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The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC.
Javitt A, Shmueli MD, Kramer MP, Kolodziejczyk AA, Cohen IJ, Radomir L, Sheban D, Kamer I, Litchfield K, Bab-Dinitz E, Zadok O, Neiens V, Ulman A, Wolf-Levy H, Eisenberg-Lerner A, Kacen A, Alon M, Rêgo AT, Stacher-Priehse E, Lindner M, Koch I, Bar J, Swanton C, Samuels Y, Levin Y, da Fonseca PCA, Elinav E, Friedman N, Meiners S, Merbl Y. Javitt A, et al. Among authors: da fonseca pca. Nat Cancer. 2023 May;4(5):629-647. doi: 10.1038/s43018-023-00557-4. Epub 2023 May 22. Nat Cancer. 2023. PMID: 37217651
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome.
Deni I, Stokes BH, Ward KE, Fairhurst KJ, Pasaje CFA, Yeo T, Akbar S, Park H, Muir R, Bick DS, Zhan W, Zhang H, Liu YJ, Ng CL, Kirkman LA, Almaliti J, Gould AE, Duffey M, O'Donoghue AJ, Uhlemann AC, Niles JC, da Fonseca PCA, Gerwick WH, Lin G, Bogyo M, Fidock DA. Deni I, et al. Among authors: da fonseca pca. Cell Chem Biol. 2023 May 18;30(5):470-485.e6. doi: 10.1016/j.chembiol.2023.03.002. Epub 2023 Mar 23. Cell Chem Biol. 2023. PMID: 36963402 Free PMC article.
ZOMES: Cell physiology determined by PCI complexes and protein turnover.
Dubiel D, da Fonseca PCA, Valášek LS, Schulze-Niemand E, Naumann M. Dubiel D, et al. Among authors: da fonseca pca. Biochim Biophys Acta Mol Cell Res. 2023 Feb;1870(2):119402. doi: 10.1016/j.bbamcr.2022.119402. Epub 2022 Nov 22. Biochim Biophys Acta Mol Cell Res. 2023. PMID: 36427552 Free article. No abstract available.
Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis.
Živković D, Sanchez Dafun A, Menneteau T, Schahl A, Lise S, Kervarrec C, Toste Rêgo A, da Fonseca PCA, Chavent M, Pineau C, Burlet-Schiltz O, Marcoux J, Bousquet MP. Živković D, et al. Among authors: da fonseca pca. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2116826119. doi: 10.1073/pnas.2116826119. Epub 2022 Apr 4. Proc Natl Acad Sci U S A. 2022. PMID: 35377789 Free PMC article.
How to build a proteasome.
Morris EP, da Fonseca PCA. Morris EP, et al. Among authors: da fonseca pca. Nat Struct Mol Biol. 2021 May;28(5):409-410. doi: 10.1038/s41594-021-00592-8. Nat Struct Mol Biol. 2021. PMID: 33927389 No abstract available.
Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents.
Stokes BH, Yoo E, Murithi JM, Luth MR, Afanasyev P, da Fonseca PCA, Winzeler EA, Ng CL, Bogyo M, Fidock DA. Stokes BH, et al. Among authors: da fonseca pca. PLoS Pathog. 2019 Jun 6;15(6):e1007722. doi: 10.1371/journal.ppat.1007722. eCollection 2019 Jun. PLoS Pathog. 2019. PMID: 31170268 Free PMC article.
High-resolution cryo-EM proteasome structures in drug development.
Morris EP, da Fonseca PCA. Morris EP, et al. Among authors: da fonseca pca. Acta Crystallogr D Struct Biol. 2017 Jun 1;73(Pt 6):522-533. doi: 10.1107/S2059798317007021. Epub 2017 May 31. Acta Crystallogr D Struct Biol. 2017. PMID: 28580914 Free PMC article.
31 results