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The human cytomegalovirus-encoded receptor US28 increases the activity of the major immediate-early promoter/enhancer.
Boomker JM, The TH, de Leij LF, Harmsen MC. Boomker JM, et al. Among authors: de leij lf. Virus Res. 2006 Jun;118(1-2):196-200. doi: 10.1016/j.virusres.2005.12.011. Epub 2006 Jan 31. Virus Res. 2006. PMID: 16448715
Viral chemokine-modulatory proteins: tools and targets.
Boomker JM, de Leij LF, The TH, Harmsen MC. Boomker JM, et al. Among authors: de leij lf. Cytokine Growth Factor Rev. 2005 Feb;16(1):91-103. doi: 10.1016/j.cytogfr.2004.12.002. Epub 2005 Jan 28. Cytokine Growth Factor Rev. 2005. PMID: 15733834 Review.
Targeted delivery of a designed sTRAIL mutant results in superior apoptotic activity towards EGFR-positive tumor cells.
Bremer E, de Bruyn M, Samplonius DF, Bijma T, ten Cate B, de Leij LF, Helfrich W. Bremer E, et al. Among authors: de leij lf. J Mol Med (Berl). 2008 Aug;86(8):909-24. doi: 10.1007/s00109-008-0348-9. Epub 2008 May 27. J Mol Med (Berl). 2008. PMID: 18504532 Free PMC article.
Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid SAINT-2.
van der Gun BT, Monami A, Laarmann S, Raskó T, Slaska-Kiss K, Weinhold E, Wasserkort R, de Leij LF, Ruiters MH, Kiss A, McLaughlin PM. van der Gun BT, et al. Among authors: de leij lf. J Control Release. 2007 Nov 20;123(3):228-38. doi: 10.1016/j.jconrel.2007.08.014. Epub 2007 Aug 23. J Control Release. 2007. PMID: 17884225
Fas receptor clustering and involvement of the death receptor pathway in rituximab-mediated apoptosis with concomitant sensitization of lymphoma B cells to fas-induced apoptosis.
Stel AJ, Ten Cate B, Jacobs S, Kok JW, Spierings DC, Dondorff M, Helfrich W, Kluin-Nelemans HC, de Leij LF, Withoff S, Kroesen BJ. Stel AJ, et al. Among authors: de leij lf. J Immunol. 2007 Feb 15;178(4):2287-95. doi: 10.4049/jimmunol.178.4.2287. J Immunol. 2007. PMID: 17277134 Free article.
Simultaneous inhibition of epidermal growth factor receptor (EGFR) signaling and enhanced activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-mediated apoptosis induction by an scFv:sTRAIL fusion protein with specificity for human EGFR.
Bremer E, Samplonius DF, van Genne L, Dijkstra MH, Kroesen BJ, de Leij LF, Helfrich W. Bremer E, et al. Among authors: de leij lf. J Biol Chem. 2005 Mar 18;280(11):10025-33. doi: 10.1074/jbc.M413673200. Epub 2005 Jan 11. J Biol Chem. 2005. PMID: 15644326
BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome.
Kroesen BJ, Jacobs S, Pettus BJ, Sietsma H, Kok JW, Hannun YA, de Leij LF. Kroesen BJ, et al. Among authors: de leij lf. J Biol Chem. 2003 Apr 25;278(17):14723-31. doi: 10.1074/jbc.M210756200. Epub 2003 Feb 10. J Biol Chem. 2003. PMID: 12578840
The role of B cell-mediated T cell costimulation in the efficacy of the T cell retargeting bispecific antibody BIS20x3.
Stel AJ, Kroesen BJ, Jacobs S, Groen H, de Leij LF, Kluin-Nelemans HC, Withoff S. Stel AJ, et al. Among authors: de leij lf. J Immunol. 2004 Nov 15;173(10):6009-16. doi: 10.4049/jimmunol.173.10.6009. J Immunol. 2004. PMID: 15528335
Kinetics of US28 gene expression during active human cytomegalovirus infection in lung-transplant recipients.
Boomker JM, Verschuuren EA, Brinker MG, de Leij LF, The TH, Harmsen MC. Boomker JM, et al. Among authors: de leij lf. J Infect Dis. 2006 Jun 1;193(11):1552-6. doi: 10.1086/503779. Epub 2006 Apr 24. J Infect Dis. 2006. PMID: 16652284
Target cell-restricted apoptosis induction of acute leukemic T cells by a recombinant tumor necrosis factor-related apoptosis-inducing ligand fusion protein with specificity for human CD7.
Bremer E, Samplonius DF, Peipp M, van Genne L, Kroesen BJ, Fey GH, Gramatzki M, de Leij LF, Helfrich W. Bremer E, et al. Among authors: de leij lf. Cancer Res. 2005 Apr 15;65(8):3380-8. doi: 10.1158/0008-5472.CAN-04-2756. Cancer Res. 2005. PMID: 15833872
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