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The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.
de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A. de Thé H, et al. Cell. 1991 Aug 23;66(4):675-84. doi: 10.1016/0092-8674(91)90113-d. Cell. 1991. PMID: 1652369
The PML-RAR alpha mRNA encodes a predicted 106 kd chimeric protein containing most of the PML sequences fused to a large part of RAR alpha, including its DNA- and hormone-binding domains. In transient expression assays, the hybrid protein exhibits altered tra
The PML-RAR alpha mRNA encodes a predicted 106 kd chimeric protein containing most of the PML sequences fused to a large part
Retinoic acid receptor alpha in acute promyelocytic leukaemia.
de Thé H, Dejean A. de Thé H, et al. Cancer Surv. 1992;14:195-203. Cancer Surv. 1992. PMID: 1330303 Review.
Acute promyelocytic leukaemia has two highly specific particularities: a t(15;17) chromosomal translocation and the ability of a differentiation inducer all-trans-RA, to revert the malignant phenotype both in vitro and in vivo. Molecular characterization of the
Acute promyelocytic leukaemia has two highly specific particularities: a t(15;17) chromosomal translocation and the ability of a diff …
A PML/retinoic acid receptor alpha fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia.
Castaigne S, Balitrand N, de Thé H, Dejean A, Degos L, Chomienne C. Castaigne S, et al. Among authors: de the h. Blood. 1992 Jun 15;79(12):3110-5. Blood. 1992. PMID: 1375840
The different types of fusion transcripts amplified were correlated to the size of the abnormal RAR alpha transcripts detected in these patients by Northern analysis, but did not prove determinant for either the phenotypic features or the retino
The different types of fusion transcripts amplified were correlated to the size of the abnormal RAR alpha transcripts d
All-trans retinoic acid modulates the retinoic acid receptor-alpha in promyelocytic cells.
Chomienne C, Balitrand N, Ballerini P, Castaigne S, de Thé H, Degos L. Chomienne C, et al. Among authors: de the h. J Clin Invest. 1991 Dec;88(6):2150-4. doi: 10.1172/JCI115547. J Clin Invest. 1991. PMID: 1661301 Free PMC article.
This results in the expression of both normal and chimeric RAR alpha transcripts in AML3 cells. The PLM-RAR alpha protein may account for the impairment of differentiation and thus leukemogenesis, but not for the paradoxical efficacy of RA in these cel …
This results in the expression of both normal and chimeric RAR alpha transcripts in AML3 cells. The PLM-RAR alpha protein may …
[Receptors of retinoic acid and oncogenesis].
Dejean A, de Thé H, Tiollais P. Dejean A, et al. Among authors: de the h. C R Seances Soc Biol Fil. 1991;185(6):402-14. C R Seances Soc Biol Fil. 1991. PMID: 1668322 Review. French. No abstract available.
[Biological parameters of the efficiency of retinoic acid in acute leukemia].
Chomienne C, Cornic M, Castaigne S, Lefebvre P, de Thé H, Dejean A, Degos L. Chomienne C, et al. Among authors: de the h. C R Seances Soc Biol Fil. 1991;185(6):456-63. C R Seances Soc Biol Fil. 1991. PMID: 1822394 Review. French.
The t(15;17) translocation is specifically found in this leukemia. We and others have shown that through this translocation the RAR alpha gene is rearranged and its expression altered in AML3 cells. The gene is truncated and fused to a novel gene (PLM). This
The t(15;17) translocation is specifically found in this leukemia. We and others have shown that through this translocation the
Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene.
de Thé H, Vivanco-Ruiz MM, Tiollais P, Stunnenberg H, Dejean A. de Thé H, et al. Nature. 1990 Jan 11;343(6254):177-80. doi: 10.1038/343177a0. Nature. 1990. PMID: 2153268
The identification of three retinoic acid receptors as members of the nuclear receptor super-family provides an explantation for the molecular action of morphogens on gene expression. ...Specific binding of the beta protein to the retinoic acid
The identification of three retinoic acid receptors as members of the nuclear receptor super-family provides an explantation f
The retinoic acid receptors.
de Thé H, Tiollais P, Dejean A. de Thé H, et al. Nouv Rev Fr Hematol. 1990;32(1):30-2. Nouv Rev Fr Hematol. 1990. PMID: 2161511 Review.
Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA. These findings suggest that the retinoic acid receptors d …
Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcript …
Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma.
Dejean A, de Thé H. Dejean A, et al. Among authors: de the h. Mol Biol Med. 1990 Jun;7(3):213-22. Mol Biol Med. 1990. PMID: 2170809 Review.
From a comparison of a single HBV integration site present in a hepatoma with the corresponding unoccupied site in the non-tumourous tissue of the same liver, we have shown that HBV DNA inserted in a putative cellular exon with striking similarity to the
From a comparison of a single HBV integration site present in a hepatoma with the corresponding unoccupied site in the non-tum …
The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.
de Thé H, Chomienne C, Lanotte M, Degos L, Dejean A. de Thé H, et al. Nature. 1990 Oct 11;347(6293):558-61. doi: 10.1038/347558a0. Nature. 1990. PMID: 2170850
We report here that, in one APL-derived cell line, the RAR alpha gene has been translocated to a locus, myl, on chromosome 15, resulting in the synthesis of a myl/RAR alpha fusion messenger RNA. Using two probes located on either side of the cloned breakpoint …
We report here that, in one APL-derived cell line, the RAR alpha gene has been translocated to a locus, myl, on chromosome 15, result …
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