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Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions.
Tissue Eng Part A. 2014 Aug;20(15-16):2243-52. doi: 10.1089/ten.TEA.2013.0553. Epub 2014 Mar 25.
Tissue Eng Part A. 2014.
PMID: 24547725
Free PMC article.
Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state.
Fahy N, de Vries-van Melle ML, Lehmann J, Wei W, Grotenhuis N, Farrell E, van der Kraan PM, Murphy JM, Bastiaansen-Jenniskens YM, van Osch GJ.
Fahy N, et al. Among authors: de vries van melle ml.
Osteoarthritis Cartilage. 2014 Aug;22(8):1167-75. doi: 10.1016/j.joca.2014.05.021. Epub 2014 Jun 7.
Osteoarthritis Cartilage. 2014.
PMID: 24911520
Free article.
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Chondrogenesis of mesenchymal stem cells in an osteochondral environment is mediated by the subchondral bone.
de Vries-van Melle ML, Narcisi R, Kops N, Koevoet WJ, Bos PK, Murphy JM, Verhaar JA, van der Kraan PM, van Osch GJ.
de Vries-van Melle ML, et al.
Tissue Eng Part A. 2014 Jan;20(1-2):23-33. doi: 10.1089/ten.TEA.2013.0080. Epub 2013 Oct 2.
Tissue Eng Part A. 2014.
PMID: 23980750
Free PMC article.
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An osteochondral culture model to study mechanisms involved in articular cartilage repair.
de Vries-van Melle ML, Mandl EW, Kops N, Koevoet WJ, Verhaar JA, van Osch GJ.
de Vries-van Melle ML, et al.
Tissue Eng Part C Methods. 2012 Jan;18(1):45-53. doi: 10.1089/ten.TEC.2011.0339. Epub 2011 Oct 18.
Tissue Eng Part C Methods. 2012.
PMID: 21875392
Free PMC article.
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Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in a simulated osteochondral environment is hydrogel dependent.
de Vries-van Melle ML, Tihaya MS, Kops N, Koevoet WJ, Murphy JM, Verhaar JA, Alini M, Eglin D, van Osch GJ.
de Vries-van Melle ML, et al.
Eur Cell Mater. 2014 Feb 3;27:112-23; discussion 123. doi: 10.22203/ecm.v027a09.
Eur Cell Mater. 2014.
PMID: 24488855
Free article.
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