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An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products.
de Los Reyes Jiménez M, Lechner A, Alessandrini F, Bohnacker S, Schindela S, Trompette A, Haimerl P, Thomas D, Henkel F, Mourão A, Geerlof A, da Costa CP, Chaker AM, Brüne B, Nüsing R, Jakobsson PJ, Nockher WA, Feige MJ, Haslbeck M, Ohnmacht C, Marsland BJ, Voehringer D, Harris NL, Schmidt-Weber CB, Esser-von Bieren J. de Los Reyes Jiménez M, et al. Sci Transl Med. 2020 Apr 22;12(540):eaay0605. doi: 10.1126/scitranslmed.aay0605. Sci Transl Med. 2020. PMID: 32321863
Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways.
Dietz K, de Los Reyes Jiménez M, Gollwitzer ES, Chaker AM, Zissler UM, Rådmark OP, Baarsma HA, Königshoff M, Schmidt-Weber CB, Marsland BJ, Esser-von Bieren J. Dietz K, et al. Among authors: de los reyes jimenez m. J Allergy Clin Immunol. 2017 Apr;139(4):1343-1354.e6. doi: 10.1016/j.jaci.2016.07.014. Epub 2016 Aug 20. J Allergy Clin Immunol. 2017. PMID: 27554815