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Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo.
Li M, de Graaf IA, de Jager MH, Groothuis GM. Li M, et al. Among authors: de jager mh, de graaf ia. Toxicol In Vitro. 2015 Aug;29(5):1070-8. doi: 10.1016/j.tiv.2015.04.011. Epub 2015 Apr 25. Toxicol In Vitro. 2015. PMID: 25917215
Intercellular communication and cell proliferation in precision-cut rat liver slices: effect of medium composition and DDT.
de Graaf IA, Tajima O, Groten JP, Wolterbeek AP. de Graaf IA, et al. Cancer Lett. 2000 Jun 1;154(1):53-62. doi: 10.1016/s0304-3835(00)00377-3. Cancer Lett. 2000. PMID: 10799739
Cryopreservation of precision-cut tissue slices for application in drug metabolism research.
de Graaf IA, Koster HJ. de Graaf IA, et al. Toxicol In Vitro. 2003 Feb;17(1):1-17. doi: 10.1016/s0887-2333(02)00117-0. Toxicol In Vitro. 2003. PMID: 12537957 Review.
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies.
van de Kerkhof EG, de Graaf IA, de Jager MH, Meijer DK, Groothuis GM. van de Kerkhof EG, et al. Among authors: de jager mh, de graaf ia. Drug Metab Dispos. 2005 Nov;33(11):1613-20. doi: 10.1124/dmd.105.005686. Epub 2005 Jul 28. Drug Metab Dispos. 2005. PMID: 16051733
Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction.
de Graaf IA, de Kanter R, de Jager MH, Camacho R, Langenkamp E, van de Kerkhof EG, Groothuis GM. de Graaf IA, et al. Among authors: de jager mh, de kanter r. Drug Metab Dispos. 2006 Apr;34(4):591-9. doi: 10.1124/dmd.105.006726. Epub 2006 Jan 13. Drug Metab Dispos. 2006. PMID: 16415126
Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.
van de Kerkhof EG, Ungell AL, Sjöberg AK, de Jager MH, Hilgendorf C, de Graaf IA, Groothuis GM. van de Kerkhof EG, et al. Among authors: de jager mh, de graaf ia. Drug Metab Dispos. 2006 Nov;34(11):1893-902. doi: 10.1124/dmd.106.011148. Epub 2006 Aug 16. Drug Metab Dispos. 2006. PMID: 16914511
Cryopreservation of rat precision-cut liver and kidney slices by rapid freezing and vitrification.
de Graaf IA, Draaisma AL, Schoeman O, Fahy GM, Groothuis GM, Koster HJ. de Graaf IA, et al. Cryobiology. 2007 Feb;54(1):1-12. doi: 10.1016/j.cryobiol.2006.09.002. Epub 2006 Dec 12. Cryobiology. 2007. PMID: 17166492
Induction of phase I and II drug metabolism in rat small intestine and colon in vitro.
van de Kerkhof EG, de Graaf IA, de Jager MH, Groothuis GM. van de Kerkhof EG, et al. Among authors: de jager mh, de graaf ia. Drug Metab Dispos. 2007 Jun;35(6):898-907. doi: 10.1124/dmd.106.014563. Epub 2007 Mar 7. Drug Metab Dispos. 2007. PMID: 17344336
In vitro methods to study intestinal drug metabolism.
van de Kerkhof EG, de Graaf IA, Groothuis GM. van de Kerkhof EG, et al. Among authors: de graaf ia. Curr Drug Metab. 2007 Oct;8(7):658-75. doi: 10.2174/138920007782109742. Curr Drug Metab. 2007. PMID: 17979654 Review.
Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro.
van de Kerkhof EG, de Graaf IA, Ungell AL, Groothuis GM. van de Kerkhof EG, et al. Among authors: de graaf ia. Drug Metab Dispos. 2008 Mar;36(3):604-13. doi: 10.1124/dmd.107.018820. Epub 2007 Dec 19. Drug Metab Dispos. 2008. PMID: 18094037
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