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32 results

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Page 1
Danazol Treatment for Telomere Diseases.
Grossmann M. Grossmann M. N Engl J Med. 2016 Sep 15;375(11):1095. doi: 10.1056/NEJMc1607752. N Engl J Med. 2016. PMID: 27626529 No abstract available.
Danazol Treatment for Telomere Diseases.
Jouneau S, Kerjouan M, Ricordel C. Jouneau S, et al. N Engl J Med. 2016 Sep 15;375(11):1095. doi: 10.1056/NEJMc1607752. N Engl J Med. 2016. PMID: 27626530 No abstract available.
Danazol Treatment for Telomere Diseases.
Townsley DM, Dumitriu B, Young NS. Townsley DM, et al. N Engl J Med. 2016 Sep 15;375(11):1095-6. doi: 10.1056/NEJMc1607752. N Engl J Med. 2016. PMID: 27626528 No abstract available.
Danazol Treatment for Telomere Diseases.
Townsley DM, Dumitriu B, Liu D, Biancotto A, Weinstein B, Chen C, Hardy N, Mihalek AD, Lingala S, Kim YJ, Yao J, Jones E, Gochuico BR, Heller T, Wu CO, Calado RT, Scheinberg P, Young NS. Townsley DM, et al. N Engl J Med. 2016 May 19;374(20):1922-31. doi: 10.1056/NEJMoa1515319. N Engl J Med. 2016. PMID: 27192671 Free PMC article. Clinical Trial.
METHODS: In a phase 1-2 prospective study involving patients with telomere diseases, we administered the synthetic sex hormone danazol orally at a dose of 800 mg per day for a total of 24 months. ...CONCLUSIONS: In our study, treatment with danazol led to …
METHODS: In a phase 1-2 prospective study involving patients with telomere diseases, we administered the synthetic sex hormone dan …
Short Telomere Syndromes in Clinical Practice: Bridging Bench and Bedside.
Mangaonkar AA, Patnaik MM. Mangaonkar AA, et al. Mayo Clin Proc. 2018 Jul;93(7):904-916. doi: 10.1016/j.mayocp.2018.03.020. Epub 2018 May 24. Mayo Clin Proc. 2018. PMID: 29804726 Free PMC article. Review.
Short telomere syndromes (STSs) are accelerated aging syndromes often caused by inheritable gene mutations resulting in decreased telomere lengths. ...Danazol, an anabolic steroid, has been associated with hematologic responses in patients with STSs and assoc …
Short telomere syndromes (STSs) are accelerated aging syndromes often caused by inheritable gene mutations resulting in decreased …
The Use of Natural Agents to Counteract Telomere Shortening: Effects of a Multi-Component Extract of Astragalus mongholicus Bunge and Danazol.
Guinobert I, Blondeau C, Colicchio B, Oudrhiri N, Dieterlen A, Jeandidier E, Deschenes G, Bardot V, Cotte C, Ripoche I, Carde P, Berthomier L, M'Kacher R. Guinobert I, et al. Biomedicines. 2020 Feb 12;8(2):31. doi: 10.3390/biomedicines8020031. Biomedicines. 2020. PMID: 32059353 Free PMC article.
Extracts of Astragalus spp. are known to stimulate telomerase activity, thereby compensating telomere shortening. We characterized a multi-component hydroethanolic root extract (HRE) of Astragalus mongholicus Bunge and assessed its effects on telomeres compared to t …
Extracts of Astragalus spp. are known to stimulate telomerase activity, thereby compensating telomere shortening. We characterized a …
TELO-SCOPE study: a randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis.
Mackintosh JA, Pietsch M, Lutzky V, Enever D, Bancroft S, Apte SH, Tan M, Yerkovich ST, Dickinson JL, Pickett HA, Selvadurai H, Grainge C, Goh NS, Hopkins P, Glaspole I, Reynolds PN, Wrobel J, Jaffe A, Corte TJ, Chambers DC. Mackintosh JA, et al. BMJ Open Respir Res. 2021 Dec;8(1):e001127. doi: 10.1136/bmjresp-2021-001127. BMJ Open Respir Res. 2021. PMID: 34857525 Free PMC article. Clinical Trial.
INTRODUCTION: Recent discoveries have identified shortened telomeres and related mutations in people with pulmonary fibrosis (PF). There is evidence to suggest that androgens, including danazol, may be effective in lengthening telomeres in peripheral blood ce …
INTRODUCTION: Recent discoveries have identified shortened telomeres and related mutations in people with pulmonary fibrosis (PF). Th …
No effect of danazol treatment in patients with advanced idiopathic pulmonary fibrosis.
Hoffman TW, van Moorsel CHM, van der Vis JJ, Biesma DH, Grutters JC. Hoffman TW, et al. ERJ Open Res. 2023 Sep 25;9(5):00131-2023. doi: 10.1183/23120541.00131-2023. eCollection 2023 Sep. ERJ Open Res. 2023. PMID: 37753281 Free PMC article.
BACKGROUND: Telomere dysfunction can underly the development of idiopathic pulmonary fibrosis (IPF), and recent work suggests that patients with telomere syndromes might benefit from treatment with androgens, such as danazol. ...In patients who were still usi …
BACKGROUND: Telomere dysfunction can underly the development of idiopathic pulmonary fibrosis (IPF), and recent work suggests that pa …
Pharmacotherapeutic Considerations on Telomere Biology: The Positive Effect of Pharmacologically Active Substances on Telomere Length.
Apetroaei MM, Fragkiadaki P, Velescu BȘ, Baliou S, Renieri E, Dinu-Pirvu CE, Drăgănescu D, Vlăsceanu AM, Nedea MII, Udeanu DI, Docea AO, Tsatsakis A, Arsene AL. Apetroaei MM, et al. Int J Mol Sci. 2024 Jul 13;25(14):7694. doi: 10.3390/ijms25147694. Int J Mol Sci. 2024. PMID: 39062937 Free PMC article. Review.
While telomere length (TL) can be genetically inherited, TL shortening has been associated with ageing and multiple xenobiotics and bioactive substances. ...This narrative review aims to provide arguments in favour of including TL measurements in a complex prognostic and d …
While telomere length (TL) can be genetically inherited, TL shortening has been associated with ageing and multiple xenobiotics and b …
32 results