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375 results

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Page 1
New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race.
Inker LA, Eneanya ND, Coresh J, Tighiouart H, Wang D, Sang Y, Crews DC, Doria A, Estrella MM, Froissart M, Grams ME, Greene T, Grubb A, Gudnason V, Gutiérrez OM, Kalil R, Karger AB, Mauer M, Navis G, Nelson RG, Poggio ED, Rodby R, Rossing P, Rule AD, Selvin E, Seegmiller JC, Shlipak MG, Torres VE, Yang W, Ballew SH, Couture SJ, Powe NR, Levey AS; Chronic Kidney Disease Epidemiology Collaboration. Inker LA, et al. N Engl J Med. 2021 Nov 4;385(19):1737-1749. doi: 10.1056/NEJMoa2102953. Epub 2021 Sep 23. N Engl J Med. 2021. PMID: 34554658 Free PMC article.
BACKGROUND: Current equations for estimated glomerular filtration rate (eGFR) that use serum creatinine or cystatin C incorporate age, sex, and race to estimate measured GFR. However, race in eGFR equations is a social and not a biologic construct. ...CONCLUS …
BACKGROUND: Current equations for estimated glomerular filtration rate (eGFR) that use serum creatinine or cystatin C incorpor …
Cystatin C as a biomarker of chronic kidney disease: latest developments.
Benoit SW, Ciccia EA, Devarajan P. Benoit SW, et al. Expert Rev Mol Diagn. 2020 Oct;20(10):1019-1026. doi: 10.1080/14737159.2020.1768849. Epub 2020 May 25. Expert Rev Mol Diagn. 2020. PMID: 32450046 Free PMC article. Review.
Therefore, augmenting clinical assessment with newer biomarkers, such as serum cystatin C, has the potential to improve disease monitoring and patient care. AREAS COVERED: The present paper assesses the utility and limitations of serum cystatin C as a …
Therefore, augmenting clinical assessment with newer biomarkers, such as serum cystatin C, has the potential to improve diseas …
New equations to estimate GFR in children with CKD.
Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL. Schwartz GJ, et al. J Am Soc Nephrol. 2009 Mar;20(3):629-37. doi: 10.1681/ASN.2008030287. Epub 2009 Jan 21. J Am Soc Nephrol. 2009. PMID: 19158356 Free PMC article.
We performed linear regression analyses assessing precision, goodness of fit, and accuracy to develop improvements in the GFR estimating formula, which was based on height, serum creatinine, cystatin C, blood urea nitrogen, and gender. The best equation was: …
We performed linear regression analyses assessing precision, goodness of fit, and accuracy to develop improvements in the GFR estimat …
New and old GFR equations: a European perspective.
Delanaye P, Cavalier E, Pottel H, Stehlé T. Delanaye P, et al. Clin Kidney J. 2023 Mar 15;16(9):1375-1383. doi: 10.1093/ckj/sfad039. eCollection 2023 Sep. Clin Kidney J. 2023. PMID: 37664574 Free PMC article. Review.
The new EKFC equation based on cystatin C (EKFC(CC)) shares the same mathematical construction, namely, it incorporates the median cystatin C value in the general population, which is independent of sex and ethnicity. EKFC(CC) is therefore a sex-free a …
The new EKFC equation based on cystatin C (EKFC(CC)) shares the same mathematical construction, namely, it incorporates the me …
GFR Estimation After Cystatin C Reference Material Change.
Benoit SW, Kathman T, Patel J, Stegman M, Cobb C, Hoehn J, Devarajan P, Nehus EJ. Benoit SW, et al. Kidney Int Rep. 2020 Dec 7;6(2):429-436. doi: 10.1016/j.ekir.2020.11.028. eCollection 2021 Feb. Kidney Int Rep. 2020. PMID: 33615068 Free PMC article.
INTRODUCTION: Glomerular filtration rate (GFR) is routinely estimated with cystatin C. In June 2010, the International Federation of Clinical Chemistry (IFCC) released a certified cystatin C reference material (ERM-DA471/IFCC), and new cystat …
INTRODUCTION: Glomerular filtration rate (GFR) is routinely estimated with cystatin C. In June 2010, the International …
Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease.
Pierce CB, Muñoz A, Ng DK, Warady BA, Furth SL, Schwartz GJ. Pierce CB, et al. Kidney Int. 2021 Apr;99(4):948-956. doi: 10.1016/j.kint.2020.10.047. Epub 2020 Dec 8. Kidney Int. 2021. PMID: 33301749 Free PMC article.
For females, the values of K ranged from 33.1 to 41.4. Constant K values for cystatin-C equations were 81.9 for males and 74.9 for females. With age-dependency, K varied non-monotonically with the highest values at age 15 for males (K of 87.2) and 12 years for femal …
For females, the values of K ranged from 33.1 to 41.4. Constant K values for cystatin-C equations were 81.9 for males and 74.9 …
How to use serum creatinine, cystatin C and GFR.
Pasala S, Carmody JB. Pasala S, et al. Arch Dis Child Educ Pract Ed. 2017 Feb;102(1):37-43. doi: 10.1136/archdischild-2016-311062. Epub 2016 Sep 19. Arch Dis Child Educ Pract Ed. 2017. PMID: 27647862 Review.
While GFR can be measured most accurately by the urinary clearance of an exogenous ideal filtration marker such as inulin, it is more clinically useful to estimate GFR using a single serum measurement of an endogenous biomarker such as creatinine or cystatin …
While GFR can be measured most accurately by the urinary clearance of an exogenous ideal filtration marker such as inulin, it is more …
A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease.
Delgado C, Baweja M, Crews DC, Eneanya ND, Gadegbeku CA, Inker LA, Mendu ML, Miller WG, Moxey-Mims MM, Roberts GV, St Peter WL, Warfield C, Powe NR. Delgado C, et al. Am J Kidney Dis. 2022 Feb;79(2):268-288.e1. doi: 10.1053/j.ajkd.2021.08.003. Epub 2021 Sep 23. Am J Kidney Dis. 2022. PMID: 34563581 Review.
RECOMMENDATIONS: (1) For US adults (>85% of whom have normal kidney function), we recommend immediate implementation of the CKD-EPI creatinine equation refit without the race variable in all laboratories in the United States because it does not include race in the calculation …
RECOMMENDATIONS: (1) For US adults (>85% of whom have normal kidney function), we recommend immediate implementation of the CKD-EPI creat …
Comparison of estimated GFR using cystatin C versus creatinine in pediatric kidney transplant recipients.
Pizzo H, Nguyen J, Schwartz GJ, Wesseling-Perry K, Ettenger R, Chambers ET, Weng P. Pizzo H, et al. Pediatr Nephrol. 2024 Jul;39(7):2177-2186. doi: 10.1007/s00467-024-06316-6. Epub 2024 Mar 1. Pediatr Nephrol. 2024. PMID: 38427073 Free PMC article.
This study compared the performance of serum creatinine (Cr) and cystatin C (CysC)-based GFR equations to measured GFR (mGFR) using iohexol among pediatric kidney transplant recipients. ...CONCLUSIONS: In this small cohort, CysC-based equations …
This study compared the performance of serum creatinine (Cr) and cystatin C (CysC)-based GFR equations to measured G …
Cystatin C Outperforms Creatinine in Predicting Cefepime Clearance in Pediatric Stem Cell Transplant Recipients.
Hambrick HR, Fei L, Pavia K, Kaplan J, Mizuno T, Tang P, Schuler E, Benoit S, Girdwood ST. Hambrick HR, et al. Transplant Cell Ther. 2024 Jun;30(6):614.e1-614.e11. doi: 10.1016/j.jtct.2024.03.021. Epub 2024 Mar 22. Transplant Cell Ther. 2024. PMID: 38522579 Free PMC article.
Serum creatinine (SCr) is routinely used to estimate glomerular filtration rate (eGFR) but varies with muscle mass, which can be significantly lower in HSCT patients, making SCr an inaccurate kidney function biomarker. Cystatin C (CysC) eGFR is independent of muscle …
Serum creatinine (SCr) is routinely used to estimate glomerular filtration rate (eGFR) but varies with muscle mass, which can be significant …
375 results