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Year Number of Results
1993 1
1994 2
2004 2
2005 4
2006 23
2007 17
2008 12
2009 16
2010 19
2011 15
2012 13
2013 16
2014 16
2015 28
2016 28
2017 15
2018 18
2019 19
2020 6
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244 results
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Filters applied: . Clear all The following term was not found in PubMed: 119356-77-3
Page 1
Capillary electrophoresis method for the determination of (R)-dapoxetine, (3S)-3-(dimethylamino)-3-phenyl-1-propanol, (S)-3-amino-3-phenyl-1-propanol and 1-naphthol as impurities of dapoxetine hydrochloride.
Harnisch H and Scriba GKE. J Pharm Biomed Anal 2019. PMID 30273816
A capillary electrophoresis method was developed and validated for the determination of the purity of dapoxetine with regard to the related substances (3S)-3-amino-3-phenylpropan-1-ol, (3S)-3-(dimethylamino)-3-phenylpropan-1-ol, 1-naphthol and the enantiomer (R)-dapoxetine. ...Data regarding the enantiomeric purity of dapoxetine obtained by the capillary electrophoresis assay were comparable to the data obtained by an enantioselective HPLC method....
A capillary electrophoresis method was developed and validated for the determination of the purity of dapoxetine with regard to the r …
Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: A randomised placebo-controlled clinical trial.
Abu El-Hamd M and Abdelhamed A. Andrologia 2018 - Clinical Trial. PMID 28497478
The aim of the study was to compare the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation (PE). ...The combined dapoxetine with sildenafil therapy could significantly improve PE patients without ED as compared to paroxetine alone or dapoxetine alone or sildenafil alone with tolerated adverse effects....
The aim of the study was to compare the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and c …
Dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized controlled trials with trial sequential analysis.
Li J, et al. Ann Saudi Med 2018 - Review. PMID 30284992 Free PMC article.
OBJECTIVE: Evaluate the efficacy and safety of dapoxetine in the treatment of patients with PE and assess the reliability of the findings. ...CONCLUSIONS: The evidence suggests that dapoxetine may be a safe and effective drug for patients with PE. REGISTRATION: Not registered, no published protocol. ...
OBJECTIVE: Evaluate the efficacy and safety of dapoxetine in the treatment of patients with PE and assess the reliability of the find …
Effects of Evodiamine on the Pharmacokinetics of Dapoxetine and Its Metabolite Desmethyl Dapoxetine in Rats.
Li RF, et al. Pharmacology 2016. PMID 26588583
The objective of this work was to investigate the effect of orally administered evodiamine on the pharmacokinetics of dapoxetine and its active metabolite desmethyl dapoxetine in rats. Twelve healthy male Sprague-Dawley rats were randomly divided into 2 groups: the control group (received oral 10 mg/kg dapoxetine alone) and the combination group (10 mg/kg dapoxetine orally co-administered with 100 mg/kg evodiamine). ...
The objective of this work was to investigate the effect of orally administered evodiamine on the pharmacokinetics of dapoxetine and …
Effects of Grapefruit and Pomegranate Juices on the Pharmacokinetic Properties of Dapoxetine and Midazolam in Healthy Subjects.
Abdlekawy KS, et al. Eur J Drug Metab Pharmacokinet 2017 - Clinical Trial. PMID 27294349
Slight but not statistically significant changes were observed in the pharmacokinetics of dapoxetine and midazolam after pretreatment with PJ. ...CONCLUSION: These results suggest that GFJ increases the extent of absorption and reduces clearance of dapoxetine possibly by inhibition of both intestinal and hepatic CYP3A4, whereas PJ has little effect on dapoxetine pharmacokinetics. ...
Slight but not statistically significant changes were observed in the pharmacokinetics of dapoxetine and midazolam after pretreatment …
Herb-drug interaction of Epimedium extract on the pharmacokinetic of dapoxetine in rats.
Hsueh TY, et al. J Chromatogr B Analyt Technol Biomed Life Sci 2016. PMID 26874879
Experimental rats were divided into the following four parallel groups: (1) dapoxetine alone (10mg/kg, i.v.); (2) oral administration of Epimedium extract (2g/kg) for 3 consecutive days and on the fourth day dapoxetine was administered (10mg/kg, i.v.); (3) dapoxetine alone (10mg/kg, p.o.); (4) oral administration of Epimedium extract (2g/kg) for 3 consecutive days and on the fourth day dapoxetine was administered (10mg/kg, p.o.). ...The oral bioavailability of dapoxetine was about 75% in rats....
Experimental rats were divided into the following four parallel groups: (1) dapoxetine alone (10mg/kg, i.v.); (2) oral administration …
Premature ejaculation: Pharmacotherapy vs group psychotherapy alone or in combination
Pavone C, et al. Arch Ital Urol Androl 2017 - Clinical Trial. PMID 28679182 Free article.
OBJECTIVES: Premature Ejaculation (PE), the commonest sexual dysfunction in males, is generally treated with local anesthetic and SSRI (Dapoxetine). ...Each group was treated with Dapoxetine, Group Psychotherapy alone and Dapoxetine and Group Psychotherapy, respectively. MATERIALS AND METHODS: Out of 1237 male outpatients, 353 received a diagnosis of Premature Ejaculation. ...
OBJECTIVES: Premature Ejaculation (PE), the commonest sexual dysfunction in males, is generally treated with local anesthetic and SSRI (D
The drug treatment of premature ejaculation
Hisasue S. Transl Androl Urol 2016 - Review. PMID 27652221 Free PMC article.
For the drug treatment for PE, gold standard is selective serotonin reuptake inhibitors (SSRIs) including dapoxetine or paroxetine. ...
For the drug treatment for PE, gold standard is selective serotonin reuptake inhibitors (SSRIs) including dapoxetine or paroxetine. . …
Results from a prospective observational study of men with premature ejaculation treated with dapoxetine or alternative care: the PAUSE study.
Mirone V, et al. Eur Urol 2014 - Clinical Trial. PMID 23993257
BACKGROUND: Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor and the first drug approved for the on-demand treatment of premature ejaculation (PE). ...OBJECTIVE: To characterize the safety profile of dapoxetine in PE treatment and to report the incidence, severity, and type of adverse events. ...
BACKGROUND: Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor and the first drug approved for the on-demand treatm …
Baseline characteristics and treatment outcomes for men with acquired or lifelong premature ejaculation with mild or no erectile dysfunction: integrated analyses of two phase 3 dapoxetine trials.
Porst H, et al. J Sex Med 2010 - Clinical Trial. PMID 20412423
AIM: To present integrated analyses of baseline characteristics and treatment outcomes from phase 3 dapoxetine trials in men with acquired or lifelong PE and mild or no ED. METHODS: Data were analyzed from two randomized, double-blind, placebo-controlled, phase 3 clinical trials (International and Asia-Pacific) that evaluated efficacy and safety of dapoxetine (30 mg or 60 mg as needed [PRN]) in patients with PE. ...
AIM: To present integrated analyses of baseline characteristics and treatment outcomes from phase 3 dapoxetine trials in men with acq …
244 results
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