Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1994 2
1997 1
1998 2
1999 1
2000 4
2002 2
2003 4
2004 2
2005 1
2006 5
2007 10
2008 7
2009 9
2010 4
2011 16
2012 22
2013 35
2014 26
2015 30
2016 30
2017 45
2018 42
2019 39
2020 31
2021 47
2022 28
2023 39
2024 31
2025 35
2026 21

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

502 results

Results by year

Filters applied: . Clear all
Page 1
Obese visceral fat tissue inflammation: from protective to detrimental?
Kolb H. Kolb H. BMC Med. 2022 Dec 27;20(1):494. doi: 10.1186/s12916-022-02672-y. BMC Med. 2022. PMID: 36575472 Free PMC article. Review.
With chronic overnutrition, these protective actions are insufficient, and death of adipocytes as well as senescence of several tissue cell types is seen. This structural damage causes the expression or release of immunostimulatory cell components resulting in influx and a …
With chronic overnutrition, these protective actions are insufficient, and death of adipocytes as well as senescence of several tissue cell …
Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2.
Ganguly S, Rosenthal SB, Ishizuka K, Troutman TD, Rohm TV, Khader N, Aleman-Muench G, Sano Y, Archilei S, Soroosh P, Olefsky JM, Feldstein AE, Kisseleva T, Loomba R, Glass CK, Brenner DA, Dhar D. Ganguly S, et al. Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2405746121. doi: 10.1073/pnas.2405746121. Epub 2024 Aug 22. Proc Natl Acad Sci U S A. 2024. PMID: 39172787 Free PMC article.
Absence of TREM2 restricted the emergence of LAMs and formation of hepatic crown-like structures. TREM2(+) macrophages are functionally important not only for restricting MASH-fibrosis progression but also for effective regression of inflammation and fibrosis …
Absence of TREM2 restricted the emergence of LAMs and formation of hepatic crown-like structures. TREM2(+) macrophages …
Adipose tissue macrophages as potential targets for obesity and metabolic diseases.
Li X, Ren Y, Chang K, Wu W, Griffiths HR, Lu S, Gao D. Li X, et al. Front Immunol. 2023 Apr 19;14:1153915. doi: 10.3389/fimmu.2023.1153915. eCollection 2023. Front Immunol. 2023. PMID: 37153549 Free PMC article. Review.
Then, we presented the identities of the newly discovered adipose tissue macrophage subtypes (e.g. metabolically activated macrophages, CD9(+) macrophages, lipid-associated macrophages, DARC(+) macrophages, and MFe(hi) macrophages), the majority of which are located in crown …
Then, we presented the identities of the newly discovered adipose tissue macrophage subtypes (e.g. metabolically activated macrophages, CD9( …
Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age.
Islam MT, Tuday E, Allen S, Kim J, Trott DW, Holland WL, Donato AJ, Lesniewski LA. Islam MT, et al. Aging Cell. 2023 Feb;22(2):e13767. doi: 10.1111/acel.13767. Epub 2023 Jan 13. Aging Cell. 2023. PMID: 36637079 Free PMC article.
This treatment also suppressed age-related increase in the expression of a subset of pro-inflammatory SASP genes (mcp1, tnf-alpha, il-1alpha, il-1beta, il-6, cxcl2, and cxcl10), crown-like structures, abundance of T cells and macrophages in pgWAT (all p 0.0 …
This treatment also suppressed age-related increase in the expression of a subset of pro-inflammatory SASP genes (mcp1, tnf-alpha, il-1alpha …
Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH.
Daemen S, Gainullina A, Kalugotla G, He L, Chan MM, Beals JW, Liss KH, Klein S, Feldstein AE, Finck BN, Artyomov MN, Schilling JD. Daemen S, et al. Cell Rep. 2021 Jan 12;34(2):108626. doi: 10.1016/j.celrep.2020.108626. Cell Rep. 2021. PMID: 33440159 Free PMC article.
The Cx3cr1/Ccr2-expressing macrophages, referred to as C-LAMs, localize to macrophage aggregates and hepatic crown-like structures (hCLSs) in the steatotic liver. In C-motif chemokine receptor 2 (Ccr2)-deficient mice, C-LAMs fail to appear in the liver, and t …
The Cx3cr1/Ccr2-expressing macrophages, referred to as C-LAMs, localize to macrophage aggregates and hepatic crown-like str …
Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence.
Kerr J, Anderson C, Lippman SM. Kerr J, et al. Lancet Oncol. 2017 Aug;18(8):e457-e471. doi: 10.1016/S1470-2045(17)30411-4. Epub 2017 Jul 26. Lancet Oncol. 2017. PMID: 28759385 Free PMC article. Review.
Obesity produces an inflammatory state, characterised by macrophages clustered around enlarged hypertrophied, dead, and dying adipocytes, forming crown-like structures. Increased concentrations of aromatase and interleukin 6 in inflamed breast tissue and an i …
Obesity produces an inflammatory state, characterised by macrophages clustered around enlarged hypertrophied, dead, and dying adipocytes, fo …
Hydrophobic-hydrophilic crown-like structure enables aquatic insects to reside effectively beneath the water surface.
Suzuki C, Takaku Y, Suzuki H, Ishii D, Shimozawa T, Nomura S, Shimomura M, Hariyama T. Suzuki C, et al. Commun Biol. 2021 Jun 10;4(1):708. doi: 10.1038/s42003-021-02228-5. Commun Biol. 2021. PMID: 34112937 Free PMC article.
Herein, we use larvae of Dixa longistyla (Diptera: Dixidae) as experimental specimens and reveal their characteristics. A complex crown-like structure on the abdomen consists of hydrophobic and hydrophilic elements. ...
Herein, we use larvae of Dixa longistyla (Diptera: Dixidae) as experimental specimens and reveal their characteristics. A complex crown …
Enzymatically-epoxidized docosahexaenoic acid, 19,20-EpDPE, suppresses hepatic crown-like structure formation and nonalcoholic steatohepatitis fibrosis through GPR120.
Aoki H, Isobe Y, Yoshida M, Kang JX, Maekawa M, Arita M. Aoki H, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Mar;1868(3):159275. doi: 10.1016/j.bbalip.2022.159275. Epub 2022 Dec 22. Biochim Biophys Acta Mol Cell Biol Lipids. 2023. PMID: 36566874 Free article.
A hepatic crown-like structure (hCLS) formed by macrophages accumulating around lipid droplets and dead cells in the liver is a unique feature of nonalcoholic steatohepatitis (NASH) that triggers progression of liver fibrosis. ...
A hepatic crown-like structure (hCLS) formed by macrophages accumulating around lipid droplets and dead cells in the li …
Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis.
Kohda H, Tanaka M, Shichino S, Arakawa S, Komori T, Ito A, Wada E, Ochi K, Yuan X, Takeda T, Saiki A, Tatsuno I, Ikeda K, Miyai Y, Enomoto A, Morikawa Y, Shimizu S, Ueha S, Matsushima K, Ogawa Y, Suganami T. Kohda H, et al. Diabetes. 2025 Jul 1;74(7):1135-1152. doi: 10.2337/db24-0762. Diabetes. 2025. PMID: 40063503 Free PMC article.
Spatial transcriptomics was used to understand local cellular interaction within crown-like structures (CLS), a characteristic histological feature of adipose tissue in obesity driving inflammation and fibrosis. ...ARTICLE HIGHLIGHTS: Adipose tissue fibrosis …
Spatial transcriptomics was used to understand local cellular interaction within crown-like structures (CLS), a charact …
Structure of anellovirus-like particles reveal a mechanism for immune evasion.
Liou SH, Boggavarapu R, Cohen NR, Zhang Y, Sharma I, Zeheb L, Mukund Acharekar N, Rodgers HD, Islam S, Pitts J, Arze C, Swaminathan H, Yozwiak N, Ong T, Hajjar RJ, Chang Y, Swanson KA, Delagrave S. Liou SH, et al. Nat Commun. 2024 Aug 22;15(1):7219. doi: 10.1038/s41467-024-51064-8. Nat Commun. 2024. PMID: 39174507 Free PMC article.
Basic features of the virus, such as the identity of its capsid protein and the structure of the viral particle, have been unclear until now. Here, we use cryogenic electron microscopy to describe the first structure of an ANV-like particle. ...The spike domains com …
Basic features of the virus, such as the identity of its capsid protein and the structure of the viral particle, have been unclear un …
502 results