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Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins.
Chelbi-Alix MK, de Thé H. Chelbi-Alix MK, et al. Among authors: de the h. Oncogene. 1999 Jan 28;18(4):935-41. doi: 10.1038/sj.onc.1202366. Oncogene. 1999. PMID: 10023669
Sp100 protein was also degraded, while another SUMO-1 conjugated protein, RanGAP1 and the IFN-induced protein kinase PKR were not. The proteasome inhibitor MG132 abrogated the HSV-1-induced PML and Sp100 degradation and partially restored their NB-localizatio …
Sp100 protein was also degraded, while another SUMO-1 conjugated protein, RanGAP1 and the IFN-induced protein kinase PKR were not. …
Retinoic acid receptor alpha in acute promyelocytic leukaemia.
de Thé H, Dejean A. de Thé H, et al. Cancer Surv. 1992;14:195-203. Cancer Surv. 1992. PMID: 1330303 Review.
Acute promyelocytic leukaemia has two highly specific particularities: a t(15;17) chromosomal translocation and the ability of a differentiation inducer all-trans-RA, to revert the malignant phenotype both in vitro and in vivo. Molecular characterization of the
Acute promyelocytic leukaemia has two highly specific particularities: a t(15;17) chromosomal translocation and the ability of a diff …
A PML/retinoic acid receptor alpha fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia.
Castaigne S, Balitrand N, de Thé H, Dejean A, Degos L, Chomienne C. Castaigne S, et al. Among authors: de the h. Blood. 1992 Jun 15;79(12):3110-5. Blood. 1992. PMID: 1375840
The different types of fusion transcripts amplified were correlated to the size of the abnormal RAR alpha transcripts detected in these patients by Northern analysis, but did not prove determinant for either the phenotypic features or the retino
The different types of fusion transcripts amplified were correlated to the size of the abnormal RAR alpha transcripts d
The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.
de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A. de Thé H, et al. Cell. 1991 Aug 23;66(4):675-84. doi: 10.1016/0092-8674(91)90113-d. Cell. 1991. PMID: 1652369
The PML-RAR alpha mRNA encodes a predicted 106 kd chimeric protein containing most of the PML sequences fused to a large part of RAR alpha, including its DNA- and hormone-binding domains. In transient expression assays, the hybrid protein exhibits altered tra
The PML-RAR alpha mRNA encodes a predicted 106 kd chimeric protein containing most of the PML sequences fused to a large part
All-trans retinoic acid modulates the retinoic acid receptor-alpha in promyelocytic cells.
Chomienne C, Balitrand N, Ballerini P, Castaigne S, de Thé H, Degos L. Chomienne C, et al. Among authors: de the h. J Clin Invest. 1991 Dec;88(6):2150-4. doi: 10.1172/JCI115547. J Clin Invest. 1991. PMID: 1661301 Free PMC article.
This results in the expression of both normal and chimeric RAR alpha transcripts in AML3 cells. The PLM-RAR alpha protein may account for the impairment of differentiation and thus leukemogenesis, but not for the paradoxical efficacy of RA in these cel …
This results in the expression of both normal and chimeric RAR alpha transcripts in AML3 cells. The PLM-RAR alpha protein may …
Sequestration of PML and Sp100 proteins in an intranuclear viral structure during herpes simplex virus type 1 infection.
Puvion-Dutilleul F, Venturini L, Guillemin MC, de Thé H, Puvion E. Puvion-Dutilleul F, et al. Among authors: de the h. Exp Cell Res. 1995 Dec;221(2):448-61. doi: 10.1006/excr.1995.1396. Exp Cell Res. 1995. PMID: 7493645
We investigated the intranuclear distribution of PML and Sp100 in HeLa cells at the ultrastructural level and examined their relocalization in response to herpes simplex virus type 1 (HSV-1) infection. ...An antiserum raised against capsid proteins intensely labeled …
We investigated the intranuclear distribution of PML and Sp100 in HeLa cells at the ultrastructural level and examined their r …
The PML growth-suppressor has an altered expression in human oncogenesis.
Koken MH, Linares-Cruz G, Quignon F, Viron A, Chelbi-Alix MK, Sobczak-Thépot J, Juhlin L, Degos L, Calvo F, de Thé H. Koken MH, et al. Among authors: de the h. Oncogene. 1995 Apr 6;10(7):1315-24. Oncogene. 1995. PMID: 7731682
Human epithelial tumors show a gradual increase of PML levels as the lesion progresses from benign dysplasia to carcinoma. A similar induction is found in the surrounding stroma and vessels, which likely results from paracrine interactions. ...These observations poi …
Human epithelial tumors show a gradual increase of PML levels as the lesion progresses from benign dysplasia to carcinoma. A similar …
Adenovirus infection induces rearrangements in the intranuclear distribution of the nuclear body-associated PML protein.
Puvion-Dutilleul F, Chelbi-Alix MK, Koken M, Quignon F, Puvion E, de Thé H. Puvion-Dutilleul F, et al. Among authors: de the h. Exp Cell Res. 1995 May;218(1):9-16. doi: 10.1006/excr.1995.1125. Exp Cell Res. 1995. PMID: 7737384
We have studied at the ultrastructural level the localization of PML protein in response to adenovirus infection in HeLa cells. ...However, as the infection progressed these two cellular PML-containing structures disappeared but significant amounts of PML acc …
We have studied at the ultrastructural level the localization of PML protein in response to adenovirus infection in HeLa cells …
The PML-RAR alpha gene product of the t(15;17) translocation inhibits retinoic acid-induced granulocytic differentiation and mediated transactivation in human myeloid cells.
Rousselot P, Hardas B, Patel A, Guidez F, Gäken J, Castaigne S, Dejean A, de Thé H, Degos L, Farzaneh F, et al. Rousselot P, et al. Among authors: de the h. Oncogene. 1994 Feb;9(2):545-51. Oncogene. 1994. PMID: 8290265
Acute promyelocytic leukemia (APL) is characterized by an arrest of granulocytic differentiation and a reciprocal t(15;17) translocation fusing the PML gene to the retinoic acid receptor alpha (RAR alpha) gene. ...The fact that high doses of all-trans retinoi …
Acute promyelocytic leukemia (APL) is characterized by an arrest of granulocytic differentiation and a reciprocal t(15;17) translocation fus …
Retinoic acid receptor alpha in acute promyelocytic leukemia.
Lavau C, De Thé H, Dejean A. Lavau C, et al. Among authors: de the h. Ann N Y Acad Sci. 1993 Jun 11;684:149-56. doi: 10.1111/j.1749-6632.1993.tb32278.x. Ann N Y Acad Sci. 1993. PMID: 8391236 Review. No abstract available.
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