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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 1
1948 1
1950 6
1951 1
1953 2
1957 2
1958 1
1959 1
1962 1
1964 2
1971 1
1977 1
1978 1
1979 1
1982 2
1984 2
1985 1
1986 1
1988 2
1989 1
1990 2
1991 3
1992 2
1994 4
1995 4
1996 3
1997 3
1998 3
1999 10
2000 15
2001 9
2002 16
2003 8
2004 25
2005 27
2006 31
2007 36
2008 32
2009 35
2010 62
2011 55
2012 64
2013 83
2014 92
2015 105
2016 106
2017 114
2018 150
2019 127
2020 140
2021 54
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1,267 results
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Clinical Applications of Saffron (Crocus sativus) and its Constituents: A Review.
Moshiri M, Vahabzadeh M, Hosseinzadeh H. Moshiri M, et al. Drug Res (Stuttg). 2015 Jun;65(6):287-95. doi: 10.1055/s-0034-1375681. Epub 2014 May 21. Drug Res (Stuttg). 2015. PMID: 24848002 Review.
Commonly known as saffron, Crocus sativus L and its active components have shown several useful pharmacological effects such as anticonvulsant, antidepressant, anti-inflammatory, antitumor, radical scavenger effects, learning and memory improving effects, etc. ...In …
Commonly known as saffron, Crocus sativus L and its active components have shown several useful pharmacological effects such a …
Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action.
Lopresti AL, Drummond PD. Lopresti AL, et al. Hum Psychopharmacol. 2014 Nov;29(6):517-27. doi: 10.1002/hup.2434. Epub 2014 Sep 22. Hum Psychopharmacol. 2014. PMID: 25384672 Review.
BACKGROUND: Saffron, a spice derived from the flower of Crocus sativus, has now undergone several trials examining its antidepressant effects and, in a recent meta-analysis, was confirmed to be effective for the treatment of major depression. ...
BACKGROUND: Saffron, a spice derived from the flower of Crocus sativus, has now undergone several trials examining its antidep …
Crocus sativus a natural food coloring and flavoring has potent anti-tumor properties.
Khorasanchi Z, Shafiee M, Kermanshahi F, Khazaei M, Ryzhikov M, Parizadeh MR, Kermanshahi B, Ferns GA, Avan A, Hassanian SM. Khorasanchi Z, et al. Phytomedicine. 2018 Apr 1;43:21-27. doi: 10.1016/j.phymed.2018.03.041. Epub 2018 Mar 19. Phytomedicine. 2018. PMID: 29747750 Review.
BACKGROUND: Saffron, the dried stigmas of Crocus sativus L., is a highly valued agricultural product that is used mainly as a food coloring and flavoring agent. Three main secondary metabolites of Crocus sativus including crocin, picrocrocin, and safra …
BACKGROUND: Saffron, the dried stigmas of Crocus sativus L., is a highly valued agricultural product that is used mainly as a …
Antioxidant Properties of Crocus Sativus L. and Its Constituents and Relevance to Neurodegenerative Diseases; Focus on Alzheimer's and Parkinson's Disease.
Hatziagapiou K, Kakouri E, Lambrou GI, Bethanis K, Tarantilis PA. Hatziagapiou K, et al. Curr Neuropharmacol. 2019;17(4):377-402. doi: 10.2174/1570159X16666180321095705. Curr Neuropharmacol. 2019. PMID: 29564976 Free PMC article. Review.
OBJECTIVE: The present study aims to address the protective role of Crocus Sativus L. in neurodegeneration with an emphasis in Parkinson's and Alzheimer's disease. ...RESULTS: Hence, the authors focused on the literature concerning the role of Crocus Sativ
OBJECTIVE: The present study aims to address the protective role of Crocus Sativus L. in neurodegeneration with an emphasis in …
Saffron (Crocus sativus L.) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies.
Heitmar R, Brown J, Kyrou I. Heitmar R, et al. Nutrients. 2019 Mar 18;11(3):649. doi: 10.3390/nu11030649. Nutrients. 2019. PMID: 30889784 Free PMC article. Review.
Saffron (Crocus sativus L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effect …
Saffron (Crocus sativus L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have …
Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials.
Hausenblas HA, Saha D, Dubyak PJ, Anton SD. Hausenblas HA, et al. J Integr Med. 2013 Nov;11(6):377-83. doi: 10.3736/jintegrmed2013056. J Integr Med. 2013. PMID: 24299602 Free PMC article.
Of these, accumulating trials reveal positive effects of the spice saffron (Crocus sativus L.) for the treatment of depression. A comprehensive and statistical review of the clinical trials examining the effects of saffron for treatment of MDD is warranted. ...
Of these, accumulating trials reveal positive effects of the spice saffron (Crocus sativus L.) for the treatment of depression …
The Protective Role of Crocus Sativus L. (Saffron) Against Ischemia- Reperfusion Injury, Hyperlipidemia and Atherosclerosis: Nature Opposing Cardiovascular Diseases.
Hatziagapiou K, Lambrou GI. Hatziagapiou K, et al. Curr Cardiol Rev. 2018;14(4):272-289. doi: 10.2174/1573403X14666180628095918. Curr Cardiol Rev. 2018. PMID: 29952263 Free PMC article. Review.
OBJECTIVE: The present study aims to address the anti-toxicant role of Crocus Sativus L. in the case of cardiovascular disease and its role towards the cardioprotective role of Crocus Sativus L. ...CONCLUSION: Literature findings represented in current …
OBJECTIVE: The present study aims to address the anti-toxicant role of Crocus Sativus L. in the case of cardiovascular disease …
Crocus sativus L. Versus Methylphenidate in Treatment of Children with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind Pilot Study.
Baziar S, Aqamolaei A, Khadem E, Mortazavi SH, Naderi S, Sahebolzamani E, Mortezaei A, Jalilevand S, Mohammadi MR, Shahmirzadi M, Akhondzadeh S. Baziar S, et al. J Child Adolesc Psychopharmacol. 2019 Apr;29(3):205-212. doi: 10.1089/cap.2018.0146. Epub 2019 Feb 11. J Child Adolesc Psychopharmacol. 2019. PMID: 30741567 Clinical Trial.
The aim of this trial is to compare the safety and efficacy of Crocus sativus (saffron) versus methylphenidate in improving symptoms of children with ADHD. ...
The aim of this trial is to compare the safety and efficacy of Crocus sativus (saffron) versus methylphenidate in improving sy …
Phytotherapic use of the Crocus sativus L. (Saffron) and its potential applications: A brief overview.
Leone S, Recinella L, Chiavaroli A, Orlando G, Ferrante C, Leporini L, Brunetti L, Menghini L. Leone S, et al. Phytother Res. 2018 Dec;32(12):2364-2375. doi: 10.1002/ptr.6181. Epub 2018 Aug 22. Phytother Res. 2018. PMID: 30136324
Crocus sativus L. (Saffron) has long been known for multiple target therapeutic uses. ...
Crocus sativus L. (Saffron) has long been known for multiple target therapeutic uses. ...
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