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Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo.
Li M, de Graaf IA, de Jager MH, Groothuis GM. Li M, et al. Among authors: de jager mh. Toxicol In Vitro. 2015 Aug;29(5):1070-8. doi: 10.1016/j.tiv.2015.04.011. Epub 2015 Apr 25. Toxicol In Vitro. 2015. PMID: 25917215
Anticancer Gold N-Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study.
Estrada-Ortiz N, Guarra F, de Graaf IAM, Marchetti L, de Jager MH, Groothuis GMM, Gabbiani C, Casini A. Estrada-Ortiz N, et al. Among authors: de jager mh. ChemMedChem. 2017 Sep 7;12(17):1429-1435. doi: 10.1002/cmdc.201700316. Epub 2017 Aug 29. ChemMedChem. 2017. PMID: 28741878
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies.
van de Kerkhof EG, de Graaf IA, de Jager MH, Meijer DK, Groothuis GM. van de Kerkhof EG, et al. Among authors: de jager mh, de graaf ia. Drug Metab Dispos. 2005 Nov;33(11):1613-20. doi: 10.1124/dmd.105.005686. Epub 2005 Jul 28. Drug Metab Dispos. 2005. PMID: 16051733
Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies.
de Graaf IA, Olinga P, de Jager MH, Merema MT, de Kanter R, van de Kerkhof EG, Groothuis GM. de Graaf IA, et al. Among authors: de jager mh, de kanter r. Nat Protoc. 2010 Sep;5(9):1540-51. doi: 10.1038/nprot.2010.111. Epub 2010 Aug 19. Nat Protoc. 2010. PMID: 20725069
Regional Differences in Human Intestinal Drug Metabolism.
Iswandana R, Irianti MI, Oosterhuis D, Hofker HS, Merema MT, de Jager MH, Mutsaers HAM, Olinga P. Iswandana R, et al. Among authors: de jager mh. Drug Metab Dispos. 2018 Dec;46(12):1879-1885. doi: 10.1124/dmd.118.083428. Epub 2018 Oct 1. Drug Metab Dispos. 2018. PMID: 30275119
Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter.
Li M, Vokral I, Evers B, de Graaf IAM, de Jager MH, Groothuis GMM. Li M, et al. Among authors: de jager mh. Eur J Pharm Sci. 2018 Aug 30;121:65-73. doi: 10.1016/j.ejps.2018.05.005. Epub 2018 May 9. Eur J Pharm Sci. 2018. PMID: 29751102 No abstract available.
The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo.
Li M, de Graaf IA, van de Steeg E, de Jager MH, Groothuis GM. Li M, et al. Among authors: de jager mh. Toxicol In Vitro. 2017 Apr;40:26-33. doi: 10.1016/j.tiv.2016.12.002. Epub 2016 Dec 7. Toxicol In Vitro. 2017. PMID: 27939799
P-gp activity and inhibition in the different regions of human intestine ex vivo.
Li M, de Graaf IA, de Jager MH, Groothuis GM. Li M, et al. Among authors: de jager mh. Biopharm Drug Dispos. 2017 Mar;38(2):127-138. doi: 10.1002/bdd.2047. Epub 2016 Nov 14. Biopharm Drug Dispos. 2017. PMID: 27757966
The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices.
Li M, de Graaf IA, Siissalo S, de Jager MH, van Dam A, Groothuis GM. Li M, et al. Among authors: de jager mh. Drug Metab Dispos. 2016 May;44(5):683-91. doi: 10.1124/dmd.115.068684. Epub 2016 Mar 1. Drug Metab Dispos. 2016. PMID: 26932816
Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine.
Siissalo S, de Waard H, de Jager MH, Hayeshi R, Frijlink HW, Hinrichs WL, Dinter-Heidorn H, van Dam A, Proost JH, Groothuis GM, de Graaf IA. Siissalo S, et al. Among authors: de jager mh, de graaf ia, de waard h. Drug Metab Dispos. 2013 Aug;41(8):1557-65. doi: 10.1124/dmd.112.049585. Epub 2013 Jun 3. Drug Metab Dispos. 2013. PMID: 23733277
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