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Changes in endocannabinoid receptors and enzymes in the spinal cord of SOD1(G93A) transgenic mice and evaluation of a Sativex(®) -like combination of phytocannabinoids: interest for future therapies in amyotrophic lateral sclerosis.
Moreno-Martet M, Espejo-Porras F, Fernández-Ruiz J, de Lago E. Moreno-Martet M, et al. Among authors: de lago e. CNS Neurosci Ther. 2014 Sep;20(9):809-15. doi: 10.1111/cns.12262. Epub 2014 Apr 7. CNS Neurosci Ther. 2014. PMID: 24703394 Free PMC article.
Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.
López-Rodríguez ML, Viso A, Ortega-Gutiérrez S, Fowler CJ, Tiger G, de Lago E, Fernández-Ruiz J, Ramos JA. López-Rodríguez ML, et al. J Med Chem. 2003 Apr 10;46(8):1512-22. doi: 10.1021/jm0210818. J Med Chem. 2003. PMID: 12672252
UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.
de Lago E, Fernández-Ruiz J, Ortega-Gutiérrez S, Cabranes A, Pryce G, Baker D, López-Rodríguez M, Ramos JA. de Lago E, et al. Eur Neuropsychopharmacol. 2006 Jan;16(1):7-18. doi: 10.1016/j.euroneuro.2005.06.001. Epub 2005 Jul 11. Eur Neuropsychopharmacol. 2006. PMID: 16006105
Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis.
Cabranes A, Venderova K, de Lago E, Fezza F, Sánchez A, Mestre L, Valenti M, García-Merino A, Ramos JA, Di Marzo V, Fernández-Ruiz J. Cabranes A, et al. Neurobiol Dis. 2005 Nov;20(2):207-17. doi: 10.1016/j.nbd.2005.03.002. Neurobiol Dis. 2005. PMID: 16242629
Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties.
García-Arencibia M, González S, de Lago E, Ramos JA, Mechoulam R, Fernández-Ruiz J. García-Arencibia M, et al. Brain Res. 2007 Feb 23;1134(1):162-70. doi: 10.1016/j.brainres.2006.11.063. Epub 2006 Dec 28. Brain Res. 2007. PMID: 17196181
Cannabinoids and neuroprotection in basal ganglia disorders.
Sagredo O, García-Arencibia M, de Lago E, Finetti S, Decio A, Fernández-Ruiz J. Sagredo O, et al. Mol Neurobiol. 2007 Aug;36(1):82-91. doi: 10.1007/s12035-007-0004-3. Epub 2007 Jun 23. Mol Neurobiol. 2007. PMID: 17952653 Review.
Cannabinoids and neuroprotection in motor-related disorders.
de Lago E, Fernández-Ruiz J. de Lago E, et al. CNS Neurol Disord Drug Targets. 2007 Dec;6(6):377-87. doi: 10.2174/187152707783399210. CNS Neurol Disord Drug Targets. 2007. PMID: 18220777 Review.
The endocannabinoid system as a target for the treatment of neuronal damage.
Fernández-Ruiz J, García C, Sagredo O, Gómez-Ruiz M, de Lago E. Fernández-Ruiz J, et al. Expert Opin Ther Targets. 2010 Apr;14(4):387-404. doi: 10.1517/14728221003709792. Expert Opin Ther Targets. 2010. PMID: 20230193 Review.
Cannabinoids, multiple sclerosis and neuroprotection.
de Lago E, Gómez-Ruiz M, Moreno-Martet M, Fernández-Ruiz J. de Lago E, et al. Expert Rev Clin Pharmacol. 2009 Nov;2(6):645-60. doi: 10.1586/ecp.09.42. Expert Rev Clin Pharmacol. 2009. PMID: 22112258
Identification of receptors and enzymes for endocannabinoids in NSC-34 cells: relevance for in vitro studies with cannabinoids in motor neuron diseases.
Moreno-Martet M, Mestre L, Loría F, Guaza C, Fernández-Ruiz J, de Lago E. Moreno-Martet M, et al. Neurosci Lett. 2012 Feb 6;508(2):67-72. doi: 10.1016/j.neulet.2011.12.020. Epub 2011 Dec 22. Neurosci Lett. 2012. PMID: 22206832
NSC-34 cells, a hybridoma cell line derived from the fusion of neuroblastoma cells with mice spinal cord cells, have been widely used as an in vitro model for the study of motor neuron diseases [i.e. amyotrophic lateral sclerosis (ALS)]. ...
NSC-34 cells, a hybridoma cell line derived from the fusion of neuroblastoma cells with mice spinal cord cells, have been widely used as an …
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