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48 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Cytisine for smoking cessation: A systematic review and meta-analysis.
Ofori S, Lu C, Olasupo OO, Dennis BB, Fairbairn N, Devereaux PJ, Mbuagbaw L. Ofori S, et al. Drug Alcohol Depend. 2023 Oct 1;251:110936. doi: 10.1016/j.drugalcdep.2023.110936. Epub 2023 Aug 25. Drug Alcohol Depend. 2023. PMID: 37678096
BACKGROUND: Cytisine is a smoking cessation medication. This systematic review incorporates recently published randomized controlled trials (RCTs) to provide an updated evidence-based assessment of cytisine's efficacy and safety. ...This can inform clinicians …
BACKGROUND: Cytisine is a smoking cessation medication. This systematic review incorporates recently published randomized controlled …
Effect of Cytisine vs Varenicline on Smoking Cessation: A Randomized Clinical Trial.
Courtney RJ, McRobbie H, Tutka P, Weaver NA, Petrie D, Mendelsohn CP, Shakeshaft A, Talukder S, Macdonald C, Thomas D, Kwan BCH, Walker N, Gartner C, Mattick RP, Paul C, Ferguson SG, Zwar NA, Richmond RL, Doran CM, Boland VC, Hall W, West R, Farrell M. Courtney RJ, et al. JAMA. 2021 Jul 6;326(1):56-64. doi: 10.1001/jama.2021.7621. JAMA. 2021. PMID: 34228066 Free PMC article. Clinical Trial.
IMPORTANCE: Cytisine is more effective than placebo and nicotine replacement therapy for smoking cessation. ...OBJECTIVE: To examine whether standard cytisine treatment (25 days) was at least as effective as standard varenicline treatment (84 days) for smoking cessa …
IMPORTANCE: Cytisine is more effective than placebo and nicotine replacement therapy for smoking cessation. ...OBJECTIVE: To examine …
Systematic review and meta-analyses of cytisine to support tobacco cessation.
Puljević C, Stjepanović D, Meciar I, Kang H, Chan G, Morphett K, Bendotti H, Kunwar G, Gartner C. Puljević C, et al. Addiction. 2024 Oct;119(10):1713-1725. doi: 10.1111/add.16592. Epub 2024 Jul 4. Addiction. 2024. PMID: 38965792
BACKGROUND AND AIMS: Cytisine (also known as cytisinicline) is a low-cost partial agonist of nicotinic acetylcholine receptors used to assist tobacco cessation. ...The differences in the number of adverse events reported by participants who received cytisine versus …
BACKGROUND AND AIMS: Cytisine (also known as cytisinicline) is a low-cost partial agonist of nicotinic acetylcholine receptors used t …
Evaluation of the effectiveness of cytisine for the treatment of smoking cessation: A systematic review and meta-analysis.
De Santi O, Orellana M, Di Niro CA, Greco V. De Santi O, et al. Addiction. 2024 Apr;119(4):649-663. doi: 10.1111/add.16399. Epub 2023 Dec 31. Addiction. 2024. PMID: 38161271
Two trials compared the efficacy of cytisine versus NRT, and the combination of both studies yields modest results in favor of cytisine. Three trials compared cytisine with varenicline, without a clear benefit for cytisine. Meta-analyses of all non-ser …
Two trials compared the efficacy of cytisine versus NRT, and the combination of both studies yields modest results in favor of cyt …
Cytisinicline for Smoking Cessation: A Randomized Clinical Trial.
Rigotti NA, Benowitz NL, Prochaska J, Leischow S, Nides M, Blumenstein B, Clarke A, Cain D, Jacobs C. Rigotti NA, et al. JAMA. 2023 Jul 11;330(2):152-160. doi: 10.1001/jama.2023.10042. JAMA. 2023. PMID: 37432430 Free PMC article. Clinical Trial.
IMPORTANCE: Cytisinicline (cytisine) is a plant-based alkaloid that, like varenicline, binds selectively to alpha4beta2 nicotinic acetylcholine receptors, which mediate nicotine dependence. ...
IMPORTANCE: Cytisinicline (cytisine) is a plant-based alkaloid that, like varenicline, binds selectively to alpha4beta2 nicotinic ace …
Efficacy of cytisine in helping smokers quit: systematic review and meta-analysis.
Hajek P, McRobbie H, Myers K. Hajek P, et al. Thorax. 2013 Nov;68(11):1037-42. doi: 10.1136/thoraxjnl-2012-203035. Epub 2013 Feb 12. Thorax. 2013. PMID: 23404838
BACKGROUND: A recent rigorous study has shown that cytisine, a low-cost drug, is effective for smoking cessation. A number of earlier studies exist, mostly from former communist countries where cytisine has been used since the 1960s. The key question now is whether …
BACKGROUND: A recent rigorous study has shown that cytisine, a low-cost drug, is effective for smoking cessation. A number of earlier …
Cytisine Versus Varenicline for Smoking Cessation in a Primary Care Setting: A Randomized Non-inferiority Trial.
Oreskovic T, Percac-Lima S, Ashburner JM, Tiljak H, Rifel J, Klemenc Ketiš Z, Oreskovic S. Oreskovic T, et al. Nicotine Tob Res. 2023 Aug 19;25(9):1547-1555. doi: 10.1093/ntr/ntad065. Nicotine Tob Res. 2023. PMID: 37291049 Clinical Trial.
RESULTS: The cessation rate after 24 weeks was 32.46% (62/191) in the varenicline group and 23.12% (43/186) in the cytisine group (odds ratio [OR]: 95%, credible interval [CI]: 0.39 to 0.98). Of 191 participants assigned to varenicline treatment 59.16% (113) were adherent, …
RESULTS: The cessation rate after 24 weeks was 32.46% (62/191) in the varenicline group and 23.12% (43/186) in the cytisine group (od …
Interventions for quitting vaping.
Butler AR, Lindson N, Livingstone-Banks J, Notley C, Turner T, Rigotti NA, Fanshawe TR, Dawkins L, Begh R, Wu AD, Brose L, Conde M, Simonavičius E, Hartmann-Boyce J. Butler AR, et al. Cochrane Database Syst Rev. 2025 Jan 8;1(1):CD016058. doi: 10.1002/14651858.CD016058.pub2. Cochrane Database Syst Rev. 2025. Update in: Cochrane Database Syst Rev. 2024 May 21;5:CD016058. doi: 10.1002/14651858.CD016058. PMID: 39777614 Free PMC article. Updated.
Zero participants reported SAEs in the studies of combination NRT versus no/minimal support (1 study, 508 participants; low-certainty evidence due to imprecision) and cytisine versus placebo (1 study, 159 participants; low-certainty evidence due to imprecision). ...Data ex …
Zero participants reported SAEs in the studies of combination NRT versus no/minimal support (1 study, 508 participants; low-certainty eviden …
Electronic cigarettes for smoking cessation.
Lindson N, Butler AR, McRobbie H, Bullen C, Hajek P, Begh R, Theodoulou A, Notley C, Rigotti NA, Turner T, Livingstone-Banks J, Morris T, Hartmann-Boyce J. Lindson N, et al. Cochrane Database Syst Rev. 2024 Jan 8;1(1):CD010216. doi: 10.1002/14651858.CD010216.pub8. Cochrane Database Syst Rev. 2024. Update in: Cochrane Database Syst Rev. 2025 Jan 29;1:CD010216. doi: 10.1002/14651858.CD010216.pub9. PMID: 38189560 Free PMC article. Updated.
Pharmacological and electronic cigarette interventions for smoking cessation in adults: component network meta-analyses.
Lindson N, Theodoulou A, Ordóñez-Mena JM, Fanshawe TR, Sutton AJ, Livingstone-Banks J, Hajizadeh A, Zhu S, Aveyard P, Freeman SC, Agrawal S, Hartmann-Boyce J. Lindson N, et al. Cochrane Database Syst Rev. 2023 Sep 12;9(9):CD015226. doi: 10.1002/14651858.CD015226.pub2. Cochrane Database Syst Rev. 2023. PMID: 37696529 Free PMC article.
Benefits We found high-certainty evidence that nicotine e-cigarettes (OR 2.37, 95% CrI 1.73 to 3.24; 16 RCTs, 3828 participants), varenicline (OR 2.33, 95% CrI 2.02 to 2.68; 67 RCTs, 16,430 participants) and cytisine (OR 2.21, 95% CrI 1.66 to 2.97; 7 RCTs, 3848 participant …
Benefits We found high-certainty evidence that nicotine e-cigarettes (OR 2.37, 95% CrI 1.73 to 3.24; 16 RCTs, 3828 participants), vareniclin …
48 results