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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 4
2007 2
2008 5
2009 6
2010 6
2011 2
2012 3
2013 2
2014 2
2015 5
2016 6
2017 5
2018 6
2019 7
2020 4
2021 5
2022 1
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74 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Dapoxetine combined with non-pharmacological approaches for lifelong premature ejaculation. A systematic review and meta-analysis.
Nieves Martín M, Marín Novoa P, Avendaño-Coy J. Nieves Martín M, et al. J Sex Med. 2025 Nov 2;22(11):1948-1957. doi: 10.1093/jsxmed/qdaf238. J Sex Med. 2025. PMID: 41020367

Pooled analysis of studies showed a significant effect of dapoxetine combined with non-pharmacological therapies in improving IELT compared to dapoxetine monotherapy (SDM = 1.6; 95%CI, 0.5-2.8; P = .01), PEDT scores (SDM = 0.9; 95%CI, 0.4-1.4; P < .001) and PEP s

…
Pooled analysis of studies showed a significant effect of dapoxetine combined with non-pharmacological therapies in improving IELT co …
Dapoxetine for premature ejaculation: an updated meta-analysis of randomized controlled trials.
Li J, Yuan H, Bai Y, Pu C, Tang Y, Dong Q, Wei Q, Han P. Li J, et al. Clin Ther. 2014 Dec 1;36(12):2003-2014. doi: 10.1016/j.clinthera.2014.09.011. Epub 2014 Oct 16. Clin Ther. 2014. PMID: 25438723
PURPOSE: Dapoxetine is the first oral agent approved for the treatment of premature ejaculation (PE). ...The goal of this meta-analysis was to provide more information about the efficacy and safety of dapoxetine in patients with PE. METHODS: We performed a meta-anal …
PURPOSE: Dapoxetine is the first oral agent approved for the treatment of premature ejaculation (PE). ...The goal of this meta-analys …
Dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized controlled trials with trial sequential analysis.
Li J, Liu D, Wu J, Fan X, Dong Q. Li J, et al. Ann Saudi Med. 2018 Sep-Oct;38(5):366-375. doi: 10.5144/0256-4947.2018.366. Ann Saudi Med. 2018. PMID: 30284992 Free PMC article. Review.
OBJECTIVE: Evaluate the efficacy and safety of dapoxetine in the treatment of patients with PE and assess the reliability of the findings. ...CONCLUSIONS: The evidence suggests that dapoxetine may be a safe and effective drug for patients with PE. REGISTRATION: Not …
OBJECTIVE: Evaluate the efficacy and safety of dapoxetine in the treatment of patients with PE and assess the reliability of the find …
[Dapoxetine in treatment of premature ejaculation: a systematic review].
Wang YB, Mao Y, Wei Q, Wu TX, Dong Q. Wang YB, et al. Beijing Da Xue Xue Bao Yi Xue Ban. 2010 Aug 18;42(4):425-32. Beijing Da Xue Xue Bao Yi Xue Ban. 2010. PMID: 20721257 Free article. Chinese.
OBJECTIVE: To assess the effectiveness of dapoxetine in the treatment of premature ejaculation. METHODS: Both English and Chinese studies involving men with prematrue ejaculation who were treated with dapoxetine from the Cochrane Library, MEDLINE, EMBASE and CNKI, C …
OBJECTIVE: To assess the effectiveness of dapoxetine in the treatment of premature ejaculation. METHODS: Both English and Chinese stu …
Efficacy and safety of dapoxetine for premature ejaculation: an updated systematic review and meta-analysis.
Zhao GJ, Guo Q, Li YF, Zhang YG. Zhao GJ, et al. Sex Health. 2019 Aug;16(4):301-313. doi: 10.1071/SH18005. Sex Health. 2019. PMID: 32172793
We conducted a systematic review and meta-analysis of published randomised controlled trials of dapoxetine for premature ejaculation. We systematically searched Embase, PubMed, Cochrane, Web of Knowledge, FDA.gov and Clinical Trials.gov for studies reporting dapoxetine …
We conducted a systematic review and meta-analysis of published randomised controlled trials of dapoxetine for premature ejaculation. …
Efficacy and safety of on-demand dapoxetine combined with phosphodiesterase-5 inhibitor compared to monotherapy dapoxetine as a treatment of premature ejaculation without erectile dysfunction: a systematic review and meta-analysis.
Mahesvara IBGA, Suarsana IW, Putra IBOW, Manuaba IBKP. Mahesvara IBGA, et al. Arch Ital Urol Androl. 2025 Sep 30;97(3):14117. doi: 10.4081/aiua.2025.14117. Epub 2025 Sep 30. Arch Ital Urol Androl. 2025. PMID: 41031773 Free article.
The European Association of Urology (EAU) guidelines state that monotherapy dapoxetine on-demand has been successfully used to treat PE throughout Europe. Several studies have stated that when dapoxetine and phosphodiesterase-5 inhibitor (PDE-5i) are used combined, …
The European Association of Urology (EAU) guidelines state that monotherapy dapoxetine on-demand has been successfully used to treat …
The role of dapoxetine hydrochloride on-demand for the treatment of men with premature ejaculation.
De Hong C, Ren LL, Yu H, Qiang W. De Hong C, et al. Sci Rep. 2014 Dec 1;4:7269. doi: 10.1038/srep07269. Sci Rep. 2014. PMID: 25434754 Free PMC article. Review.
Ultimately, a total of seven RCTs with 8039 patients were included. Our meta-analysis demonstrated that dapoxetine (in the 30 mg and 60 mg subgroup) resulted in significantly higher IELT, PGIC, and AE incidence relative to the placebo, with higher proportions observed for …
Ultimately, a total of seven RCTs with 8039 patients were included. Our meta-analysis demonstrated that dapoxetine (in the 30 mg and …
Efficacy and Safety of "On-Demand" Dapoxetine in Treatment of Patients with Premature Ejaculation: A Meta-Analysis.
Du Y, Jiang Y, Zhang J, Tian G, Zhang N, Wu D, Bai X. Du Y, et al. Med Sci Monit. 2019 Jun 7;25:4225-4232. doi: 10.12659/MSM.913606. Med Sci Monit. 2019. PMID: 31171764 Free PMC article.
We found that IELT, PGIC, and PCOE in PE patients with "on-demand" dapoxetine were significantly higher than in the control group, and we observed higher proportions in 60 mg vs. 30 mg dapoxetine. The AEs were mild and tolerable. CONCLUSIONS "On-demand" dapoxetin …
We found that IELT, PGIC, and PCOE in PE patients with "on-demand" dapoxetine were significantly higher than in the control group, an …
Efficacy of Dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized clinical trials on intravaginal ejaculatory latency time, patient-reported outcomes, and adverse events.
Yue FG, Dong L, Hu TT, Qu XY. Yue FG, et al. Urology. 2015 Apr;85(4):856-61. doi: 10.1016/j.urology.2015.01.009. Urology. 2015. PMID: 25817107 Review.
OBJECTIVE: To evaluate the efficacy of dapoxetine in the treatment of premature ejaculation (PE) with a meta-analysis method. METHOD: We looked for randomized controlled trials (RCTs) from MEDLINE, EMBASE, Cochrane library, "International Standard Randomized Controlled Tri …
OBJECTIVE: To evaluate the efficacy of dapoxetine in the treatment of premature ejaculation (PE) with a meta-analysis method. METHOD: …
[Dapoxetine hydrochloride versus paroxetine for the treatment of primary premature ejaculation].
Zhou TY, Li Z, Kang Y, Gong DL, Zhou Q, Li TS. Zhou TY, et al. Zhonghua Nan Ke Xue. 2025 May;31(5):432-437. Zhonghua Nan Ke Xue. 2025. PMID: 40788214 Clinical Trial. Chinese.
OBJECTIVE: To investigate the clinical effect and adverse reactions of dapoxetine hydrochloride versus paroxetine in the treatment of primary premature ejaculation by cross-comparison. ...CONCLUSION: In term of overall effectiveness, paroxetine was superior to dapoxetin …
OBJECTIVE: To investigate the clinical effect and adverse reactions of dapoxetine hydrochloride versus paroxetine in the treatment of …
74 results