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Year Number of Results
1926 2
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1931 1
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1933 1
1934 1
1936 1
1937 1
1941 1
1946 4
1947 5
1948 2
1949 5
1950 2
1951 2
1952 2
1953 4
1954 7
1955 5
1956 3
1957 7
1958 5
1959 2
1960 13
1961 8
1962 18
1963 35
1964 95
1965 81
1966 92
1967 115
1968 198
1969 198
1970 175
1971 264
1972 262
1973 298
1974 371
1975 365
1976 322
1977 295
1978 265
1979 338
1980 330
1981 377
1982 409
1983 516
1984 480
1985 543
1986 523
1987 541
1988 572
1989 585
1990 631
1991 625
1992 655
1993 608
1994 619
1995 601
1996 614
1997 605
1998 650
1999 674
2000 684
2001 758
2002 646
2003 781
2004 834
2005 884
2006 936
2007 974
2008 945
2009 1030
2010 1106
2011 1154
2012 1215
2013 1194
2014 1228
2015 1258
2016 1244
2017 1231
2018 1228
2019 1305
2020 1372
2021 1276
2022 1342
2023 1199
2024 952

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Page 1
Role of D-mannose in urinary tract infections - a narrative review.
Ala-Jaakkola R, Laitila A, Ouwehand AC, Lehtoranta L. Ala-Jaakkola R, et al. Nutr J. 2022 Mar 22;21(1):18. doi: 10.1186/s12937-022-00769-x. Nutr J. 2022. PMID: 35313893 Free PMC article. Review.
In this review, we provide an overview of UTIs, E. coli pathogenesis and D-mannose and outline the existing clinical evidence of D-mannose in reducing the risk of UTI and its recurrence. Furthermore, we discuss the potential effect mechanisms of D …
In this review, we provide an overview of UTIs, E. coli pathogenesis and D-mannose and outline the existing clinical evidence …
D-mannose for preventing and treating urinary tract infections.
Cooper TE, Teng C, Howell M, Teixeira-Pinto A, Jaure A, Wong G. Cooper TE, et al. Cochrane Database Syst Rev. 2022 Aug 30;8(8):CD013608. doi: 10.1002/14651858.CD013608.pub2. Cochrane Database Syst Rev. 2022. PMID: 36041061 Free PMC article. Review.
The D-mannose-based inhibitors can block uropathogenic Escherichia coli adhesion and invasion of the uroepithelial cells. ...AUTHORS' CONCLUSIONS: There is currently little to no evidence to support or refute the use of D-mannose to prevent or treat UT …
The D-mannose-based inhibitors can block uropathogenic Escherichia coli adhesion and invasion of the uroepithelial cells. ...A …
D-mannose suppresses macrophage IL-1beta production.
Torretta S, Scagliola A, Ricci L, Mainini F, Di Marco S, Cuccovillo I, Kajaste-Rudnitski A, Sumpton D, Ryan KM, Cardaci S. Torretta S, et al. Nat Commun. 2020 Dec 11;11(1):6343. doi: 10.1038/s41467-020-20164-6. Nat Commun. 2020. PMID: 33311467 Free PMC article.
D-mannose is a monosaccharide approximately a hundred times less abundant than glucose in human blood. ...Here, we show that D-mannose suppresses LPS-induced macrophage activation by impairing IL-1beta production. ...
D-mannose is a monosaccharide approximately a hundred times less abundant than glucose in human blood. ...Here, we show that …
D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1.
Zhang R, Yang Y, Dong W, Lin M, He J, Zhang X, Tian T, Yang Y, Chen K, Lei QY, Zhang S, Xu Y, Lv L. Zhang R, et al. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2114851119. doi: 10.1073/pnas.2114851119. Proc Natl Acad Sci U S A. 2022. PMID: 35181605 Free PMC article.
D-mannose-mediated PD-L1 degradation promotes T cell activation and T cell killing of tumor cells. ...This function of D-mannose may be useful for clinical treatment of TNBC....
D-mannose-mediated PD-L1 degradation promotes T cell activation and T cell killing of tumor cells. ...This function of D …
D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis.
Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. Lenger SM, et al. Am J Obstet Gynecol. 2020 Aug;223(2):265.e1-265.e13. doi: 10.1016/j.ajog.2020.05.048. Epub 2020 Jun 1. Am J Obstet Gynecol. 2020. PMID: 32497610 Free PMC article.
Meta-analysis inclusion: stated D-mannose dose, follow-up time 6 months, a comparison arm to D-mannose, and data available from women 18 years of age. ...Pooled relative risk of urinary tract infection recurrence comparing D-mannose to pl …
Meta-analysis inclusion: stated D-mannose dose, follow-up time 6 months, a comparison arm to D-mannose, and data …
D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2alpha-dependent manner.
Zhou X, Zheng Y, Sun W, Zhang Z, Liu J, Yang W, Yuan W, Yi Y, Wang J, Liu J. Zhou X, et al. Cell Prolif. 2021 Nov;54(11):e13134. doi: 10.1111/cpr.13134. Epub 2021 Sep 25. Cell Prolif. 2021. PMID: 34561933 Free PMC article.
HIF-2alpha was identified as a central mediator in D-mannose-induced ferroptosis resistance of chondrocytes. Furthermore, overexpression of HIF-2alpha in chondrocytes by Ad-Epas1 intra-articular injection abolished the chondroprotective effect of D-mannose …
HIF-2alpha was identified as a central mediator in D-mannose-induced ferroptosis resistance of chondrocytes. Furthermore, over …
Role of D-Mannose in the Prevention of Recurrent Urinary Tract Infections: Evidence from a Systematic Review of the Literature.
Kyriakides R, Jones P, Somani BK. Kyriakides R, et al. Eur Urol Focus. 2021 Sep;7(5):1166-1169. doi: 10.1016/j.euf.2020.09.004. Epub 2020 Sep 22. Eur Urol Focus. 2021. PMID: 32972899 Review.
We performed a systematic review to assess the effect of D-mannose in the prevention of recurrent UTIs. Of the eight studies reporting on D-mannose in this context, six were clinical and included 695 individuals. Three studies reported that time to UTI …
We performed a systematic review to assess the effect of D-mannose in the prevention of recurrent UTIs. Of the eight studies r …
D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial.
Kranjčec B, Papeš D, Altarac S. Kranjčec B, et al. World J Urol. 2014 Feb;32(1):79-84. doi: 10.1007/s00345-013-1091-6. Epub 2013 Apr 30. World J Urol. 2014. PMID: 23633128 Clinical Trial.
PURPOSE: To test whether D-mannose powder is effective for recurrent urinary tract infection (UTI) prevention. ...More studies will be needed to validate the results of this study, but initial findings show that D-mannose may be useful for UTI preventi …
PURPOSE: To test whether D-mannose powder is effective for recurrent urinary tract infection (UTI) prevention. ...More studies …
D-mannose: a promising support for acute urinary tract infections in women. A pilot study.
Domenici L, Monti M, Bracchi C, Giorgini M, Colagiovanni V, Muzii L, Benedetti Panici P. Domenici L, et al. Eur Rev Med Pharmacol Sci. 2016 Jul;20(13):2920-5. Eur Rev Med Pharmacol Sci. 2016. PMID: 27424995 Free article.
OBJECTIVE: Urinary tract infections still represent a significant bother for women and result in high costs to the health system. D-mannose is a simple sugar; it seems able to hinder bacteria adhesion to the urothelium. The present study aimed to determine whether …
OBJECTIVE: Urinary tract infections still represent a significant bother for women and result in high costs to the health system. D- …
d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial.
Hayward G, Mort S, Hay AD, Moore M, Thomas NPB, Cook J, Robinson J, Williams N, Maeder N, Edeson R, Franssen M, Grabey J, Glogowska M, Yang Y, Allen J, Butler CC. Hayward G, et al. JAMA Intern Med. 2024 Jun 1;184(6):619-628. doi: 10.1001/jamainternmed.2024.0264. JAMA Intern Med. 2024. PMID: 38587819 Free PMC article. Clinical Trial.
OBJECTIVE: To determine whether d-mannose taken for 6 months reduces the proportion of women with recurrent UTI experiencing a medically attended UTI. ...CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, daily d-mannose did not reduce the p …
OBJECTIVE: To determine whether d-mannose taken for 6 months reduces the proportion of women with recurrent UTI experiencing a …
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