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Mutation of arginine 86 to proline in the insulin receptor alpha subunit causes lack of transport of the receptor to the plasma membrane, loss of binding affinity and a constitutively activated tyrosine kinase in transfected cells.
Grønskov K, Vissing H, Shymko RM, Tornqvist H, De Meyts P. Grønskov K, et al. Among authors: de meyts p. Biochem Biophys Res Commun. 1993 Apr 30;192(2):905-11. doi: 10.1006/bbrc.1993.1501. Biochem Biophys Res Commun. 1993. PMID: 8484793
Cooperativity in ligand binding: a new graphic analysis.
De Meyts P, Roth J. De Meyts P, et al. Biochem Biophys Res Commun. 1975 Oct 27;66(4):1118-26. doi: 10.1016/0006-291x(75)90473-8. Biochem Biophys Res Commun. 1975. PMID: 1191281 No abstract available.
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