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Year Number of Results
1982 1
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2008 3
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63 results

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Page 1
Clinical pharmacokinetics of paracetamol.
Forrest JA, Clements JA, Prescott LF. Forrest JA, et al. Clin Pharmacokinet. 1982 Mar-Apr;7(2):93-107. doi: 10.2165/00003088-198207020-00001. Clin Pharmacokinet. 1982. PMID: 7039926 Review.
In therapeutic doses paracetamol is a safe analgesic, but in overdosage it can cause severe hepatic necrosis. Following oral administration it is rapidly absorbed from the gastrointestinal tract, its systemic bioavailability being dose-dependent and ranging from 70 …
In therapeutic doses paracetamol is a safe analgesic, but in overdosage it can cause severe hepatic necrosis. Following oral administ …
The enhancement of N-acetylcysteine on intestinal absorption and oral bioavailability of hydrophobic curcumin.
Zhang S, Asghar S, Yu F, Hu Z, Ping Q, Chen Z, Shao F, Xiao Y. Zhang S, et al. Eur J Pharm Sci. 2020 Nov 1;154:105506. doi: 10.1016/j.ejps.2020.105506. Epub 2020 Aug 5. Eur J Pharm Sci. 2020. PMID: 32763460
To solve the low oral bioavailability of curcumin (CUR) due to the limits imposed by gastrointestinal (GI) barrier, we constructed a nano delivery system to evaluate the effect of N-acetyl-L-cysteine (NAC) on intestinal absorption and oral bi …
To solve the low oral bioavailability of curcumin (CUR) due to the limits imposed by gastrointestinal (GI) barrier, we constru …
Pharmacokinetics of S-Allyl-l-cysteine in Rats Is Characterized by High Oral Absorption and Extensive Renal Reabsorption.
Amano H, Kazamori D, Itoh K. Amano H, et al. J Nutr. 2016 Feb;146(2):456S-459S. doi: 10.3945/jn.114.201749. Epub 2016 Jan 13. J Nutr. 2016. PMID: 26764325 Free article.
RESULTS: After oral administration, SAC was well absorbed with a bioavailability of 98%. Two major metabolites of SAC, N-acetyl-S-allylcysteine (NAc-SAC) and N-acetyl-S-allylcysteine sulfoxide (NAc-SACS), were detected in plasma, but their concentrations were marked …
RESULTS: After oral administration, SAC was well absorbed with a bioavailability of 98%. Two major metabolites of SAC, N-acety …
Pluronic-poly (acrylic acid)-cysteine/Pluronic L121 mixed micelles improve the oral bioavailability of paclitaxel.
Zhao Y, Li Y, Ge J, Li N, Li LB. Zhao Y, et al. Drug Dev Ind Pharm. 2014 Nov;40(11):1483-93. doi: 10.3109/03639045.2013.829487. Epub 2013 Aug 23. Drug Dev Ind Pharm. 2014. PMID: 23971495
The aim of the study is to synthesize a thiolated Pluronic copolymer, Pluronic-poly (acrylic acid)-cysteine copolymer, to construct a mixed micelle system with the Pluronic-poly (acrylic acid)-cysteine copolymer and Pluronic L121 (PL121) and to evaluate the potentia …
The aim of the study is to synthesize a thiolated Pluronic copolymer, Pluronic-poly (acrylic acid)-cysteine copolymer, to construct a …
Captopril: pharmacology, metabolism and disposition.
Migdalof BH, Antonaccio MJ, McKinstry DN, Singhvi SM, Lan SJ, Egli P, Kripalani KJ. Migdalof BH, et al. Drug Metab Rev. 1984;15(4):841-69. doi: 10.3109/03602538409041080. Drug Metab Rev. 1984. PMID: 6437780 Review.
In SHR, daily oral doses of captopril progressively lowered blood pressure; normal levels were attained by the sixth month. ...Studies in rodents indicated that ingestion of food caused a reduction in the extent of absorption and bioavailability of captopril. …
In SHR, daily oral doses of captopril progressively lowered blood pressure; normal levels were attained by the sixth month. ...Studie …
Insulin-loaded liposomes packaged in alginate hydrogels promote the oral bioavailability of insulin.
Wu H, Nan J, Yang L, Park HJ, Li J. Wu H, et al. J Control Release. 2023 Jan;353:51-62. doi: 10.1016/j.jconrel.2022.11.032. Epub 2022 Nov 23. J Control Release. 2023. PMID: 36410613
For oral delivery, both liposomes and alginate hydrogels face many challenges, including early burst release of the encapsulated drug and poor intestinal drug absorption. Also, adhesion to the intestinal mucosa remains weak, which all result in a low bioavailabil …
For oral delivery, both liposomes and alginate hydrogels face many challenges, including early burst release of the encapsulated drug …
Enhancing the Oral Bioavailability of Glutathione Using Innovative Analogue Approaches.
Yin N, Harris PWR, Liu M, Sun J, Chen G, Wen J, Brimble MA. Yin N, et al. Pharmaceutics. 2025 Mar 18;17(3):385. doi: 10.3390/pharmaceutics17030385. Pharmaceutics. 2025. PMID: 40143049 Free PMC article.
Background: Glutathione (GSH) is an essential antioxidant that protects against oxidative stress, but its oral bioavailability is below 1% due to enzymatic degradation and poor gastrointestinal absorption. Improving the oral bioavailability of G …
Background: Glutathione (GSH) is an essential antioxidant that protects against oxidative stress, but its oral bioavailability …
N-acetyl-L-cysteine functionalized nanostructured lipid carrier for improving oral bioavailability of curcumin: preparation, in vitro and in vivo evaluations.
Tian C, Asghar S, Wu Y, Kambere Amerigos D, Chen Z, Zhang M, Yin L, Huang L, Ping Q, Xiao Y. Tian C, et al. Drug Deliv. 2017 Nov;24(1):1605-1616. doi: 10.1080/10717544.2017.1391890. Drug Deliv. 2017. PMID: 29063815 Free PMC article.
In order to enhance mucoadhesion and mucus penetration of curcumin (Cur)-loaded nanostructured lipid carrier (NLC) after oral administration, a new multifunctional conjugate, N-acetyl-L-cysteine-polyethylene glycol (100)-monostearate (NAPG), was synthesized. ...In s …
In order to enhance mucoadhesion and mucus penetration of curcumin (Cur)-loaded nanostructured lipid carrier (NLC) after oral adminis …
Pediatric oral formulation of dendrimer-N-acetyl-l-cysteine conjugates for the treatment of neuroinflammation.
Yellepeddi VK, Mohammadpour R, Kambhampati SP, Sayre C, Mishra MK, Kannan RM, Ghandehari H. Yellepeddi VK, et al. Int J Pharm. 2018 Jul 10;545(1-2):113-116. doi: 10.1016/j.ijpharm.2018.04.040. Epub 2018 Apr 20. Int J Pharm. 2018. PMID: 29680280 Free PMC article.
However, NAC suffers from drawbacks such as poor oral bioavailability and suboptimal blood-brain-barrier (BBB) permeability limiting its clinical success. It was previously demonstrated that intravenous administration of dendrimer-NAC (D-NAC) conjugates have shown s …
However, NAC suffers from drawbacks such as poor oral bioavailability and suboptimal blood-brain-barrier (BBB) permeability li …
GLUT-Targeted Adhesive Nanoparticles Enhance the Oral Absorption and Anti-Tumor Effects of 2-Methoxyestradiol.
Xing Y, Hu W, Li Y, Zhang Y, Zhang Y, Wang B, Guo X. Xing Y, et al. Int J Nanomedicine. 2025 Apr 14;20:4661-4675. doi: 10.2147/IJN.S506086. eCollection 2025. Int J Nanomedicine. 2025. PMID: 40255672 Free PMC article.
In this study, we aimed to design a novel oral delivery system for 2-ME using a dual-target modification strategy to address the inherent drawbacks associated with poor absorption and rapid elimination, as well as to enhance oral bioavailability and an …
In this study, we aimed to design a novel oral delivery system for 2-ME using a dual-target modification strategy to address the inhe …
63 results