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Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy.
Kidd PM. Kidd PM. Altern Med Rev. 2010 Sep;15(3):199-222. Altern Med Rev. 2010. PMID: 21155624 Free article. Review.
Their metabolic and physiologic roles overlap considerably, as evidenced in the bone and cardiovascular systems. Vitamin D3 (cholecalciferol, D3) is the prehormone for the vitamin D endocrine system. ...Along with coagulation factors (II, VII, IX, X, and prothrombin …
Their metabolic and physiologic roles overlap considerably, as evidenced in the bone and cardiovascular systems. Vitamin D3 (cholecal …
Warfarin accelerated vascular calcification and worsened cardiac dysfunction in remnant kidney mice.
Tsai MT, Chen YY, Chang WJ, Li SY. Tsai MT, et al. J Chin Med Assoc. 2018 Apr;81(4):324-330. doi: 10.1016/j.jcma.2017.08.021. Epub 2018 Feb 13. J Chin Med Assoc. 2018. PMID: 29395943 Free article.
BACKGROUND: Vascular calcification is highly prevalent in end-stage renal disease (ESRD) and is a significant risk factor for future cardiovascular events and death. Warfarin use results in dysfunction of matrix Gla protein, an inhibitor of vascular calcification. H …
BACKGROUND: Vascular calcification is highly prevalent in end-stage renal disease (ESRD) and is a significant risk factor for future cardiov …
Steady-state vitamin K2 (menaquinone-7) plasma concentrations after intake of dairy products and soft gel capsules.
Knapen MH, Braam LA, Teunissen KJ, Van't Hoofd CM, Zwijsen RM, van den Heuvel EG, Vermeer C. Knapen MH, et al. Eur J Clin Nutr. 2016 Jul;70(7):831-6. doi: 10.1038/ejcn.2016.3. Epub 2016 Feb 24. Eur J Clin Nutr. 2016. PMID: 26908424 Clinical Trial.
BACKGROUND: In a previous human intervention study, we observed an improved vitamin K status after 8 weeks of intake of a yogurt that was fortified with vitamin K2 (as menaquinone-7, MK-7) and enriched with vitamins C and D3, magnesium and polyunsaturated fatty acid …
BACKGROUND: In a previous human intervention study, we observed an improved vitamin K status after 8 weeks of intake of a yogurt that was fo …
Vitamin K2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro.
Koshihara Y, Hoshi K. Koshihara Y, et al. J Bone Miner Res. 1997 Mar;12(3):431-8. doi: 10.1359/jbmr.1997.12.3.431. J Bone Miner Res. 1997. PMID: 9076586 Free article.
Moreover, the gamma-carboxyglutamic acid (Gla)-containing osteocalcin level was increased by the vitamin K2 plus 1,25(OH)2D3 treatment. These results proved that vitamin K2 increased Gla-containing osteocalcin, which accumulated osteocalcin in the extr …
Moreover, the gamma-carboxyglutamic acid (Gla)-containing osteocalcin level was increased by the vitamin K2 plus 1,25(OH)2D3 t …