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446 results

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Page 1
Creatine as a Therapeutic Target in Alzheimer's Disease.
Smith AN, Morris JK, Carbuhn AF, Herda TJ, Keller JE, Sullivan DK, Taylor MK. Smith AN, et al. Curr Dev Nutr. 2023 Sep 29;7(11):102011. doi: 10.1016/j.cdnut.2023.102011. eCollection 2023 Nov. Curr Dev Nutr. 2023. PMID: 37881206 Free PMC article. Review.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, affecting approximately 6.5 million older adults in the United States. ...Impaired brain energy metabolism is another pathological hallmark that precedes the onset of AD that may provid …
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, affecting approximately 6.5 million older adu …
Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition.
Smith AN, Choi IY, Lee P, Sullivan DK, Burns JM, Swerdlow RH, Kelly E, Taylor MK. Smith AN, et al. Alzheimers Dement (N Y). 2025 May 19;11(2):e70101. doi: 10.1002/trc2.70101. eCollection 2025 Apr-Jun. Alzheimers Dement (N Y). 2025. PMID: 40395689 Free PMC article.
BACKGROUND: Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. However, there is currently no clinical evidence demonstrating the effects of CrM in patients with AD. ...TRIAL REGISTRATION: C …
BACKGROUND: Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) …
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A, Loginicheva E, Gilfillan S, Cella M, Virgin HW, Unanue ER, Wang Y, Artyomov MN, Holtzman DM, Colonna M. Ulland TK, et al. Cell. 2017 Aug 10;170(4):649-663.e13. doi: 10.1016/j.cell.2017.07.023. Cell. 2017. PMID: 28802038 Free PMC article.
Elevated risk of developing Alzheimer's disease (AD) is associated with hypomorphic variants of TREM2, a surface receptor required for microglial responses to neurodegeneration, including proliferation, survival, clustering, and phagocytosis. ...Metabolic derailment …
Elevated risk of developing Alzheimer's disease (AD) is associated with hypomorphic variants of TREM2, a surface receptor requ …
Creatine Supplementation and Brain Health.
Roschel H, Gualano B, Ostojic SM, Rawson ES. Roschel H, et al. Nutrients. 2021 Feb 10;13(2):586. doi: 10.3390/nu13020586. Nutrients. 2021. PMID: 33578876 Free PMC article. Review.
This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in c …
This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine suppleme …
Creatine Supplementation and the Brain: Have We Put the Cart Before the Horse?
Candow DG, Pratt J, Fabiano N, Gordji-Nejad A, Smith A, Rawson ES, Moriarty T, Forbes SC, Kerksick CM. Candow DG, et al. J Diet Suppl. 2026;23(2):175-204. doi: 10.1080/19390211.2026.2616440. Epub 2026 Jan 20. J Diet Suppl. 2026. PMID: 41556609 Review.
Creatine is an important regulator of brain bioenergetics, yet the efficacy of creatine supplementation (CrS) in the brain remains largely unknown. ...Emerging clinical data also suggest potential therapeutic effects from CrS for Alzheimer's disease, m …
Creatine is an important regulator of brain bioenergetics, yet the efficacy of creatine supplementation (CrS) in the brain rem …
Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer's disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies.
Song T, Song X, Zhu C, Patrick R, Skurla M, Santangelo I, Green M, Harper D, Ren B, Forester BP, Öngür D, Du F. Song T, et al. Ageing Res Rev. 2021 Dec;72:101503. doi: 10.1016/j.arr.2021.101503. Epub 2021 Oct 29. Ageing Res Rev. 2021. PMID: 34751136 Free PMC article. Review.
Accumulating evidence demonstrates that metabolic changes in the brain associated with neuroinflammation, oxidative stress, and mitochondrial dysfunction play an important role in the pathophysiology of mild cognitive impairment (MCI) and Alzheimer's disease (AD). H …
Accumulating evidence demonstrates that metabolic changes in the brain associated with neuroinflammation, oxidative stress, and mitochondria …
Multi-proteomic analyses of 5xFAD mice reveal new molecular signatures of early-stage Alzheimer's disease.
Lee S, Jang KI, Lee H, Jo YS, Kwon D, Park G, Bae S, Kwon YW, Jang JH, Oh YS, Lee C, Yoon JH. Lee S, et al. Aging Cell. 2024 Jun;23(6):e14137. doi: 10.1111/acel.14137. Epub 2024 Mar 4. Aging Cell. 2024. PMID: 38436501 Free PMC article.
An early diagnosis of Alzheimer's disease is crucial as treatment efficacy is limited to the early stages. However, the current diagnostic methods are limited to mid or later stages of disease development owing to the limitations of clinical examinations and …
An early diagnosis of Alzheimer's disease is crucial as treatment efficacy is limited to the early stages. However, the curren …
Characterization of reduced astrocyte creatine kinase levels in Alzheimer's disease.
Zheng T, Kotol D, Sjöberg R, Mitsios N, Uhlén M, Zhong W, Edfors F, Mulder J. Zheng T, et al. Glia. 2024 Sep;72(9):1590-1603. doi: 10.1002/glia.24569. Epub 2024 Jun 10. Glia. 2024. PMID: 38856187
The creatine-phosphocreatine cycle serves as a crucial temporary energy buffering system in the brain, regulated by brain creatine kinase (CKB), in maintaining Adenosine triphosphate (ATP) levels. Alzheimer's disease (AD) has been linked to increased C …
The creatine-phosphocreatine cycle serves as a crucial temporary energy buffering system in the brain, regulated by brain creatine …
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce.
Sarris J, Ravindran A, Yatham LN, Marx W, Rucklidge JJ, McIntyre RS, Akhondzadeh S, Benedetti F, Caneo C, Cramer H, Cribb L, de Manincor M, Dean O, Deslandes AC, Freeman MP, Gangadhar B, Harvey BH, Kasper S, Lake J, Lopresti A, Lu L, Metri NJ, Mischoulon D, Ng CH, Nishi D, Rahimi R, Seedat S, Sinclair J, Su KP, Zhang ZJ, Berk M. Sarris J, et al. World J Biol Psychiatry. 2022 Jul;23(6):424-455. doi: 10.1080/15622975.2021.2013041. Epub 2022 Mar 21. World J Biol Psychiatry. 2022. PMID: 35311615 Free article.
Monotherapy omega-3 (+/-), folic acid (-), vitamin C (-), tryptophan (+/-), creatine (+/-), inositol (-), magnesium (-), and n-acetyl cysteine (NAC) (+/-) and SAMe (+/-) were not supported for this use. ...
Monotherapy omega-3 (+/-), folic acid (-), vitamin C (-), tryptophan (+/-), creatine (+/-), inositol (-), magnesium (-), and n-acetyl …
Intraventricular Creatine Treatment Attenuates Alzheimer's Disease-Related Neuropathological Changes and Memory Impairment via Inhibiting STAT1 Phosphorylation.
Shao X, Sun J, Wang X, Yin XS, Chen Z, Xu Y, Wang T, Yuan B, Qiu W, Liu F, Chen Y, Ma C. Shao X, et al. ACS Chem Neurosci. 2025 Oct 1;16(19):3790-3800. doi: 10.1021/acschemneuro.5c00475. Epub 2025 Sep 18. ACS Chem Neurosci. 2025. PMID: 40968664
The importance of neuroinflammation in Alzheimer's disease (AD) has attracted increasing attention, and the functions of the STAT1 signaling pathway have also generated widespread interest. ...The alleviation effects of intraventricular creatine in FAD mice m …
The importance of neuroinflammation in Alzheimer's disease (AD) has attracted increasing attention, and the functions of the S …
446 results