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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1989 1
1990 2
1991 3
1992 2
1993 3
1995 5
1996 6
1997 6
1998 4
1999 2
2000 8
2001 3
2002 3
2003 3
2004 6
2005 3
2006 2
2007 3
2008 7
2009 9
2010 14
2011 17
2012 24
2013 22
2014 29
2015 41
2016 31
2017 21
2018 25
2019 29
2020 25
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318 results
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Page 1
Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications.
Tataranni T, Piccoli C. Tataranni T, et al. Oxid Med Cell Longev. 2019 Nov 14;2019:8201079. doi: 10.1155/2019/8201079. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31827705 Free PMC article. Review.
An extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administration in cancer therapy is still limited to clinical trials. ...Interestingly, DCA could significantly affect cancer stem …
An extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administrat …
Dichloroacetate Affects Mitochondrial Function and Stemness-Associated Properties in Pancreatic Cancer Cell Lines.
Tataranni T, Agriesti F, Pacelli C, Ruggieri V, Laurenzana I, Mazzoccoli C, Sala GD, Panebianco C, Pazienza V, Capitanio N, Piccoli C. Tataranni T, et al. Cells. 2019 May 18;8(5):478. doi: 10.3390/cells8050478. Cells. 2019. PMID: 31109089 Free PMC article.
Targeting metabolism represents a possible successful approach to treat cancer. Dichloroacetate (DCA) is a drug known to divert metabolism from anaerobic glycolysis to mitochondrial oxidative phosphorylation by stimulation of PDH. ...In a xenograft pancreatic …
Targeting metabolism represents a possible successful approach to treat cancer. Dichloroacetate (DCA) is a drug known t …
Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway.
Liang Y, Hou L, Li L, Li L, Zhu L, Wang Y, Huang X, Hou Y, Zhu D, Zou H, Gu Y, Weng X, Wang Y, Li Y, Wu T, Yao M, Gross I, Gaiddon C, Luo M, Wang J, Meng X. Liang Y, et al. Oncogene. 2020 Jan;39(2):469-485. doi: 10.1038/s41388-019-1035-8. Epub 2019 Oct 9. Oncogene. 2020. PMID: 31597953 Free PMC article.
The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as a metabolic regulator in the treatment of metabolic diseases; here, DCA was assayed to identi …
The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate
Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells.
Li B, Li X, Ni Z, Zhang Y, Zeng Y, Yan X, Huang Y, He J, Lyu X, Wu Y, Wang Y, Zheng Y, He F. Li B, et al. Oncotarget. 2016 Sep 13;7(37):59458-59470. doi: 10.18632/oncotarget.10694. Oncotarget. 2016. PMID: 27449090 Free PMC article.
Both dichloroacetate (DCA) and metformin (Met) have shown promising antitumor efficacy by regulating cancer cell metabolism. ...These results may pave a way for developing novel strategies for the treatment of ovarian cancer based on the combined use o …
Both dichloroacetate (DCA) and metformin (Met) have shown promising antitumor efficacy by regulating cancer cell metabo …
Dichloroacetate and cancer: new home for an orphan drug?
Kankotia S, Stacpoole PW. Kankotia S, et al. Biochim Biophys Acta. 2014 Dec;1846(2):617-29. doi: 10.1016/j.bbcan.2014.08.005. Epub 2014 Aug 23. Biochim Biophys Acta. 2014. PMID: 25157892 Review.
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and congenital disorders of mitochondrial intermediary metabolism. Inhibition by DCA of mitochondrial pyruvate dehydrogenase kinases and …
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and …
Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis.
El Sayed SM, Baghdadi H, Ahmed NS, Almaramhy HH, Mahmoud AA, El-Sawy SA, Ayat M, Elshazley M, Abdel-Aziz W, Abdel-Latif HM, Ibrahim W, Aboonq MS. El Sayed SM, et al. Med Hypotheses. 2019 Jan;122:206-209. doi: 10.1016/j.mehy.2018.11.012. Epub 2018 Nov 22. Med Hypotheses. 2019. PMID: 30593413
Dichloroacetate (DCA) is a promising safe anticancer drug that cured a patient with chemoresistant non-Hodgkin's lymphoma and treated lactic acidosis effectively. ...We hypothesize that DCA exerts its anticancer effects via depriving cancer of a
Dichloroacetate (DCA) is a promising safe anticancer drug that cured a patient with chemoresistant non-Hodgkin's lympho
Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium(I)-DCA conjugate.
Yang J, Cao Q, Zhang H, Hao L, Zhou D, Gan Z, Li Z, Tong YX, Ji LN, Mao ZW. Yang J, et al. Biomaterials. 2018 Sep;176:94-105. doi: 10.1016/j.biomaterials.2018.05.040. Epub 2018 May 25. Biomaterials. 2018. PMID: 29870900
We have developed a multi-functional Re-dca conjugate (Re-dca 2) by conjugating the metabolic modulator dichloroacetate (DCA) to mitochondria-targeted rhenium(I) complex, allowing its efficient penetration into cancer cells and selective accumul …
We have developed a multi-functional Re-dca conjugate (Re-dca 2) by conjugating the metabolic modulator dichloroacetate
Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway.
Liang Y, Zhu D, Zhu L, Hou Y, Hou L, Huang X, Li L, Wang Y, Li L, Zou H, Wu T, Yao M, Wang J, Meng X. Liang Y, et al. J Cancer. 2019 Oct 15;10(24):6037-6047. doi: 10.7150/jca.34650. eCollection 2019. J Cancer. 2019. PMID: 31762813 Free PMC article.
Chemoresistance is responsible for most colorectal cancer (CRC) related deaths. In this study, we found that dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, can be used as a sensitizer for oxaliplatin (L-OHP) chemoresistant CRC cells. …
Chemoresistance is responsible for most colorectal cancer (CRC) related deaths. In this study, we found that dichloroacetate ( …
Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.
James MO, Jahn SC, Zhong G, Smeltz MG, Hu Z, Stacpoole PW. James MO, et al. Pharmacol Ther. 2017 Feb;170:166-180. doi: 10.1016/j.pharmthera.2016.10.018. Epub 2016 Oct 19. Pharmacol Ther. 2017. PMID: 27771434 Free PMC article. Review.
Dichloroacetate (DCA) has several therapeutic applications based on its pharmacological property of inhibiting pyruvate dehydrogenase kinase. ...Although administration of high doses to rodents can result in liver cancer, there is no evidence that DCA
Dichloroacetate (DCA) has several therapeutic applications based on its pharmacological property of inhibiting pyruvate dehydr
Propranolol Promotes Glucose Dependence and Synergizes with Dichloroacetate for Anti-Cancer Activity in HNSCC.
Lucido CT, Miskimins WK, Vermeer PD. Lucido CT, et al. Cancers (Basel). 2018 Nov 30;10(12):476. doi: 10.3390/cancers10120476. Cancers (Basel). 2018. PMID: 30513596 Free PMC article.
Here, we show that glucose deprivation synergizes with propranolol for anti-cancer activity, and that the rational combination of propranolol and dichloroacetate (DCA), a clinically available glycolytic inhibitor, dramatically attenuates tumor cell metabolism …
Here, we show that glucose deprivation synergizes with propranolol for anti-cancer activity, and that the rational combination of pro …
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