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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1952 5
1953 27
1954 36
1955 41
1956 25
1957 28
1958 15
1959 19
1960 25
1961 31
1962 33
1963 64
1964 87
1965 49
1966 44
1967 59
1968 52
1969 55
1970 51
1971 46
1972 47
1973 55
1974 49
1975 47
1976 53
1977 45
1978 52
1979 36
1980 32
1981 45
1982 67
1983 85
1984 99
1985 104
1986 100
1987 100
1988 80
1989 100
1990 109
1991 78
1992 71
1993 72
1994 70
1995 85
1996 57
1997 49
1998 51
1999 40
2000 52
2001 53
2002 49
2003 45
2004 69
2005 79
2006 89
2007 85
2008 96
2009 79
2010 102
2011 126
2012 119
2013 127
2014 116
2015 127
2016 132
2017 163
2018 143
2019 155
2020 181
2021 143
2022 158
2023 144
2024 56

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4,989 results

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Page 1
Topical Stabilized Cysteamine as a New Treatment for Hyperpigmentation Disorders: Melasma, Post-Inflammatory Hyperpigmentation, and Lentigines.
Desai S, Hartman C, Grimes P, Shah S. Desai S, et al. J Drugs Dermatol. 2021 Dec 1;20(12):1276-1279. doi: 10.36849/jdd.6367. J Drugs Dermatol. 2021. PMID: 34898155 Clinical Trial.
Cysteamine is an aminothiol naturally present in cells of the human body as an antioxidant resulting from the degradation of Coenzyme A. ...Multiple studies now document that cysteamine is a potent skin depigmenting agent. Historically, its rapid oxidation and very …
Cysteamine is an aminothiol naturally present in cells of the human body as an antioxidant resulting from the degradation of Coenzyme …
Is cysteamine use effective in the treatment of melasma? A systematic review and meta-analysis.
Dos Santos-Neto AG, da Silva ÍCV, Melo CR, Santana AAM, de Albuquerque-Junior RLC. Dos Santos-Neto AG, et al. Dermatol Ther. 2022 Dec;35(12):e15961. doi: 10.1111/dth.15961. Epub 2022 Nov 2. Dermatol Ther. 2022. PMID: 36285354 Review.

A total of six studies containing 120 melasma patients treated with 5% cysteamine were included in this meta-analysis. The meta-analysis demonstrated that 5% cysteamine is effective for the treatment of patients with melasma (MD 6.26 [95% CI 3.68-8.83], p < 0.000

…
A total of six studies containing 120 melasma patients treated with 5% cysteamine were included in this meta-analysis. The meta-analy …
Cysteamine: an old drug with new potential.
Besouw M, Masereeuw R, van den Heuvel L, Levtchenko E. Besouw M, et al. Drug Discov Today. 2013 Aug;18(15-16):785-92. doi: 10.1016/j.drudis.2013.02.003. Epub 2013 Feb 14. Drug Discov Today. 2013. PMID: 23416144 Review.
Cysteamine is an amino thiol with the chemical formula HSCH2CH2NH2. ...The recent development of an enteric-coated cysteamine formulation makes cysteamine more patient friendly and will extend its applicability for both old and new indications....
Cysteamine is an amino thiol with the chemical formula HSCH2CH2NH2. ...The recent development of an enteric-coated cysteamine …
Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo.
Jeitner TM, Pinto JT, Cooper AJL. Jeitner TM, et al. Biosci Rep. 2018 Sep 5;38(5):BSR20180691. doi: 10.1042/BSR20180691. Print 2018 Oct 31. Biosci Rep. 2018. PMID: 30054429 Free PMC article. Review.
This disulphide undergoes reduction in vivo to the aminothiol compound, cysteamine. Thus, the mechanism by which cystamine inhibits transglutaminase activity in vivo could be due to either cystamine or cysteamine, which depends on the local redox environment. ...The …
This disulphide undergoes reduction in vivo to the aminothiol compound, cysteamine. Thus, the mechanism by which cystamine inhibits t …
Cysteamine as a novel disease-modifying compound for Parkinson's disease: Over a decade of research supporting a clinical trial.
Cicchetti F, David LS, Siddu A, Denis HL. Cicchetti F, et al. Neurobiol Dis. 2019 Oct;130:104530. doi: 10.1016/j.nbd.2019.104530. Epub 2019 Jul 10. Neurobiol Dis. 2019. PMID: 31301344 Review.
There is therefore an urgent need to identify and/or develop therapeutic strategies that will demonstrate 'disease modifying' capacities. The molecule cystamine, and its reduced form cysteamine, act via a number of pathways determined to be critical to the pathogenesis of …
There is therefore an urgent need to identify and/or develop therapeutic strategies that will demonstrate 'disease modifying' capacities. Th …
Cysteamine hydrochloride affects ocular development and triggers associated inflammation in zebrafish.
Chen C, Zuo Y, Hu H, Shao Y, Dong S, Zeng J, Huang L, Liu Z, Shen Q, Liu F, Liao X, Cao Z, Zhong Z, Lu H, Bi Y, Chen J. Chen C, et al. J Hazard Mater. 2023 Oct 5;459:132175. doi: 10.1016/j.jhazmat.2023.132175. Epub 2023 Jul 27. J Hazard Mater. 2023. PMID: 37517235
The increasing use of cosmetics has raised widespread concerns regarding their ingredients. Cysteamine hydrochloride (CSH) is a newly identified allergenic component in cosmetics, and therefore its potential toxicity needs further elucidation. ...
The increasing use of cosmetics has raised widespread concerns regarding their ingredients. Cysteamine hydrochloride (CSH) is a newly …
Use of Cysteamine and Glutaraldehyde Chemicals for Robust Functionalization of Substrates with Protein Biomarkers-An Overview on the Construction of Biosensors with Different Transductions.
Ionescu RE. Ionescu RE. Biosensors (Basel). 2022 Jul 29;12(8):581. doi: 10.3390/bios12080581. Biosensors (Basel). 2022. PMID: 36004978 Free PMC article. Review.
In this context, for the first time, the present overview summarizes the pre-functionalization of standard and nanostructured solid/flexible supports with cysteamine (Cys) and glutaraldehyde (GA) chemicals for robust protein immobilization and detection of biomarkers in bo …
In this context, for the first time, the present overview summarizes the pre-functionalization of standard and nanostructured solid/flexible …
Cysteamine assay for the evaluation of bioactive electrophiles.
Novák D, Vrba J, Zatloukalová M, Roubalová L, Stolarczyk K, Dorčák V, Vacek J. Novák D, et al. Free Radic Biol Med. 2021 Feb 20;164:381-389. doi: 10.1016/j.freeradbiomed.2021.01.007. Epub 2021 Jan 9. Free Radic Biol Med. 2021. PMID: 33429019
The decrease in analytical responses of cysteamine was monitored to evaluate the reactivity of three electrophilic activators of the Nrf2 pathway, which mediates the cellular stress response. ...Although other factors in addition to chemical reactivity play a role in biolo …
The decrease in analytical responses of cysteamine was monitored to evaluate the reactivity of three electrophilic activators of the …
A systematic literature review of cysteamine bitartrate in the treatment of nephropathic cystinosis.
Medic G, van der Weijden M, Karabis A, Hemels M. Medic G, et al. Curr Med Res Opin. 2017 Nov;33(11):2065-2076. doi: 10.1080/03007995.2017.1354288. Epub 2017 Aug 3. Curr Med Res Opin. 2017. PMID: 28692321 Review.
All publicly available clinical reports on the use of delayed-release (DR) cysteamine bitartrate (Procysbi (1) ) or immediate-release (IR) cysteamine bitartrate (Cystagon (2) ) in patients with cystinosis were included. RESULTS: We identified a total of 103 publicat …
All publicly available clinical reports on the use of delayed-release (DR) cysteamine bitartrate (Procysbi (1) ) or immediate-release …
What role for cysteamine in the defence against infection?
Fraser-Pitt D, Mercer D. Fraser-Pitt D, et al. Emerg Top Life Sci. 2021 Nov 12;5(5):629-635. doi: 10.1042/ETLS20200351. Emerg Top Life Sci. 2021. PMID: 34027984
The aminothiol cysteamine has many potential therapeutic applications and is also an endogenous molecule, produced in the body via the activity of pantetheinase enzymes such as vanin-1. This simple small molecule is highly reactive in biological settings and much is yet un …
The aminothiol cysteamine has many potential therapeutic applications and is also an endogenous molecule, produced in the body via th …
4,989 results