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Using anti-biofilm peptides to treat antibiotic-resistant bacterial infections.
de la Fuente-Núñez C, Hancock RE. de la Fuente-Núñez C, et al. Postdoc J. 2015 Feb;3(2):1-8. doi: 10.14304/surya.jpr.v3n2.1. Postdoc J. 2015. PMID: 27563687 Free PMC article.
Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide.
de la Fuente-Núñez C, Korolik V, Bains M, Nguyen U, Breidenstein EB, Horsman S, Lewenza S, Burrows L, Hancock RE. de la Fuente-Núñez C, et al. Antimicrob Agents Chemother. 2012 May;56(5):2696-704. doi: 10.1128/AAC.00064-12. Epub 2012 Feb 21. Antimicrob Agents Chemother. 2012. PMID: 22354291 Free PMC article.
The bacterial surface layer provides protection against antimicrobial peptides.
de la Fuente-Núñez C, Mertens J, Smit J, Hancock RE. de la Fuente-Núñez C, et al. Appl Environ Microbiol. 2012 Aug;78(15):5452-6. doi: 10.1128/AEM.01493-12. Epub 2012 May 25. Appl Environ Microbiol. 2012. PMID: 22635987 Free PMC article.
Effect of nitroxides on swarming motility and biofilm formation, multicellular behaviors in Pseudomonas aeruginosa.
de la Fuente-Núñez C, Reffuveille F, Fairfull-Smith KE, Hancock RE. de la Fuente-Núñez C, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4877-81. doi: 10.1128/AAC.01381-13. Epub 2013 Jul 22. Antimicrob Agents Chemother. 2013. PMID: 23877682 Free PMC article.
Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies.
de la Fuente-Núñez C, Reffuveille F, Fernández L, Hancock RE. de la Fuente-Núñez C, et al. Curr Opin Microbiol. 2013 Oct;16(5):580-9. doi: 10.1016/j.mib.2013.06.013. Epub 2013 Jul 20. Curr Opin Microbiol. 2013. PMID: 23880136 Review.
Broad-spectrum anti-biofilm peptide that targets a cellular stress response.
de la Fuente-Núñez C, Reffuveille F, Haney EF, Straus SK, Hancock RE. de la Fuente-Núñez C, et al. PLoS Pathog. 2014 May 22;10(5):e1004152. doi: 10.1371/journal.ppat.1004152. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24852171 Free PMC article.
A broad-spectrum antibiofilm peptide enhances antibiotic action against bacterial biofilms.
Reffuveille F, de la Fuente-Núñez C, Mansour S, Hancock RE. Reffuveille F, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5363-71. doi: 10.1128/AAC.03163-14. Epub 2014 Jun 30. Antimicrob Agents Chemother. 2014. PMID: 24982074 Free PMC article.
Peptide IDR-1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic-resistant bacterial infections.
Mansour SC, de la Fuente-Núñez C, Hancock RE. Mansour SC, et al. J Pept Sci. 2015 May;21(5):323-9. doi: 10.1002/psc.2708. Epub 2014 Oct 31. J Pept Sci. 2015. PMID: 25358509 Review.
D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections.
de la Fuente-Núñez C, Reffuveille F, Mansour SC, Reckseidler-Zenteno SL, Hernández D, Brackman G, Coenye T, Hancock RE. de la Fuente-Núñez C, et al. Chem Biol. 2015 Feb 19;22(2):196-205. doi: 10.1016/j.chembiol.2015.01.002. Chem Biol. 2015. PMID: 25699603 Free PMC article.
Cationic amphipathic peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria.
Anunthawan T, de la Fuente-Núñez C, Hancock RE, Klaynongsruang S. Anunthawan T, et al. Biochim Biophys Acta. 2015 Jun;1848(6):1352-8. doi: 10.1016/j.bbamem.2015.02.021. Epub 2015 Mar 10. Biochim Biophys Acta. 2015. PMID: 25767037
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