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Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions.
van Beuningen HM, de Vries-van Melle ML, Vitters EL, Schreurs W, van den Berg WB, van Osch GJ, van der Kraan PM. van Beuningen HM, et al. Among authors: de vries van melle ml. Tissue Eng Part A. 2014 Aug;20(15-16):2243-52. doi: 10.1089/ten.TEA.2013.0553. Epub 2014 Mar 25. Tissue Eng Part A. 2014. PMID: 24547725 Free PMC article.
Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state.
Fahy N, de Vries-van Melle ML, Lehmann J, Wei W, Grotenhuis N, Farrell E, van der Kraan PM, Murphy JM, Bastiaansen-Jenniskens YM, van Osch GJ. Fahy N, et al. Among authors: de vries van melle ml. Osteoarthritis Cartilage. 2014 Aug;22(8):1167-75. doi: 10.1016/j.joca.2014.05.021. Epub 2014 Jun 7. Osteoarthritis Cartilage. 2014. PMID: 24911520 Free article.