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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies.
Sanders RW, Derking R, Cupo A, Julien JP, Yasmeen A, de Val N, Kim HJ, Blattner C, de la Peña AT, Korzun J, Golabek M, de Los Reyes K, Ketas TJ, van Gils MJ, King CR, Wilson IA, Ward AB, Klasse PJ, Moore JP. Sanders RW, et al. Among authors: de val n, de la pena at, de los reyes k. PLoS Pathog. 2013 Sep;9(9):e1003618. doi: 10.1371/journal.ppat.1003618. Epub 2013 Sep 19. PLoS Pathog. 2013. PMID: 24068931 Free PMC article.
A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene.
Pugach P, Ozorowski G, Cupo A, Ringe R, Yasmeen A, de Val N, Derking R, Kim HJ, Korzun J, Golabek M, de Los Reyes K, Ketas TJ, Julien JP, Burton DR, Wilson IA, Sanders RW, Klasse PJ, Ward AB, Moore JP. Pugach P, et al. Among authors: de val n, de los reyes k. J Virol. 2015 Mar;89(6):3380-95. doi: 10.1128/JVI.03473-14. Epub 2015 Jan 14. J Virol. 2015. PMID: 25589637 Free PMC article.
Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens.
Schiffner T, de Val N, Russell RA, de Taeye SW, de la Peña AT, Ozorowski G, Kim HJ, Nieusma T, Brod F, Cupo A, Sanders RW, Moore JP, Ward AB, Sattentau QJ. Schiffner T, et al. Among authors: de val n, de la pena at, de taeye sw. J Virol. 2015 Oct 28;90(2):813-28. doi: 10.1128/JVI.01942-15. Print 2016 Jan 15. J Virol. 2015. PMID: 26512083 Free PMC article.
Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.
Schiffner T, Pallesen J, Russell RA, Dodd J, de Val N, LaBranche CC, Montefiori D, Tomaras GD, Shen X, Harris SL, Moghaddam AE, Kalyuzhniy O, Sanders RW, McCoy LE, Moore JP, Ward AB, Sattentau QJ. Schiffner T, et al. Among authors: de val n. PLoS Pathog. 2018 May 10;14(5):e1006986. doi: 10.1371/journal.ppat.1006986. eCollection 2018 May. PLoS Pathog. 2018. PMID: 29746590 Free PMC article.
Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers.
Schorcht A, van den Kerkhof TLGM, Cottrell CA, Allen JD, Torres JL, Behrens AJ, Schermer EE, Burger JA, de Taeye SW, Torrents de la Peña A, Bontjer I, Gumbs S, Ozorowski G, LaBranche CC, de Val N, Yasmeen A, Klasse PJ, Montefiori DC, Moore JP, Schuitemaker H, Crispin M, van Gils MJ, Ward AB, Sanders RW. Schorcht A, et al. Among authors: de val n, de taeye sw. J Virol. 2020 Nov 23;94(24):e01214-20. doi: 10.1128/JVI.01214-20. Print 2020 Nov 23. J Virol. 2020. PMID: 32999024 Free PMC article.
Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer.
Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, Klasse PJ, Burton DR, Sanders RW, Moore JP, Carragher B, Wilson IA, Ward AB. Lyumkis D, et al. Among authors: de val n. Science. 2013 Dec 20;342(6165):1484-90. doi: 10.1126/science.1245627. Epub 2013 Oct 31. Science. 2013. PMID: 24179160 Free PMC article.
77 results