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1994 1
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2001 4
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2003 2
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2008 5
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108 results

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Page 1
Correction to "Novel Scaffold Unlocks Potent Cross-Peptidase and Cross-Species Inhibitors as Promising Antimalarial Agents".
Mansouri M, De Paoli A, Giannangelo C, Chowdury M, Ngo A, Shackleford DM, Webb CT, Lowes KN, Creek DJ, Charman SA, De Koning-Ward TF, McGowan S, Scammells PJ. Mansouri M, et al. Among authors: de koning ward tf. J Med Chem. 2026 Apr 9;69(7):8640. doi: 10.1021/acs.jmedchem.6c00778. Epub 2026 Mar 20. J Med Chem. 2026. PMID: 41860896 No abstract available.
Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1.
Nguyen W, Boulet C, Dans MG, Loi K, Jarman KE, Barnes CBG, Yeo T, Sheth T, Mukherjee P, Chakraborty A, Famodimu MT, Delves MJ, Pollard H, Sutherland CJ, Coyle R, Sevilleno N, Boonyalai N, Lee MCS, Rabie T, Birkholtz LM, Baud D, Brand S, Chowdury M, de Koning-Ward TF, Fidock DA, Gilson PR, Sleebs BE. Nguyen W, et al. Among authors: de koning ward tf. J Med Chem. 2025 Aug 14;68(15):16613-16644. doi: 10.1021/acs.jmedchem.5c01471. Epub 2025 Jul 18. J Med Chem. 2025. PMID: 40680058 Free PMC article.
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
Awalt JK, Ooi ZK, Ashton TD, Mansouri M, Calic PPS, Zhou Q, Vasanthan S, Lee S, Loi K, Jarman KE, Penington JS, Qiu D, Zhang X, Lehane AM, Mao EY, Gancheva MR, Wilson DW, Giannangelo C, MacRaild CA, Creek DJ, Yeo T, Sheth T, Fidock DA, Churchyard A, Baum J, Famodimu MT, Delves MJ, Kristan M, Stewart L, Sutherland CJ, Coyle R, Jagoe H, Lee MCS, Chowdury M, de Koning-Ward TF, Baud D, Brand S, Jackson PF, Cowman AF, Dans MG, Sleebs BE. Awalt JK, et al. Among authors: de koning ward tf. J Med Chem. 2025 Apr 24;68(8):8933-8966. doi: 10.1021/acs.jmedchem.5c00614. Epub 2025 Apr 14. J Med Chem. 2025. PMID: 40228810 Free PMC article.
PfGCN5 is essential for Plasmodium falciparum survival and transmission and regulates Pf H2B.Z acetylation and chromatin structure.
Tang J, Yeoh LM, Grotz MD, Goodman CD, Chisholm SA, Nguyen HHT, Yu C, Pareek K, McPherson F, Cozijnsen A, Hustadt SA, Josling GA, Day KP, Schulz D, McFadden GI, de Koning-Ward TF, Petter M, Duffy MF. Tang J, et al. Among authors: de koning ward tf. Nucleic Acids Res. 2025 Mar 20;53(6):gkaf218. doi: 10.1093/nar/gkaf218. Nucleic Acids Res. 2025. PMID: 40156869 Free PMC article.
Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b.
Awalt JK, Su W, Nguyen W, Loi K, Jarman KE, Penington JS, Ramesh S, Fairhurst KJ, Yeo T, Park H, Uhlemann AC, Chandra Maity B, De N, Mukherjee P, Chakraborty A, Churchyard A, Famodimu MT, Delves MJ, Baum J, Mittal N, Winzeler EA, Papenfuss AT, Chowdury M, de Koning-Ward TF, Maier AG, van Dooren GG, Baud D, Brand S, Fidock DA, Jackson PF, Cowman AF, Dans MG, Sleebs BE. Awalt JK, et al. Among authors: de koning ward tf. Eur J Med Chem. 2024 Dec 15;280:116921. doi: 10.1016/j.ejmech.2024.116921. Epub 2024 Oct 3. Eur J Med Chem. 2024. PMID: 39388903 Free PMC article.
Author Correction: Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1.
Dans MG, Boulet C, Watson GM, Nguyen W, Dziekan JM, Evelyn C, Reaksudsan K, Mehra S, Razook Z, Geoghegan ND, Mlodzianoski MJ, Goodman CD, Ling DB, Jonsdottir TK, Tong J, Famodimu MT, Kristan M, Pollard H, Stewart LB, Brandner-Garrod L, Sutherland CJ, Delves MJ, McFadden GI, Barry AE, Crabb BS, de Koning-Ward TF, Rogers KL, Cowman AF, Tham WH, Sleebs BE, Gilson PR. Dans MG, et al. Among authors: de koning ward tf. Nat Commun. 2024 Sep 30;15(1):8459. doi: 10.1038/s41467-024-52849-7. Nat Commun. 2024. PMID: 39349462 Free PMC article. No abstract available.
Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4.
Ashton TD, Calic PPS, Dans MG, Kang Ooi Z, Zhou Q, Loi K, Jarman KE, Palandri J, Qiu D, Lehane AM, Maity B, De N, Famodimu MT, Delves MJ, Mao EY, Gancheva MR, Wilson DW, Chowdury M, de Koning-Ward TF, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Ashton TD, et al. Among authors: de koning ward tf. ChemMedChem. 2024 Dec 16;19(24):e202400549. doi: 10.1002/cmdc.202400549. Epub 2024 Oct 29. ChemMedChem. 2024. PMID: 39210733 Free PMC article.
108 results