Ederveen THA, Skelton M, Martin DP, Chimusa ER, 't Hoen PAC. Agamah FE, et al. Front Mol Biosci. 2024 Jul 8;11:1393240. doi: 10.3389/fmolb.2024.1393240. eCollection 2024. Front Mol Biosci. 2024. PMID: 39040605 Free PMC article.
BACKGROUND: COVID-19 disease is characterized by a spectrum of disease phases (mild, moderate, and severe). ...The World Health Organization Ordinal Scale WHO Ordinal Scale was used as a disease severity reference to harmonize COVID-19 patient m …
BACKGROUND: COVID-19 disease is characterized by a spectrum of disease phases (mild, moderate, and severe). ...The World Healt …
Blood proteomics of COVID-19 infection: An update.
Alexovič M, Bondarchuk T, Uličná C, Sabo J. Alexovič M, et al. Clin Chim Acta. 2024 Aug 15;562:119881. doi: 10.1016/j.cca.2024.119881. Epub 2024 Jul 19. Clin Chim Acta. 2024. PMID: 39033952 Review.
Despite significant progress in understanding SARS-CoV-2 and its impact, a deeper comprehension of the molecular changes in the host following infection is still lacking. Proteomic analysis of COVID-19 infected patients can provide …
Despite significant progress in understanding SARS-CoV-2 and its impact, a deeper comprehension of the molecular change …
Molecular overlaps of neurological manifestations of COVID-19 and schizophrenia from a proteomic perspective.
Antunes ASLM, Reis-de-Oliveira G, Martins-de-Souza D. Antunes ASLM, et al. Eur Arch Psychiatry Clin Neurosci. 2025 Feb;275(1):109-122. doi: 10.1007/s00406-024-01842-8. Epub 2024 Jul 19. Eur Arch Psychiatry Clin Neurosci. 2025. PMID: 39028452
In addition, clinical evidence indicates that a diagnosis of a schizophrenia spectrum disorder is a risk factor for mortality in patients with COVID-19. ...Specifically, the COVID-19 brain proteome enriches processes that are hallm …
In addition, clinical evidence indicates that a diagnosis of a schizophrenia spectrum disorder is a risk factor for mortality in p …
Changes in neuroinflammatory biomarkers correlate with disease severity and neuroimaging alterations in patients with COVID-19 neurological complications.
Barros-Aragão FGQ, Pinto TP, Carregari VC, Rezende NBS, Pinheiro TL, Reis-de-Oliveira G, Cabral-Castro MJ, Queiroz DC, Fonseca PLC, Gonçalves AL, de Freitas GR, Sudo FK, Mattos P, Bozza FA, Rodrigues EC, Aguiar RS, Rodrigues RS, Brandão CO, Souza AS, Martins-de-Souza D, De Felice FG, Tovar-Moll F. Barros-Aragão FGQ, et al. Brain Behav Immun Health. 2024 Jun 13;39:100805. doi: 10.1016/j.bbih.2024.100805. eCollection 2024 Aug. Brain Behav Immun Health. 2024. PMID: 39022627 Free PMC article.
To illuminate possible mechanisms leading to COVID-19 neurological disease, we retrospectively investigated in detail a cohort of 35 COVID-19 mild and severe hospitalized patients presenting neurological alterations subject to clinically …
To illuminate possible mechanisms leading to COVID-19 neurological disease, we retrospectively investigated in detail a cohort …
Polymyalgia Rheumatica Following Respiratory Syncytial Virus (RSV) Vaccination.
El Labban M, Oluic S, Guleid H, Hassan M, Diab R, Rida MA. El Labban M, et al. Eur J Case Rep Intern Med. 2024 Jun 27;11(7):004636. doi: 10.12890/2024_004636. eCollection 2024. Eur J Case Rep Intern Med. 2024. PMID: 38984193 Free PMC article.
Studies have previously linked the onset and relapse of polymyalgia rheumatica symptoms to the influenza and COVID-19 vaccines. The Food and Drug Administration approved the respiratory syncytial virus (RSV) vaccine, which is a recombinant protein vaccine for …
Studies have previously linked the onset and relapse of polymyalgia rheumatica symptoms to the influenza and COVID-19 vacci …
Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19.
Kanth SM, Huapaya JA, Gairhe S, Wang H, Tian X, Demirkale CY, Hou C, Ma J, Kuhns DB, Fink DL, Malayeri A, Turkbey E, Harmon SA, Chen MY, Regenold D, Lynch NF, Ramelli S, Li W, Krack J, Kuruppu J, Lionakis MS, Strich JR, Davey R, Childs R, Chertow DS, Kovacs JA, Parizi PT, Suffredini AF; COVID-ARC Study Group. Kanth SM, et al. Cell Rep Med. 2024 Jul 16;5(7):101642. doi: 10.1016/j.xcrm.2024.101642. Epub 2024 Jul 8. Cell Rep Med. 2024. PMID: 38981485 Free PMC article.
In order to assess homeostatic mechanisms in the lung after COVID-19, changes in the protein signature of bronchoalveolar lavage from 45 patients with mild to moderate disease at three phases (acute, recovery, and convalescent) are evaluated over a year. ...W …
In order to assess homeostatic mechanisms in the lung after COVID-19, changes in the protein signature of bronchoalveolar lava …
Clinical features and multiomics profiles indicate coagulation and platelet dysfunction in COVID-19 viral sepsis.
Xiao Z, Lin M, Song N, Wu X, Hou J, Wang L, Tian X, An C, Dela Cruz CS, Sharma L, Chang D. Xiao Z, et al. iScience. 2024 May 25;27(6):110110. doi: 10.1016/j.isci.2024.110110. eCollection 2024 Jun 21. iScience. 2024. PMID: 38974472 Free PMC article.
Increased cases of sepsis during COVID-19 in the absence of known bacterial pathogens highlighted role of viruses as causative agents of sepsis. In this study, we investigated clinical, laboratory, proteomic, and metabolomic characteristics of viral se …
Increased cases of sepsis during COVID-19 in the absence of known bacterial pathogens highlighted role of viruses as causative …
Extracellular matrix remodelling pathway in peripheral blood mononuclear cells from severe COVID-19 patients: an explorative study.
Murphy SL, Balzer NR, Ranheim T, Sagen EL, Huse C, Bjerkeli V, Michelsen AE, Finbråten AK, Heggelund L, Dyrhol-Riise AM, Tveita A, Holten AR, Trøseid M, Ueland T, Ulas T, Aukrust P, Barratt-Due A, Halvorsen B, Dahl TB. Murphy SL, et al. Front Immunol. 2024 Jun 18;15:1379570. doi: 10.3389/fimmu.2024.1379570. eCollection 2024. Front Immunol. 2024. PMID: 38957465 Free PMC article.
There is a reciprocal relationship between extracellular matrix (ECM) remodelling and inflammation that could be operating in the progression of severe COVID-19. To explore the immune-driven ECM remodelling in COVID-19, we in this explorative study ana …
There is a reciprocal relationship between extracellular matrix (ECM) remodelling and inflammation that could be operating in the progressio …
Sex differences and immune correlates of Long COVID development, persistence, and resolution.
Hamlin RE, Pienkos SM, Chan L, Stabile MA, Pinedo K, Rao M, Grant P, Bonilla H, Holubar M, Singh U, Jacobson KB, Jagannathan P, Maldonado Y, Holmes SP, Subramanian A, Blish CA. Hamlin RE, et al. bioRxiv [Preprint]. 2024 Jun 19:2024.06.18.599612. doi: 10.1101/2024.06.18.599612. bioRxiv. 2024. Update in: Sci Transl Med. 2024 Nov 13;16(773):eadr1032. doi: 10.1126/scitranslmed.adr1032. PMID: 38948732 Free PMC article. Updated. Preprint.
Sex differences have been observed in acute COVID-19 and Long COVID (LC) outcomes, with greater disease severity and mortality during acute infection in males and a greater proportion of females developing LC. ...To investigate the immunologic underpinnings of LC de …
Sex differences have been observed in acute COVID-19 and Long COVID (LC) outcomes, with greater disease severity and mortality …
Molecular mimicry of SARS-COV-2 antigens as a possible natural anti-cancer preventive immunization.
Ragone C, Mauriello A, Cavalluzzo B, Cavalcanti E, Russo L, Manolio C, Mangano S, Cembrola B, Tagliamonte M, Buonaguro L. Ragone C, et al. Front Immunol. 2024 Jun 14;15:1398002. doi: 10.3389/fimmu.2024.1398002. eCollection 2024. Front Immunol. 2024. PMID: 38947322 Free PMC article.
BACKGROUND: In the present study we investigated whether peptides derived from the entire SARS-CoV-2 proteome share homology to TAAs (tumor-associated antigens) and cross-reactive CD8+ T cell can be elicited by the BNT162b2 preventive vaccine or the …
BACKGROUND: In the present study we investigated whether peptides derived from the entire SARS-CoV-2 proteome sh …
An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy.
Pechous RD, Malaviarachchi PA, Banerjee SK, Byrum SD, Alkam DH, Ghaffarieh A, Kurten RC, Kennedy JL, Zhang X. Pechous RD, et al. J Virol. 2024 Jul 23;98(7):e0079424. doi: 10.1128/jvi.00794-24. Epub 2024 Jun 28. J Virol. 2024. PMID: 38940558 Free PMC article.
Coronavirus disease 2019 (COVID-19) has claimed millions of lives since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and lung disease appears the primary cause of …
Coronavirus disease 2019 (COVID-19) has claimed millions of lives since the emergence of severe acute …
Value of a secretomic approach for distinguishing patients with COVID-19 viral pneumonia among patients with respiratory distress admitted to intensive care unit.
Blangy-Letheule A, Vergnaud A, Dupas T, Habert D, Montnach J, Oulehri W, Hassoun D, Denis M, Lecomte J, Persello A, Roquilly A, Courty J, Seve M, Leroux AA, Rozec B, Bourgoin-Voillard S, De Waard M, Lauzier B. Blangy-Letheule A, et al. J Med Virol. 2024 Jun;96(6):e29756. doi: 10.1002/jmv.29756. J Med Virol. 2024. PMID: 38899468
In intensive care units, COVID-19 viral pneumonia patients (VPP) present symptoms similar to those of other patients with Nonviral infection (NV-ICU). ...The objective of this study is to identify the secretomic signatures of VPP with those of NV-ICU. …
In intensive care units, COVID-19 viral pneumonia patients (VPP) present symptoms similar to those of other patients …
A Targeted LC-MRM(3) Proteomic Approach for the Diagnosis of SARS-CoV-2 Infection in Nasopharyngeal Swabs.
Drouin N, Elfrink HL, Boers SA, van Hugten S, Wessels E, de Vries JJC, Groeneveld GH, Miggiels P, Van Puyvelde B, Dhaenens M, Budding AE, Ran L, Masius R, Takats Z, Boogaerds A, Bulters M, Muurlink W, Oostvogel P, Harms AC, van der Lubben M, Hankemeier T. Drouin N, et al. Mol Cell Proteomics. 2024 Jul;23(7):100805. doi: 10.1016/j.mcpro.2024.100805. Epub 2024 Jun 17. Mol Cell Proteomics. 2024. PMID: 38897290 Free PMC article.
Since its first appearance, severe acute respiratory syndrome coronavirus 2 quickly spread around the world and the lack of adequate PCR testing capacities, especially during the early pandemic, led the scientific community to explore new …
Since its first appearance, severe acute respiratory syndrome coronavirus 2 quickly spread around …
Activation of the MAPK network provides a survival advantage during the course of COVID-19-induced sepsis: a real-world evidence analysis of a multicenter COVID-19 Sepsis Cohort.
Witowski A, Palmowski L, Rahmel T, Nowak H, Ehrentraut SF, Putensen C, von Groote T, Zarbock A, Babel N, Anft M, Sitek B, Bracht T, Bayer M, Weber M, Weisheit C, Pfänder S, Eisenacher M, Adamzik M, Katharina R, Koos B, Ziehe D; CovidDataNet.NRW research group. Witowski A, et al. Infection. 2025 Feb;53(1):107-115. doi: 10.1007/s15010-024-02325-7. Epub 2024 Jun 19. Infection. 2025. PMID: 38896372 Free PMC article.
PURPOSE: There is evidence that lower activity of the RAF/MEK/ERK network is associated with positive outcomes in mild and moderate courses of COVID-19. The effect of this cascade in COVID-19 sepsis is still undetermined. Therefore, we tested the hypot …
PURPOSE: There is evidence that lower activity of the RAF/MEK/ERK network is associated with positive outcomes in mild and moderate courses …
Proteomic lung analysis revealed hyper-activation of neutrophil extracellular trap formation in cases of fatal COVID-19.
Song S, Zeng L, Xu J, Shi L, Lu L, Ling Y, Zhang L. Song S, et al. Heliyon. 2024 May 24;10(11):e31878. doi: 10.1016/j.heliyon.2024.e31878. eCollection 2024 Jun 15. Heliyon. 2024. PMID: 38882332 Free PMC article.
The molecular pathology of lung injury in patients with Corona Virus Disease 2019 (COVID-19) remain unclear. In this study, we performed a proteomic study of lung tissues from seven patients with COVID-19, and eight without. ...Fur …
The molecular pathology of lung injury in patients with Corona Virus Disease 2019 (COVID-19) remain unclear. In this st …
Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants.
Maaß H, Ynga-Durand M, Milošević M, Krstanović F, Matešić MP, Žuža I, Jonjić S, Brizić I, Šustić A, Bloos F; SepNet Critical Care Trials Group; Protić A, Čičin-Šain L. Maaß H, et al. Sci Rep. 2024 Jun 13;14(1):13605. doi: 10.1038/s41598-024-64384-y. Sci Rep. 2024. PMID: 38871772 Free PMC article.
The aim of this study was to characterize the systemic cytokine signature of critically ill COVID-19 patients in a high mortality setting aiming to identify biomarkers of severity, and to explore their associations with viral loads and clinical charact …
The aim of this study was to characterize the systemic cytokine signature of critically ill COVID-19 patients in a high …
Long-lasting, biochemically modified mRNA, and its frameshifted recombinant spike proteins in human tissues and circulation after COVID-19 vaccination.
Boros LG, Kyriakopoulos AM, Brogna C, Piscopo M, McCullough PA, Seneff S. Boros LG, et al. Pharmacol Res Perspect. 2024 Jun;12(3):e1218. doi: 10.1002/prp2.1218. Pharmacol Res Perspect. 2024. PMID: 38867495 Free PMC article. Review.
According to the CDC, both Pfizer and Moderna COVID-19 vaccines contain nucleoside-modified messenger RNA (mRNA) encoding the viral spike glycoprotein of severe acute respiratory syndrome caused by corona virus (SARS-CoV-2), administered …
According to the CDC, both Pfizer and Moderna COVID-19 vaccines contain nucleoside-modified messenger RNA (mRNA) encodi …
Plasma taurine level is linked to symptom burden and clinical outcomes in post-COVID condition.
Khoramjoo M, Wang K, Srinivasan K, Gheblawi M, Mandal R, Rousseau S, Wishart D, Prasad V, Richer L, Cheung AM, Oudit GY. Khoramjoo M, et al. PLoS One. 2024 Jun 5;19(6):e0304522. doi: 10.1371/journal.pone.0304522. eCollection 2024. PLoS One. 2024. PMID: 38837993 Free PMC article.
BACKGROUND: A subset of individuals (10-20%) experience post-COVID condition (PCC) subsequent to initial SARS-CoV-2 infection, which lacks effective treatment. PCC carries a substantial global burden associated with negative economic and health impacts. This …
BACKGROUND: A subset of individuals (10-20%) experience post-COVID condition (PCC) subsequent to initial SARS-CoV-2 inf …
Potential Immune-Inflammatory Proteome Biomarkers for Guiding the Treatment of Patients with Primary Acute Angle-Closure Glaucoma Caused by COVID-19.
Gong Q, Fu M, Wang J, Zhao S, Wang H. Gong Q, et al. J Proteome Res. 2024 Jul 5;23(7):2587-2597. doi: 10.1021/acs.jproteome.4c00325. Epub 2024 Jun 5. J Proteome Res. 2024. PMID: 38836775 Free PMC article.
This is the first study to explore the specific inflammatory proteomic landscape in SARS-CoV-2-induced PAACG. The expression of 92 inflammation-related proteins in 19 aqueous humor samples from PAACGs or cataract patients was detected using the …
This is the first study to explore the specific inflammatory proteomic landscape in SARS-CoV-2-induced PAACG. Th …
Exploring the relationship between HCMV serostatus and outcomes in COVID-19 sepsis.
Ziehe D, Wolf A, Rahmel T, Nowak H, Haberl H, Bergmann L, Rump K, Dyck B, Palmowski L, Marko B, Witowski A, Willemsen KM, Pfaender S, Eisenacher M, Anft M, Babel N, Bracht T, Sitek B, Bayer M, Zarbock A, von Groote T, Putensen C, Ehrentraut SF, Weisheit C, Adamzik M, Unterberg M, Koos B. Ziehe D, et al. Front Immunol. 2024 May 8;15:1386586. doi: 10.3389/fimmu.2024.1386586. eCollection 2024. Front Immunol. 2024. PMID: 38779663 Free PMC article.
However, among patients aged 60 years, HCMV seropositivity was significantly higher in COVID-19 sepsis patients compared to controls (86% vs 61%, respectively; p = 0.030). ...DISCUSSION: These findings confirm the association between HCMV seropositivit …
However, among patients aged 60 years, HCMV seropositivity was significantly higher in COVID-19 sepsis patients …
Proteomic snapshot of saliva samples predicts new pathways implicated in SARS-CoV-2 pathogenesis.
Moreno E, Ciordia S, Fátima SM, Jiménez D, Martínez-Sanz J, Vizcarra P, Ron R, Sánchez-Conde M, Bargiela R, Sanchez-Carrillo S, Moreno S, Corrales F, Ferrer M, Serrano-Villar S. Moreno E, et al. Clin Proteomics. 2024 May 22;21(1):37. doi: 10.1186/s12014-024-09482-9. Clin Proteomics. 2024. PMID: 38778280 Free PMC article.
BACKGROUND: Information on the microbiome's human pathways and active members that can affect SARS-CoV-2 susceptibility and pathogenesis in the salivary proteome is very scarce. Here, we studied a unique collection of samples harvested from April to Ju …
BACKGROUND: Information on the microbiome's human pathways and active members that can affect SARS-CoV-2 susceptibility …
A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learning.
Patel MA, Daley M, Van Nynatten LR, Slessarev M, Cepinskas G, Fraser DD. Patel MA, et al. Clin Proteomics. 2024 May 17;21(1):33. doi: 10.1186/s12014-024-09488-3. Clin Proteomics. 2024. PMID: 38760690 Free PMC article.
BACKGROUND: COVID-19 is a complex, multi-system disease with varying severity and symptoms. Identifying changes in critically ill COVID-19 patients' proteomes enables a better understanding of markers associated with susceptibility, sympt …
BACKGROUND: COVID-19 is a complex, multi-system disease with varying severity and symptoms. Identifying changes in critically …
Serum proteomics reveals hemophagocytic lymphohistiocytosis-like phenotype in a subset of patients with multisystem inflammatory syndrome in children.
Tulling AJ, Holierhoek MG, Jansen-Hoogendijk AM, Hoste L, Haerynck F, Tavernier SJ, Oostenbrink R, Buysse CMP, Bannier MAGE, Bekhof J, Breukels M, Hammer SC, Jacobs MAM, Kamps AWA, van der Linden JW, Lebon A, Oudshoorn JH, Tramper-Stranders GA, Vastert SJ, Wieringa JW, Terheggen-Lagro SWJ, Wildenbeest JG, von Asmuth EGJ, van den Akker EB, van Gijn ME, Lugthart G, Buddingh EP. Tulling AJ, et al. Clin Immunol. 2024 Jul;264:110252. doi: 10.1016/j.clim.2024.110252. Epub 2024 May 12. Clin Immunol. 2024. PMID: 38744408 Free article.
We hypothesized that thrombocytopenic MIS-C patients have more features of HLH. Clinical characteristics and routine laboratory parameters were collected from 228 MIS-C patients, of whom 85 (37%) were thrombocytopenic. Thrombocytopenic patients had inc …
We hypothesized that thrombocytopenic MIS-C patients have more features of HLH. Clinical characteristics and routine laborator …
Bioinformation Analysis of Differential Expression Proteins in Different Processes of COVID-19.
Guo N, Han X, Han G, Dai M, Han Z, Li Q. Guo N, et al. Viral Immunol. 2024 May;37(4):194-201. doi: 10.1089/vim.2023.0094. Viral Immunol. 2024. PMID: 38717820
COVID-19 is a highly infectious respiratory disease whose progression has been associated with multiple factors. From SARS-CoV-2 infection to death, biomarkers capable of predicting different disease processes are needed to help us further under …
COVID-19 is a highly infectious respiratory disease whose progression has been associated with multiple factors. From SARS …
Multi-cohort study on cytokine and chemokine profiles in the progression of COVID-19.
Huang C, Hu X, Wang D, Gong R, Wang Q, Ren F, Wu Y, Chen J, Xiong X, Li H, Wang Q, Long G, Zhang D, Han Y. Huang C, et al. Sci Rep. 2024 May 6;14(1):10324. doi: 10.1038/s41598-024-61133-z. Sci Rep. 2024. PMID: 38710800 Free PMC article.
Various substances in the blood plasma serve as prognostic indicators of the progression of COVID-19. Consequently, multi-omics studies, such as proteomic and metabolomics, are ongoing to identify accurate biomarkers. ...To determine the relationship between …
Various substances in the blood plasma serve as prognostic indicators of the progression of COVID-19. Consequently, multi-omic …
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