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DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA Jr, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N. Jiao Y, et al. Among authors: de wilde rf. Science. 2011 Mar 4;331(6021):1199-203. doi: 10.1126/science.1200609. Epub 2011 Jan 20. Science. 2011. PMID: 21252315 Free PMC article.
Molecular characteristics of pancreatic ductal adenocarcinoma.
Ottenhof NA, de Wilde RF, Maitra A, Hruban RH, Offerhaus GJ. Ottenhof NA, et al. Among authors: de wilde rf. Patholog Res Int. 2011 Mar 27;2011:620601. doi: 10.4061/2011/620601. Patholog Res Int. 2011. PMID: 21512581 Free PMC article.
Altered telomeres in tumors with ATRX and DAXX mutations.
Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK. Heaphy CM, et al. Among authors: de wilde rf. Science. 2011 Jul 22;333(6041):425. doi: 10.1126/science.1207313. Epub 2011 Jun 30. Science. 2011. PMID: 21719641 Free PMC article.
Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas.
Dal Molin M, Hong SM, Hebbar S, Sharma R, Scrimieri F, de Wilde RF, Mayo SC, Goggins M, Wolfgang CL, Schulick RD, Lin MT, Eshleman JR, Hruban RH, Maitra A, Matthaei H. Dal Molin M, et al. Among authors: de wilde rf. Hum Pathol. 2012 Apr;43(4):585-91. doi: 10.1016/j.humpath.2011.06.009. Epub 2011 Sep 21. Hum Pathol. 2012. PMID: 21940037 Free PMC article.
Molecular determinants of retinoic acid sensitivity in pancreatic cancer.
Gupta S, Pramanik D, Mukherjee R, Campbell NR, Elumalai S, de Wilde RF, Hong SM, Goggins MG, De Jesus-Acosta A, Laheru D, Maitra A. Gupta S, et al. Among authors: de jesus acosta a, de wilde rf. Clin Cancer Res. 2012 Jan 1;18(1):280-9. doi: 10.1158/1078-0432.CCR-11-2165. Epub 2011 Oct 18. Clin Cancer Res. 2012. PMID: 22010213 Free PMC article.
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.
Wu J, Jiao Y, Dal Molin M, Maitra A, de Wilde RF, Wood LD, Eshleman JR, Goggins MG, Wolfgang CL, Canto MI, Schulick RD, Edil BH, Choti MA, Adsay V, Klimstra DS, Offerhaus GJ, Klein AP, Kopelovich L, Carter H, Karchin R, Allen PJ, Schmidt CM, Naito Y, Diaz LA Jr, Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B. Wu J, et al. Among authors: de wilde rf. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21188-93. doi: 10.1073/pnas.1118046108. Epub 2011 Dec 8. Proc Natl Acad Sci U S A. 2011. PMID: 22158988 Free PMC article.
Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors.
Yachida S, Vakiani E, White CM, Zhong Y, Saunders T, Morgan R, de Wilde RF, Maitra A, Hicks J, Demarzo AM, Shi C, Sharma R, Laheru D, Edil BH, Wolfgang CL, Schulick RD, Hruban RH, Tang LH, Klimstra DS, Iacobuzio-Donahue CA. Yachida S, et al. Among authors: de wilde rf. Am J Surg Pathol. 2012 Feb;36(2):173-84. doi: 10.1097/PAS.0b013e3182417d36. Am J Surg Pathol. 2012. PMID: 22251937 Free PMC article.
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors.
de Wilde RF, Heaphy CM, Maitra A, Meeker AK, Edil BH, Wolfgang CL, Ellison TA, Schulick RD, Molenaar IQ, Valk GD, Vriens MR, Borel Rinkes IH, Offerhaus GJ, Hruban RH, Matsukuma KE. de Wilde RF, et al. Mod Pathol. 2012 Jul;25(7):1033-9. doi: 10.1038/modpathol.2012.53. Epub 2012 May 11. Mod Pathol. 2012. PMID: 22575867 Free PMC article.
59 results