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Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age.
Islam MT, Tuday E, Allen S, Kim J, Trott DW, Holland WL, Donato AJ, Lesniewski LA. Islam MT, et al. Aging Cell. 2023 Feb;22(2):e13767. doi: 10.1111/acel.13767. Epub 2023 Jan 13. Aging Cell. 2023. PMID: 36637079 Free PMC article.
However, the effect of this intervention on metabolic function in old age remains poorly understood. Here, we demonstrate that dasatinib and quercetin (D&Q) have senolytic effects, reducing age-related increase in senescence-associated beta- …
However, the effect of this intervention on metabolic function in old age remains poorly understood. Here, we demonstrate that dasatinib …
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL. Hickson LJ, et al. EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18. EBioMedicine. 2019. PMID: 31542391 Free PMC article.
BACKGROUND: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. Senolytics, including the combination of D …
BACKGROUND: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotyp …
Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice.
Novais EJ, Tran VA, Johnston SN, Darris KR, Roupas AJ, Sessions GA, Shapiro IM, Diekman BO, Risbud MV. Novais EJ, et al. Nat Commun. 2021 Sep 3;12(1):5213. doi: 10.1038/s41467-021-25453-2. Nat Commun. 2021. PMID: 34480023 Free PMC article.
Due to the link between disc degeneration and senescence, we explored the ability of the Dasatinib and Quercetin drug combination (D + Q) to prevent an age-dependent progression of disc degeneration in mice. We treated C57BL/6 mice beginning at 6, 14, …
Due to the link between disc degeneration and senescence, we explored the ability of the Dasatinib and Quercetin drug combinat …
Long-term senolytic therapy with Dasatinib and Quercetin alleviates lipofuscin-dependent retinal degeneration in mice.
Yang B, Yang K, Xi R, Li S, Chen J, Wu Y. Yang B, et al. Redox Biol. 2025 Sep;85:103716. doi: 10.1016/j.redox.2025.103716. Epub 2025 Jun 6. Redox Biol. 2025. PMID: 40493982 Free PMC article.
Although there is already evidence suggesting a link between cellular senescence and age-related diseases, it is still unclear whether long-term senolytic therapy with Dasatinib and Quercetin (D + Q) can slow the progression of dry AMD and ultim …
Although there is already evidence suggesting a link between cellular senescence and age-related diseases, it is still unclear whether long- …
Cellular senescence drives age-dependent hepatic steatosis.
Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D. Ogrodnik M, et al. Nat Commun. 2017 Jun 13;8:15691. doi: 10.1038/ncomms15691. Nat Commun. 2017. PMID: 28608850 Free PMC article.
The elimination of senescent cells by suicide gene-meditated ablation of p16(Ink4a)-expressing senescent cells in INK-ATTAC mice or by treatment with a combination of the senolytic drugs dasatinib and quercetin (D+Q) reduces overall hepatic stea …
The elimination of senescent cells by suicide gene-meditated ablation of p16(Ink4a)-expressing senescent cells in INK-ATTAC mice or by treat …
Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial.
Gonzales MM, Garbarino VR, Kautz TF, Palavicini JP, Lopez-Cruzan M, Dehkordi SK, Mathews JJ, Zare H, Xu P, Zhang B, Franklin C, Habes M, Craft S, Petersen RC, Tchkonia T, Kirkland JL, Salardini A, Seshadri S, Musi N, Orr ME. Gonzales MM, et al. Nat Med. 2023 Oct;29(10):2481-2488. doi: 10.1038/s41591-023-02543-w. Epub 2023 Sep 7. Nat Med. 2023. PMID: 37679434 Free PMC article. Clinical Trial.
An open-label, proof-of-concept, phase I clinical trial of orally delivered senolytic therapy, dasatinib (D) and quercetin (Q), was conducted in early-stage symptomatic patients with AD to assess central nervous system (CNS) penetrance, safety, …
An open-label, proof-of-concept, phase I clinical trial of orally delivered senolytic therapy, dasatinib (D) and que …
Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability.
Nambiar A, Kellogg D 3rd, Justice J, Goros M, Gelfond J, Pascual R, Hashmi S, Masternak M, Prata L, LeBrasseur N, Limper A, Kritchevsky S, Musi N, Tchkonia T, Kirkland J. Nambiar A, et al. EBioMedicine. 2023 Apr;90:104481. doi: 10.1016/j.ebiom.2023.104481. Epub 2023 Feb 28. EBioMedicine. 2023. PMID: 36857968 Free PMC article. Clinical Trial.
IPF is associated with increased senescent cells burden, which may be alleviated with administration of senescent cell targeting drugs termed 'senolytics'. We previously conducted an open-label single-arm pilot study of the senolytic combination of dasatinib …
IPF is associated with increased senescent cells burden, which may be alleviated with administration of senescent cell targeting drugs terme …
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.
Zhu Y, Tchkonia T, Fuhrmann-Stroissnigg H, Dai HM, Ling YY, Stout MB, Pirtskhalava T, Giorgadze N, Johnson KO, Giles CB, Wren JD, Niedernhofer LJ, Robbins PD, Kirkland JL. Zhu Y, et al. Aging Cell. 2016 Jun;15(3):428-35. doi: 10.1111/acel.12445. Epub 2016 Mar 18. Aging Cell. 2016. PMID: 26711051 Free PMC article.
Using a hypothesis-driven bioinformatics-based approach, we recently identified pro-survival pathways in human senescent cells that contribute to their resistance to apoptosis. This led to identification of dasatinib (D) and quercetin (Q) as senolyt …
Using a hypothesis-driven bioinformatics-based approach, we recently identified pro-survival pathways in human senescent cells that contribu …
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo.
Takaya K, Kishi K. Takaya K, et al. Biogerontology. 2024 Aug;25(4):691-704. doi: 10.1007/s10522-024-10103-z. Epub 2024 Apr 15. Biogerontology. 2024. PMID: 38619669
Accordingly, we aimed to examine the effects of dasatinib in combination with quercetin (D + Q) on senescent human skin fibroblasts and aging human skin. ...Our findings suggest that D + Q could be developed as an effective therapeutic ap …
Accordingly, we aimed to examine the effects of dasatinib in combination with quercetin (D + Q) on senescent hum …
Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer.
Kovacovicova K, Skolnaja M, Heinmaa M, Mistrik M, Pata P, Pata I, Bartek J, Vinciguerra M. Kovacovicova K, et al. Front Oncol. 2018 Oct 30;8:459. doi: 10.3389/fonc.2018.00459. eCollection 2018. Front Oncol. 2018. PMID: 30425964 Free PMC article.
An increased number of senescent cells are associated with age-related tissue degeneration during NAFLD-induced HCC, or during chemotherapeutic treatment. Senolytic agents target selectively senescent cells. A combination of the senolytic drugs dasatinib and …
An increased number of senescent cells are associated with age-related tissue degeneration during NAFLD-induced HCC, or during chemotherapeu …
129 results