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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1974 1
1975 2
1977 1
1978 1
1980 1
1981 2
1982 1
1983 1
1984 1
1985 1
1986 2
1987 3
1988 2
1989 2
1990 1
1991 2
1992 2
1993 2
1994 4
1995 4
1996 1
1997 1
1998 9
1999 5
2000 4
2001 6
2002 7
2003 5
2004 5
2005 3
2006 13
2007 11
2008 15
2009 19
2010 16
2011 11
2012 11
2013 8
2014 14
2015 10
2016 17
2017 26
2018 19
2019 25
2020 18
2021 24
2022 28
2023 34
2024 31
2025 52
2026 30

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461 results

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Page 1
Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation.
Zhang YH, Dai CS, Wang YJ, Wang WY, Qi TT, Xia MC, Zhou G, Cui YM. Zhang YH, et al. Nat Commun. 2025 May 19;16(1):4623. doi: 10.1038/s41467-025-59916-7. Nat Commun. 2025. PMID: 40389439 Free PMC article.
Trillions of intestinal microbiota are essential to the permeability of orally administered drugs. However, identifying microbial-drug interactions remains challenging due to the highly variable composition of intestinal flora among individuals. ...In contrast with …
Trillions of intestinal microbiota are essential to the permeability of orally administered drugs. However, identifying microbial-dru …
Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut.
Duan J, Matute JD, Unger LW, Hanley T, Schnell A, Lin X, Krupka N, Griebel P, Lambden C, Sit B, Grootjans J, Pyzik M, Sommer F, Kaiser S, Falk-Paulsen M, Grasberger H, Kao JY, Fuhrer T, Li H, Paik D, Lee Y, Refetoff S, Glickman JN, Paton AW, Bry L, Paton JC, Sauer U, Macpherson AJ, Rosenstiel P, Kuchroo VK, Waldor MK, Huh JR, Kaser A, Blumberg RS. Duan J, et al. Immunity. 2023 May 9;56(5):1115-1131.e9. doi: 10.1016/j.immuni.2023.02.018. Epub 2023 Mar 13. Immunity. 2023. PMID: 36917985 Free PMC article.
Intestinal IL-17-producing T helper (Th17) cells are dependent on adherent microbes in the gut for their development. However, how microbial adherence to intestinal epithelial cells (IECs) promotes Th17 cell differentiation remains enigmatic. ...
Intestinal IL-17-producing T helper (Th17) cells are dependent on adherent microbes in the gut for their development. However, …
Polystyrene Nanoplastics Toxicity to Zebrafish: Dysregulation of the Brain-Intestine-Microbiota Axis.
Teng M, Zhao X, Wang C, Wang C, White JC, Zhao W, Zhou L, Duan M, Wu F. Teng M, et al. ACS Nano. 2022 May 24;16(5):8190-8204. doi: 10.1021/acsnano.2c01872. Epub 2022 May 4. ACS Nano. 2022. PMID: 35507640
Although nanoplastics (NPs) have been shown to cause intestinal and neural toxicity in fish, the role of the neurotransmitter and intestinal microbiota interactions in the underlying mechanism of toxicity, particularly at environmentally relevant contaminant concent …
Although nanoplastics (NPs) have been shown to cause intestinal and neural toxicity in fish, the role of the neurotransmitter and …
CRIP1 fosters MDSC trafficking and resets tumour microenvironment via facilitating NF-κB/p65 nuclear translocation in pancreatic ductal adenocarcinoma.
Liu X, Tang R, Xu J, Tan Z, Liang C, Meng Q, Lei Y, Hua J, Zhang Y, Liu J, Zhang B, Wang W, Yu X, Shi S. Liu X, et al. Gut. 2023 Nov 24;72(12):2329-2343. doi: 10.1136/gutjnl-2022-329349. Gut. 2023. PMID: 37541772 Free PMC article.
An in vitro coculture system, an orthotopic PDAC allograft tumour model, flow cytometry and immunohistochemistry were used to explore the biological functions of cysteine-rich intestinal protein 1 (CRIP1) in tumour progression and TIME formation. RNA sequencing, mas …
An in vitro coculture system, an orthotopic PDAC allograft tumour model, flow cytometry and immunohistochemistry were used to explore the bi …
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation.
Bonetti L, Horkova V, Grusdat M, Longworth J, Guerra L, Kurniawan H, Franchina DG, Soriano-Baguet L, Binsfeld C, Verschueren C, Spath S, Ewen A, Koncina E, Gérardy JJ, Kobayashi T, Dostert C, Farinelle S, Härm J, Fan YT, Chen Y, Harris IS, Lang PA, Vasiliou V, Waisman A, Letellier E, Becher B, Mittelbronn M, Brenner D. Bonetti L, et al. Cell Metab. 2024 Aug 6;36(8):1726-1744.e10. doi: 10.1016/j.cmet.2024.06.010. Epub 2024 Jul 9. Cell Metab. 2024. PMID: 38986617 Free article.
The intestinal tract generates significant reactive oxygen species (ROS), but the role of T cell antioxidant mechanisms in maintaining intestinal homeostasis is poorly understood. We used T cell-specific ablation of the catalytic subunit of glutamate cysteine …
The intestinal tract generates significant reactive oxygen species (ROS), but the role of T cell antioxidant mechanisms in maintainin …
Cysteine Attenuates Intestinal Inflammation by Regulating the Gut Microbiota and TLR4-JNK/MAPK-NF-kappaB Pathway in Piglets.
Liu R, Qin P, Liu Z, Liu W, Jiang S, Yuan X, Yang W, Huang C, Jiao N. Liu R, et al. Int J Mol Sci. 2025 Dec 12;26(24):11991. doi: 10.3390/ijms262411991. Int J Mol Sci. 2025. PMID: 41465419 Free PMC article.
As a nutritionally important amino acid, cysteine (Cys) could attenuate oxidative damage on growth performance and intestinal barrier function in piglets. ...In conclusion, Cys is critical to nutrition through attenuating intestinal inflammation by regulating …
As a nutritionally important amino acid, cysteine (Cys) could attenuate oxidative damage on growth performance and intestinal …
Immune sensing of food allergens promotes avoidance behaviour.
Florsheim EB, Bachtel ND, Cullen JL, Lima BGC, Godazgar M, Carvalho F, Chatain CP, Zimmer MR, Zhang C, Gautier G, Launay P, Wang A, Dietrich MO, Medzhitov R. Florsheim EB, et al. Nature. 2023 Aug;620(7974):643-650. doi: 10.1038/s41586-023-06362-4. Epub 2023 Jul 12. Nature. 2023. PMID: 37437602 Free PMC article.
Allergen avoidance requires immunoglobulin E (IgE) antibodies and mast cells but precedes the development of gut allergic inflammation. The ability of allergen-specific IgE and mast cells to promote avoidance requires cysteinyl leukotrienes and growth and differentiation f …
Allergen avoidance requires immunoglobulin E (IgE) antibodies and mast cells but precedes the development of gut allergic inflammatio …
Cysteine-derived hydrogen sulfide and gut health: a matter of endogenous or bacterial origin.
Blachier F, Beaumont M, Kim E. Blachier F, et al. Curr Opin Clin Nutr Metab Care. 2019 Jan;22(1):68-75. doi: 10.1097/MCO.0000000000000526. Curr Opin Clin Nutr Metab Care. 2019. PMID: 30461448 Review.
PURPOSE OF REVIEW: Hydrogen sulfide (H2S) is produced in the gut from cysteine by epithelial cells and by the intestinal microbiota. Initially considered as a toxic gas, the pleiotropic effects of H2S are now recognized, especially in the colonic mucosa. The …
PURPOSE OF REVIEW: Hydrogen sulfide (H2S) is produced in the gut from cysteine by epithelial cells and by the intestinal …
Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice.
Hoyt LR, Liu E, Olson EC, Jacobsen DR, Siniscalco ER, Krier-Burris RA, Greenfield KG, McBride CD, Alfajaro MM, Amat JAR, Zhao Z, Xu L, Philip V, Verma A, Fourati S, Senger DL, Zhang L, Bunyavanich S, Glass SE, Coffey RJ, Wilen CB, Williams A, Eisenbarth SC. Hoyt LR, et al. Science. 2025 Aug 7;389(6760):eadp0240. doi: 10.1126/science.adp0240. Epub 2025 Aug 7. Science. 2025. PMID: 40773557
We studied strains of mice with different sensitivities to anaphylaxis when orally challenged with allergen to identify possible causes. In resistant C57BL/6 mice, intestinal goblet cells transported less food allergen than did anaphylaxis-susceptible strains, even before …
We studied strains of mice with different sensitivities to anaphylaxis when orally challenged with allergen to identify possible causes. In …
Porphyromonas gingivalis induces intestinal inflammation through gingipain-dependent gut microbiome dysbiosis.
Li M, Cui J, Qu R, Liu R, Sun Y, Li P, Liu J, Low A, Huang X, Gan F, Xu ZZ. Li M, et al. Microbiome. 2026 Apr 2;14(1):148. doi: 10.1186/s40168-026-02389-7. Microbiome. 2026. PMID: 41923122 Free PMC article.
However, as a periodontal pathogen that can directly enter the lower gastrointestinal tract via saliva, its potential impact on the gut microbiome, intestinal inflammation, and its underlying mechanisms remains largely elusive. RESULTS: Here, we observed that oral a …
However, as a periodontal pathogen that can directly enter the lower gastrointestinal tract via saliva, its potential impact on the gut …
461 results