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SLV330, a cannabinoid CB1 receptor antagonist, ameliorates deficits in the T-maze, object recognition and Social Recognition Tasks in rodents.
de Bruin NM, Prickaerts J, Lange JH, Akkerman S, Andriambeloson E, de Haan M, Wijnen J, van Drimmelen M, Hissink E, Heijink L, Kruse CG. de Bruin NM, et al. Among authors: de haan m. Neurobiol Learn Mem. 2010 May;93(4):522-31. doi: 10.1016/j.nlm.2010.01.010. Epub 2010 Feb 2. Neurobiol Learn Mem. 2010. PMID: 20132903
N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT₆R) antagonists with unique structural features.
van Loevezijn A, Venhorst J, Iwema Bakker WI, de Korte CG, de Looff W, Verhoog S, van Wees JW, van Hoeve M, van de Woestijne RP, van der Neut MA, Borst AJ, van Dongen MJ, de Bruin NM, Keizer HG, Kruse CG. van Loevezijn A, et al. J Med Chem. 2011 Oct 27;54(20):7030-54. doi: 10.1021/jm200466r. Epub 2011 Sep 26. J Med Chem. 2011. PMID: 21866910
Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket.
van Loevezijn A, Venhorst J, Iwema Bakker WI, Lange JHM, de Looff W, Henzen R, de Vries J, van de Woestijne RP, den Hartog AP, Verhoog S, van der Neut MAW, de Bruin NMWJ, Kruse CG. van Loevezijn A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1605-1611. doi: 10.1016/j.bmcl.2016.02.001. Epub 2016 Feb 2. Bioorg Med Chem Lett. 2016. PMID: 26876931
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