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A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect on platelet function and bleeding diathesis.
Palma-Barqueros V, Crescente M, de la Morena ME, Chan MV, Almarza E, Revilla N, Bohdan N, Miñano A, Padilla J, Allan HE, Maffucci T, Edin ML, Zeldin DC, Mesa-Nuñez C, Damian C, Marín-Quilez A, Benito R, Martínez-Martínez I, Bermejo N, Casas-Aviles I, Rodríguez-Alen A, González-Porras JR, Hernández-Rivas JM, Vicente V, Corral J, Lozano ML, Warner TD, Bastida JM, Rivera J. Palma-Barqueros V, et al. Among authors: de la morena me. Am J Hematol. 2021 Mar 1;96(3):E83-E88. doi: 10.1002/ajh.26076. Epub 2021 Jan 5. Am J Hematol. 2021. PMID: 33326144 Free PMC article. No abstract available.
Neutrophil extracellular traps and von Willebrand factor are allies that negatively influence COVID-19 outcomes.
Fernández-Pérez MP, Águila S, Reguilón-Gallego L, de Los Reyes-García AM, Miñano A, Bravo-Pérez C, de la Morena ME, Corral J, García-Barberá N, Gómez-Verdú JM, Bernal E, Herranz MT, Vicente V, Martínez C, González-Conejero R, Lozano ML. Fernández-Pérez MP, et al. Among authors: de la morena me. Clin Transl Med. 2021 Jan;11(1):e268. doi: 10.1002/ctm2.268. Clin Transl Med. 2021. PMID: 33463053 Free PMC article. No abstract available.