Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 1
1971 1
1972 3
1973 3
1974 1
1975 1
1977 2
1978 2
1979 2
1980 2
1982 3
1983 1
1984 1
1985 4
1986 1
1987 3
1988 15
1989 13
1990 5
1991 8
1992 6
1993 6
1994 16
1995 13
1996 7
1997 21
1998 9
1999 17
2000 14
2001 12
2002 10
2003 18
2004 13
2005 23
2006 13
2007 13
2008 18
2009 17
2010 13
2011 15
2012 22
2013 32
2014 23
2015 22
2016 36
2017 42
2018 50
2019 48
2020 60
2021 69
2022 50
2023 66
2024 26

Text availability

Article attribute

Article type

Publication date

Search Results

818 results

Results by year

Filters applied: . Clear all
Page 1
Efficacy of micronized purified flavonoid fraction (Daflon) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials.
Kakkos SK, Nicolaides AN. Kakkos SK, et al. Int Angiol. 2018 Apr;37(2):143-154. doi: 10.23736/S0392-9590.18.03975-5. Epub 2018 Jan 31. Int Angiol. 2018. PMID: 29385792 Free article. Review.
The aim of this systematic review and meta-analysis was to study the effectiveness of the micronized purified flavonoid fraction (MPFF, Daflon) across the spectrum of defined venous symptoms, signs, quality of life (QoL) and treatment assessment by the physician. ...
The aim of this systematic review and meta-analysis was to study the effectiveness of the micronized purified flavonoid fraction (MPFF, D
Clinical benefits of Daflon 500 mg in the most severe stages of chronic venous insufficiency.
Ramelet AA. Ramelet AA. Angiology. 2001 Aug;52 Suppl 1:S49-56. doi: 10.1177/0003319701052001S07. Angiology. 2001. PMID: 11510597 Review.
Chronic venous insufficiency (CVI) affects a large number of people in Western countries, and is responsible for considerable inconvenience, discomfort, suffering, and costs. Micronized purified flavonoid fraction (MPFF, 450 mg diosmin plus 50 mg hesperidin-Daflon 5 …
Chronic venous insufficiency (CVI) affects a large number of people in Western countries, and is responsible for considerable inconvenience, …
Efficacy and Safety of Daflon in the Treatment of Idiopathic Epistaxis.
Attia TM. Attia TM. Am J Rhinol Allergy. 2019 Jan;33(1):62-68. doi: 10.1177/1945892418809237. Epub 2018 Nov 5. Am J Rhinol Allergy. 2019. PMID: 30394805 Clinical Trial.
OBJECTIVE: To assess the efficacy and safety of Daflon in the treatment of idiopathic epistaxis. METHODS: This is an open-label randomized clinical trial conducted on patients with idiopathic epistaxis comparing 1 group receiving Daflon for 1 month and a second grou …
OBJECTIVE: To assess the efficacy and safety of Daflon in the treatment of idiopathic epistaxis. METHODS: This is an open-label rando …
Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review.
Gerges SH, Wahdan SA, Elsherbiny DA, El-Demerdash E. Gerges SH, et al. Eur J Drug Metab Pharmacokinet. 2022 Jan;47(1):1-18. doi: 10.1007/s13318-021-00731-y. Epub 2021 Oct 23. Eur J Drug Metab Pharmacokinet. 2022. PMID: 34687440 Review.
Daflon is an oral phlebotonic flavonoid combination containing diosmin and hesperidin (9:1) that is commonly used for the management of blood vessel disorders. ...Moreover, toxicological studies showed that diosmin has a favorable safety profile. Accordingly,
Daflon is an oral phlebotonic flavonoid combination containing diosmin and hesperidin (9:1) that is commonly used for the mana
From symptoms to leg edema: efficacy of Daflon 500 mg.
Nicolaides AN. Nicolaides AN. Angiology. 2003 Jul-Aug;54 Suppl 1:S33-44. doi: 10.1177/0003319703054001S05. Angiology. 2003. PMID: 12934755 Review.
Its efficacy in decreasing CVI edema and ankle swelling has been proven in rigorous studies that are reviewed in this paper. Daflon 500 mg, a well-established oral flavonoid that consists of 90% micronized diosmin and 10% flavonoids expressed as hesperidin, may be p …
Its efficacy in decreasing CVI edema and ankle swelling has been proven in rigorous studies that are reviewed in this paper. Daflon 5 …
Phlebotonics for venous insufficiency.
Martinez-Zapata MJ, Vernooij RW, Simancas-Racines D, Uriona Tuma SM, Stein AT, Moreno Carriles RMM, Vargas E, Bonfill Cosp X. Martinez-Zapata MJ, et al. Cochrane Database Syst Rev. 2020 Nov 3;11(11):CD003229. doi: 10.1002/14651858.CD003229.pub4. Cochrane Database Syst Rev. 2020. PMID: 33141449 Free PMC article.
Effect of daflon-500(), a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats.
Olatunji AO, Ayo JO, Suleiman MM, Ambali SF, Shittu M, Akorede GJ, Raji LO, Atata JA, Biobaku KT, Azeez MO. Olatunji AO, et al. Toxicol Res. 2022 Jan 10;38(3):345-353. doi: 10.1007/s43188-021-00120-2. eCollection 2022 Jul. Toxicol Res. 2022. PMID: 35874508 Free PMC article.
Group I (DW) received distilled water (2 ml/kg); group II (SO) was dosed with soya oil (2 ml/kg); Group III (DAF) received daflon-500 () at 1000 mg/kg ~ 1/5th of LD50 ( 5000 mg/kg); group IV (CP) was administered chlorpyriphos at 7.74 mg/kg ~ 1/10th of LD(50) (77.4 mg/kg) …
Group I (DW) received distilled water (2 ml/kg); group II (SO) was dosed with soya oil (2 ml/kg); Group III (DAF) received daflon-500 …
Three treatments for chronic venous insufficiency: escin, hydroxyethylrutoside, and Daflon.
Frick RW. Frick RW. Angiology. 2000 Mar;51(3):197-205. doi: 10.1177/000331970005100303. Angiology. 2000. PMID: 10744007 Review.
Escin, hydroxyethylrutoside (HR), and Daflon have been shown to be safe and effective for the treatment of chronic venous insufficiency (CVI). ...Additional independent effects that would be useful for the treatment of CVI are that they reduce permeability and fragility; H …
Escin, hydroxyethylrutoside (HR), and Daflon have been shown to be safe and effective for the treatment of chronic venous insufficien …
Daflon for haemorrhoids: a prospective, multi-centre observational study.
Meshikhes AW. Meshikhes AW. Surgeon. 2004 Dec;2(6):335-8, 361. doi: 10.1016/s1479-666x(04)80032-5. Surgeon. 2004. PMID: 15712573 Clinical Trial.
BACKGROUND: Daflon, a phlebotropic agent, is of proven efficacy in the treatment of various venous disorders. ...However, prospective randomised trials and longer follow-up are needed to confirm the findings of this study and delineate more precisely the role of Daflon
BACKGROUND: Daflon, a phlebotropic agent, is of proven efficacy in the treatment of various venous disorders. ...However, prospective …
Daflon 500 mg and venous leg ulcer: new results from a meta-analysis.
Smith PC. Smith PC. Angiology. 2005 Sep-Oct;56 Suppl 1:S33-9. doi: 10.1177/00033197050560i106. Angiology. 2005. PMID: 16193225
The objective of this study was to assess the effect of oral treatment with Daflon 500 mg (micronized purified flavonoid fraction [MPFF]) on leg ulcer healing. ...These results confirm that venous ulcer healing is accelerated by Daflon 500 mg treatment. Daflon
The objective of this study was to assess the effect of oral treatment with Daflon 500 mg (micronized purified flavonoid fraction [MP …
818 results