de Kok TMCM - Search Results

1

The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro.

Jiang J, Pieterman CD, Ertaylan G, Peeters RLM, de Kok TMCM. Jiang J, et al. Among authors: de kok tmcm. Arch Toxicol. 2019 Nov;93(11):3067-3098. doi: 10.1007/s00204-019-02585-5. Epub 2019 Oct 5. Arch Toxicol. 2019. PMID: 31586243 Review.

2

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis.

van Breda SG, Claessen SM, Lo K, van Herwijnen M, Brauers KJ, Lisanti S, Theunissen DH, Jennen DG, Gaj S, de Kok TM, Kleinjans JC. van Breda SG, et al. Arch Toxicol. 2015 Nov;89(11):1959-69. doi: 10.1007/s00204-014-1351-2. Epub 2014 Sep 9. Arch Toxicol. 2015. PMID: 25199682

3

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.

Jiang J, Briedé JJ, Jennen DG, Van Summeren A, Saritas-Brauers K, Schaart G, Kleinjans JC, de Kok TM. Jiang J, et al. Toxicol Lett. 2015 Apr 16;234(2):139-50. doi: 10.1016/j.toxlet.2015.02.012. Epub 2015 Feb 19. Toxicol Lett. 2015. PMID: 25704631

4

Response to cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.

Jiang J, Briedé JJ, Jennen DG, Kleinjans JC, de Kok TM. Jiang J, et al. Toxicol Lett. 2015 Jun 15;235(3):218-9. doi: 10.1016/j.toxlet.2015.04.003. Epub 2015 Apr 17. Toxicol Lett. 2015. PMID: 25895633 No abstract available.

5

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma.

Rieswijk L, Claessen SM, Bekers O, van Herwijnen M, Theunissen DH, Jennen DG, de Kok TM, Kleinjans JC, van Breda SG. Rieswijk L, et al. Toxicology. 2016 Mar 28;350-352:31-9. doi: 10.1016/j.tox.2016.05.002. Epub 2016 May 3. Toxicology. 2016. PMID: 27153756

6

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.

Wolters JE, van Herwijnen MH, Theunissen DH, Jennen DG, Van den Hof WF, de Kok TM, Schaap FG, van Breda SG, Kleinjans JC. Wolters JE, et al. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174. doi: 10.1021/acs.chemrestox.6b00337. Epub 2016 Dec 2. Chem Res Toxicol. 2016. PMID: 27989131

7

Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes.

Wolters JEJ, van Breda SGJ, Caiment F, Claessen SM, de Kok TMCM, Kleinjans JCS. Wolters JEJ, et al. Among authors: de kok tmcm. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13. Chem Res Toxicol. 2017. PMID: 28853863 Free PMC article.

8

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction.

van Breda SGJ, Claessen SMH, van Herwijnen M, Theunissen DHJ, Jennen DGJ, de Kok TMCM, Kleinjans JCS. van Breda SGJ, et al. Among authors: de kok tmcm. Toxicology. 2018 Jan 15;393:160-170. doi: 10.1016/j.tox.2017.11.013. Epub 2017 Nov 14. Toxicology. 2018. PMID: 29154799 Free article.

9

Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator.

O'Donovan SD, Lenz M, Goossens GH, van der Kallen CJH, Eussen SJMP, Stehouwer CDA, van Greevenbroek MM, Schram MT, Sep SJ, Peeters RLM, Blaak EE, van Riel NAW, de Kok TMCM, Arts ICW. O'Donovan SD, et al. Among authors: de kok tmcm. Sci Rep. 2019 Jun 28;9(1):9388. doi: 10.1038/s41598-019-45858-w. Sci Rep. 2019. PMID: 31253846 Free PMC article.

10

A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data.

O'Donovan SD, Lenz M, Vink RG, Roumans NJT, de Kok TMCM, Mariman ECM, Peeters RLM, van Riel NAW, van Baak MA, Arts ICW. O'Donovan SD, et al. Among authors: de kok tmcm. PLoS Comput Biol. 2019 Oct 3;15(10):e1007400. doi: 10.1371/journal.pcbi.1007400. eCollection 2019 Oct. PLoS Comput Biol. 2019. PMID: 31581241 Free PMC article.

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