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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1984 2
1985 1
1986 1
1988 3
1989 2
1992 1
1994 1
1995 1
1996 1
1997 1
1998 2
1999 5
2000 5
2001 5
2002 1
2003 12
2004 7
2005 8
2006 13
2007 11
2008 13
2009 11
2010 17
2011 12
2012 17
2013 16
2014 25
2015 18
2016 30
2017 40
2018 36
2019 47
2020 47
2021 42
2022 46
2023 38
2024 51
2025 76
2026 44

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607 results

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Page 1
Role of nrf2 in oxidative stress and toxicity.
Ma Q. Ma Q. Annu Rev Pharmacol Toxicol. 2013;53:401-26. doi: 10.1146/annurev-pharmtox-011112-140320. Annu Rev Pharmacol Toxicol. 2013. PMID: 23294312 Free PMC article. Review.
Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are traditionally viewed as being harmful. ...This review discusses the impact of Nrf2 on oxidative st …
Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen and nitrog …
Strategic and Chemical Advances in Antibody-Drug Conjugates.
Alradwan IA, Alnefaie MK, Al Fayez N, Aodah AH, Majrashi MA, Alturki M, Fallatah MM, Almughem FA, Tawfik EA, Alshehri AA. Alradwan IA, et al. Pharmaceutics. 2025 Sep 5;17(9):1164. doi: 10.3390/pharmaceutics17091164. Pharmaceutics. 2025. PMID: 41012501 Free PMC article. Review.
This review critically examines established and emerging conjugation strategies, including lysine- and cysteine-based chemistries, enzymatic tagging, glycan remodeling, non-canonical amino acid incorporation, and affinity peptide-mediated methods, and discusses how conjuga …
This review critically examines established and emerging conjugation strategies, including lysine- and cysteine-based chemistries, en …
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Akakpo JY, Ramachandran A, Curry SC, Rumack BH, Jaeschke H. Akakpo JY, et al. Arch Toxicol. 2022 Feb;96(2):453-465. doi: 10.1007/s00204-021-03211-z. Epub 2022 Jan 3. Arch Toxicol. 2022. PMID: 34978586 Free PMC article. Review.
Furthermore, the formation of oxidative metabolites was eliminated in healthy volunteers using the established treatment protocol for fomepizole in toxic alcohol and ethylene glycol poisoning. These mechanistic findings, together with the excellent safety profile af …
Furthermore, the formation of oxidative metabolites was eliminated in healthy volunteers using the established treatment protocol for fomepi …
Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione.
Pem B, Pongrac IM, Ulm L, Pavičić I, Vrček V, Domazet Jurašin D, Ljubojević M, Krivohlavek A, Vinković Vrček I. Pem B, et al. Beilstein J Nanotechnol. 2019 Sep 2;10:1802-1817. doi: 10.3762/bjnano.10.175. eCollection 2019. Beilstein J Nanotechnol. 2019. PMID: 31579097 Free PMC article.
The toxicity of these nanoparticles was considerably lower compared to their ionic metal forms (i.e., Ag(+) and Au(3+)). ...In vitro evaluation on human cells demonstrated that the toxicity of AgNPs and AuNPs prepared in the presence of cysteine was similar t …
The toxicity of these nanoparticles was considerably lower compared to their ionic metal forms (i.e., Ag(+) and Au(3+)). ...In vitro …
Bacterial Cysteine-Inducible Cysteine Resistance Systems.
Takumi K, Nonaka G. Takumi K, et al. J Bacteriol. 2016 Apr 14;198(9):1384-92. doi: 10.1128/JB.01039-15. Print 2016 May. J Bacteriol. 2016. PMID: 26883827 Free PMC article.
We propose that ccdA and cefA function as safety valves that maintain homeostasis when the intra- or extracellular cysteine concentration fluctuates. ...We propose that this novel mechanism for sensing and regulating cysteine levels is a safety valve e …
We propose that ccdA and cefA function as safety valves that maintain homeostasis when the intra- or extracellular cysteine co …
Challenges and Advances in the Bioproduction of L-Cysteine.
Caballero Cerbon DA, Gebhard L, Dokuyucu R, Ertl T, Härtl S, Mazhar A, Weuster-Botz D. Caballero Cerbon DA, et al. Molecules. 2024 Jan 18;29(2):486. doi: 10.3390/molecules29020486. Molecules. 2024. PMID: 38257399 Free PMC article. Review.
Due to safety and environmental issues in extracting L-cysteine from animal hair and feathers, the fermentative production of L-cysteine offers an attractive alternative using renewable feedstocks. ...Concerning the metabolic engineering strategies, the overe …
Due to safety and environmental issues in extracting L-cysteine from animal hair and feathers, the fermentative production of …
99mTc-Labeled, PEGylated (NαHis)Ac-β3hLys-βAla-βAla-Gln7-Trp8-Ala9-Val10-Gly11-His12-Cha13-Nle14-NH2.
Shan L. Shan L. 2012 Mar 12 [updated 2012 Apr 11]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2012 Mar 12 [updated 2012 Apr 11]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 22514805 Free Books & Documents. Review.
PEG possesses three key properties: great flexibility due to the absence of bulky substituents along the chain; high hydration of the polymeric backbone; and a high degree of safety, with toxicity only at very high doses (1, 3, 4). Furthermore, PEG can be coupled wi …
PEG possesses three key properties: great flexibility due to the absence of bulky substituents along the chain; high hydration of the polyme …
Perioperative N-acetylcysteine: evidence and indications.
Wilson PR, Bridges KH, Scofield M, Wilson SH. Wilson PR, et al. Pain Manag. 2024;14(7):385-396. doi: 10.1080/17581869.2024.2388504. Epub 2024 Aug 21. Pain Manag. 2024. PMID: 39166871 Free PMC article. Review.
N-acetylcysteine (NAC), the primary treatment of acetaminophen toxicity, may have perioperative indications, including analgesia. NAC impacts glutathione synthesis, oxidant scavenging, glutamate receptor modulation and neuroinflammation. ...NAC is generally well tolerated …
N-acetylcysteine (NAC), the primary treatment of acetaminophen toxicity, may have perioperative indications, including analgesia. NAC …
Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design.
Zhang XY, Elfarra AA. Zhang XY, et al. Expert Opin Drug Discov. 2018 Sep;13(9):815-824. doi: 10.1080/17460441.2018.1508207. Epub 2018 Aug 13. Expert Opin Drug Discov. 2018. PMID: 30101640 Free PMC article. Review.
The first approach was based upon bioactivation of trichloroethylene-cysteine S-conjugate by renal cysteine S-conjugate beta-lyases. The prodrugs obtained were kidney-selective but exhibited low turnover rates. The second approach was based on the t …
The first approach was based upon bioactivation of trichloroethylene-cysteine S-conjugate by renal cysteine S-co …
Exploring therapeutic and diagnostic potential of cysteine cathepsin as targets for cancer therapy with nanomedicine.
Giri A, Hong IS, Kwon TK, Kang JS, Jeong JH, Kweon S, Yook S. Giri A, et al. Int J Biol Macromol. 2025 Jun;315(Pt 1):144324. doi: 10.1016/j.ijbiomac.2025.144324. Epub 2025 May 19. Int J Biol Macromol. 2025. PMID: 40398760 Review.
Cysteine cathepsins have been discovered to be substantially expressed in multiple types of cancer. ...This review explores cathepsins from the papain-like enzyme family (C1) within the cysteine peptidase clan (CA), emphasizing the role of cathepsin-responsive nanop …
Cysteine cathepsins have been discovered to be substantially expressed in multiple types of cancer. ...This review explores cathepsin …
607 results