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Mdm2 induces mono-ubiquitination of FOXO4.
Brenkman AB, de Keizer PL, van den Broek NJ, Jochemsen AG, Burgering BM. Brenkman AB, et al. Among authors: de keizer pl. PLoS One. 2008 Jul 30;3(7):e2819. doi: 10.1371/journal.pone.0002819. PLoS One. 2008. PMID: 18665269 Free PMC article.
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity.
Dansen TB, Smits LM, van Triest MH, de Keizer PL, van Leenen D, Koerkamp MG, Szypowska A, Meppelink A, Brenkman AB, Yodoi J, Holstege FC, Burgering BM. Dansen TB, et al. Among authors: de keizer pl. Nat Chem Biol. 2009 Sep;5(9):664-72. doi: 10.1038/nchembio.194. Epub 2009 Aug 2. Nat Chem Biol. 2009. PMID: 19648934
Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling.
Kruiswijk F, Hasenfuss SC, Sivapatham R, Baar MP, Putavet D, Naipal KA, van den Broek NJ, Kruit W, van der Spek PJ, van Gent DC, Brenkman AB, Campisi J, Burgering BM, Hoeijmakers JH, de Keizer PL. Kruiswijk F, et al. Among authors: de keizer pl. Oncogene. 2016 Apr 28;35(17):2166-77. doi: 10.1038/onc.2015.282. Epub 2015 Aug 17. Oncogene. 2016. PMID: 26279295 Free PMC article.
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ. Baar MP, et al. Among authors: de keizer plj. Cell. 2017 Mar 23;169(1):132-147.e16. doi: 10.1016/j.cell.2017.02.031. Cell. 2017. PMID: 28340339 Free PMC article.
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