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Wingless-independent association of Pygopus with dTCF target genes.
de la Roche M, Bienz M. de la Roche M, et al. Curr Biol. 2007 Mar 20;17(6):556-61. doi: 10.1016/j.cub.2007.01.063. Epub 2007 Feb 22. Curr Biol. 2007. PMID: 17320388
An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.
de la Roche M, Rutherford TJ, Gupta D, Veprintsev DB, Saxty B, Freund SM, Bienz M. de la Roche M, et al. Nat Commun. 2012 Feb 21;3:680. doi: 10.1038/ncomms1680. Nat Commun. 2012. PMID: 22353711 Free PMC article.
LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.
de la Roche M, Ibrahim AE, Mieszczanek J, Bienz M. de la Roche M, et al. Cancer Res. 2014 Mar 1;74(5):1495-505. doi: 10.1158/0008-5472.CAN-13-2682. Epub 2014 Jan 13. Cancer Res. 2014. PMID: 24419084 Free PMC article.
Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer.
Metcalfe C, Ibrahim AE, Graeb M, de la Roche M, Schwarz-Romond T, Fiedler M, Winton DJ, Corfield A, Bienz M. Metcalfe C, et al. Among authors: de la roche m. Cancer Res. 2010 Aug 15;70(16):6629-38. doi: 10.1158/0008-5472.CAN-10-1616. Epub 2010 Jul 27. Cancer Res. 2010. PMID: 20663899 Free PMC article.
A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.
Mieszczanek J, de la Roche M, Bienz M. Mieszczanek J, et al. Among authors: de la roche m. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19324-9. doi: 10.1073/pnas.0806098105. Epub 2008 Nov 26. Proc Natl Acad Sci U S A. 2008. PMID: 19036929 Free PMC article.
The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells.
de la Roche M, Worm J, Bienz M. de la Roche M, et al. BMC Cancer. 2008 Jul 15;8:199. doi: 10.1186/1471-2407-8-199. BMC Cancer. 2008. PMID: 18627596 Free PMC article.
Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.
Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvönen M, Verma C, Spring DR, Itzhaki LS. Xu W, et al. Among authors: de la roche m. J Am Chem Soc. 2017 Feb 15;139(6):2245-2256. doi: 10.1021/jacs.6b10234. Epub 2017 Feb 7. J Am Chem Soc. 2017. PMID: 28084734 Free PMC article.
Structural and functional properties of glycerol-3-phosphate dehydrogenase from a mammalian hibernator.
de la Roche M, Tessier SN, Storey KB. de la Roche M, et al. Protein J. 2012 Feb;31(2):109-19. doi: 10.1007/s10930-011-9376-3. Protein J. 2012. PMID: 22180227
Substrate affinities for hibernator muscle G3PDH were stable (NAD) or increased significantly (K(m) G3P and DHAP decreased) at low temperature whereas K(m) NAD and DHAP of rabbit G3PDH increased. Prairie dog G3PDH showed greater conservation of K(m) G3P over …
Substrate affinities for hibernator muscle G3PDH were stable (NAD) or increased significantly (K(m) G3P and DHAP decreased) at low te …
Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights.
Farooqi AA, de la Roche M, Djamgoz MBA, Siddik ZH. Farooqi AA, et al. Among authors: de la roche m. Semin Cancer Biol. 2019 Oct;58:65-79. doi: 10.1016/j.semcancer.2019.01.001. Epub 2019 Jan 8. Semin Cancer Biol. 2019. PMID: 30633978 Review.
Organoid culture media formulated with growth factors of defined cellular activity.
Urbischek M, Rannikmae H, Foets T, Ravn K, Hyvönen M, de la Roche M. Urbischek M, et al. Among authors: de la roche m. Sci Rep. 2019 Apr 17;9(1):6193. doi: 10.1038/s41598-019-42604-0. Sci Rep. 2019. PMID: 30996238 Free PMC article.
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