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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 2
1991 1
1992 13
1993 33
1994 75
1995 143
1996 205
1997 264
1998 272
1999 364
2000 409
2001 396
2002 400
2003 408
2004 446
2005 438
2006 444
2007 453
2008 453
2009 445
2010 512
2011 508
2012 509
2013 496
2014 518
2015 556
2016 457
2017 409
2018 384
2019 398
2020 367
2021 342
2022 220
2023 212
2024 258
2025 286
2026 167

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11,114 results

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Page 1
Cell cycle proteins as promising targets in cancer therapy.
Otto T, Sicinski P. Otto T, et al. Nat Rev Cancer. 2017 Jan 27;17(2):93-115. doi: 10.1038/nrc.2016.138. Nat Rev Cancer. 2017. PMID: 28127048 Free PMC article. Review.
Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant activity of various cell cycle proteins. Therefore, cell cycle regulators are considered attractive targets in cancer therapy. ...After decades of research on the physiological …
Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant activity of various cell cycle proteins. Th …
The Cyclin-dependent kinase 1: more than a cell cycle regulator.
Massacci G, Perfetto L, Sacco F. Massacci G, et al. Br J Cancer. 2023 Nov;129(11):1707-1716. doi: 10.1038/s41416-023-02468-8. Epub 2023 Oct 28. Br J Cancer. 2023. PMID: 37898722 Free PMC article. Review.
The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. ...Here, we provide a comprehensive catalogue of the CDK1 upstream regulators a …
The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cy …
A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022).
Kovalová M, Baraka JP, Mik V, Jorda R, Luo L, Shao H, Kryštof V. Kovalová M, et al. Expert Opin Ther Pat. 2023 Feb;33(2):67-87. doi: 10.1080/13543776.2023.2195547. Epub 2023 Apr 10. Expert Opin Ther Pat. 2023. PMID: 36975020 Free article. Review.
INTRODUCTION: Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family of serine/threonine protein kinases and participates in the regulation of the cell cycle and mRNA transcription. ...Highly potent and selective inh …
INTRODUCTION: Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family of serine/threonine prote …
Fibronectin receptor modulates cyclin-dependent kinase activity.
Symington BE. Symington BE. J Biol Chem. 1992 Dec 25;267(36):25744-7. J Biol Chem. 1992. PMID: 1464591 Free article.
Expression of this integrin is altered by chemical and viral transformation, suggesting that FNR dysfunction may play a role in growth control. This study demonstrates that exposing FA-K562 cells to glycine-arginine-glycine-aspartate-serine (GRGDS), a peptide ligand …
Expression of this integrin is altered by chemical and viral transformation, suggesting that FNR dysfunction may play a role in growth co …
Structure-based design of cyclin-dependent kinase inhibitors.
Davies TG, Pratt DJ, Endicott JA, Johnson LN, Noble ME. Davies TG, et al. Pharmacol Ther. 2002 Feb-Mar;93(2-3):125-33. doi: 10.1016/s0163-7258(02)00182-1. Pharmacol Ther. 2002. PMID: 12191605 Review.
The eukaryotic cell cycle is tightly regulated by the sequential activation and deactivation of the cyclin-dependent kinases (CDKs). ...The strong genetic link between CDKs and the molecular pathology of cancer has provided the rationale for dev …
The eukaryotic cell cycle is tightly regulated by the sequential activation and deactivation of the cyclin-dependent …
The regulation and functions of cdk7.
Shuttleworth J. Shuttleworth J. Prog Cell Cycle Res. 1995;1:229-40. doi: 10.1007/978-1-4615-1809-9_18. Prog Cell Cycle Res. 1995. PMID: 9552366 Review.
cdk7 started its life rather anonymously as a kinase called MO15, identified during a search for cDNA's which encode protein kinases related to cdc2. ...MO15(cdk7) has therefore been established paradoxically as both a new member and a regulator of the …
cdk7 started its life rather anonymously as a kinase called MO15, identified during a search for cDNA's which encode protein …
Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators.
Tang D, Wang JH. Tang D, et al. Prog Cell Cycle Res. 1996;2:205-16. doi: 10.1007/978-1-4615-5873-6_20. Prog Cell Cycle Res. 1996. PMID: 9552397 Review.
While cyclin-dependent kinase 5 (Cdk5) is widely distributed in mammalian tissues and in cultured cell lines, Cdk5-associated kinase activity has been demonstrated only in mammalian brains. ...The protein is essential for the kinase …
While cyclin-dependent kinase 5 (Cdk5) is widely distributed in mammalian tissues and in cultured cell lines, Cdk5-asso …
Regulation of cyclin-dependent kinase 2 activity by ceramide.
Lee JY, Bielawska AE, Obeid LM. Lee JY, et al. Exp Cell Res. 2000 Dec 15;261(2):303-11. doi: 10.1006/excr.2000.5028. Exp Cell Res. 2000. PMID: 11112337
Cyclin-dependent kinases have been implicated in the inactivation of retinoblastoma (Rb) protein and cell cycle progression. ...Using purified protein phosphatases, we showed that ceramide activated both protein phosphatase 1 and …
Cyclin-dependent kinases have been implicated in the inactivation of retinoblastoma (Rb) protein and cell cycle …
Regulation of protein kinase cascades by protein phosphatase 2A.
Millward TA, Zolnierowicz S, Hemmings BA. Millward TA, et al. Trends Biochem Sci. 1999 May;24(5):186-91. doi: 10.1016/s0968-0004(99)01375-4. Trends Biochem Sci. 1999. PMID: 10322434 Review.
Many protein kinases themselves are regulated by reversible phosphorylation. Upon cell stimulation, specific kinases are transiently phosphorylated and activated. Several of these protein kinases are substrates for protein p …
Many protein kinases themselves are regulated by reversible phosphorylation. Upon cell stimulation, specific kinases …
Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection.
Hossain A, Holt T, Ciacci-Zanella J, Jones C. Hossain A, et al. J Gen Virol. 1997 Dec;78 ( Pt 12):3341-8. doi: 10.1099/0022-1317-78-12-3341. J Gen Virol. 1997. PMID: 9400986
Two hours after infection steady-state levels of the S-phase-specific cyclin, cyclin A, increased. S-phase cyclin-dependent kinase activity (CDK2) was stimulated 10-fold 8 h after infection but decreased at 16 or 24 h after infection. Mitotic CDK ac …
Two hours after infection steady-state levels of the S-phase-specific cyclin, cyclin A, increased. S-phase cyclin-dependent …
11,114 results
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