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Page 1
Creatine Supplementation in Women's Health: A Lifespan Perspective.
Smith-Ryan AE, Cabre HE, Eckerson JM, Candow DG. Smith-Ryan AE, et al. Nutrients. 2021 Mar 8;13(3):877. doi: 10.3390/nu13030877. Nutrients. 2021. PMID: 33800439 Free PMC article. Review.
Understanding creatine metabolism pre- and post-menopause yields important implications for creatine supplementation for performance and health among females. ...Creatine supplementation among pre-menopausal females appears to be effective for i …
Understanding creatine metabolism pre- and post-menopause yields important implications for creatine supplementation fo …
Creatine in women's health: bridging the gap from menstruation through pregnancy to menopause.
Smith-Ryan AE, DelBiondo GM, Brown AF, Kleiner SM, Tran NT, Ellery SJ. Smith-Ryan AE, et al. J Int Soc Sports Nutr. 2025 Dec;22(1):2502094. doi: 10.1080/15502783.2025.2502094. Epub 2025 May 15. J Int Soc Sports Nutr. 2025. PMID: 40371844 Free PMC article. Review.
Additionally, creatine may improve mood and cognitive function, potentially alleviating symptoms of depression. Emerging evidence suggests creatine's benefits during pregnancy and post-menopause, though data on perimenopausal women remains limited. ...
Additionally, creatine may improve mood and cognitive function, potentially alleviating symptoms of depression. Emerging evide …
The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial.
Korovljev D, Ostojic J, Panic J, Ranisavljev M, Todorovic N, Nedeljkovic D, Kuzmanovic J, Vranes M, Stajer V, Ostojic SM. Korovljev D, et al. J Am Nutr Assoc. 2026 Mar-Apr;45(3):199-210. doi: 10.1080/27697061.2025.2551184. Epub 2025 Aug 25. J Am Nutr Assoc. 2026. PMID: 40854087 Clinical Trial.
OBJECTIVE: To investigate the effects of an 8-week supplementation with varying doses of creatine hydrochloride, administered alone or in combination with creatine ethyl ester, on cognitive function, clinical outcomes, brain creatine concentrations, an …
OBJECTIVE: To investigate the effects of an 8-week supplementation with varying doses of creatine hydrochloride, administered alone o …
Neurophysiological correlates of subjective cognitive decline in perimenopausal and postmenopausal midlife women at risk for Alzheimer's disease.
Mosconi L, Williams S, Carlton C, Andy C, Fauci F, Zarate C, Boneu C, Ajila T, Nerattini M, Jett S, Battista M, Pahlajani S, Fink ME, Brinton RD, Dyke JP. Mosconi L, et al. Menopause. 2025 May 1;32(5):433-442. doi: 10.1097/GME.0000000000002512. Menopause. 2025. PMID: 40067757
OBJECTIVE: This study aimed to investigate neurophysiological correlates of subjective cognitive decline (SCD) among midlife women at risk for Alzheimer's disease (AD). METHODS: We examined 156 cognitively normal perimenopausal and postmenopausal women aged 40 to 65 …
OBJECTIVE: This study aimed to investigate neurophysiological correlates of subjective cognitive decline (SCD) among midlife women at …
Sex and menopause impact (31)P-Magnetic Resonance Spectroscopy brain mitochondrial function in association with (11)C-PiB PET amyloid-beta load.
Jett S, Dyke JP, Andy C, Schelbaum E, Jang G, Boneu Yepez C, Pahlajani S, Diaz I, Diaz Brinton R, Mosconi L. Jett S, et al. Sci Rep. 2022 Dec 21;12(1):22087. doi: 10.1038/s41598-022-26573-5. Sci Rep. 2022. PMID: 36543814 Free PMC article.
This profile was evident in frontal cortex at the pre-menopausal and peri-menopausal stage and extended to the other regions at the post-menopausal stage (p = 0.001). Results were significant after multi-variable adjustment for age, APOE-4 status, midlife hea …
This profile was evident in frontal cortex at the pre-menopausal and peri-menopausal stage and extended to the other regions a …
Brain creatine, estradiol and neurocognitive complaints in perimenopausal women: an exploratory cross-sectional study.
Ostojic SM, Ostojic J. Ostojic SM, et al. Neurosci Lett. 2026 Jun 15;880:138616. doi: 10.1016/j.neulet.2026.138616. Epub 2026 Apr 28. Neurosci Lett. 2026. PMID: 42061673
Beyond structural alterations, reduced cerebral bioenergetics could underlie the cognitive complaints often reported during this period. Because creatine serves as a key neuronal energy buffer and is influenced by estrogen, this study examined brain creatine …
Beyond structural alterations, reduced cerebral bioenergetics could underlie the cognitive complaints often reported during this peri …
[Effects of estrogen replacement therapy on cognitive function of ovariectomized rats].
Liu X, Wang L, Peng D, Wang Y, Ren M. Liu X, et al. Zhonghua Fu Chan Ke Za Zhi. 2014 Jan;49(1):42-7. Zhonghua Fu Chan Ke Za Zhi. 2014. PMID: 24694917 Chinese.
OBJECTIVE: To investigate the effect of estrogen replacement therapy applied in different periods to ovariectomized rats and to evaluate the cognitive function of the rats. METHODS: Totally 40 rats were ovariectomized to be postmenopausal models. ...CONCLUSION: Earlier est …
OBJECTIVE: To investigate the effect of estrogen replacement therapy applied in different periods to ovariectomized rats and to evaluate the …
Hormone replacement therapy-related changes in the early postmenopausal period (critical window): an in vivo brain proton magnetic resonance spectroscopy study.
Mahmutyazicioğlu K, Beşır FH, Bardakçi M, Tanriverdi HA, Ankarali H. Mahmutyazicioğlu K, et al. Turk J Med Sci. 2014;44(5):853-61. Turk J Med Sci. 2014. PMID: 25539557
Metabolite ratios [N-acetyl aspartate/choline (NAA/Cho), NAA/creatine (Cr), and Cho/Cr] were evaluated. RESULTS: Cho/Cr ratios were significantly increased and NAA/Cho ratios significantly decreased in all 4 regions in the HRT user group compared to the other group after e …
Metabolite ratios [N-acetyl aspartate/choline (NAA/Cho), NAA/creatine (Cr), and Cho/Cr] were evaluated. RESULTS: Cho/Cr ratios were s …
Effects of long-term, low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes.
Yue Y, Hu L, Tian QJ, Jiang JM, Dong YL, Jin ZY, Cheng YH, Hong X, Ge QS, Zuo PP. Yue Y, et al. Acta Pharmacol Sin. 2007 Aug;28(8):1129-35. doi: 10.1111/j.1745-7254.2007.00618.x. Acta Pharmacol Sin. 2007. PMID: 17640473
Proton magnetic resonance spectroscopy was used to detect the biochemical changes in the anterior cingulate cortex and hippocampus in apoE epsilon4 and epsilon3 carriers. Six common cognitive tests were used to make an overall evaluation of cognitive function. RESUL …
Proton magnetic resonance spectroscopy was used to detect the biochemical changes in the anterior cingulate cortex and hippocampus in apoE e …
Evaluation of neuroprotective effects of long-term low dose hormone replacement therapy on postmenopausal women brain hippocampus using magnetic resonance scanner.
Hu L, Yue Y, Zuo PP, Jin ZY, Feng F, You H, Li ML, Ge QS. Hu L, et al. Chin Med Sci J. 2006 Dec;21(4):214-8. Chin Med Sci J. 2006. PMID: 17249194
OBJECTIVE: To investigate the effects of long-term low dose hormone replacement therapy (HRT) on postmenopausal women in hormone level, cognition score, hippocampus volume, and magnetic resonance spectroscopy (MRS) parameters. ...The results of 1H MRS for the subjects with …
OBJECTIVE: To investigate the effects of long-term low dose hormone replacement therapy (HRT) on postmenopausal women in hormone level, c …