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Cuproptosis: A Copper-Mediated Programmed Cell Death.
Meena R, Sahoo SS, Sunil A, Manna D. Meena R, et al. Chem Asian J. 2025 Feb 17;20(4):e202400934. doi: 10.1002/asia.202400934. Epub 2024 Nov 27. Chem Asian J. 2025. PMID: 39520466 Review.
It has been found that various heavy metals can initiate different types of regulated cell deaths. Among these metals, copper, an essential trace micronutrient that plays a major role in a lot of physiological processes, also can initiate cell death. . …
It has been found that various heavy metals can initiate different types of regulated cell deaths. Among these metals, copper, …
Cuproptosis: mechanisms and links with cancers.
Xie J, Yang Y, Gao Y, He J. Xie J, et al. Mol Cancer. 2023 Mar 7;22(1):46. doi: 10.1186/s12943-023-01732-y. Mol Cancer. 2023. PMID: 36882769 Free PMC article. Review.
Cuproptosis was a copper-dependent and unique kind of cell death that was separate from existing other forms of cell death. The last decade has witnessed a considerable increase in investigations of programmed cell death …
Cuproptosis was a copper-dependent and unique kind of cell death that was separate from existing other forms of …
Cuproptosis mediates copper-induced testicular spermatogenic cell death.
Zhang JY, Yu XJ, Li JJ, Xiao Y, Li GS, Yang F, Dong L. Zhang JY, et al. Asian J Androl. 2024 May 1;26(3):295-301. doi: 10.4103/aja202383. Epub 2024 Jan 26. Asian J Androl. 2024. PMID: 38284772 Free PMC article.
Cuproptosis, a novel mechanism of programmed cell death, has not been fully explored in the context of spermatogenic cells. ...Further analyses revealed pathological lesions and blood-testis barrier destruction in the testicular tissue, accompanied by …
Cuproptosis, a novel mechanism of programmed cell death, has not been fully explored in the context of spermatog …
Enzalutamide Sensitizes Castration-Resistant Prostate Cancer to Copper-Mediated Cell Death.
Gao X, Zhao H, Liu J, Wang M, Dai Z, Hao W, Wang Y, Wang X, Zhang M, Liu P, Cheng H, Liu Z. Gao X, et al. Adv Sci (Weinh). 2024 Aug;11(30):e2401396. doi: 10.1002/advs.202401396. Epub 2024 Jun 10. Adv Sci (Weinh). 2024. PMID: 38859590 Free PMC article.
Despite the initial efficacy of enzalutamide in castration-resistant prostate cancer (CRPC), inevitable resistance remains a significant challenge. Here, the synergistic induction of copper-dependent cell death (cuproptosis) in CRPC cells is reported b …
Despite the initial efficacy of enzalutamide in castration-resistant prostate cancer (CRPC), inevitable resistance remains a significant cha …
Copper homeostasis and cuproptosis in cancer immunity and therapy.
Liu WQ, Lin WR, Yan L, Xu WH, Yang J. Liu WQ, et al. Immunol Rev. 2024 Jan;321(1):211-227. doi: 10.1111/imr.13276. Epub 2023 Sep 16. Immunol Rev. 2024. PMID: 37715546 Review.
Excess copper results in the aggregation of lipoylated dihydrolipoamide S-acetyltransferase (DLAT), which correlates to the mitochondrial tricarboxylic acid (TCA) cycle, resulting in proteotoxic stress and eliciting a novel cell death modality: cuproptosis …
Excess copper results in the aggregation of lipoylated dihydrolipoamide S-acetyltransferase (DLAT), which correlates to the mitochond …
Cuproptosis Induced by ROS Responsive Nanoparticles with Elesclomol and Copper Combined with alphaPD-L1 for Enhanced Cancer Immunotherapy.
Guo B, Yang F, Zhang L, Zhao Q, Wang W, Yin L, Chen D, Wang M, Han S, Xiao H, Xing N. Guo B, et al. Adv Mater. 2023 Jun;35(22):e2212267. doi: 10.1002/adma.202212267. Epub 2023 Apr 2. Adv Mater. 2023. PMID: 36916030
Cuproptosis is a new cell death that depends on copper (Cu) ionophores to transport Cu into cancer cells, which induces cell death. ...Additionally, NP@ESCu is further combined with anti-programmed cell death protein …
Cuproptosis is a new cell death that depends on copper (Cu) ionophores to transport Cu into cancer cells, which …
Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance.
Lei G, Lu Z, Xu Z, Braun C, Huo D, Gao J, Tan L, Hong T, Wu S, Sun M, Zhao X, Li Q, Chen X, Yan Y, Lee H, Mao C, Zhuang L, Ku LT, Puebla N, Barsoumian H, Yao J, Hong L, Zhang J, Tran H, Lee JJ, Gibbons D, Vaporciyan A, Heymach J, Lin C, Gottlieb E, You MJ, Welsh JW, Lin SH, Zang X, Li Z, Gan B. Lei G, et al. Cell. 2026 Jun 22:S0092-8674(26)00636-7. doi: 10.1016/j.cell.2026.05.036. Online ahead of print. Cell. 2026. PMID: 42330950 Free article.
Cuproptosis is a recently identified form of copper-dependent cell death that depends on ferredoxin 1 (FDX1)-mediated protein lipoylation. ...Consequently, combining a cuproptosis inducer with anti-programmed cell death liga …
Cuproptosis is a recently identified form of copper-dependent cell death that depends on ferredoxin 1 (FDX1)-med …
Glutathione-Scavenging Celastrol-Cu Nanoparticles Induce Self-Amplified Cuproptosis for Augmented Cancer Immunotherapy.
Lu S, Li Y, Yu Y. Lu S, et al. Adv Mater. 2024 Aug;36(35):e2404971. doi: 10.1002/adma.202404971. Epub 2024 Jul 4. Adv Mater. 2024. PMID: 38935977
Cuproptosis is a novel copper-dependent programmed cell death. The efficacy of cuproptosis is highly dependent on intracellular copper accumulation and counteracted by a high level of glutathione (GSH) in tumor cells. ...Notably, C …
Cuproptosis is a novel copper-dependent programmed cell death. The efficacy of cuproptosis is high …
Mechanisms of copper metabolism and cuproptosis: implications for liver diseases.
Chen H, Li D, Zhang H, Zhang M, Lin Y, He H, Liu A, Shen S, Wang Y, Han Z. Chen H, et al. Front Immunol. 2025 Jul 30;16:1633711. doi: 10.3389/fimmu.2025.1633711. eCollection 2025. Front Immunol. 2025. PMID: 40808953 Free PMC article. Review.
Copper is an essential trace element in the human body, involved in various biological processes, including cell metabolism, nerve development, and immune function. Its homeostasis is vital for maintaining normal cellular functions, and disruptions in copper …
Copper is an essential trace element in the human body, involved in various biological processes, including cell metabolism, n …
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia.
Lewis AC, Gruber E, Franich R, Armstrong J, Kelly MJ, Opazo CM, Low YC, Flippe L, Wijanarko K, Rowe CL, Mawal CH, Birrell A, So J, Vaidyanathan S, Ting K, Semcesen LN, Last K, Ang CS, Pomilio G, Brown FC, Wei AH, Powell JA, Ng ES, Frazier AE, McArthur K, Lalaoui N, Stroud DA, Brown KK, Johnstone RW, Kats LM. Lewis AC, et al. Cell. 2026 Jan 8;189(1):215-232.e24. doi: 10.1016/j.cell.2025.10.028. Epub 2025 Nov 19. Cell. 2026. PMID: 41265435 Free article.
Inhibition of HBEs causes the collapse of mitochondrial Complex IV and dysregulates the copper-chaperone system, inducing cuproptosis, a form of programmed cell death brought about by the oligomerization of lipoylated proteins by copper. …
Inhibition of HBEs causes the collapse of mitochondrial Complex IV and dysregulates the copper-chaperone system, inducing cupropto …
437 results