Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1931 1
1948 1
1956 1
1962 1
1964 2
1965 1
1966 5
1967 5
1968 6
1969 15
1970 13
1971 10
1972 10
1973 9
1974 8
1975 30
1976 19
1977 9
1978 16
1979 10
1980 17
1981 23
1982 19
1983 22
1984 34
1985 39
1986 33
1987 38
1988 26
1989 44
1990 31
1991 40
1992 40
1993 39
1994 35
1995 38
1996 32
1997 26
1998 30
1999 44
2000 35
2001 39
2002 30
2003 46
2004 39
2005 33
2006 48
2007 47
2008 45
2009 46
2010 47
2011 36
2012 52
2013 53
2014 42
2015 49
2016 57
2017 44
2018 57
2019 37
2020 53
2021 52
2022 60
2023 45
2024 49
2025 54
2026 41

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,913 results

Results by year

Filters applied: . Clear all
Page 1
Effects of Creatine Supplementation on Brain Function and Health.
Forbes SC, Cordingley DM, Cornish SM, Gualano B, Roschel H, Ostojic SM, Rawson ES, Roy BD, Prokopidis K, Giannos P, Candow DG. Forbes SC, et al. Nutrients. 2022 Feb 22;14(5):921. doi: 10.3390/nu14050921. Nutrients. 2022. PMID: 35267907 Free PMC article. Review.
Preliminary studies indicate that creatine supplementation (and guanidinoacetic acid; GAA) has the ability to increase brain creatine content in humans. Furthermore, creatine has shown some promise for attenuating symptoms of concussion, mild traumatic brain …
Preliminary studies indicate that creatine supplementation (and guanidinoacetic acid; GAA) has the ability to increase brain creat …
Creatine Supplementation and Brain Health.
Roschel H, Gualano B, Ostojic SM, Rawson ES. Roschel H, et al. Nutrients. 2021 Feb 10;13(2):586. doi: 10.3390/nu13020586. Nutrients. 2021. PMID: 33578876 Free PMC article. Review.
This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in c …
This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine suppleme …
International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine.
Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, Candow DG, Kleiner SM, Almada AL, Lopez HL. Kreider RB, et al. J Int Soc Sports Nutr. 2017 Jun 13;14:18. doi: 10.1186/s12970-017-0173-z. eCollection 2017. J Int Soc Sports Nutr. 2017. PMID: 28615996 Free PMC article. Review.
Creatine is one of the most popular nutritional ergogenic aids for athletes. Studies have consistently shown that creatine supplementation increases intramuscular creatine concentrations which may help explain the observed improvements in high intensity exerc …
Creatine is one of the most popular nutritional ergogenic aids for athletes. Studies have consistently shown that creatine sup …
Creatine for the Treatment of Depression.
Kious BM, Kondo DG, Renshaw PF. Kious BM, et al. Biomolecules. 2019 Aug 23;9(9):406. doi: 10.3390/biom9090406. Biomolecules. 2019. PMID: 31450809 Free PMC article. Review.
Depressed mood, which can occur in the context of major depressive disorder, bipolar disorder, and other conditions, represents a serious threat to public health and wellness. ...There is growing evidence from human neuroimaging, genetics, epidemiology …
Depressed mood, which can occur in the context of major depressive disorder, bipolar disorder, and other conditi …
Creatine in women's health: bridging the gap from menstruation through pregnancy to menopause.
Smith-Ryan AE, DelBiondo GM, Brown AF, Kleiner SM, Tran NT, Ellery SJ. Smith-Ryan AE, et al. J Int Soc Sports Nutr. 2025 Dec;22(1):2502094. doi: 10.1080/15502783.2025.2502094. Epub 2025 May 15. J Int Soc Sports Nutr. 2025. PMID: 40371844 Free PMC article. Review.
The review also considers the impact of hormonal changes on creatine metabolism and effectiveness as a dietary supplementation. METHODS: This is a narrative overview of historical and recent research evaluating the effects of creatine in women. ...Additionally, c …
The review also considers the impact of hormonal changes on creatine metabolism and effectiveness as a dietary supplementation. METHO …
"Heads Up" for Creatine Supplementation and its Potential Applications for Brain Health and Function.
Candow DG, Forbes SC, Ostojic SM, Prokopidis K, Stock MS, Harmon KK, Faulkner P. Candow DG, et al. Sports Med. 2023 Dec;53(Suppl 1):49-65. doi: 10.1007/s40279-023-01870-9. Epub 2023 Jun 27. Sports Med. 2023. PMID: 37368234 Free PMC article. Review.
There is emerging interest regarding the potential beneficial effects of creatine supplementation on indices of brain health and function. Creatine supplementation can increase brain creatine stores, which may help explain some of the positive effects on meas …
There is emerging interest regarding the potential beneficial effects of creatine supplementation on indices of brain health and func …
Efficacy and safety profile of oral creatine monohydrate in add-on to cognitive-behavioural therapy in depression: An 8-week pilot, double-blind, randomised, placebo-controlled feasibility and exploratory trial in an under-resourced area.
Sherpa NN, De Giorgi R, Ostinelli EG, Choudhury A, Dolma T, Dorjee S. Sherpa NN, et al. Eur Neuropsychopharmacol. 2025 Jan;90:28-35. doi: 10.1016/j.euroneuro.2024.10.004. Epub 2024 Nov 1. Eur Neuropsychopharmacol. 2025. PMID: 39488067 Free article. Clinical Trial.
We calculated effect sizes adjusted for age, sex, and baseline depression score. One-hundred participants (50 females, mean age= 30.4 7.4 years) with depression (mean PHQ-9 = 17.6 6.3) were randomised to either creatine+CBT (N = 50) or placebo+CBT (N = 50 …
We calculated effect sizes adjusted for age, sex, and baseline depression score. One-hundred participants (50 females, mean age= 30.4 …
Creatine supplementation for treating symptoms of depression: a systematic review and meta-analysis.
Eckert I, Lima J, Dariva AA. Eckert I, et al. Br J Nutr. 2025 Dec 14;134(11):947-959. doi: 10.1017/S0007114525105588. Epub 2025 Nov 5. Br J Nutr. 2025. PMID: 41189312
Nutraceuticals are increasingly of interest in nutritional psychiatry, where creatine has been investigated in several randomised trials for its effects on depressive symptoms. ...We conducted a systematic review to assess the effects of creatine supplementat …
Nutraceuticals are increasingly of interest in nutritional psychiatry, where creatine has been investigated in several randomised tri …
Creatine Supplementation and the Brain: Have We Put the Cart Before the Horse?
Candow DG, Pratt J, Fabiano N, Gordji-Nejad A, Smith A, Rawson ES, Moriarty T, Forbes SC, Kerksick CM. Candow DG, et al. J Diet Suppl. 2026;23(2):175-204. doi: 10.1080/19390211.2026.2616440. Epub 2026 Jan 20. J Diet Suppl. 2026. PMID: 41556609 Review.
Creatine is an important regulator of brain bioenergetics, yet the efficacy of creatine supplementation (CrS) in the brain remains largely unknown. ...Emerging clinical data also suggest potential therapeutic effects from CrS for Alzheimer's disease, major depres …
Creatine is an important regulator of brain bioenergetics, yet the efficacy of creatine supplementation (CrS) in the brain rem …
The gut microbiota alleviates depression by remodeling gut-brain energy metabolism.
Lu CL, Ren J, Lei Y, Lian XY, Jiang HT, Guo F, Chen LY, Mo JW, Mao H, Fan J, Wu G, Ye WQ, Wen YL, Sun H, He Y, Zhao J, Cao X. Lu CL, et al. Cell Metab. 2026 Jun 2;38(6):1201-1217.e8. doi: 10.1016/j.cmet.2026.03.002. Epub 2026 Mar 31. Cell Metab. 2026. PMID: 41923613
Although peripheral-brain crosstalk regulates energy metabolism, its role in depression remains unclear. Here, we used metabolic profiling to reveal elevated fecal creatine alongside reduced plasma and cerebrospinal fluid creatine in both patients with dep …
Although peripheral-brain crosstalk regulates energy metabolism, its role in depression remains unclear. Here, we used metabolic prof …
1,913 results